{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:56:33Z","timestamp":1790283393650,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":2152,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1016\/j.bbamem.2007.05.001","type":"journal-article","created":{"date-parts":[[2007,5,24]],"date-time":"2007-05-24T07:39:32Z","timestamp":1179992372000},"page":"2421-2431","source":"Crossref","is-referenced-by-count":27,"title":["Biophysical analysis of the interaction of granulysin-derived peptides with enterobacterial endotoxins"],"prefix":"10.1016","volume":"1768","author":[{"given":"Xi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Howe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Andr\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"R\u00f6ssle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula Galv\u00e3o","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan M.","family":"Krensky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Clayberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Brandenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamem.2007.05.001_bib1","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1097\/00003246-200104000-00039","article-title":"New strategies for clinical trials in patients with sepsis and septic shock","volume":"29","author":"Cohen","year":"2001","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.bbamem.2007.05.001_bib2","first-page":"39","article-title":"Bacterial endotoxin: Chemical constitution, biological recognition, host response, and immunological detoxification","volume":"216","author":"Rietschel","year":"1996","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.bbamem.2007.05.001_bib3","series-title":"Immunological Adjuvants and Vaccines Plenum Corporation","first-page":"61","article-title":"Bacterial Endotoxins: Relationships between chemical structure and biological activity","author":"Rietschel","year":"1989"},{"key":"10.1016\/j.bbamem.2007.05.001_bib4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.iy.13.040195.000425","article-title":"Peptide antibiotics and their role in innate immunity","volume":"13","author":"Boman","year":"1995","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbamem.2007.05.001_bib5","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1517\/13543784.9.8.1723","article-title":"Cationic antimicrobial peptides: towards clinical applications","volume":"9","author":"Hancock","year":"2000","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.bbamem.2007.05.001_bib6","first-page":"261","article-title":"Mechanisms of endotoxin neutralization by synthetic cationic compounds","volume":"12","author":"Andr\u00e4","year":"2006","journal-title":"J. Endotoxin Res."},{"key":"10.1016\/j.bbamem.2007.05.001_bib7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/smim.1997.0061","article-title":"Granulysin, a new human cytolytic granule-associated protein with possible involvement in cell-mediated cytotoxicity","volume":"9","author":"Pena","year":"1997","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.bbamem.2007.05.001_bib8","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1111\/j.1600-6143.2005.00970.x","article-title":"Granulysin: a novel host defense molecule","volume":"5","author":"Krensky","year":"2005","journal-title":"Am. J. Transp."},{"key":"10.1016\/j.bbamem.2007.05.001_bib9","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0022-2836(02)01234-2","article-title":"Granulysin crystal structure and a structure-derived lytic mechanism","volume":"325","author":"Anderson","year":"2003","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbamem.2007.05.001_bib10","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.4049\/jimmunol.165.3.1486","article-title":"Bactericidal and tumoricidal activities of synthetic peptides derived from granulysin","volume":"165","author":"Wang","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbamem.2007.05.001_bib11","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1128\/IAI.67.1.201-205.1999","article-title":"Interaction of NK lysin, a peptide produced by cytolytic lymphocytes, with endotoxin","volume":"67","author":"Andersson","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bbamem.2007.05.001_bib12","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1128\/AAC.48.5.1593-1599.2004","article-title":"Biophysical characterization of endotoxin inactivation by NK-2, an antimicrobial peptide derived from mammalian NK-lysin","volume":"48","author":"Andr\u00e4","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbamem.2007.05.001_bib13","doi-asserted-by":"crossref","first-page":"13503","DOI":"10.1073\/pnas.0606026103","article-title":"The PhoP\/PhoQ two-component system stabilizes the alternative sigma factor RpoS in Salmonella enterica","volume":"103","author":"Tu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2007.05.001_bib14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1432-1033.1969.tb00601.x","article-title":"A new method for the extraction of R lipopolysaccharides","volume":"9","author":"Galanos","year":"1969","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbamem.2007.05.001_bib15","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1515\/znb-1952-0303","article-title":"Uber die Extraktion von Bakterien mit Phenol\/Wasser","volume":"7","author":"Westphal","year":"1952","journal-title":"Z. Naturforsch."},{"key":"10.1016\/j.bbamem.2007.05.001_bib16","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1046\/j.1432-1327.2001.02338.x","article-title":"Interaction of hemoglobin with enterobacterial lipopolysaccharide and lipid A. Physicochemical characterization and biological activity","volume":"268","author":"J\u00fcrgens","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbamem.2007.05.001_bib17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0009-3084(98)00078-4","article-title":"Infrared spectroscopy of glycolipids","volume":"96","author":"Brandenburg","year":"1998","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.bbamem.2007.05.001_bib18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/masy.19880150106","article-title":"Instruments and methods for small-angle scattering with synchrotron radiation","volume":"15","author":"Koch","year":"1988","journal-title":"Makromol. Chem., Macromol. Symp."},{"key":"10.1016\/j.bbamem.2007.05.001_bib19","doi-asserted-by":"crossref","first-page":"5972","DOI":"10.1046\/j.1432-1033.2002.03333.x","article-title":"Biophysical characterization of the interaction of high-density lipoprotein (HDL) with endotoxins","volume":"269","author":"Brandenburg","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbamem.2007.05.001_bib20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0014-5793(96)01338-5","article-title":"Lipopolysaccharide-binding protein mediates CD14-independent intercalation of lipopolysaccharide into phospholipid membranes","volume":"399","author":"Schromm","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbamem.2007.05.001_bib21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2739\/kurumemedj.50.99","article-title":"Interactions of a small linear cationic peptide with lipopolysaccharide and lipoteichoic acid","volume":"50","author":"Hamamoto","year":"2003","journal-title":"Kurume Med. J."},{"key":"10.1016\/j.bbamem.2007.05.001_bib22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1042\/BJ20041270","article-title":"Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide","volume":"385","author":"Andr\u00e4","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbamem.2007.05.001_bib23","doi-asserted-by":"crossref","first-page":"26307","DOI":"10.1074\/jbc.M401231200","article-title":"Aggregates are the biologically active units of endotoxin","volume":"279","author":"Mueller","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2007.05.001_bib24","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1006\/jsbi.1993.1026","article-title":"Structural polymorphisms of rough mutant lipopolysaccharides Rd to Ra from Salmonella minnesota","volume":"110","author":"Seydel","year":"1993","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.bbamem.2007.05.001_bib25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/1047-8477(92)90010-8","article-title":"Phase diagram of deep rough mutant lipopolysaccharide from Salmonella minnesota R595","volume":"108","author":"Brandenburg","year":"1992","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.bbamem.2007.05.001_bib26","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.1039\/b004188m","article-title":"Lipopolysaccharide-binding protein-mediated interaction of lipid A from different origin with phospholipid membanes","volume":"2","author":"Gutsmann","year":"2000","journal-title":"Phys. Chem. Chem. Phys"},{"key":"10.1016\/j.bbamem.2007.05.001_bib27","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1111\/j.1432-1033.2004.04134.x","article-title":"Biophysical characterization of the interaction of Limulus polyphemus endotoxin neutralizing protein with lipopolysaccharide","volume":"271","author":"Andr\u00e4","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbamem.2007.05.001_bib28","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1432-1033.1989.tb14676.x","article-title":"Characterization of the lipid A component of genuine smooth-form lipopolysaccharide","volume":"180","author":"Jiao","year":"1989","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbamem.2007.05.001_bib29","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1096\/fasebj.8.2.8119492","article-title":"Bacterial endotoxin: molecular relationships of structure to activity and function","volume":"8","author":"Riestchel","year":"1994","journal-title":"FASEB J."},{"key":"10.1016\/j.bbamem.2007.05.001_bib30","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.2174\/1568026043388213","article-title":"Endotoxins: relationships between structure, function, and activity","volume":"4","author":"Brandenburg","year":"2004","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bbamem.2007.05.001_bib31","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.bcp.2004.05.054","article-title":"Cyclic antimicrobial peptides based on Limulus anti-lipopolysaccharide factor for neutralization of lipopolysaccharide","volume":"68","author":"Andr\u00e4","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbamem.2007.05.001_bib32","series-title":"Microbial Toxins","first-page":"127","article-title":"The Physical Structure of Bacterial Lipopolysacchrides","author":"Shands","year":"1971"},{"key":"10.1016\/j.bbamem.2007.05.001_bib33","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1084\/jem.179.1.269","article-title":"Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14","volume":"179","author":"Hailman","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbamem.2007.05.001_bib34","first-page":"195","article-title":"A biophysical view on the function and activity of endotoxins","author":"Seydel","year":"1999"},{"key":"10.1016\/j.bbamem.2007.05.001_bib35","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1529\/biophysj.104.047944","article-title":"Temperature dependence of the binding of endotoxins to the polycationic peptides polymyxin B and its nonapeptide","volume":"88","author":"Brandenburg","year":"2005","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbamem.2007.05.001_bib36","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0040-6031(01)00731-6","article-title":"Biophysical investigations into the interaction of lipopolysaccharide with polymyxins","volume":"382","author":"Brandenburg","year":"2002","journal-title":"Thermochim. Acta"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273607001642?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273607001642?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T08:27:05Z","timestamp":1587544025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0005273607001642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S0005273607001642"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamem.2007.05.001","relation":{},"ISSN":["0005-2736"],"issn-type":[{"value":"0005-2736","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}