{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:25:10Z","timestamp":1792895110479,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009261","name":"Natural Resources Wales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.bbamem.2014.05.007","type":"journal-article","created":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T02:30:17Z","timestamp":1400553017000},"page":"2716-2727","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Biophysical investigations of the structure and function of the tear fluid lipid layers and the effect of ectoine. Part B: Artificial lipid films"],"prefix":"10.1016","volume":"1838","author":[{"given":"Mridula","family":"Dwivedi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Brinkk\u00f6tter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh Kumar","family":"Harishchandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Joachim","family":"Galla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamem.2014.05.007_bb0005","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0014-4835(73)90064-X","article-title":"Formation and rupture of tear film","volume":"15","author":"Holly","year":"1973","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0010","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00006324-199701000-00014","article-title":"Importance of the lipid layer in human tear film stability and evaporation","volume":"74","author":"Craig","year":"1997","journal-title":"Optom. Vis. Sci."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0015","first-page":"S544","article-title":"Deterioration of retinal image quality due to breakup of the corneal tear film","volume":"40","author":"Thibos","year":"1999","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0020","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1023\/A:1017987608937","article-title":"The lipid layer: the outer surface of the ocular surface tear film","volume":"21","author":"McCulley","year":"2001","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0025","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1076\/ceyr.26.2.89.14515","article-title":"Polar lipids in human meibomian gland secretions","volume":"26","author":"Shine","year":"2003","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0030","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1194\/jlr.M900252-JLR200","article-title":"Human tear film and meibum. Very long chain wax esters and (O-acyl)-omega-hydroxy fatty acids of meibum","volume":"50","author":"Butovich","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0035","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1194\/jlr.M700237-JLR200","article-title":"Lipids of human meibum: mass-spectrometric analysis and structural elucidation","volume":"48","author":"Butovich","year":"2007","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0040","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s11745-007-3080-2","article-title":"Liquid chromatography\u2013mass spectrometric analysis of lipids present in human meibomian gland secretions","volume":"42","author":"Butovich","year":"2007","journal-title":"Lipids"},{"key":"10.1016\/j.bbamem.2014.05.007_bb0045","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/978-1-4615-0717-8_63","article-title":"Impact of androgen deficiency on the lipid profiles in human meibomian gland secretions","volume":"506","author":"Sullivan","year":"2002","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0050","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1001\/archopht.124.9.1286","article-title":"Influence of aging on the polar and neutral lipid profiles in human meibomian gland secretions","volume":"124","author":"Sullivan","year":"2006","journal-title":"Arch. Ophthalmol. Chic."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0055","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1097\/ICO.0b013e3181cda38f","article-title":"Topical azithromycin therapy for meibomian gland dysfunction: clinical response and lipid alterations","volume":"29","author":"Foulks","year":"2010","journal-title":"Cornea"},{"key":"10.1016\/j.bbamem.2014.05.007_bb0060","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/bip.20798","article-title":"Temperature-induced conformational changes in human tear lipids hydrocarbon chains","volume":"87","author":"Borchman","year":"2007","journal-title":"Biopolymers"},{"key":"10.1016\/j.bbamem.2014.05.007_bb0065","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.chemphyslip.2007.04.001","article-title":"Spectroscopic evaluation of human tear lipids","volume":"147","author":"Borchman","year":"2007","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.bbamem.2014.05.007_bb0070","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/BF02764296","article-title":"Effective methods for the investigation of human tear film proteins and lipids","volume":"228","author":"Wollensak","year":"1990","journal-title":"Graefes Arch. Clin. Exp."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0075","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/978-1-4615-0717-8_54","article-title":"Meibomian gland and tear film lipids: structure, function and control","volume":"506","author":"McCulley","year":"2002","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0080","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1167\/iovs.11-8551","article-title":"Differences in human meibum lipid composition with meibomian gland dysfunction using NMR and principal component analysis","volume":"53","author":"Borchman","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0085","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/ICL.0b013e3181ef0d37","article-title":"Meibomian gland dysfunction: the past, present, and future","volume":"36","author":"Foulks","year":"2010","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.bbamem.2014.05.007_bb0090","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1167\/iovs.10-6514","article-title":"Human meibum lipid conformation and thermodynamic changes with meibomian-gland dysfunction","volume":"52","author":"Borchman","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0095","first-page":"3926","article-title":"Meibomian gland secretion polar lipids associated with chronic blepharitis disease groups","volume":"37","author":"Shine","year":"1996","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0100","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1432-1033.1985.tb08903.x","article-title":"1,4,5,6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid \u2014 a novel cyclic amino-acid from halophilic phototrophic bacteria of the genus Ectothiorhodospira","volume":"149","author":"Galinski","year":"1985","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0105","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF00174204","article-title":"Enzyme stabilization by ectoine-type compatible solutes \u2014 protection against heating, freezing and drying","volume":"37","author":"Lippert","year":"1992","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0110","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1016\/j.bbamem.2011.08.022","article-title":"Compatible solutes: ectoine and hydroxyectoine improve functional nanostructures in artificial lung surfactants","volume":"1808","author":"Harishchandra","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2014.05.007_bb0115","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bpc.2011.09.007","article-title":"Properties of compatible solutes in aqueous solution","volume":"160","author":"Smiatek","year":"2012","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0120","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S0006-3495(00)76346-6","article-title":"Formation of three-dimensional protein\u2013lipid aggregates in monolayer films induced by surfactant protein B","volume":"79","author":"Krol","year":"2000","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0125","doi-asserted-by":"crossref","first-page":"7158","DOI":"10.1021\/la970898e","article-title":"A close look at domain formation in DPPC monolayers","volume":"13","author":"McConlogue","year":"1997","journal-title":"Langmuir"},{"key":"10.1016\/j.bbamem.2014.05.007_bb0130","doi-asserted-by":"crossref","first-page":"6820","DOI":"10.1021\/j100195a053","article-title":"Line tension between liquid domains in lipid monolayers","volume":"96","author":"Benvegnu","year":"1992","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0135","doi-asserted-by":"crossref","first-page":"6686","DOI":"10.1021\/j100127a019","article-title":"Surface dipole densities in lipid monolayers","volume":"97","author":"Benvegnu","year":"1993","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0140","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.pc.42.100191.001131","article-title":"Structures and transitions in lipid monolayers at the air\u2013water interface","volume":"42","author":"McConnell","year":"1991","journal-title":"Annu. Rev. Phys. Chem."},{"key":"10.1016\/j.bbamem.2014.05.007_bb0145","doi-asserted-by":"crossref","first-page":"17092","DOI":"10.1021\/la304366d","article-title":"Role of neutral lipids in tear fluid lipid layer: coarse-grained simulation study","volume":"28","author":"Telenius","year":"2012","journal-title":"Langmuir"},{"key":"10.1016\/j.bbamem.2014.05.007_bb0150","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.1167\/iovs.12-10022","article-title":"Analysis of comparison of human meibomian lipid films and mixtures with cholesteryl esters in vitro films using high resolution color microscopy","volume":"53","author":"Millar","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273614001795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273614001795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T08:44:20Z","timestamp":1757753060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0005273614001795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0005273614001795"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamem.2014.05.007","relation":{},"ISSN":["0005-2736"],"issn-type":[{"value":"0005-2736","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biophysical investigations of the structure and function of the tear fluid lipid layers and the effect of ectoine. Part B: Artificial lipid films","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Biomembranes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamem.2014.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}