{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:41:39Z","timestamp":1789915299276,"version":"4.0.1"},"reference-count":67,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["HL20948"],"award-info":[{"award-number":["HL20948"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 GM07145701A1"],"award-info":[{"award-number":["R01 GM07145701A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Perot Family Foundation"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.bbamem.2013.03.031","type":"journal-article","created":{"date-parts":[[2013,4,7]],"date-time":"2013-04-07T08:15:15Z","timestamp":1365322515000},"page":"2801-2807","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["The site-2 protease"],"prefix":"10.1016","volume":"1828","author":[{"given":"Robert B.","family":"Rawson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bbamem.2013.03.031_bb0005","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0092-8674(00)80675-3","article-title":"Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans","volume":"100","author":"Brown","year":"2000","journal-title":"Cell"},{"issue":"35","key":"10.1016\/j.bbamem.2013.03.031_bb0010","doi-asserted-by":"crossref","first-page":"11223","DOI":"10.1021\/bi991080q","article-title":"Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease","volume":"38","author":"Wolfe","year":"1999","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.bbamem.2013.03.031_bb0015","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S1097-2765(00)80006-4","article-title":"Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs","volume":"1","author":"Rawson","year":"1997","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbamem.2013.03.031_bb0020","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev.genet.41.110306.130315","article-title":"Regulation of sterol synthesis in eukaryotes","volume":"41","author":"Espenshade","year":"2007","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.bbamem.2013.03.031_bb0025","series-title":"Intramembrane-Cleaving Proteases (I-CLiPs)","first-page":"1","article-title":"The site-2 protease at Ten","author":"Rawson","year":"2007"},{"issue":"3","key":"10.1016\/j.bbamem.2013.03.031_bb0030","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF02254759","article-title":"Somatic cell genetic and biochemical characterization of cell lines resulting from human genomic DNA transfections of Chinese hamster ovary cell mutants defective in sterol-dependent activation of sterol synthesis and LDL receptor expression","volume":"20","author":"Hasan","year":"1994","journal-title":"Somat. Cell Mol. Genet."},{"key":"10.1016\/j.bbamem.2013.03.031_bb0035","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0076-6879(95)48015-3","article-title":"Evolutionary families of metallopeptidases","volume":"248","author":"Rawlings","year":"1995","journal-title":"Methods Enzymol."},{"issue":"31","key":"10.1016\/j.bbamem.2013.03.031_bb0040","doi-asserted-by":"crossref","first-page":"21973","DOI":"10.1074\/jbc.274.31.21973","article-title":"Membrane topology of S2P, a protein required for intramembranous cleavage of sterol regulatory element-binding proteins","volume":"274","author":"Zelenski","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"26","key":"10.1016\/j.bbamem.2013.03.031_bb0045","doi-asserted-by":"crossref","first-page":"14765","DOI":"10.1073\/pnas.96.26.14765","article-title":"A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors","volume":"96","author":"Rudner","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5856","key":"10.1016\/j.bbamem.2013.03.031_bb0050","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1126\/science.1150755","article-title":"Structure of a site-2 protease family intramembrane metalloprotease","volume":"318","author":"Feng","year":"2007","journal-title":"Science"},{"issue":"38","key":"10.1016\/j.bbamem.2013.03.031_bb0055","doi-asserted-by":"crossref","first-page":"16174","DOI":"10.1073\/pnas.0901455106","article-title":"Intramembrane proteolytic cleavage of a membrane-tethered transcription factor by a metalloprotease depends on ATP","volume":"106","author":"Zhou","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bbamem.2013.03.031_bb0060","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1110\/ps.051766506","article-title":"Site-2 protease regulated intramembrane proteolysis: sequence homologs suggest an ancient signaling cascade","volume":"15","author":"Kinch","year":"2006","journal-title":"Protein Sci."},{"issue":"32","key":"10.1016\/j.bbamem.2013.03.031_bb0065","doi-asserted-by":"crossref","first-page":"22795","DOI":"10.1074\/jbc.274.32.22795","article-title":"Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins","volume":"274","author":"Espenshade","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.bbamem.2013.03.031_bb0070","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)81668-2","article-title":"Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi","volume":"99","author":"DeBose-Boyd","year":"1999","journal-title":"Cell"},{"issue":"41","key":"10.1016\/j.bbamem.2013.03.031_bb0075","doi-asserted-by":"crossref","first-page":"43046","DOI":"10.1074\/jbc.M408466200","article-title":"Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6","volume":"279","author":"Shen","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bbamem.2013.03.031_bb0080","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S1534-5807(01)00119-8","article-title":"The SREBP pathway in Drosophila: regulation by palmitate, not sterols","volume":"2","author":"Seegmiller","year":"2002","journal-title":"Dev. Cell"},{"issue":"50","key":"10.1016\/j.bbamem.2013.03.031_bb0085","doi-asserted-by":"crossref","first-page":"35042","DOI":"10.1074\/jbc.M806603200","article-title":"A pair of circularly permutated PDZ domains control RseP, the S2P family intramembrane protease of Escherichia coli","volume":"283","author":"Inaba","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.bbamem.2013.03.031_bb0090","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.1073\/pnas.97.10.5123","article-title":"Asparagine\u2013proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease","volume":"97","author":"Ye","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.bbamem.2013.03.031_bb0095","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S1097-2765(02)00655-X","article-title":"Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis","volume":"10","author":"Lemberg","year":"2002","journal-title":"Mol. Cell"},{"issue":"6","key":"10.1016\/j.bbamem.2013.03.031_bb0100","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/S1097-2765(03)00181-3","article-title":"Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain","volume":"11","author":"Urban","year":"2003","journal-title":"Mol. Cell"},{"issue":"11","key":"10.1016\/j.bbamem.2013.03.031_bb0105","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1110\/ps.8.11.2533","article-title":"Common protein architecture and binding sites in proteases utilizing a Ser\/Lys dyad mechanism","volume":"8","author":"Paetzel","year":"1999","journal-title":"Protein Sci."},{"issue":"7116","key":"10.1016\/j.bbamem.2013.03.031_bb0110","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature05255","article-title":"Crystal structure of a rhomboid family intramembrane protease","volume":"444","author":"Wang","year":"2006","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bbamem.2013.03.031_bb0115","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1073\/pnas.0609981104","article-title":"The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis","volume":"104","author":"Lemieux","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.bbamem.2013.03.031_bb0120","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.semcdb.2008.11.006","article-title":"Structure and mechanism of intramembrane protease","volume":"20","author":"Ha","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.bbamem.2013.03.031_bb0125","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.febslet.2005.12.098","article-title":"A chloroplastic inner envelope membrane protease is essential for plant development","volume":"580","author":"Bolter","year":"2006","journal-title":"FEBS Lett."},{"issue":"10","key":"10.1016\/j.bbamem.2013.03.031_bb0130","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.tplants.2008.06.008","article-title":"Membrane-bound transcription factors in plants","volume":"13","author":"Seo","year":"2008","journal-title":"Trends Plant Sci."},{"issue":"3","key":"10.1016\/j.bbamem.2013.03.031_bb0135","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1365-2958.2009.06895.x","article-title":"Cryptococcus neoformans Site-2 protease is required for virulence and survival in the presence of azole drugs","volume":"74","author":"Bien","year":"2009","journal-title":"Mol. Microbiol."},{"issue":"6","key":"10.1016\/j.bbamem.2013.03.031_bb0140","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/S1097-2765(00)00133-7","article-title":"ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs","volume":"6","author":"Ye","year":"2000","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.bbamem.2013.03.031_bb0145","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cell.2005.11.040","article-title":"Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response","volume":"124","author":"Zhang","year":"2006","journal-title":"Cell"},{"issue":"21","key":"10.1016\/j.bbamem.2013.03.031_bb0150","doi-asserted-by":"crossref","first-page":"12027","DOI":"10.1073\/pnas.1534923100","article-title":"Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes","volume":"100","author":"Horton","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.bbamem.2013.03.031_bb0155","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.cmet.2008.10.008","article-title":"Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance","volume":"8","author":"Radhakrishnan","year":"2008","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.bbamem.2013.03.031_bb0160","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S1097-2765(00)80150-1","article-title":"Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells","volume":"2","author":"Sakai","year":"1998","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.bbamem.2013.03.031_bb0165","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1073\/pnas.96.4.1321","article-title":"Mammalian subtilisin\/kexin isozyme SKI-1: a widely expressed proprotein convertase with a unique cleavage specificity and cellular localization","volume":"96","author":"Seidah","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.bbamem.2013.03.031_bb0170","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0092-8674(00)81304-5","article-title":"Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment","volume":"85","author":"Sakai","year":"1996","journal-title":"Cell"},{"issue":"19","key":"10.1016\/j.bbamem.2013.03.031_bb0175","doi-asserted-by":"crossref","first-page":"12778","DOI":"10.1074\/jbc.272.19.12778","article-title":"Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2","volume":"272","author":"Duncan","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbamem.2013.03.031_bb0180","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0092-8674(94)90234-8","article-title":"SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis","volume":"77","author":"Wang","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.bbamem.2013.03.031_bb0185","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0021-9258(18)75823-7","article-title":"Synthesis and destruction of cholesterol in the organism","volume":"103","author":"Schoenheimer","year":"1933","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bbamem.2013.03.031_bb0190","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/BF02255839","article-title":"Somatic cell genetic analysis of two classes of CHO cell mutants expressing opposite phenotypes in sterol-dependent regulation of cholesterol metabolism","volume":"20","author":"Hasan","year":"1994","journal-title":"Somat. Cell Mol. Genet."},{"issue":"11","key":"10.1016\/j.bbamem.2013.03.031_bb0195","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1073\/pnas.75.11.5452","article-title":"Mammalian cell mutant requiring cholesterol and unsaturated fatty acid for growth","volume":"75","author":"Limanek","year":"1978","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.bbamem.2013.03.031_bb0200","doi-asserted-by":"crossref","first-page":"5175","DOI":"10.1128\/MCB.13.9.5175","article-title":"Loss of transcriptional activation of three sterol-regulated genes in mutant hamster cells","volume":"13","author":"Evans","year":"1993","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.bbamem.2013.03.031_bb0205","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1073\/pnas.73.1.24","article-title":"Isolation and characterization of an unsaturated fatty acid-requiring mutant of cultured mammalian cells","volume":"73","author":"Chang","year":"1976","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.bbamem.2013.03.031_bb0210","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1091\/mbc.10.11.3787","article-title":"Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress","volume":"10","author":"Haze","year":"1999","journal-title":"Mol. Biol. Cell"},{"issue":"4","key":"10.1016\/j.bbamem.2013.03.031_bb0215","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1152\/physrev.00001.2011","article-title":"The unfolded protein response: integrating stress signals through the stress sensor IRE1\u03b1","volume":"91","author":"Hetz","year":"2011","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.bbamem.2013.03.031_bb0220","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1128\/MCB.25.3.921-932.2005","article-title":"Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response","volume":"25","author":"Shen","year":"2005","journal-title":"Mol. Cell. Biol."},{"issue":"5","key":"10.1016\/j.bbamem.2013.03.031_bb0225","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1128\/MCB.01552-06","article-title":"BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer","volume":"27","author":"Kondo","year":"2007","journal-title":"Mol. Cell. Biol."},{"issue":"4","key":"10.1016\/j.bbamem.2013.03.031_bb0230","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/iub.433","article-title":"Physiological unfolded protein response regulated by OASIS family members, transmembrane bZIP transcription factors","volume":"63","author":"Kondo","year":"2011","journal-title":"IUBMB Life"},{"issue":"4","key":"10.1016\/j.bbamem.2013.03.031_bb0235","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.cmet.2010.02.016","article-title":"Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH","volume":"11","author":"Lee","year":"2010","journal-title":"Cell Metab."},{"issue":"12","key":"10.1016\/j.bbamem.2013.03.031_bb0240","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1111\/j.1600-0854.2007.00654.x","article-title":"Trafficking of the bZIP transmembrane transcription factor CREB-H into alternate pathways of ERAD and stress-regulated intramembrane proteolysis","volume":"8","author":"Bailey","year":"2007","journal-title":"Traffic"},{"issue":"11\u201312","key":"10.1016\/j.bbamem.2013.03.031_bb0245","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1016\/j.molimm.2010.04.019","article-title":"DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation","volume":"47","author":"Eleveld-Trancikova","year":"2010","journal-title":"Mol. Immunol."},{"issue":"4","key":"10.1016\/j.bbamem.2013.03.031_bb0250","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1111\/j.1471-4159.2005.03596.x","article-title":"Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress","volume":"96","author":"Murakami","year":"2006","journal-title":"J. Neurochem."},{"issue":"10","key":"10.1016\/j.bbamem.2013.03.031_bb0255","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/ncb1963","article-title":"Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation","volume":"11","author":"Murakami","year":"2009","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.bbamem.2013.03.031_bb0260","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ajhg.2009.03.014","article-title":"IFAP syndrome is caused by deficiency in MBTPS2, an intramembrane zinc metalloprotease essential for cholesterol homeostasis and ER stress response","volume":"84","author":"Oeffner","year":"2009","journal-title":"Am. J. Hum. Genet."},{"issue":"10","key":"10.1016\/j.bbamem.2013.03.031_bb0265","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/humu.21335","article-title":"Keratosis follicularis spinulosa decalvans is caused by mutations in MBTPS2","volume":"31","author":"Aten","year":"2010","journal-title":"Hum. Mutat."},{"issue":"41","key":"10.1016\/j.bbamem.2013.03.031_bb0270","doi-asserted-by":"crossref","first-page":"14551","DOI":"10.1073\/pnas.0503590102","article-title":"Dual roles for cholesterol in mammalian cells","volume":"102","author":"Xu","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.bbamem.2013.03.031_bb0275","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.cmet.2006.04.011","article-title":"Fatty acid auxotrophy in Drosophila larvae lacking SREBP","volume":"3","author":"Kunte","year":"2006","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.bbamem.2013.03.031_bb0280","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1534\/genetics.108.093450","article-title":"Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster","volume":"181","author":"Matthews","year":"2009","journal-title":"Genetics"},{"issue":"15","key":"10.1016\/j.bbamem.2013.03.031_bb0285","doi-asserted-by":"crossref","first-page":"9674","DOI":"10.1074\/jbc.M900346200","article-title":"Activation of sterol regulatory element-binding protein by the caspase Drice in Drosophila larvae","volume":"284","author":"Amarneh","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"30","key":"10.1016\/j.bbamem.2013.03.031_bb0290","doi-asserted-by":"crossref","first-page":"18044","DOI":"10.1074\/jbc.270.30.18044","article-title":"Purification of an interleukin-1 beta converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembrane domains","volume":"270","author":"Wang","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.bbamem.2013.03.031_bb0295","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1073\/pnas.93.11.5437","article-title":"Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins","volume":"93","author":"Pai","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"16","key":"10.1016\/j.bbamem.2013.03.031_bb0300","doi-asserted-by":"crossref","first-page":"5639","DOI":"10.1128\/MCB.22.16.5639-5649.2002","article-title":"Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis","volume":"22","author":"Raggo","year":"2002","journal-title":"Mol. Cell. Biol."},{"issue":"17","key":"10.1016\/j.bbamem.2013.03.031_bb0305","doi-asserted-by":"crossref","first-page":"7156","DOI":"10.1158\/0008-5472.CAN-08-1085","article-title":"CREB3L2-PPARgamma fusion mutation identifies a thyroid signaling pathway regulated by intramembrane proteolysis","volume":"68","author":"Lui","year":"2008","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bbamem.2013.03.031_bb0310","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1091\/mbc.E05-06-0500","article-title":"CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P","volume":"17","author":"Stirling","year":"2006","journal-title":"Mol. Biol. Cell"},{"issue":"2","key":"10.1016\/j.bbamem.2013.03.031_bb0315","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1152\/physiolgenomics.00097.2007","article-title":"Transcriptional profiling of genes that are regulated by the endoplasmic reticulum-bound transcription factor AIbZIP\/CREB3L4 in prostate cells","volume":"31","author":"Ben Aicha","year":"2007","journal-title":"Physiol. Genomics"},{"issue":"2","key":"10.1016\/j.bbamem.2013.03.031_bb0320","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.semcdb.2008.10.006","article-title":"Rhomboids: 7years of a new protease family","volume":"20","author":"Freeman","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"issue":"10","key":"10.1016\/j.bbamem.2013.03.031_bb0325","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/gb-2011-12-10-231","article-title":"The rhomboid protease family: a decade of progress on function and mechanism","volume":"12","author":"Urban","year":"2011","journal-title":"Genome Biol."},{"issue":"6","key":"10.1016\/j.bbamem.2013.03.031_bb0330","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1074\/jbc.M007273200","article-title":"Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells","volume":"276","author":"Hannah","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbamem.2013.03.031_bb0335","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1534\/genetics.110.114975","article-title":"Activation of sterol regulatory element binding proteins in the absence of Scap in Drosophila melanogaster","volume":"185","author":"Matthews","year":"2010","journal-title":"Genetics"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273613001004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273613001004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T06:55:19Z","timestamp":1644735319000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0005273613001004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":67,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0005273613001004"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamem.2013.03.031","relation":{},"ISSN":["0005-2736"],"issn-type":[{"value":"0005-2736","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The site-2 protease","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Biomembranes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamem.2013.03.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}