{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:19:53Z","timestamp":1782407993210,"version":"3.54.5"},"reference-count":68,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T00:00:00Z","timestamp":1416355200000},"content-version":"vor","delay-in-days":2240,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.bbamem.2008.04.007","type":"journal-article","created":{"date-parts":[[2008,4,28]],"date-time":"2008-04-28T07:33:06Z","timestamp":1209367986000},"page":"2165-2176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Psychotropic drugs interfere with the tight coupling of polyphosphoinositide cycle metabolites in human platelets: A result of receptor-independent drug intercalation in the plasma membrane?"],"prefix":"10.1016","volume":"1778","author":[{"given":"Ramadhan","family":"Oruch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erlend","family":"Hodneland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian F.","family":"Pryme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holm","family":"Holmsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamem.2008.04.007_bib1","series-title":"Handbook of Platelet Physiology and Pharmacology","first-page":"188","article-title":"Biochemistry of platelet activation","author":"Ryningen","year":"1999"},{"key":"10.1016\/j.bbamem.2008.04.007_bib2","series-title":"Platelets","first-page":"319","article-title":"Signal transduction during platelet plug formation","author":"Brass","year":"2007"},{"key":"10.1016\/j.bbamem.2008.04.007_bib3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0167-4889(86)90103-5","article-title":"Phosphate turnover of phosphatidylinositol in resting and thrombin-stimulated platelets","volume":"889","author":"Tysnes","year":"1986","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2008.04.007_bib4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1432-1033.1988.tb14064.x","article-title":"Rates of production and consumption of phosphatidic acid upon thrombin stimulation of human platelets","volume":"174","author":"Tysnes","year":"1988","journal-title":"Eur. J. Biochem. FEBS"},{"key":"10.1016\/j.bbamem.2008.04.007_bib5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0163-7827(84)90001-8","article-title":"Intracellular translocation of phosphatidate phosphohydrolase and its possible role in the control of glycerolipid synthesis","volume":"23","author":"Brindley","year":"1984","journal-title":"Prog. Lipid Res."},{"issue":"3","key":"10.1016\/j.bbamem.2008.04.007_bib6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/09537100701777329","article-title":"Phospholipase D in human platelets: presence of isoenzymes and participation of autocrine stimulation during thrombin activation","volume":"19","author":"Vorland","year":"2008","journal-title":"Platelets"},{"key":"10.1016\/j.bbamem.2008.04.007_bib7","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0167-4889(87)90007-3","article-title":"Studies on the preferential incorporation of [3H]glycerol over [32P]phosphate into major phospholipids of human platelets","volume":"930","author":"Tysnes","year":"1987","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2008.04.007_bib8","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0031-6997(25)06931-5","article-title":"The membrane actions of anesthetics and tranquilizers","volume":"24","author":"Seeman","year":"1972","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbamem.2008.04.007_bib9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0027-5107(92)90044-3","article-title":"Chlorpromazine-induced damage on nucleic acids: a combined cytogenetic and biochemical study","volume":"265","author":"Lialiaris","year":"1992","journal-title":"Mutat. Res."},{"key":"10.1016\/j.bbamem.2008.04.007_bib10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1098\/rspb.1986.0008","article-title":"Influence of dietary lipids on the effect of chlorpromazine on membrane properties of rabbit red cells","volume":"227","author":"Housley","year":"1986","journal-title":"Proc. R. Soc. Lond., B,"},{"key":"10.1016\/j.bbamem.2008.04.007_bib11","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/0006-8993(89)90607-0","article-title":"Effects of chlordiazepoxide, chlorpromazine, diazepam, diphenylhydantoin, flunitrazepam and haloperidol on the voltage-dependent sodium current of isolated mammalian brain neurons","volume":"494","author":"Wakamori","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/j.bbamem.2008.04.007_bib12","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0022-3565(25)23810-1","article-title":"Inhibition of K+ channels by chlorpromazine in rat ventricular myocytes","volume":"271","author":"Kon","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbamem.2008.04.007_bib13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0014-2999(91)90569-C","article-title":"Chlorpromazine and related phenothiazines inhibit the ATP-sensitive K+ channel","volume":"198","author":"Muller","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbamem.2008.04.007_bib14","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0006-3495(92)81617-X","article-title":"Spin-labeling studies of the conformation of the Ca(2+)-regulatory protein calmodulin in solution and bound to the membrane skeleton in erythrocyte ghosts: implications to transmembrane signaling","volume":"63","author":"Yacko","year":"1992","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbamem.2008.04.007_bib15","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1016\/0006-2952(89)90475-9","article-title":"Effects of chlorpromazine and trifluoperazine on choline metabolism and phosphatidylcholine biosynthesis in cultured chick heart cells under normoxic and anoxic conditions","volume":"38","author":"Rabkin","year":"1989","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbamem.2008.04.007_bib16","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/0006-2952(92)90104-Q","article-title":"Chlorpromazine increases the turnover of metabolically active phosphoinositides and elevates the steady-state level of phosphatidylinositol-4-phosphate in human platelets","volume":"44","author":"Frolich","year":"1992","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbamem.2008.04.007_bib17","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/0005-2736(86)90037-4","article-title":"Partition of chlorpromazine into lipid bilayer membranes: the effect of membrane structure and composition","volume":"856","author":"Luxnat","year":"1986","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2008.04.007_bib18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF03191315","article-title":"Incorporation of chlorpromazine into bilayer liposomes for protection against microsomal metabolism and liver absorption","volume":"13","author":"Schwendener","year":"1988","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.bbamem.2008.04.007_bib19","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1139\/y87-064","article-title":"Effect of chlorpromazine on the synthesis, hydrolysis, and transfer of microsomal cytidine liponucleotides and mitochondrial polyglycerophosphatides","volume":"65","author":"Stuhne-Sekalec","year":"1987","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.bbamem.2008.04.007_bib20","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0006-2952(01)00542-1","article-title":"Chlorpromazine-induced increase in dipalmitoylphosphatidylserine surface area in monolayers at room temperature","volume":"61","author":"Agasosler","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbamem.2008.04.007_bib21","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0049-3848(84)90298-6","article-title":"Differential effects of trifluoperazine on arachidonate liberation, secretion and myosin phosphorylation in intact platelets","volume":"36","author":"Holmsen","year":"1984","journal-title":"Thromb. Res."},{"key":"10.1016\/j.bbamem.2008.04.007_bib22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0006-2952(90)90701-L","article-title":"Chlorpromazine makes the platelet plasma membrane permeable for low-molecular weight substances and reduces ATP production","volume":"40","author":"Holmsen","year":"1990","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbamem.2008.04.007_bib23","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0006-2952(00)00445-7","article-title":"The stimulatory effects of cationic amphiphilic drugs on human platelets treated with thrombin","volume":"60","author":"Tharmapathy","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbamem.2008.04.007_bib24","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s002100000339","article-title":"Dopamine receptors in human platelets","volume":"363","author":"Ricci","year":"2001","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.bbamem.2008.04.007_bib25","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bpc.2005.05.002","article-title":"Importance of polyunsaturated acyl chains in chlorpromazine interaction with phosphatidylserines: a 13C and 31P solid-state NMR study","volume":"117","author":"Chen","year":"2005","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.bbamem.2008.04.007_bib26","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0005-2736(00)00125-5","article-title":"Chlorpromazine interaction with glycerophospholipid liposomes studied by magic angle spinning solid state (13)C-NMR and differential scanning calorimetry","volume":"1464","author":"Nerdal","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2008.04.007_bib27","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbalip.2004.01.004","article-title":"Chlorpromazine interaction with phosphatidylserines: a (13)C and (31)P solid-state NMR study","volume":"1682","author":"Underhaug Gjerde","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2008.04.007_bib28","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1055\/s-0038-1647307","article-title":"Trifluoperazine enhances accumulation and inhibits phosphohydrolysis of phosphatidate in thrombin-stimulated platelets","volume":"64","author":"Holmsen","year":"1990","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.bbamem.2008.04.007_bib29","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/bj2630621","article-title":"Evidence for tight metabolic control of the receptor-activated polyphosphoinositide cycle in human platelets","volume":"263","author":"Steen","year":"1989","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbamem.2008.04.007_bib30","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0014-5793(90)80757-A","article-title":"Evidence that chlorpromazine and prostaglandin E1 but not neomycin interfere with the inositol phospholipid metabolism in intact human platelets","volume":"264","author":"Tysnes","year":"1990","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbamem.2008.04.007_bib31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1432-1033.1987.tb13475.x","article-title":"Turnover of the phosphomonoester groups of polyphosphoinositol lipids in unstimulated human platelets","volume":"166","author":"Verhoeven","year":"1987","journal-title":"Eur. J. biochem. FEBS"},{"key":"10.1016\/j.bbamem.2008.04.007_bib32","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0049-3848(85)90268-3","article-title":"Thin-layer chromatography of polyphosphoinositides from platelet extracts: interference by an unknown phospholipid","volume":"40","author":"Tysnes","year":"1985","journal-title":"Thromb. Res."},{"key":"10.1016\/j.bbamem.2008.04.007_bib33","first-page":"811","article-title":"Studies on gel-filtered human platelets: isolation and characterization in a medium containing no added Ca2+, Mg2+, or K+","volume":"85","author":"Lages","year":"1975","journal-title":"J. lab. Clin. Med."},{"key":"10.1016\/j.bbamem.2008.04.007_bib34","doi-asserted-by":"crossref","first-page":"9393","DOI":"10.1016\/S0021-9258(19)68772-7","article-title":"Thrombin-induced platelet responses differ in requirement for receptor occupancy. Evidence for tight coupling of occupancy and compartmentalized phosphatidic acid formation","volume":"256","author":"Holmsen","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2008.04.007_bib35","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1021\/la061628b","article-title":"Trifluoperazine causes a disturbance in glycerophospholipid monolayers containing phosphatidylserine (PS): effects of pH, acyl unsaturation, and proportion of PS","volume":"23","author":"Broniec","year":"2007","journal-title":"Langmuir"},{"key":"10.1016\/j.bbamem.2008.04.007_bib36","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/0006-2952(87)90058-X","article-title":"Enzymatic hydrolysis of haloperidol decanoate and its inhibition by proteins","volume":"36","author":"Nambu","year":"1987","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbamem.2008.04.007_bib37","first-page":"238","article-title":"Application of solid-phase microextraction in the investigation of protein binding of pharmaceuticals","volume":"830","author":"Theodoridis","year":"2006","journal-title":"J. Chromatog."},{"key":"10.1016\/j.bbamem.2008.04.007_bib38","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1016\/0006-2952(83)90019-9","article-title":"Binding of phenothiazine neuroleptics to plasma proteins","volume":"32","author":"Verbeeck","year":"1983","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbamem.2008.04.007_bib39","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.jpba.2004.02.019","article-title":"Protein binding study of clozapine by capillary electrophoresis in the frontal analysis mode","volume":"35","author":"Zhou","year":"2004","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.bbamem.2008.04.007_bib40","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0166-2236(03)00178-4","article-title":"Visualizing phosphoinositide signalling in single neurons gets a green light","volume":"26","author":"Nahorski","year":"2003","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbamem.2008.04.007_bib41","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev.cellbio.21.021704.102317","article-title":"Regulation of protein activities by phosphoinositide phosphates","volume":"21","author":"Niggli","year":"2005","journal-title":"Ann. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.bbamem.2008.04.007_bib42","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nrm1100","article-title":"Nuclear lipid signalling","volume":"4","author":"Irvine","year":"2003","journal-title":"Nat. Rev."},{"key":"10.1016\/j.bbamem.2008.04.007_bib43","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.tips.2005.10.004","article-title":"An emerging role for PtdIns(4,5)P2-mediated signalling in human disease","volume":"26","author":"Halstead","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbamem.2008.04.007_bib44","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0167-4889(88)90015-8","article-title":"Phosphatidylinositol kinase of bovine adrenal chromaffin granules: kinetic properties and inhibition by low concentrations of Ca2+","volume":"968","author":"Husebye","year":"1988","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2008.04.007_bib45","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/0167-4889(89)90169-9","article-title":"Purification and kinetic properties of a soluble phosphatidylinositol-4-phosphate kinase of the bovine adrenal medulla with emphasis on its inhibition by calcium ions","volume":"1010","author":"Husebye","year":"1989","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2008.04.007_bib46","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0003-9861(89)90251-8","article-title":"Regulation of polyphosphoinositide synthesis in cardiac membranes","volume":"271","author":"Quist","year":"1989","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbamem.2008.04.007_bib47","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0005-2760(90)90161-P","article-title":"Purification and kinetic properties of a membrane-bound phosphatidylinositol kinase of the bovine adrenal medulla","volume":"1042","author":"Husebye","year":"1990","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2008.04.007_bib48","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/0006-3223(91)90354-O","article-title":"Effects of chlorpromazine on phosphatidylinositol turnover following thrombin stimulation of human platelets","volume":"29","author":"Wakatabe","year":"1991","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbamem.2008.04.007_bib49","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1471-4159.1985.tb05483.x","article-title":"Calcium- and calmodulin-dependent phosphorylation of diphosphoinositide in acetylcholine receptor-rich membranes from electroplax of Narke japonica","volume":"45","author":"Hayashi","year":"1985","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbamem.2008.04.007_bib50","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1042\/bj2190471","article-title":"Ca2+-sensitive phosphatidylinositol 4-phosphate metabolism in a rat beta-cell tumour","volume":"219","author":"Tooke","year":"1984","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbamem.2008.04.007_bib51","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0009-3084(01)00175-X","article-title":"Comparison of the effects of clozapine, chlorpromazine, and haloperidol on membrane lateral heterogeneity","volume":"112","author":"Jutila","year":"2001","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.bbamem.2008.04.007_bib52","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/0006-2952(89)90065-8","article-title":"Partition coefficients of dopamine antagonists in brain membranes and liposomes","volume":"38","author":"Oliveira","year":"1989","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbamem.2008.04.007_bib53","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0003-9861(92)90502-N","article-title":"Partitioning and membrane disordering effects of dopamine antagonists: influence of lipid peroxidation, temperature, and drug concentration","volume":"295","author":"Palmeira","year":"1992","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbamem.2008.04.007_bib54","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jcis.2008.01.034","article-title":"Modification of membrane heterogeneity by antipsychotic drugs: an X-ray diffraction comparative study","volume":"320","author":"Tessier","year":"2008","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.bbamem.2008.04.007_bib55","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0005-2736(83)90317-6","article-title":"The effect of trifluoroperazine on the sarcoplasmic reticulum membrane","volume":"730","author":"Ho","year":"1983","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2008.04.007_bib56","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0005-2736(86)90044-1","article-title":"Trifluoperazine inhibits Sendai virus-induced hemolysis","volume":"856","author":"MacDonald","year":"1986","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2008.04.007_bib57","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0005-2736(98)00090-X","article-title":"Contribution of trifluoperazine\/lipid ratio and drug ionization to hemolysis","volume":"1373","author":"Malheiros","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2008.04.007_bib58","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0301-4622(99)00125-8","article-title":"Pathways involved in trifluoperazine-, dibucaine- and praziquantel-induced hemolysis","volume":"83","author":"Malheiros","year":"2000","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.bbamem.2008.04.007_bib59","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1006\/bbrc.1998.9590","article-title":"Inhibition of protein import into mitochondria by amphiphilic cations: potential targets and mechanism of action","volume":"252","author":"Pavlov","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbamem.2008.04.007_bib60","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bpc.2005.11.007","article-title":"Existence of lipid microdomains in bilayer of dipalmitoyl phosphatidylcholine (DPPC) and 1-stearoyl-2-docosahexenoyl phosphatidylserine (SDPS) and their perturbation by chlorpromazine: a 13C and 31P solid-state NMR study","volume":"120","author":"Song","year":"2006","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.bbamem.2008.04.007_bib61","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0301-4622(01)00152-1","article-title":"Chlorpromazine associates with phosphatidylserines to cause an increase in the lipid's own interfacial molecular area\u2014role of the fatty acyl composition","volume":"91","author":"Varnier Agasoster","year":"2001","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.bbamem.2008.04.007_bib62","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1248\/cpb.53.147","article-title":"Effects of phosphatidylserine and phosphatidylethanolamine content on partitioning of triflupromazine and chlorpromazine between phosphatidylcholine-aminophospholipid bilayer vesicles and water studied by second-derivative spectrophotometry","volume":"53","author":"Takegami","year":"2005","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.bbamem.2008.04.007_bib63","doi-asserted-by":"crossref","first-page":"8804","DOI":"10.1021\/jp056678o","article-title":"Molecular dynamics simulations of neutral chlorpromazine in zwitterionic phospholipid monolayers","volume":"110","author":"Pickholz","year":"2006","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.bbamem.2008.04.007_bib64","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.bpc.2006.10.010","article-title":"Interactions of chlorpromazine with phospholipid monolayers: effects of the ionization state of the drug","volume":"125","author":"Pickholz","year":"2007","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.bbamem.2008.04.007_bib65","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.2042-7158.1993.tb05660.x","article-title":"Partition of dopamine antagonists into synthetic lipid bilayers: the effect of membrane structure and composition","volume":"45","author":"Sarmento","year":"1993","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.bbamem.2008.04.007_bib66","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1440-1681.2007.04650.x","article-title":"In vitro effects of antipsychotics on human platelet adhesion and aggregation and plasma coagulation","volume":"34","author":"Axelsson","year":"2007","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.bbamem.2008.04.007_bib67","first-page":"142","article-title":"Phenothiazine compounds enhance phentolamine effects on platelet aggregation and thromboxane B2 production","volume":"307","author":"Anfossi","year":"1990","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.bbamem.2008.04.007_bib68","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0049-3848(83)90126-3","article-title":"TFP inhibits the expression of the endogenous platelet lectin and secretion of alpha-granules","volume":"29","author":"Gartner","year":"1983","journal-title":"Thromb. Res."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273608001405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273608001405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:45:43Z","timestamp":1762091143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0005273608001405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":68,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0005273608001405"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamem.2008.04.007","relation":{},"ISSN":["0005-2736"],"issn-type":[{"value":"0005-2736","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Psychotropic drugs interfere with the tight coupling of polyphosphoinositide cycle metabolites in human platelets: A result of receptor-independent drug intercalation in the plasma membrane?","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Biomembranes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamem.2008.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}