{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:37:56Z","timestamp":1791221876606,"version":"4.1.0"},"reference-count":125,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.bbamem.2013.08.013","type":"journal-article","created":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T05:45:57Z","timestamp":1377582357000},"page":"244-253","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":87,"special_numbering":"PB","title":["The sodium\/iodide symporter: State of the art of its molecular characterization"],"prefix":"10.1016","volume":"1838","author":[{"given":"Elisabeth","family":"Darrouzet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Lindenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Marcellin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Pellequer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Pourcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamem.2013.08.013_bb0005","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/379458a0","article-title":"Cloning and characterization of the thyroid iodide transporter","volume":"379","author":"Dai","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0010","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1006\/bbrc.1996.1358","article-title":"Cloning of the human sodium iodide symporter","volume":"226","author":"Smanik","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0015","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1677\/joe.0.1700185","article-title":"Cloning of the mouse sodium iodide symporter and its expression in the mammary gland and other tissues","volume":"170","author":"Perron","year":"2001","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0020","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1210\/en.2002-220971","article-title":"The porcine sodium\/iodide symporter gene exhibits an uncommon expression pattern related to the use of alternative splice sites not present in the human or murine species","volume":"144","author":"Selmi-Ruby","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0025","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1152\/physrev.2000.80.3.1083","article-title":"Molecular analysis of the sodium\/iodide symporter: impact on thyroid and extrathyroid pathophysiology","volume":"80","author":"De La Vieja","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0030","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0014-5793(02)03184-8","article-title":"The sodium\/substrate symporter family: structural and functional features","volume":"529","author":"Jung","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0035","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1210\/er.2001-0029","article-title":"The sodium\/iodide Symporter (NIS): characterization, regulation, and medical significance","volume":"24","author":"Dohan","year":"2003","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0040","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.pharmthera.2012.06.007","article-title":"The sodium iodide symporter (NIS): regulation and approaches to targeting for cancer therapeutics","volume":"135","author":"Kogai","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0045","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1530\/eje.1.02257","article-title":"A perspective view of sodium iodide symporter research and its clinical implications","volume":"155","author":"Riesco-Eizaguirre","year":"2006","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0050","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/ncpendmet0449","article-title":"Defects in iodide metabolism in thyroid cancer and implications for the follow-up and treatment of patients","volume":"3","author":"Schlumberger","year":"2007","journal-title":"Nat. Clin. Pract. Endocrinol. Metab."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0055","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1590\/S0004-27302007000500004","article-title":"The importance of sodium\/iodide symporter (NIS) for thyroid cancer management","volume":"51","author":"Carvalho","year":"2007","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0060","doi-asserted-by":"crossref","first-page":"242","DOI":"10.2174\/156800910791054194","article-title":"The biology of the sodium iodide symporter and its potential for targeted gene delivery","volume":"10","author":"Hingorani","year":"2010","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0065","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1056\/NEJMoa1209288","article-title":"Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer","volume":"368","author":"Ho","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0070","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/j.biochi.2006.07.015","article-title":"From the molecular characterization of iodide transporters to the prevention of radioactive iodide exposure","volume":"88","author":"Dayem","year":"2006","journal-title":"Biochimie"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0075","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1046\/j.1365-2265.2002.01640.x","article-title":"The sodium iodide symporter: its pathophysiological and therapeutic implications","volume":"57","author":"Spitzweg","year":"2002","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0080","doi-asserted-by":"crossref","first-page":"8045","DOI":"10.1158\/0008-5472.CAN-04-0893","article-title":"Long-term radioiodine retention and regression of liver cancer after sodium iodide symporter gene transfer in wistar rats","volume":"64","author":"Faivre","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0085","doi-asserted-by":"crossref","first-page":"E1435","DOI":"10.1210\/jc.2010-2373","article-title":"Telomerase-driven expression of the sodium iodide symporter (NIS) for in vivo radioiodide treatment of cancer: a new broad-spectrum NIS-mediated antitumor approach","volume":"96","author":"Riesco-Eizaguirre","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0090","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3892\/ol.2012.1055","article-title":"The glial fibrillary acidic protein promoter directs sodium\/iodide symporter gene expression for radioiodine therapy of malignant glioma","volume":"5","author":"Li","year":"2013","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0095","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1089\/hum.2012.104","article-title":"Stromal targeting of sodium iodide symporter using mesenchymal stem cells allows enhanced imaging and therapy of hepatocellular carcinoma","volume":"24","author":"Knoop","year":"2013","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0100","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1210\/endo.139.10.6329","article-title":"An immunohistochemical study of Na+\/I\u2212 symporter in human thyroid tissues and salivary gland tissues","volume":"139","author":"Jhiang","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0105","doi-asserted-by":"crossref","DOI":"10.1089\/thy.2012.0571","article-title":"Modulation of sodium\/iodide symporter expression in the salivary gland","author":"La Perle","year":"2013","journal-title":"Thyroid"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0110","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/78630","article-title":"The mammary gland iodide transporter is expressed during lactation and in breast cancer","volume":"6","author":"Tazebay","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0115","first-page":"2936","article-title":"Hormonal regulation of radioiodide uptake activity and Na+\/I\u2212 symporter expression in mammary glands","volume":"85","author":"Cho","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0120","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1113\/jphysiol.2004.071548","article-title":"Transcellular thiocyanate transport by human airway epithelia","volume":"561","author":"Fragoso","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0125","doi-asserted-by":"crossref","first-page":"C654","DOI":"10.1152\/ajpcell.00509.2008","article-title":"The Na+\/I\u2212 symporter mediates active iodide uptake in the intestine","volume":"296","author":"Nicola","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0130","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1006\/clin.1998.4595","article-title":"Characterization of gastric Na+\/I\u2212 symporter of the rat","volume":"89","author":"Kotani","year":"1998","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0135","first-page":"4367","article-title":"Expression of Na+\/I\u2212 symporter and Pendred syndrome genes in trophoblast cells","volume":"85","author":"Bidart","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0140","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s12020-011-9469-y","article-title":"Expression and localization of the sodium\/iodide symporter (NIS) in testicular cells","volume":"40","author":"Russo","year":"2011","journal-title":"Endocrine"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0145","doi-asserted-by":"crossref","first-page":"27230","DOI":"10.1074\/jbc.272.43.27230","article-title":"Thyroid Na+\/I\u2212 symporter. Mechanism, stoichiometry, and specificity","volume":"272","author":"Eskandari","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0150","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1210\/en.2002-220744","article-title":"Anion selectivity by the sodium iodide symporter","volume":"144","author":"Van Sande","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0155","doi-asserted-by":"crossref","first-page":"20250","DOI":"10.1073\/pnas.0707207104","article-title":"The Na+\/I symporter (NIS) mediates electroneutral active transport of the environmental pollutant perchlorate","volume":"104","author":"Dohan","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0160","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1113\/jphysiol.2005.100933","article-title":"Water transport by Na+-coupled cotransporters of glucose (SGLT1) and of iodide (NIS). The dependence of substrate size studied at high resolution","volume":"570","author":"Zeuthen","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0165","doi-asserted-by":"crossref","first-page":"18245","DOI":"10.1074\/jbc.272.29.18245","article-title":"Characterization of the rat thyroid iodide transporter using anti-peptide antibodies. Relationship between its expression and activity","volume":"272","author":"Paire","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0170","doi-asserted-by":"crossref","first-page":"22657","DOI":"10.1074\/jbc.273.35.22657","article-title":"N-linked glycosylation of the thyroid Na+\/I\u2212 symporter (NIS). Implications for its secondary structure model","volume":"273","author":"Levy","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0175","doi-asserted-by":"crossref","first-page":"5568","DOI":"10.1073\/pnas.94.11.5568","article-title":"Characterization of the thyroid Na+\/I\u2212 symporter with an anti-COOH terminus antibody","volume":"94","author":"Levy","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0180","doi-asserted-by":"crossref","first-page":"36820","DOI":"10.1074\/jbc.M706817200","article-title":"Identification of in vivo phosphorylation sites and their functional significance in the sodium iodide symporter","volume":"282","author":"Vadysirisack","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0185","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1126\/science.1160406","article-title":"The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+\/sugar symport","volume":"321","author":"Faham","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0190","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/nature09580","article-title":"The mechanism of sodium and substrate release from the binding pocket of vSGLT","volume":"468","author":"Watanabe","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0195","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0968-0004(02)02077-7","article-title":"Quaternary structure and function of transport proteins","volume":"27","author":"Veenhoff","year":"2002","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0200","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1124\/mi.4.1.38","article-title":"Sodium-dependent neurotransmitter transporters: oligomerization as a determinant of transporter function and trafficking","volume":"4","author":"Sitte","year":"2004","journal-title":"Mol. Interv."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0205","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1677\/joe.0.1630495","article-title":"Monoclonal antibodies against the human sodium iodide symporter: utility for immunocytochemistry of thyroid cancer","volume":"163","author":"Castro","year":"1999","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0210","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1530\/EJE-08-0505","article-title":"Immunoanalysis indicates that the sodium iodide symporter is not overexpressed in intracellular compartments in thyroid and breast cancers","volume":"160","author":"Peyrottes","year":"2009","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0215","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1677\/JOE-07-0455","article-title":"Comparison of expressed human and mouse sodium\/iodide symporters reveals differences in transport properties and subcellular localization","volume":"197","author":"Dayem","year":"2008","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0220","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bbamem.2010.08.013","article-title":"Characterisation of the purified human sodium\/iodide symporter reveals that the protein is mainly present in a dimeric form and permits the detailed study of a native C-terminal fragment","volume":"1808","author":"Huc-Brandt","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0225","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1046\/j.1523-1755.2001.0590031013.x","article-title":"Expression of the sodium iodide symporter in human kidney","volume":"59","author":"Spitzweg","year":"2001","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0230","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1432-1033.1991.tb21068.x","article-title":"Inhibition of the Na+\/I\u2212 symporter by harmaline and 3-amino-1-methyl-5H-pyrido(4,3-b)indole acetate in thyroid cells and membrane vesicles","volume":"200","author":"Kaminsky","year":"1991","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0235","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1006\/bbrc.1994.2599","article-title":"Chloride channel blockers inhibit the Na+\/I\u2212 symporter in thyroid follicles in culture","volume":"204","author":"Gerard","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0240","first-page":"259","article-title":"The Na+-I\u2212 cotransporter of the thyroid: characterisation of new inhibitors","volume":"435","author":"Vroye","year":"1998","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0245","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/cmdc.200800049","article-title":"Discovery of aryltrifluoroborates as potent sodium\/iodide symporter (NIS) inhibitors","volume":"3","author":"Lecat-Guillet","year":"2008","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0250","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1089\/adt.2007.068","article-title":"A 96-well automated radioiodide uptake assay for sodium\/iodide symporter inhibitors","volume":"5","author":"Lecat-Guillet","year":"2007","journal-title":"Assay Drug Dev. Technol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0255","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/cbic.200700682","article-title":"Small-molecule inhibitors of sodium iodide symporter function","volume":"9","author":"Lecat-Guillet","year":"2008","journal-title":"Chembiochem"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0260","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1677\/JOE-08-0246","article-title":"Characterization of small-molecule inhibitors of the sodium iodide symporter","volume":"200","author":"Lindenthal","year":"2009","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0265","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/cmdc.201200417","article-title":"Synthesis and evaluation of 3,4-dihydropyrimidin-2(1H)-ones as sodium iodide symporter inhibitors","author":"Lacotte","year":"2013","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0270","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.ejmech.2013.01.043","article-title":"Synthesis, evaluation and absolute configuration assignment of novel dihydropyrimidin-2-ones as picomolar sodium iodide symporter inhibitors","volume":"62","author":"Lacotte","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0275","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/sj.cgt.7700525","article-title":"The rat sodium iodide symporter gene permits more effective radioisotope concentration than the human sodium iodide symporter gene in human and rodent cancer cells","volume":"10","author":"Heltemes","year":"2003","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0280","doi-asserted-by":"crossref","first-page":"6131","DOI":"10.1210\/jc.2005-0895","article-title":"Cell surface targeting accounts for the difference in iodide uptake activity between human Na+\/I\u2212 symporter and rat Na+\/I\u2212 symporter","volume":"90","author":"Zhang","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0285","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0304-4157(94)90003-5","article-title":"A functional superfamily of sodium\/solute symporters","volume":"1197","author":"Reizer","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0290","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s00424-003-1192-y","article-title":"The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins","volume":"447","author":"Hediger","year":"2004","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0295","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/1479-7364-3-2-195","article-title":"Analysis and update of the human solute carrier (SLC) gene superfamily","volume":"3","author":"He","year":"2009","journal-title":"Hum. Genomics"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0300","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s00424-003-1202-0","article-title":"The sodium\/glucose cotransport family SLC5","volume":"447","author":"Wright","year":"2004","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0305","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.mam.2012.11.002","article-title":"Glucose transport families SLC5 and SLC50","volume":"34","author":"Wright","year":"2013","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0310","doi-asserted-by":"crossref","first-page":"11753","DOI":"10.1073\/pnas.1733027100","article-title":"A glucose sensor hiding in a family of transporters","volume":"100","author":"Diez-Sampedro","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0315","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1074\/jbc.M110.167197","article-title":"Surprising substrate versatility in SLC5A6: Na+-coupled I\u2212 transport by the human Na+\/multivitamin transporter (hSMVT)","volume":"286","author":"de Carvalho","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0320","doi-asserted-by":"crossref","first-page":"13367","DOI":"10.1073\/pnas.93.23.13367","article-title":"Cotransport of water by the Na+\/glucose cotransporter","volume":"93","author":"Loo","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Pt 2","key":"10.1016\/j.bbamem.2013.08.013_bb0325","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1469-7793.2000.00251.x","article-title":"Urea transport by cotransporters","volume":"528","author":"Leung","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0330","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1469-7793.2001.00419.x","article-title":"Mapping the urea channel through the rabbit Na(+)-glucose cotransporter SGLT1","volume":"535","author":"Panayotova-Heiermann","year":"2001","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0335","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1152\/physiol.00026.2004","article-title":"Surprising versatility of Na+\u2013glucose cotransporters: SLC5","volume":"19","author":"Wright","year":"2004","journal-title":"Physiology (Bethesda)"},{"issue":"Pt 1","key":"10.1016\/j.bbamem.2013.08.013_bb0340","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1469-7793.1999.0195r.x","article-title":"Passive water and ion transport by cotransporters","volume":"518","author":"Loo","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0345","doi-asserted-by":"crossref","first-page":"25711","DOI":"10.1074\/jbc.M003127200","article-title":"Molecular characterization of Vibrio parahaemolyticus vSGLT: a model for sodium-coupled sugar cotransporters","volume":"275","author":"Turk","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0350","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.sbi.2009.06.002","article-title":"Structure and function of Na(+)-symporters with inverted repeats","volume":"19","author":"Abramson","year":"2009","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0355","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1021\/bi992442x","article-title":"Spin labeling analysis of structure and dynamics of the Na(+)\/proline transporter of Escherichia coli","volume":"39","author":"Wegener","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0360","doi-asserted-by":"crossref","first-page":"13391","DOI":"10.1021\/bi701562k","article-title":"Sodium-dependent reorganization of the sugar-binding site of SGLT1","volume":"46","author":"Hirayama","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0365","doi-asserted-by":"crossref","first-page":"25222","DOI":"10.1074\/jbc.M704190200","article-title":"Three surface subdomains form the vestibule of the Na+\/glucose cotransporter SGLT1","volume":"282","author":"Puntheeranurak","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0370","doi-asserted-by":"crossref","first-page":"4631","DOI":"10.1021\/bi963063w","article-title":"Aspartate 55 in the Na+\/proline permease of Escherichia coli is essential for Na+-coupled proline uptake","volume":"36","author":"Quick","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0375","doi-asserted-by":"crossref","first-page":"8790","DOI":"10.1074\/jbc.M111008200","article-title":"Sites important for Na+ and substrate binding in the Na+\/proline transporter of Escherichia coli, a member of the Na+\/solute symporter family","volume":"277","author":"Pirch","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0380","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.jmb.2008.07.070","article-title":"Function of transmembrane domain IX in the Na+\/proline transporter PutP","volume":"382","author":"Raba","year":"2008","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0385","doi-asserted-by":"crossref","first-page":"C64","DOI":"10.1152\/ajpcell.90602.2007","article-title":"Transmembrane IV of the high-affinity sodium-glucose cotransporter participates in sugar binding","volume":"295","author":"Liu","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0390","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1074\/jbc.M805082200","article-title":"C-terminal loop 13 of Na+\/glucose cotransporter 1 contains both stereospecific and non-stereospecific sugar interaction sites","volume":"284","author":"Wimmer","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0395","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.mce.2010.02.007","article-title":"Genetics and phenomics of hypothyroidism and goiter due to NIS mutations","volume":"322","author":"Spitzweg","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0400","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1006\/bbrc.1997.7594","article-title":"Hypothyroidism in a Brazilian kindred due to iodide trapping defect caused by a homozygous mutation in the sodium\/iodide symporter gene","volume":"240","author":"Pohlenz","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0405","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1172\/JCI1504","article-title":"Congenital hypothyroidism due to mutations in the sodium\/iodide symporter. Identification of a nonsense mutation producing a downstream cryptic 3\u2032 splice site","volume":"101","author":"Pohlenz","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0410","doi-asserted-by":"crossref","first-page":"3830","DOI":"10.1210\/jcem.87.8.8767","article-title":"A novel peculiar mutation in the sodium\/iodide symporter gene in Spanish siblings with iodide transport defect","volume":"87","author":"Kosugi","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0415","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1046\/j.1365-2265.2003.01877.x","article-title":"Congenital hypothyroidism due to a new deletion in the sodium\/iodide symporter protein","volume":"59","author":"Tonacchera","year":"2003","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0420","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.canlet.2004.12.036","article-title":"A novel loss-of-function deletion in sodium\/iodide symporter gene in follicular thyroid adenoma","volume":"230","author":"Liang","year":"2005","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0425","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1089\/thy.2009.0080","article-title":"Congenital hypothyroidism and late-onset goiter: identification and characterization of a novel mutation in the sodium\/iodide symporter of the proband and family members","volume":"19","author":"Montanelli","year":"2009","journal-title":"Thyroid"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0430","first-page":"3966","article-title":"A homozygous missense mutation of the sodium\/iodide symporter gene causing iodide transport defect","volume":"82","author":"Matsuda","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0435","first-page":"3373","article-title":"Novel, missense and loss-of-function mutations in the sodium\/iodide symporter gene causing iodide transport defect in three Japanese patients","volume":"83","author":"Kosugi","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0440","first-page":"3248","article-title":"A novel mutation in the sodium\/iodide symporter gene in the largest family with iodide transport defect","volume":"84","author":"Kosugi","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0445","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1089\/thy.2000.10.471","article-title":"A novel V59E missense mutation in the sodium iodide symporter gene in a family with iodide transport defect","volume":"10","author":"Fujiwara","year":"2000","journal-title":"Thyroid"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0450","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1210\/jc.2005-1832","article-title":"Extending the clinical heterogeneity of iodide transport defect (ITD): a novel mutation R124H of the sodium\/iodide symporter gene and review of genotype\u2013phenotype correlations in ITD","volume":"91","author":"Szinnai","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0455","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1210\/en.2008-0027","article-title":"Molecular characterization of V59E NIS, a Na+\/I\u2212 symporter mutant that causes congenital I\u2212 transport defect","volume":"149","author":"Reed-Tsur","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0460","doi-asserted-by":"crossref","first-page":"17933","DOI":"10.1073\/pnas.1108278108","article-title":"Mechanism of anion selectivity and stoichiometry of the Na+\/I\u2212 symporter (NIS)","volume":"108","author":"Paroder-Belenitsky","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0465","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1242\/jcs.120246","article-title":"The iodide transport defect-causing mutation R124H: a delta-amino group at position 124 is critical for maturation and trafficking of the Na+\/I\u2212 symporter (NIS)","volume":"126","author":"Paroder","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0470","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1242\/jcs.00898","article-title":"The Q267E mutation in the sodium\/iodide symporter (NIS) causes congenital iodide transport defect (ITD) by decreasing the NIS turnover number","volume":"117","author":"De La Vieja","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0475","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0014-5793(98)00522-5","article-title":"Identification of a structural requirement for thyroid Na+\/I\u2212 symporter (NIS) function from analysis of a mutation that causes human congenital hypothyroidism","volume":"429","author":"Levy","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0480","doi-asserted-by":"crossref","first-page":"25290","DOI":"10.1074\/jbc.M700147200","article-title":"Amino acid residues in transmembrane segment IX of the Na+\/I\u2212 symporter play a role in its Na+ dependence and are critical for transport activity","volume":"282","author":"De la Vieja","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0485","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1210\/me.2002-0071","article-title":"Na(+)\/I(\u2212) symporter activity requires a small and uncharged amino acid residue at position 395","volume":"16","author":"Dohan","year":"2002","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0490","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1096\/fj.13-229138","article-title":"Asn441 plays a key role in folding and function of the Na+\/I\u2212 symporter (NIS)","volume":"27","author":"Li","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0495","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1210\/me.2005-0162","article-title":"Molecular analysis of a congenital iodide transport defect: G543E impairs maturation and trafficking of the Na+\/I\u2212 symporter","volume":"19","author":"De la Vieja","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0500","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1677\/JOE-08-0249","article-title":"Histidine residue at position 226 is critical for iodide uptake activity of human sodium\/iodide symporter","volume":"199","author":"Wu","year":"2008","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0505","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1423-0127-17-89","article-title":"Conserved charged amino acid residues in the extracellular region of sodium\/iodide symporter are critical for iodide transport activity","volume":"17","author":"Li","year":"2010","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0510","doi-asserted-by":"crossref","first-page":"R73","DOI":"10.1530\/JME-10-0150","article-title":"Epigenetics of thyroid cancer and novel therapeutic targets","volume":"46","author":"Russo","year":"2011","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0515","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1210\/endo.138.6.5189","article-title":"Regulation by thyroid-stimulating hormone of sodium\/iodide symporter gene expression and protein levels in FRTL-5 cells","volume":"138","author":"Kogai","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0520","doi-asserted-by":"crossref","first-page":"21458","DOI":"10.1074\/jbc.M100561200","article-title":"Post-transcriptional regulation of the sodium\/iodide symporter (NIS) by thyrotropin","volume":"276","author":"Riedel","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0525","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1210\/endo.140.8.6893","article-title":"Escape from the acute Wolff\u2013Chaikoff effect is associated with a decrease in thyroid sodium\/iodide symporter messenger ribonucleic acid and protein","volume":"140","author":"Eng","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0530","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1530\/eje.0.1440139","article-title":"Regulation of the sodium iodide symporter by iodide in FRTL-5 cells","volume":"144","author":"Eng","year":"2001","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0535","first-page":"2697","article-title":"Rapid communication: predominant intracellular overexpression of the Na(+)\/I(\u2212) symporter (NIS) in a large sampling of thyroid cancer cases","volume":"86","author":"Dohan","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0540","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1210\/jc.2002-021544","article-title":"Immunohistochemical profile of the sodium\/iodide symporter in thyroid, breast, and other carcinomas using high density tissue microarrays and conventional sections","volume":"88","author":"Wapnir","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0545","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1677\/JOE-08-0333","article-title":"Phosphoinositide-3-kinase inhibition induces sodium\/iodide symporter expression in rat thyroid cells and human papillary thyroid cancer cells","volume":"199","author":"Kogai","year":"2008","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0550","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/1471-2407-7-137","article-title":"PI3K activation is associated with intracellular sodium\/iodide symporter protein expression in breast cancer","volume":"7","author":"Knostman","year":"2007","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0555","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1677\/erc.1.01263","article-title":"MEK signaling modulates sodium iodide symporter at multiple levels and in a paradoxical manner","volume":"14","author":"Vadysirisack","year":"2007","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0560","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1530\/ERC-12-0342","article-title":"MEK inhibition leads to lysosome-mediated Na+\/I\u2212 symporter protein degradation in human breast cancer cells","volume":"20","author":"Zhang","year":"2013","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0565","doi-asserted-by":"crossref","first-page":"43990","DOI":"10.1074\/jbc.M407503200","article-title":"Inhibition of heat shock protein 90, a novel RET\/PTC1-associated protein, increases radioiodide accumulation in thyroid cells","volume":"279","author":"Marsee","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0570","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1242\/jcs.045427","article-title":"A novel mechanism of sodium iodide symporter repression in differentiated thyroid cancer","volume":"122","author":"Smith","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0575","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1158\/0008-5472.CAN-12-0516","article-title":"Iodide transporter NIS regulates cancer cell motility and invasiveness by interacting with the Rho guanine nucleotide exchange factor LARG","volume":"72","author":"Lacoste","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0580","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1152\/physrev.1964.44.1.45","article-title":"Transport of iodide and other anions in the thyroid gland","volume":"44","author":"Wolff","year":"1964","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0585","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ab.2011.04.017","article-title":"Intracellular anion fluorescence assay for sodium\/iodide symporter substrates","volume":"415","author":"Di Bernardo","year":"2011","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0590","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1089\/thy.2004.14.1012","article-title":"Relative potencies and additivity of perchlorate, thiocyanate, nitrate, and iodide on the inhibition of radioactive iodide uptake by the human sodium iodide symporter","volume":"14","author":"Tonacchera","year":"2004","journal-title":"Thyroid"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0595","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1006\/bbrc.1997.6178","article-title":"Different electrophysiological character of I\u2212, ClO4\u2212, and SCN\u2212 in the transport by Na+\/I\u2212 symporter","volume":"231","author":"Yoshida","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0600","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","article-title":"ClustalW and ClustalX version 2","volume":"23","author":"Larkin","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0605","first-page":"2366","article-title":"Failure of membrane targeting causes the functional defect of two mutant sodium iodide symporters","volume":"85","author":"Pohlenz","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0610","doi-asserted-by":"crossref","first-page":"595","DOI":"10.2174\/0929867043455891","article-title":"Identification of functionally important residues in proteins using comparative models","volume":"11","author":"Chen","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0615","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1093\/bioinformatics\/bti474","article-title":"INTERALIGN: interactive alignment editor for distantly related protein sequences","volume":"21","author":"Pible","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbamem.2013.08.013_bb0620","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1055\/s-0037-1614127","article-title":"Three-dimensional model of coagulation factor Va bound to activated protein C","volume":"84","author":"Pellequer","year":"2000","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.bbamem.2013.08.013_bb0625","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD: visual molecular dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graph."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273613002903?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273613002903?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T04:00:18Z","timestamp":1563768018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0005273613002903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":125,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0005273613002903"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamem.2013.08.013","relation":{},"ISSN":["0005-2736"],"issn-type":[{"value":"0005-2736","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The sodium\/iodide symporter: State of the art of its molecular characterization","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Biomembranes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamem.2013.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}