{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:46:55Z","timestamp":1788245215216,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.bbamem.2012.09.021","type":"journal-article","created":{"date-parts":[[2012,9,29]],"date-time":"2012-09-29T05:48:42Z","timestamp":1348897722000},"page":"677-686","source":"Crossref","is-referenced-by-count":55,"title":["A novel antimicrobial peptide derived from modified N-terminal domain of bovine lactoferrin: Design, synthesis, activity against multidrug-resistant bacteria and Candida"],"prefix":"10.1016","volume":"1828","author":[{"given":"Biswajit","family":"Mishra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geeta Devi","family":"Leishangthem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamaldeep","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swagata","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kusum","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Immaculata","family":"Xess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Dinda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arti","family":"Kapil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishan K.","family":"Patro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmistha","family":"Dey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamem.2012.09.021_bb0005","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jinf.2007.04.007","article-title":"Mortality following bacteraemic infection caused by extended spectrum beta-lactamase (ESBL) producing E. coli compared to non-ESBL producing E. coli","volume":"55","author":"Melzer","year":"2007","journal-title":"J. Infect."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0010","doi-asserted-by":"crossref","first-page":"309","DOI":"10.4103\/0255-0857.83920","article-title":"Species distribution and anti-fungal susceptibility of Candidaemia at a multi super-specialty center in Southern India","volume":"29","author":"Adhikary","year":"2011","journal-title":"Indian J. Med. Microbiol."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0015","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/jac\/dkl056","article-title":"Activity of novel non-amphipathic cationic antimicrobial peptides against Candida species","volume":"57","author":"Burrows","year":"2006","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0020","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1016\/j.bbamem.2007.04.018","article-title":"Solution structures and model membrane interactions of lactoferrampin, an antimicrobial peptide derived from bovine lactoferrin","volume":"1768","author":"Haney","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2012.09.021_bb0025","series-title":"Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies","author":"Wang","year":"2011"},{"key":"10.1016\/j.bbamem.2012.09.021_bb0030","doi-asserted-by":"crossref","first-page":"D933","DOI":"10.1093\/nar\/gkn823","article-title":"APD2: the updated antimicrobial peptide database and its application in peptide design","volume":"37","author":"Wang","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0035","doi-asserted-by":"crossref","first-page":"457","DOI":"10.7326\/0003-4819-115-6-457","article-title":"The pathogenesis of sepsis","volume":"115","author":"Bone","year":"1991","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0040","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1749-6632.1974.tb43261.x","article-title":"The barrier function of the gram-negative envelope","volume":"235","author":"Leive","year":"1974","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0045","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0960-0760(01)00187-X","article-title":"Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells","volume":"80","author":"Richards","year":"2002","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"Suppl. 2","key":"10.1016\/j.bbamem.2012.09.021_bb0050","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1016\/j.injury.2006.04.007","article-title":"Antimicrobial peptides: review of their application in musculoskeletal infections","volume":"37","author":"Stallmann","year":"2006","journal-title":"Injury"},{"key":"10.1016\/j.bbamem.2012.09.021_bb0055","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/nbt1267","article-title":"Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies","volume":"24","author":"Hancock","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0060","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.1128\/AAC.48.12.4919-4921.2004","article-title":"The synthetic N-terminal peptide of human lactoferrin, hLF(1\u201311), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii","volume":"48","author":"Dijkshoorn","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0065","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.3168\/jds.S0022-0302(93)77594-3","article-title":"Forms of lactoferrin: their antibacterial effect on enterotoxigenic Escherichia coli","volume":"76","author":"Dionysius","year":"1993","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0070","doi-asserted-by":"crossref","first-page":"667","DOI":"10.3168\/jds.S0022-0302(97)75985-X","article-title":"Antibacterial peptides of bovine lactoferrin: purification and characterization","volume":"80","author":"Dionysius","year":"1997","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0075","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ijantimicag.2010.08.020","article-title":"Fungicidal activity of human lactoferrin-derived peptides based on the antimicrobial \u03b1\u03b2 region","volume":"37","author":"Kondori","year":"2011","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.bbamem.2012.09.021_bb0080","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1128\/AAC.00908-09","article-title":"Structure-microbicidal activity relationship of synthetic fragments derived from the antibacterial alpha-helix of human lactoferrin","volume":"54","author":"H\u00e5versen","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0085","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/nsb1096-815","article-title":"Folding proteins into membranes","volume":"3","author":"Deber","year":"1996","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0090","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/protein\/5.3.213","article-title":"The function of tryptophan residues in membrane proteins","volume":"5","author":"Schiffer","year":"1992","journal-title":"Protein Eng."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0095","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1128\/AAC.44.12.3257-3263.2000","article-title":"Candidacidal activities of human lactoferrin peptides derived from the N terminus","volume":"44","author":"Lupetti","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0100","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1128\/IAI.69.3.1469-1476.2001","article-title":"Human lactoferrin and peptides derived from its N terminus are highly effective against infections with antibiotic-resistant bacteria","volume":"69","author":"Nibbering","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0105","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1128\/iai.28.3.893-898.1980","article-title":"Bactericidal activity of human lactoferrin: sensitivity of a variety of microorganisms","volume":"28","author":"Arnold","year":"1980","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0110","doi-asserted-by":"crossref","first-page":"5748","DOI":"10.1021\/ja00722a043","article-title":"9-Fluorenylmethoxycarbonyl function, a new base-sensitive amino-protecting group","volume":"92","author":"Carpino","year":"1970","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0115","series-title":"m27\u2013a3, reference method for broth dilution antifungal susceptibility testing of yeast","author":"Rex","year":"2008"},{"key":"10.1016\/j.bbamem.2012.09.021_bb0120","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1111\/j.1600-0463.2003.t01-1-apm1111110.x","article-title":"New antimicrobial cystatin C-based peptide active against gram-positive bacterial pathogens, including methicillin-resistant Staphylococcus aureus and multiresistant coagulase-negative staphylococci","volume":"111","author":"Jasir","year":"2003","journal-title":"APMIS"},{"key":"10.1016\/j.bbamem.2012.09.021_bb0125","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1128\/AAC.46.7.2279-2283.2002","article-title":"Structure\u2013function relationship studies on the frog skin antimicrobial peptide tigerinin 1: design of analogs with improved activity and their action on clinical bacterial isolates","volume":"46","author":"Sitaram","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0130","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF01181748","article-title":"Enhanced visualization of peripheral nerve and sensory receptors in the scanning electron microscope using cryofracture and osmium\u2013thiocarbohydrazide\u2013osmium impregnation","volume":"10","author":"Friedman","year":"1981","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0135","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1515\/zna-1968-1247","article-title":"Radiative decay of nonradiative surface plasmon excited by light","volume":"23A","author":"Kretschmann","year":"1968","journal-title":"Z. Naturforsch."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0140","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0250-6874(82)80008-5","article-title":"Gas detection by means of surface plasmon resonance","volume":"3","author":"Nylander","year":"1982","journal-title":"Sens. Actuators"},{"key":"10.1016\/j.bbamem.2012.09.021_bb0145","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/BF01391532","article-title":"Excitation of nonradiative surface plasma waves in silver by the method of frustrated total reflection","volume":"216","author":"Otto","year":"1968","journal-title":"Z. Phys."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0150","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bbrc.2007.06.122","article-title":"Surface plasmon resonance studies and biochemical evaluation of a potent peptide inhibitor against cyclooxygenase-2 as an anti-inflammatory agent","volume":"361","author":"Somvanshi","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0155","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s00726-010-0618-z","article-title":"SD-8, a novel therapeutic agent active against multidrug-resistant Gram positive cocci","volume":"39","author":"Mishra","year":"2010","journal-title":"Amino Acids"},{"key":"10.1016\/j.bbamem.2012.09.021_bb0160","doi-asserted-by":"crossref","first-page":"12316","DOI":"10.1074\/jbc.M413406200","article-title":"Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity\/therapeutic index","volume":"280","author":"Chen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0165","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00253-011-3793-2","article-title":"Bactericidal activity of Musca domestica cecropin (Mdc) on multidrug-resistant clinical isolate of Escherichia coli","volume":"95","author":"Lu","year":"2012","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0170","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s15010-007-6144-6","article-title":"Epidemiology of candidemia in a tertiary care centre of north India: 5-year study","volume":"35","author":"Xess","year":"2007","journal-title":"Infection"},{"key":"10.1016\/j.bbamem.2012.09.021_bb0175","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/S0140-6736(05)65949-1","article-title":"Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients","volume":"348","author":"Kelly","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.bbamem.2012.09.021_bb0180","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0167-4838(92)90346-F","article-title":"Identification of the bactericidal domain of lactoferrin","volume":"1121","author":"Bellamy","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2012.09.021_bb0185","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1128\/AAC.43.6.1317","article-title":"Peptide antibiotics","volume":"43","author":"Hancock","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0190","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1128\/AAC.48.9.3349-3357.2004","article-title":"De novo design of potent antimicrobial peptides","volume":"48","author":"Frecer","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0195","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.bbrc.2006.08.094","article-title":"Design and mechanism of action of a novel bacteria-selective antimicrobial peptide from the cell-penetrating peptide Pep-1","volume":"349","author":"Zhu","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0200","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/infdis\/165.6.1033","article-title":"beta-Lactam antibiotic-induced release of free endotoxin: in vitro comparison of penicillin-binding protein (PBP) 2-specific imipenem and PBP 3-specific ceftazidime","volume":"165","author":"Jackson","year":"1992","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0205","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature01326","article-title":"The immunopathogenesis of sepsis","volume":"420","author":"Cohen","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbamem.2012.09.021_bb0210","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1136\/bmj.327.7421.974","article-title":"Disseminated intravascular coagulation: old disease, new hope","volume":"327","author":"Toh","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.bbamem.2012.09.021_bb0215","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0140-6736(97)80051-7","article-title":"Peptide antibiotics","volume":"349","author":"Hancock","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.bbamem.2012.09.021_bb0220","doi-asserted-by":"crossref","first-page":"7235","DOI":"10.1021\/bi9826299","article-title":"Mechanism of interaction of different classes of cationic antimicrobial peptides with planar bilayers and with the cytoplasmic membrane of Escherichia coli","volume":"38","author":"Wu","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamem.2012.09.021_bb0225","doi-asserted-by":"crossref","first-page":"18872","DOI":"10.1074\/jbc.274.27.18872","article-title":"Salivary histatin 5 induces non-lytic release of ATP from Candida albicans leading to cell death","volume":"274","author":"Koshlukova","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0230","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/jac\/dki402","article-title":"Antimicrobial peptides enhance the candidacidal activity of antifungal drugs by promoting the efflux of ATP from Candida cells","volume":"57","author":"Tanida","year":"2006","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0235","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF00189377","article-title":"Killing of Candida albicans by lactoferricin B, a potent antimicrobial peptide derived from the N-terminal region of bovine lactoferrin","volume":"182","author":"Bellamy","year":"1993","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0240","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1128\/AAC.49.7.2583-2588.2005","article-title":"Different anti-Candida activities of two human lactoferrin-derived peptides, Lfpep and kaliocin-1","volume":"49","author":"Viejo-D\u00edaz","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0245","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1128\/CDLI.11.6.1111-1119.2004","article-title":"Regulation of fungal infection by a combination of amphotericin B and peptide 2, a lactoferrin peptide that activates neutrophils","volume":"11","author":"Okamoto","year":"2004","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.bbamem.2012.09.021_bb0250","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1126\/science.8420003","article-title":"Molecular mapping and detoxification of the lipid A binding site by synthetic peptide","volume":"259","author":"Rustici","year":"1993","journal-title":"Sci."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273612003422?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273612003422?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T18:47:58Z","timestamp":1643482078000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0005273612003422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0005273612003422"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamem.2012.09.021","relation":{},"ISSN":["0005-2736"],"issn-type":[{"value":"0005-2736","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}