{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:08:04Z","timestamp":1769155684688,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"vor","delay-in-days":2574,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.bbamem.2006.02.019","type":"journal-article","created":{"date-parts":[[2006,3,16]],"date-time":"2006-03-16T12:16:49Z","timestamp":1142511409000},"page":"942-947","source":"Crossref","is-referenced-by-count":18,"title":["Infrared imaging microscopy of bone: Illustrations from a mouse model of Fabry disease"],"prefix":"10.1016","volume":"1758","author":[{"given":"Adele L.","family":"Boskey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamem.2006.02.019_bib1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3233\/THC-1998-65-605","article-title":"A review of magnetic resonance (MR) imaging of trabecular bone micro-architecture: contribution to the prediction of biomechanical properties and fracture prevalence","volume":"6","author":"Majumdar","year":"1998","journal-title":"Technol. Health Care"},{"key":"10.1016\/j.bbamem.2006.02.019_bib2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0950-3579(97)80017-9","article-title":"How can we measure bone quality?","volume":"11","author":"Hans","year":"1997","journal-title":"Bailliere's Clin. Rheumatol."},{"key":"10.1016\/j.bbamem.2006.02.019_bib3","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00223-003-1002-8","article-title":"Mineral analysis provides insights into the mechanism of biomineralization","volume":"72","author":"Boskey","year":"2003","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bbamem.2006.02.019_bib4","doi-asserted-by":"crossref","first-page":"031102","DOI":"10.1117\/1.1922927","article-title":"Infrared analysis of bone in health and disease","volume":"10","author":"Boskey","year":"2005","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.bbamem.2006.02.019_bib5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.vibspec.2005.02.015","article-title":"Infrared spectroscopic characterization of mineralized tissues","volume":"38","author":"Boskey","year":"2005","journal-title":"Vibr. Spectrosc."},{"key":"10.1016\/j.bbamem.2006.02.019_bib6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF02409422","article-title":"Formation and structure of Ca-deficient hydroxyapatite","volume":"33","author":"Blumenthal","year":"1981","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bbamem.2006.02.019_bib7","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s002239900561","article-title":"MicroRaman spectral study of the PO4 and CO3 vibrational modes in synthetic and biological apatites","volume":"63","author":"Penel","year":"1998","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bbamem.2006.02.019_bib8","first-page":"7","article-title":"The physicochemical structure of bone: cellular and noncellular elements","volume":"20","author":"Green","year":"1994","journal-title":"Miner. Electrolyte Metab."},{"key":"10.1016\/j.bbamem.2006.02.019_bib9","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1210\/en.2004-1343","article-title":"Minireview: transcriptional regulation in development of bone","volume":"146","author":"Kobayashi","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbamem.2006.02.019_bib10","first-page":"107","article-title":"The Biochemistry of Bone","volume":"vol 1","author":"Gokhale","year":"2001"},{"key":"10.1016\/j.bbamem.2006.02.019_bib11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/8756-3282(95)00210-5","article-title":"Effect of abnormal mineralization on the mechanical behavior of X-linked hypophosphatemic mice femora","volume":"17","author":"Camacho","year":"1995","journal-title":"Bone"},{"key":"10.1016\/j.bbamem.2006.02.019_bib12","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0002-9440(10)62481-9","article-title":"Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase\/nucleotide pyrophosphatase phosphodiesterase 1 double-deficient mice","volume":"166","author":"Anderson","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbamem.2006.02.019_bib13","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0002-9440(10)63172-0","article-title":"Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice","volume":"164","author":"Anderson","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbamem.2006.02.019_bib14","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1074\/jbc.M203250200","article-title":"Targeted disruption of the osteoblast\/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass","volume":"278","author":"Gowen","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2006.02.019_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0079-6336(96)80011-8","article-title":"Lipids and biomineralizations","volume":"31","author":"Goldberg","year":"1996","journal-title":"Prog. Histochem. Cytochem."},{"key":"10.1016\/j.bbamem.2006.02.019_bib16","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0021-9290(03)00122-2","article-title":"A rate-dependent microcrack-bridging model that can explain the strain rate dependency of cortical bone apparent yield strength","volume":"36","author":"Yeni","year":"2003","journal-title":"J. Biomech."},{"key":"10.1016\/j.bbamem.2006.02.019_bib17","first-page":"404","article-title":"Non-invasive measurements of bone strength: promise and peril","volume":"4","author":"Bouxsein","year":"2004","journal-title":"J. Musculoskelet. Neuronal. Interact."},{"key":"10.1016\/j.bbamem.2006.02.019_bib18","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1080\/03008200390223918","article-title":"Spectroscopically determined collagen Pyr\/deH-DHLNL cross-link ratio and crystallinity indices differ markedly in recombinant congenic mice with divergent calculated bone tissue strength","volume":"44","author":"Blank","year":"2003","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.bbamem.2006.02.019_bib19","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1359\/jbmr.1997.12.11.1936","article-title":"Inferior mechanical properties, lower bone mineral densities, and altered mineral structure of canine bones after calcitonin treatment","volume":"12","author":"Pienkowski","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbamem.2006.02.019_bib20","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.bone.2004.08.019","article-title":"Infrared imaging of calcified tissue in bone biopsies from adults with osteomalacia","volume":"36","author":"Faibish","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.bbamem.2006.02.019_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF02509540","article-title":"Fourier transform infrared spectroscopy of the solution mediated conversion of amorphous calcium phosphate to hydroxyapatite: new correlations between X-ray diffraction to infrared data","volume":"58","author":"Gadaleta","year":"1996","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bbamem.2006.02.019_bib22","first-page":"S69","article-title":"Preparation, analysis, and characterization of carbonated apatites","volume":"34","author":"Nelson","year":"1982","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bbamem.2006.02.019_bib23","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1359\/jbmr.2001.16.10.1821","article-title":"Spectroscopic characterization of collagen cross-links in bone","volume":"16","author":"Paschalis","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbamem.2006.02.019_bib24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0005-2736(84)90173-1","article-title":"Fourier transform infrared spectroscopic studies of lipid\u2013protein interaction in native and reconstituted sarcoplasmic reticulum","volume":"775","author":"Mendelsohn","year":"1984","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.bbamem.2006.02.019_bib25","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3109\/03008209609029214","article-title":"The role of type X collagen in endochondral ossification as deduced by Fourier transform infrared microscopy analysis","volume":"35","author":"Paschalis","year":"1996","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.bbamem.2006.02.019_bib26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S8756-3282(98)00092-1","article-title":"Fourier transform infrared microspectroscopic analysis of bones of osteocalcin-deficient mice provides insight into the function of osteocalcin","volume":"23","author":"Boskey","year":"1998","journal-title":"Bone"},{"key":"10.1016\/j.bbamem.2006.02.019_bib27","series-title":"Chemistry and Biology of Mineralized Tissues","first-page":"63","article-title":"Mineral characterization of bones and soft tissues in matrix glia protein deficient mice","author":"Boskey","year":"2000"},{"key":"10.1016\/j.bbamem.2006.02.019_bib28","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/1746","article-title":"Targeted disruption of the biglycan gene leads to osteoporosis in mice","volume":"20","author":"Xu","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbamem.2006.02.019_bib29","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00223-001-1121-z","article-title":"Osteopontin deficiency increases mineral content and mineral crystallinity in mouse bone","volume":"71","author":"Boskey","year":"2002","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bbamem.2006.02.019_bib30","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1359\/jbmr.2003.18.6.1005","article-title":"Infrared analysis of the mineral and matrix in bones of osteonectin-null mice and their wildtype controls","volume":"18","author":"Boskey","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbamem.2006.02.019_bib31","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1359\/JBMR.050815","article-title":"DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis","volume":"20","author":"Ling","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbamem.2006.02.019_bib32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00223-004-0076-2","article-title":"Overexpression of IGF-binding protein 5 alters mineral and matrix properties in mouse femora: an infrared imaging study","volume":"76","author":"Atti","year":"2005","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bbamem.2006.02.019_bib33","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00223-002-2139-6","article-title":"Targeted overexpression of vitamin D receptor in osteoblasts increases calcium concentration without affecting structural properties of bone mineral crystals","volume":"73","author":"Misof","year":"2003","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bbamem.2006.02.019_bib34","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S8756-3282(02)00905-5","article-title":"Effects of transforming growth factor-beta deficiency on bone development: a Fourier transform-infrared imaging analysis","volume":"31","author":"Atti","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.bbamem.2006.02.019_bib35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1096-7192(02)00151-8","article-title":"Structural basis of Fabry disease","volume":"77","author":"Garman","year":"2002","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bbamem.2006.02.019_bib36","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/08035320510031045","article-title":"Genotype and phenotype in Fabry disease: analysis of the Fabry Outcome Survey","volume":"94","author":"Schaefer","year":"2005","journal-title":"Acta Paediatr., Suppl."},{"key":"10.1016\/j.bbamem.2006.02.019_bib37","first-page":"36","article-title":"Fabry disease, a disease with rheumatic aspects: radiology of soft tissue and bone changes in the hand","volume":"45","author":"Fischer","year":"1986","journal-title":"Z. Rheumatol."},{"key":"10.1016\/j.bbamem.2006.02.019_bib38","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1399-0004.2005.00457.x","article-title":"Osteopenia and osteoporosis: previously unrecognized manifestations of Fabry disease","volume":"68","author":"Germain","year":"2005","journal-title":"Clin. Genet."},{"key":"10.1016\/j.bbamem.2006.02.019_bib39","first-page":"192","article-title":"Bilateral femoral head and distal tibial osteonecrosis in a patient with Fabry disease","volume":"34","author":"Lien","year":"2005","journal-title":"Am. J. Orthop."},{"key":"10.1016\/j.bbamem.2006.02.019_bib40","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1002\/art.10391","article-title":"Avascular necrosis of the femoral head in a patient with Fabry's disease: identification of ceramide trihexoside in the bone by delayed-extraction matrix-assisted laser desorption ionization-time-of-flight mass spectrometry","volume":"46","author":"Horiuchi","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbamem.2006.02.019_bib41","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1073\/pnas.94.6.2540","article-title":"\u00c1-galactosidase A deficient mice: a model of Fabry disease","volume":"94","author":"Oshima","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2006.02.019_bib42","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s00223-001-1016-z","article-title":"Optimal methods for processing mineralized tissues for Fourier transform infrared microspectroscopy","volume":"70","author":"Aparicio","year":"2002","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bbamem.2006.02.019_bib43","first-page":"265","article-title":"Dentin and enamel phenotype in Fabry mice","volume":"4","author":"Goldberg","year":"2005","journal-title":"Oral Biosci. Med."},{"key":"10.1016\/j.bbamem.2006.02.019_bib44","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1442-200x.2004.01983.x","article-title":"Long-term expressed human alpha-galactosidase A in tissues of HalphaG transgenic mice","volume":"46","author":"Hoshikawa","year":"2004","journal-title":"Pediatr. Int."},{"key":"10.1016\/j.bbamem.2006.02.019_bib45","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1359\/JBMR.050710","article-title":"Novel assessment of bone using time-resolved transcutaneous Raman spectroscopy","volume":"20","author":"Draper","year":"2005","journal-title":"J. Bone Miner. Res."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000527360600071X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000527360600071X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T06:54:40Z","timestamp":1586760880000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000527360600071X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S000527360600071X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamem.2006.02.019","relation":{},"ISSN":["0005-2736"],"issn-type":[{"value":"0005-2736","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}