{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:37:52Z","timestamp":1765294672081,"version":"3.40.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.bbamem.2014.06.003","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T23:51:15Z","timestamp":1402962675000},"page":"2439-2450","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["The application of solid-state NMR spectroscopy to study candesartan cilexetil (TCV-116) membrane interactions. Comparative study with the AT1R antagonist drug olmesartan"],"prefix":"10.1016","volume":"1838","author":[{"given":"Dimitrios","family":"Ntountaniotis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahsin","family":"Kellici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Tzakos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinelopi","family":"Kolokotroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore","family":"Tselios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Becker-Baldus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens","family":"Glaubitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonyan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandros","family":"Makriyannis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Mavromoustakos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamem.2014.06.003_bb0005","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1021\/jm980499w","article-title":"An effort to understand the molecular basis of hypertension through the study of conformational analysis of Losartan and Sarmesin using a combination of nuclear magnetic resonance spectroscopy and theoretical calculations","volume":"42","author":"Mavromoustakos","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbamem.2014.06.003_bb0010","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0031-6997(24)01458-3","article-title":"International union of pharmacology. XXIII. The angiotensin II receptors","volume":"52","author":"De Gasparo","year":"2000","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbamem.2014.06.003_bb0015","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0009-3084(03)00053-7","article-title":"Losartan's molecular basis of interaction with membranes and AT 1 receptor","volume":"125","author":"Zoumpoulakis","year":"2003","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.bbamem.2014.06.003_bb0020","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.2174\/092986710791111233","article-title":"Drug-membrane interactions: significance for medicinal chemistry","volume":"17","author":"L\u00facio","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbamem.2014.06.003_bb0025","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1039\/b813853m","article-title":"Drug interactions with lipid membranes","volume":"38","author":"Seddon","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bbamem.2014.06.003_bb0030","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1023\/A:1021729909456","article-title":"Functional antagonism of different angiotensin II type I receptor blockers in human arteries","volume":"16","author":"Wagenaar","year":"2002","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.bbamem.2014.06.003_bb0035","doi-asserted-by":"crossref","first-page":"6180","DOI":"10.1021\/jp110371k","article-title":"Comparative biophysical studies of sartan class drug molecules losartan and candesartan (CV-11974) with membrane bilayers","volume":"115","author":"Fotakis","year":"2011","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.bbamem.2014.06.003_bb0040","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.jpba.2008.02.021","article-title":"Identification of a degradation product in stressed tablets of olmesartan medoxomil by the complementary use of HPLC hyphenated techniques","volume":"47","author":"Murakami","year":"2008","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.bbamem.2014.06.003_bb0045","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1097\/01.fjc.0000180902.78230.fd","article-title":"A review of the structural and functional features of olmesartan medoxomil, an angiotensin receptor blocker","volume":"46","author":"Mire","year":"2005","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.bbamem.2014.06.003_bb0050","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/mrc.2690","article-title":"Heteronuclear chemical shift correlation and J-resolved MAS NMR spectroscopy of lipid membranes","volume":"48","author":"Zorin","year":"2010","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.bbamem.2014.06.003_bb0055","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s11745-004-1336-x","article-title":"What's so special about cholesterol?","volume":"39","author":"Mouritsen","year":"2004","journal-title":"Lipids"},{"key":"10.1016\/j.bbamem.2014.06.003_bb0060","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.bbamem.2009.08.012","article-title":"Cholesterol reduces pardaxin's dynamics\u2014a barrel-stave mechanism of membrane disruption investigated by solid-state NMR","volume":"1798","author":"Ramamoorthy","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2014.06.003_bb0065","first-page":"1","article-title":"Membrane lipid composition and the interaction of pardaxin: the role of cholesterol","volume":"13","author":"Epand","year":"2006","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.bbamem.2014.06.003_bb0070","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1016\/j.bbamem.2012.07.021","article-title":"Does cholesterol suppress the antimicrobial peptide induced disruption of lipid raft containing membranes?","volume":"1818","author":"McHenry","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2014.06.003_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2012.00195","article-title":"Does cholesterol play a role in the bacterial selectivity of antimicrobial peptides?","volume":"3","author":"Brender","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbamem.2014.06.003_bb0080","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/mrc.1327","article-title":"Effects of antidepressants on the conformation of phospholipid headgroups studied by solid-state NMR","volume":"42","author":"Santos","year":"2004","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.bbamem.2014.06.003_bb0085","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1590\/S0100-879X2009005000012","article-title":"Structural properties of lipid reconstructs and lipid composition of normotensive and hypertensive rat vascular smooth muscle cell membranes","volume":"42","author":"Oliveira","year":"2009","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.bbamem.2014.06.003_bb0090","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/BF02867955","article-title":"Characterisation of the canine cardiac sarcolemma in experimental myocardial ischemia","volume":"12","author":"Netticadan","year":"1997","journal-title":"Indian J. Clin. Biochem."},{"key":"10.1016\/j.bbamem.2014.06.003_bb0095","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0304-4157(98)00006-9","article-title":"Phases and phase transitions of the phosphatidylcholines","volume":"1376","author":"Koynova","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2014.06.003_bb0100","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1021\/bi00388a016","article-title":"Kinetics of the subtransition in dipalmitoylphosphatidyicholine","volume":"26","author":"Tristram-Nagle","year":"1987","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamem.2014.06.003_bb0105","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0006-3495(75)85888-7","article-title":"Tilted hydrocarbon chains of dipalmitoyl lecithin become perpendicular to the bilayer before melting","volume":"15","author":"Rand","year":"1975","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbamem.2014.06.003_bb0110","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0006-3495(80)85128-9","article-title":"Differences in hydrocarbon chain tilt between hydrated phosphatidylethanolamine and phosphatidylcholine bilayers. A molecular packing model","volume":"29","author":"McIntosh","year":"1980","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbamem.2014.06.003_bb0115","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0006-3495(82)84551-7","article-title":"Amplitude of rippling in the P beta phase of dipalmitoylphosphatidylcholine bilayers","volume":"38","author":"Stamatoff","year":"1982","journal-title":"Biophys. J."},{"year":"1990","series-title":"Introduction to infrared and Raman spectroscopy","author":"Colthup","key":"10.1016\/j.bbamem.2014.06.003_bb0120"},{"key":"10.1016\/j.bbamem.2014.06.003_bb0125","doi-asserted-by":"crossref","first-page":"5926","DOI":"10.1021\/ja00386a015","article-title":"Phase-transition behavior of saturated, symmetric chain phospholipid bilayer dispersions determined by Raman spectroscopy: correlation between spectral and thermodynamic parameters","volume":"104","author":"Huang","year":"1982","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bbamem.2014.06.003_bb0130","first-page":"1101a","article-title":"Fourier transform raman spectroscopy of biological materials","volume":"62","author":"Levin","year":"1990","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbamem.2014.06.003_bb0135","doi-asserted-by":"crossref","first-page":"4000","DOI":"10.1103\/PhysRevE.62.4000","article-title":"Structural information from multilamellar liposomes at full hydration: full q-range fitting with high quality X-ray data","volume":"62","author":"Pabst","year":"2000","journal-title":"Phys. Rev. E Stat. Phys. Plasmas Fluids"},{"key":"10.1016\/j.bbamem.2014.06.003_bb0140","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/S0006-3495(02)73949-0","article-title":"Cholesterol-induced modifications in lipid bilayers: a simulation study","volume":"83","author":"Chiu","year":"2002","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbamem.2014.06.003_bb0145","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1016\/j.bbamem.2011.08.001","article-title":"Thermal, dynamic and structural properties of drug AT 1 antagonist olmesartan in lipid bilayers","volume":"1808","author":"Ntountaniotis","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2014.06.003_bb0150","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1016\/j.bbamem.2012.08.009","article-title":"Comparative study of the AT1 receptor prodrug antagonist candesartan cilexetil with other sartans on the interactions with membrane bilayers","volume":"1818","author":"Fotakis","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2014.06.003_bb0155","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.bbamem.2013.12.012","article-title":"Insights into the molecular basis of action of the AT1 antagonist losartan using a combined NMR spectroscopy and computational approach","volume":"1838","author":"Zervou","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2014.06.003_bb0160","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.1039\/c2cp40134g","article-title":"Losartan's affinity to fluid bilayers modulates lipid\u2013cholesterol interactions","volume":"14","author":"Hodzic","year":"2012","journal-title":"PCCP"},{"key":"10.1016\/j.bbamem.2014.06.003_bb0165","doi-asserted-by":"crossref","first-page":"6693","DOI":"10.1021\/jp4034003","article-title":"2D 1H\/1H RFDR and NOESY NMR experiments on a membrane-bound antimicrobial peptide under magic angle spinning","volume":"117","author":"Ramamoorthy","year":"2013","journal-title":"J. Phys. Chem. B"},{"year":"2012","series-title":"MacroModel, version 9.9, Schr\u00f6dinger","key":"10.1016\/j.bbamem.2014.06.003_bb0170"},{"key":"10.1016\/j.bbamem.2014.06.003_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0005-2736(75)90037-1","article-title":"Bilayers of dipalmitoyl 3 sn phosphatidylcholine. Conformational differences between the fatty acyl chains","volume":"406","author":"Seelig","year":"1975","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2014.06.003_bb0180","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0005-2736(92)90053-O","article-title":"Amphipathic interactions of cannabinoids with membranes. A comparison between \u03948-THC and its O-methyl analog using differential scanning calorimetry, X-ray diffraction and solid state 2H-NMR","volume":"1103","author":"Yang","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2014.06.003_bb0185","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1124\/pr.112.007278","article-title":"A systematic comparison of the properties of clinically used angiotensin II type 1 receptor antagonists","volume":"65","author":"Michel","year":"2013","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbamem.2014.06.003_bb0190","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.1021\/bi00720a024","article-title":"The dynamic structure of fatty acyl chains in a phospholipid bilayer measured by deuterium magnetic resonance","volume":"13","author":"Seelig","year":"1974","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamem.2014.06.003_bb0195","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0005-2736(95)00153-T","article-title":"Effects of the anesthetic steroid alphaxalone and its inactive \u039416-analog on the thermotropic properties of membrane bilayers. A model for membrane perturbation","volume":"1239","author":"Mavromoustakos","year":"1995","journal-title":"Biomembranes"},{"key":"10.1016\/j.bbamem.2014.06.003_bb0200","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/(SICI)1097-458X(199602)34:2<137::AID-OMR841>3.0.CO;2-Q","article-title":"Structure investigation and proton and carbon-13 assignments of digitonin and cholesterol using multidimensional NMR techniques","volume":"34","author":"Muhr","year":"1996","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.bbamem.2014.06.003_bb0205","doi-asserted-by":"crossref","first-page":"o309","DOI":"10.1107\/S1600536805000097","article-title":"Candesartan cilexetil, an antihypertensive agent containing an extended double ester chain","volume":"61","author":"Fern\u00e1ndez","year":"2005","journal-title":"Acta Crystallogr. Sect. E Struct. Rep. Online"},{"key":"10.1016\/j.bbamem.2014.06.003_bb0210","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/hlca.200890051","article-title":"Physicochemical profiling of sartans: a detailed study of ionization constants and distribution coefficients","volume":"91","author":"Tosco","year":"2008","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.bbamem.2014.06.003_bb0215","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0009-3084(98)00005-X","article-title":"A combined use of 13C-cross polarization\/magic angle spinning, 13C-magic angle spinning and 31P-nuclear magnetic resonance spectroscopy with differential scanning calorimetry to study cannabinoid\u2013membrane interactions","volume":"92","author":"Mavromoustakos","year":"1998","journal-title":"Chem. Phys. Lipids"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273614002120?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273614002120?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T10:36:47Z","timestamp":1746268607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0005273614002120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0005273614002120"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamem.2014.06.003","relation":{},"ISSN":["0005-2736"],"issn-type":[{"type":"print","value":"0005-2736"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The application of solid-state NMR spectroscopy to study candesartan cilexetil (TCV-116) membrane interactions. Comparative study with the AT1R antagonist drug olmesartan","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Biomembranes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamem.2014.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}