{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:05:39Z","timestamp":1791295539785,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"vor","delay-in-days":2543,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.bbamem.2006.02.018","type":"journal-article","created":{"date-parts":[[2006,3,14]],"date-time":"2006-03-14T13:45:47Z","timestamp":1142343947000},"page":"1085-1093","source":"Crossref","is-referenced-by-count":270,"title":["Three distinct roles of aquaporin-4 in brain function revealed by knockout mice"],"prefix":"10.1016","volume":"1758","author":[{"given":"A.S.","family":"Verkman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devin K.","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orin","family":"Bloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurtis","family":"Auguste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios C.","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamem.2006.02.018_bib1","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1056\/NEJM197510022931407","article-title":"Brain edema","volume":"293","author":"Fishman","year":"1975","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbamem.2006.02.018_bib2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1152\/ajplegacy.1919.48.4.531","article-title":"Experimental alteration of brain bulk","volume":"48","author":"Weed","year":"1919","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbamem.2006.02.018_bib3","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.1016\/S0021-9258(17)37486-0","article-title":"Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues","volume":"269","author":"Hasegawa","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2006.02.018_bib4","doi-asserted-by":"crossref","first-page":"22907","DOI":"10.1074\/jbc.270.39.22907","article-title":"cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units","volume":"270","author":"Yang","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2006.02.018_bib5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1523\/JNEUROSCI.17-01-00171.1997","article-title":"Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain","volume":"17","author":"Nielsen","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbamem.2006.02.018_bib6","doi-asserted-by":"crossref","first-page":"11981","DOI":"10.1073\/pnas.95.20.11981","article-title":"Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord","volume":"95","author":"Rash","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2006.02.018_bib7","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.neuroscience.2004.03.016","article-title":"Expression of aquaporin water channels in mouse spinal cord","volume":"127","author":"Oshio","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbamem.2006.02.018_bib8","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/glia.20196","article-title":"Distribution of Aquaporin 4 in rodent spinal cord: relationship with astrocyte markers and chondroitin sulfate proteoglycans","volume":"51","author":"Vitellaro-Zuccarello","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.bbamem.2006.02.018_bib9","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1242\/jcs.108.9.2993","article-title":"Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues","volume":"108","author":"Frigeri","year":"1995","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamem.2006.02.018_bib10","doi-asserted-by":"crossref","first-page":"4577","DOI":"10.1074\/jbc.271.9.4577","article-title":"The mercurial insensitive water channel (AQP-4) forms orthogonal arrays in stably transfected Chinese hamster ovary cells","volume":"271","author":"Yang","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2006.02.018_bib11","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1242\/jcs.110.22.2855","article-title":"Absence of orthogonal arrays in kidney, brain and muscle from transgenic knockout mice lacking water channel aquaporin-4","volume":"110","author":"Verbavatz","year":"1997","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamem.2006.02.018_bib12","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1172\/JCI231","article-title":"Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4","volume":"100","author":"Ma","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbamem.2006.02.018_bib13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/72256","article-title":"Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke","volume":"6","author":"Manley","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbamem.2006.02.018_bib14","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1096\/fj.04-1723fje","article-title":"Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema","volume":"18","author":"Papadopoulos","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.bbamem.2006.02.018_bib15","first-page":"3","article-title":"Evolution of brain edema concepts","volume":"60","author":"Klatzo","year":"1994","journal-title":"Acta Neurochir., Suppl. (Wien)"},{"key":"10.1016\/j.bbamem.2006.02.018_bib16","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3171\/jns.1995.83.6.1051","article-title":"Current concepts of brain edema. Review of laboratory investigations","volume":"83","author":"Kimelberg","year":"1995","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.bbamem.2006.02.018_bib17","first-page":"H514","article-title":"Brain edema resolution by CSF pathways and brain vasculature in cats","volume":"267","author":"Marmarou","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbamem.2006.02.018_bib18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3171\/jns.1977.46.1.0024","article-title":"Role of pressure gradients and bulk flow in dynamics of vasogenic brain edema","volume":"46","author":"Reulen","year":"1977","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.bbamem.2006.02.018_bib19","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0165-0270(01)00481-2","article-title":"Optical measurement of swelling and water transport in spinal cord slices from aquaporin null mice","volume":"113","author":"Solenov","year":"2002","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bbamem.2006.02.018_bib20","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/jnr.20439","article-title":"Noninvasive early detection of brain edema in mice by near-infrared light scattering","volume":"80","author":"Thiagarajah","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbamem.2006.02.018_bib21","doi-asserted-by":"crossref","first-page":"C426","DOI":"10.1152\/ajpcell.00298.2003","article-title":"Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching method","volume":"286","author":"Solenov","year":"2004","journal-title":"Am. J. Physiol., Cell Physiol."},{"key":"10.1016\/j.bbamem.2006.02.018_bib22","doi-asserted-by":"crossref","first-page":"13906","DOI":"10.1074\/jbc.M413627200","article-title":"Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis","volume":"280","author":"Papadopoulos","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2006.02.018_bib23","doi-asserted-by":"crossref","first-page":"13131","DOI":"10.1073\/pnas.192457099","article-title":"Delayed onset of brain edema and mislocalization of aquaporin-4 in dystrophin-null transgenic mice","volume":"99","author":"Vajda","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2006.02.018_bib24","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/glia.10216","article-title":"Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice","volume":"42","author":"Nico","year":"2003","journal-title":"Glia"},{"key":"10.1016\/j.bbamem.2006.02.018_bib25","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1471-4159.2005.03362.x","article-title":"Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess","volume":"95","author":"Bloch","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbamem.2006.02.018_bib26","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.neuint.2003.11.006","article-title":"Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology","volume":"45","author":"Abbott","year":"2004","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.bbamem.2006.02.018_bib27","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1023\/A:1025783326667","article-title":"The brain's interstitial clefts and their glial walls","volume":"31","author":"Brightman","year":"2002","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.bbamem.2006.02.018_bib28","doi-asserted-by":"crossref","unstructured":"O. Bloch, G.T. Manley, A.S. Verkman.Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4 deficient mice, J. Cereb. Blood Flow Metab. (in press)","DOI":"10.1038\/sj.jcbfm.9600306"},{"key":"10.1016\/j.bbamem.2006.02.018_bib29","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nature03460","article-title":"Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption","volume":"434","author":"Saadoun","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bbamem.2006.02.018_bib30","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.neuroscience.2004.05.028","article-title":"The responses of oligodendrocyte precursor cells, astrocytes and microglia to a cortical stab injury, in the brain","volume":"127","author":"Hampton","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbamem.2006.02.018_bib31","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0306-4522(86)90047-3","article-title":"Migration of host astrocytes into superior cervical sympathetic ganglia autografted into the septal nuclei or choroid fissure of adult rats","volume":"17","author":"Zhou","year":"1986","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbamem.2006.02.018_bib32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0306-4522(03)00285-9","article-title":"Inhibiting cell proliferation during formation of the glial scar: effects on axon regeneration in the CNS","volume":"120","author":"Rhodes","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbamem.2006.02.018_bib33","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.brainres.2004.07.086","article-title":"Vimentin-expressing proximal reactive astrocytes correlate with migration rather than proliferation following focal brain injury","volume":"1024","author":"Wang","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.bbamem.2006.02.018_bib34","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1523\/JNEUROSCI.3547-03.2004","article-title":"Reactive astrocytes protect tissue and preserve function after spinal cord injury","volume":"24","author":"Faulkner","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbamem.2006.02.018_bib35","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0896-6273(00)80781-3","article-title":"Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice","volume":"23","author":"Bush","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.bbamem.2006.02.018_bib36","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nrn1326","article-title":"Regeneration beyond the glial scar","volume":"5","author":"Silver","year":"2004","journal-title":"Nat. Rev., Neurosci."},{"key":"10.1016\/j.bbamem.2006.02.018_bib37","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/(SICI)1098-1136(199910)28:1<40::AID-GLIA5>3.0.CO;2-6","article-title":"Diffusion barriers evoked in the rat cortex by reactive astrogliosis","volume":"28","author":"Roitbak","year":"1999","journal-title":"Glia"},{"key":"10.1016\/j.bbamem.2006.02.018_bib38","doi-asserted-by":"crossref","first-page":"5691","DOI":"10.1242\/jcs.02680","article-title":"Involvement of aquaporin-4 in astroglial cell migration and glial scar formation","volume":"118","author":"Saadoun","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamem.2006.02.018_bib39","doi-asserted-by":"crossref","first-page":"F739","DOI":"10.1152\/ajprenal.2001.280.5.F739","article-title":"Function and spatial distribution of ion channels and transporters in cell migration","volume":"280","author":"Schwab","year":"2001","journal-title":"Am. J. Physiol., Renal. Physiol."},{"key":"10.1016\/j.bbamem.2006.02.018_bib40","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1242\/jcs.1987.Supplement_8.3","article-title":"The physics of cell motility","volume":"8","author":"Oster","year":"1987","journal-title":"J. Cell Sci., Suppl."},{"key":"10.1016\/j.bbamem.2006.02.018_bib41","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/dvg.1020110504","article-title":"Mechanisms of amoeboid chemotaxis: an evaluation of the cortical expansion model","volume":"11","author":"Condeelis","year":"1990","journal-title":"Dev. Genet."},{"key":"10.1016\/j.bbamem.2006.02.018_bib42","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1085\/jgp.115.5.599","article-title":"Polarization of Na+\/H+ and Cl\u2212\/HCO3\u2212 exchangers in migrating renal epithelial cells","volume":"115","author":"Klein","year":"2000","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.bbamem.2006.02.018_bib43","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/ncb0405-336","article-title":"Cell polarization mechanisms during directed cell migration","volume":"7","author":"Huttenlocher","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbamem.2006.02.018_bib44","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0079-6123(00)25030-9","article-title":"Volume transmission in the year 2000","volume":"125","author":"Nicholson","year":"2000","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.bbamem.2006.02.018_bib45","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1177\/107385849700300113","volume":"3","author":"Sykova","year":"1997","journal-title":"Neuroscientist"},{"key":"10.1016\/j.bbamem.2006.02.018_bib46","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1073\/pnas.0308408100","article-title":"Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk","volume":"101","author":"Piet","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2006.02.018_bib47","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/5692","volume":"2","author":"Grosche","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbamem.2006.02.018_bib48","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0079-6123(01)32080-0","article-title":"Calcium signaling in retinal glial cells and its effect on neuronal activity","volume":"132","author":"Newman","year":"2001","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.bbamem.2006.02.018_bib49","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1126\/science.298.5593.556","article-title":"New insights into neuron\u2013glia communication","volume":"298","author":"Fields","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bbamem.2006.02.018_bib50","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.tins.2003.08.008","article-title":"New roles for astrocytes: redefining the functional architecture of the brain","volume":"26","author":"Nedergaard","year":"2003","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbamem.2006.02.018_bib51","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/glia.20060","article-title":"Synaptic signaling between neurons and glia","volume":"47","author":"Lin","year":"2004","journal-title":"Glia"},{"key":"10.1016\/j.bbamem.2006.02.018_bib52","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1242\/jcs.02515","article-title":"Synaptic transmission onto hippocampal glial cells with hGFAP promoter activity","volume":"118","author":"Jabs","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamem.2006.02.018_bib53","doi-asserted-by":"crossref","first-page":"31233","DOI":"10.1074\/jbc.M104368200","article-title":"Impaired hearing in mice lacking aquaporin-4 water channels","volume":"276","author":"Li","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2006.02.018_bib54","first-page":"573","article-title":"Mildly abnormal retinal function in transgenic mice without Muller cell aquaporin-4 water channels","volume":"43","author":"Li","year":"2002","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbamem.2006.02.018_bib55","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/00001756-200402090-00009","article-title":"Increased seizure threshold in mice lacking aquaporin-4 water channels","volume":"15","author":"Binder","year":"2004","journal-title":"NeuroReport"},{"key":"10.1016\/j.bbamem.2006.02.018_bib56","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/glia.20318","article-title":"Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels","volume":"53","author":"Binder","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.bbamem.2006.02.018_bib57","doi-asserted-by":"crossref","first-page":"8049","DOI":"10.1523\/JNEUROSCI.2294-04.2004","article-title":"In vivo measurement of brain extracellular space diffusion by cortical surface photobleaching","volume":"24","author":"Binder","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbamem.2006.02.018_bib58","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1096\/fj.04-2834fje","article-title":"Enhanced macromolecular diffusion in brain extracellular space in mouse models of vasogenic edema measured by cortical surface photobleaching","volume":"19","author":"Papadopoulos","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.bbamem.2006.02.018_bib59","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1529\/biophysj.105.068114","article-title":"Extracellular space diffusion in central nervous system: anisotropic diffusion measured by elliptical surface photobleaching","volume":"89","author":"Papadopoulos","year":"2005","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbamem.2006.02.018_bib60","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/nmeth801","article-title":"K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator","volume":"2","author":"Padmawar","year":"2005","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbamem.2006.02.018_bib61","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neuroscience.2005.08.051","article-title":"Differential effect of alpha-syntrophin knockout on aquaporin-4 and Kir4.1 expression in retinal macroglial cells in mice","volume":"139","author":"Puwarawuttipanit","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbamem.2006.02.018_bib62","doi-asserted-by":"crossref","first-page":"13615","DOI":"10.1073\/pnas.2336064100","article-title":"Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice","volume":"100","author":"Amiry-Moghaddam","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273606000459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273606000459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T20:35:29Z","timestamp":1627158929000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0005273606000459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":62,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S0005273606000459"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamem.2006.02.018","relation":{},"ISSN":["0005-2736"],"issn-type":[{"value":"0005-2736","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}