{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:41:05Z","timestamp":1789713665927,"version":"4.0.1"},"reference-count":73,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.bbamem.2016.02.002","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T15:25:25Z","timestamp":1454426725000},"page":"872-882","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Membrane-binding properties of gating modifier and pore-blocking toxins: Membrane interaction is not a prerequisite for modification of channel gating"],"prefix":"10.1016","volume":"1858","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2052-5536","authenticated-orcid":false,"given":"Evelyne","family":"Deplazes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f3nia Troeira","family":"Henriques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn F.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Craik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan E.","family":"Mark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina I.","family":"Schroeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamem.2016.02.002_bb0005","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1113\/jphysiol.2011.224204","article-title":"Voltage-gated sodium channels at 60: structure, function and pathophysiology","volume":"590","author":"Catterall","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0010","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1124\/pr.57.4.13","article-title":"Overview of molecular relationships in the voltage-gated ion channel superfamily","volume":"57","author":"Yu","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0015","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1517\/14728222.11.3.265","article-title":"Advantages of voltage-gated ion channels as drug targets","volume":"11","author":"McGivern","year":"2007","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0020","series-title":"Voltage-Gated Ion Channels as Drug Targets","author":"Triggle","year":"2006"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0025","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/nrd2983","article-title":"Voltage-gated potassium channels as therapeutic targets","volume":"8","author":"Wulff","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0030","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.3390\/md10081812","article-title":"Sea anemone (cnidaria, anthozoa, actiniaria) toxins: an overview","volume":"10","author":"Fraz\u00e3o","year":"2012","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0035","doi-asserted-by":"crossref","first-page":"D653","DOI":"10.1093\/nar\/gkq1058","article-title":"Arachnoserver 2.0, an updated online resource for spider toxin sequences and structures","volume":"39","author":"Herzig","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0040","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1124\/pr.111.005322","article-title":"Conus venom peptide pharmacology","volume":"64","author":"Lewis","year":"2012","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0045","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0041-0101(01)00199-4","article-title":"Pharmacology and biochemistry of spider venoms","volume":"40","author":"Rash","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0050","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.toxicon.2006.09.015","article-title":"The interaction of spider gating modifier peptides with voltage-gated potassium channels","volume":"49","author":"Huang","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0055","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.toxicon.2012.04.337","article-title":"Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads","volume":"60","author":"Klint","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0060","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.3390\/toxins4111236","article-title":"Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics?","volume":"4","author":"Knapp","year":"2012","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0065","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.toxicon.2009.02.028","article-title":"Sea anemone toxins affecting voltage-gated sodium channels\u2014molecular and evolutionary features","volume":"54","author":"Moran","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0070","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.2174\/0929867043363947","article-title":"Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases","volume":"11","author":"Norton","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0075","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.toxicon.2006.09.014","article-title":"ProTx-I and ProTx-II: gating modifiers of voltage-gated sodium channels","volume":"49","author":"Priest","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0080","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.toxicon.2006.09.024","article-title":"Tarantula toxins interacting with voltage sensors in potassium channels","volume":"49","author":"Swartz","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0085","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1517\/14712598.2011.621940","article-title":"Venoms as a platform for human drugs: translating toxins into therapeutics","volume":"11","author":"King","year":"2011","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0090","series-title":"Venoms to Drugs:","author":"King","year":"2015"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0095","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1111\/bph.13081","article-title":"Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach","volume":"172","author":"Klint","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0100","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.3390\/toxins2122851","article-title":"Spider-venom peptides as therapeutics","volume":"2","author":"Saez","year":"2010","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0105","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.tips.2009.12.007","article-title":"Targeting sodium channel voltage sensors with spider toxins","volume":"31","author":"Bosmans","year":"2010","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0110","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1126\/science.280.5360.69","article-title":"The structure of the potassium channel: molecular basis of K+ conduction and selectivity","volume":"280","author":"Doyle","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0115","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nature01580","article-title":"X-ray structure of a voltage-dependent K+ channel","volume":"423","author":"Jiang","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0120","doi-asserted-by":"crossref","first-page":"8585","DOI":"10.1073\/pnas.95.15.8585","article-title":"Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca2+ and K+ channels","volume":"95","author":"Li-Smerin","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0125","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1126\/science.1116269","article-title":"Crystal structure of a mammalian voltage-dependent shaker family K+ channel","volume":"309","author":"Long","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0130","doi-asserted-by":"crossref","first-page":"6015","DOI":"10.1021\/bi0477034","article-title":"Solution structure and lipid membrane partitioning of VSTx1, an inhibitor of the kvap potassium channel","volume":"44","author":"Jung","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0135","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature02632","article-title":"A membrane-access mechanism of ion channel inhibition by voltage sensor toxins","volume":"430","author":"Lee","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0140","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.bpj.2010.04.061","article-title":"Structure and orientation of a voltage-sensor toxin in lipid membranes","volume":"99","author":"Jung","year":"2010","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0145","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1085\/jgp.200709869","article-title":"Tarantula toxins interact with voltage sensors within lipid membranes","volume":"130","author":"Milescu","year":"2007","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0150","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nature03873","article-title":"Voltage-sensor activation with a tarantula toxin as cargo","volume":"436","author":"Phillips","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0155","doi-asserted-by":"crossref","first-page":"11127","DOI":"10.1074\/jbc.M412552200","article-title":"Differential phospholipid binding by site 3 and site 4 toxins: implications for structural variability between voltage-sensitive sodium channel domains","volume":"280","author":"Smith","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0160","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.toxicon.2007.09.008","article-title":"Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels","volume":"51","author":"Xiao","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0165","doi-asserted-by":"crossref","first-page":"20673","DOI":"10.1074\/jbc.M603212200","article-title":"Direct evidence that receptor site-4 of sodium channel gating modifiers is not dipped in the phospholipid bilayer of neuronal membranes","volume":"281","author":"Cohen","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0170","doi-asserted-by":"crossref","first-page":"L20","DOI":"10.1529\/biophysj.107.112375","article-title":"Is lipid bilayer binding a common property of inhibitor cysteine knot ion-channel blockers?","volume":"93","author":"Posokhov","year":"2007","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0175","doi-asserted-by":"crossref","first-page":"11844","DOI":"10.1021\/bi061111z","article-title":"VSTx1, a modifier of KV channel gating, localizes to the interfacial region of lipid bilayers","volume":"45","author":"Bemporad","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0180","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00249-006-0044-z","article-title":"Interaction between K+ channel gate modifier hanatoxin and lipid bilayer membranes analyzed by molecular dynamics simulation","volume":"35","author":"Nishizawa","year":"2006","journal-title":"Eur. Biophys. J."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0185","doi-asserted-by":"crossref","first-page":"L07","DOI":"10.1529\/biophysj.106.098681","article-title":"SGTx1, a KV channel gating-modifier toxin, binds to the interfacial region of lipid bilayers","volume":"92","author":"Wee","year":"2007","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0190","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0041-0101(95)00013-C","article-title":"Characterization of a potassium channel toxin from the caribbean sea anemone Stichodactyla helianthus","volume":"33","author":"Castaneda","year":"1995","journal-title":"Toxicon"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0195","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1399-3011.1995.tb01068.x","article-title":"Chemical synthesis and characterization of ShK toxin: a potent potassium channel inhibitor from a sea anemone","volume":"46","author":"Pennington","year":"1995","journal-title":"Int. J. Pept. Protein Res."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0200","doi-asserted-by":"crossref","first-page":"16407","DOI":"10.1021\/bi962463g","article-title":"An essential binding surface for ShK toxin interaction with rat brain potassium channels","volume":"35","author":"Pennington","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0205","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nsb0496-317","article-title":"Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone","volume":"3","author":"Tudor","year":"1996","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0210","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1021\/bi801998a","article-title":"Structure of the analgesic \u03bc-conotoxin KIIIA and effects on the structure and function of disulfide deletion","volume":"48","author":"Khoo","year":"2009","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0215","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1124\/mol.111.073460","article-title":"Interactions of key charged residues contributing to selective block of neuronal sodium channels by \u03bc-conotoxin KIIIA","volume":"80","author":"McArthur","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0220","doi-asserted-by":"crossref","first-page":"30699","DOI":"10.1074\/jbc.M704616200","article-title":"Structure\/function characterization of \u03bc-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels","volume":"282","author":"Zhang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0225","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1111\/j.1742-4658.2011.08264.x","article-title":"Importance of position 8 in mu-conotoxin KIIIA for voltage-gated sodium channel selectivity","volume":"278","author":"Van Der Haegen","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0230","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1756-6606-7-36","article-title":"Block of t-type calcium channels by protoxins i and ii","volume":"7","author":"Bladen","year":"2014","journal-title":"Mol. Brain"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0235","doi-asserted-by":"crossref","first-page":"14734","DOI":"10.1021\/bi026546a","article-title":"Two tarantula peptides inhibit activation of multiple sodium channels","volume":"41","author":"Middleton","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0240","doi-asserted-by":"crossref","first-page":"7259","DOI":"10.1021\/bi0473408","article-title":"Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels","volume":"44","author":"Bulaj","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0245","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1529\/biophysj.108.131458","article-title":"PrP(106-126) does not interact with membranes under physiological conditions","volume":"95","author":"Henriques","year":"2008","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0250","doi-asserted-by":"crossref","first-page":"4198","DOI":"10.1021\/bi900009d","article-title":"The toxicity of prion protein fragment PrP(106\u2212126) is not mediated by membrane permeabilization as shown by a M112W substitution","volume":"48","author":"Henriques","year":"2009","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0255","doi-asserted-by":"crossref","first-page":"24231","DOI":"10.1074\/jbc.M111.253393","article-title":"Decoding the membrane activity of the cyclotide kalata B1: the importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities J","volume":"286","author":"Henriques","year":"2011","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0260","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1006\/abio.1999.4389","article-title":"A vesicle capture sensor chip for kinetic analysis of interactions with membrane-bound receptors","volume":"277","author":"Cooper","year":"2000","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0265","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1002\/cbic.201100450","article-title":"A synthetic mirror image of kalata B1 reveals that cyclotide activity is independent of a protein receptor","volume":"12","author":"Sando","year":"2011","journal-title":"ChemBioChem"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0270","doi-asserted-by":"crossref","first-page":"33629","DOI":"10.1074\/jbc.M112.372011","article-title":"Phosphatidylethanolamine binding is a conserved feature of cyclotide-membrane interactions","volume":"287","author":"Henriques","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0275","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.bbamem.2012.12.002","article-title":"Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria","volume":"1828","author":"Torcato","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0280","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.cub.2014.01.013","article-title":"A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the s1\u2013s4 gating domain","volume":"24","author":"Gui","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0285","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1021\/ct900487a","article-title":"On the validation of molecular dynamics simulations of saturated and cis-monounsaturated phosphatidylcholine lipid bilayers: a comparison with experiment","volume":"6","author":"Poger","year":"2010","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0290","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1089\/cmb.2012.0239","article-title":"Charge group partitioning in biomolecular simulation","volume":"20","author":"Canzar","year":"2013","journal-title":"J. Comput. Biol."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0295","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10822-014-9713-7","article-title":"Testing and validation of the automated topology builder (ATB) version 2.0: prediction of hydration free enthalpies","volume":"28","author":"Koziara","year":"2014","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0300","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1021\/ct200196m","article-title":"An automated force field topology builder (ATB) and repository: Version 1.0","volume":"7","author":"Malde","year":"2011","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0305","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible and free","volume":"26","author":"van der Spoel","year":"2005","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0310","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s00249-011-0700-9","article-title":"Definition and testing of the GROMOS force-field versions 54a7 and 54b7","volume":"40","author":"Schmid","year":"2011","journal-title":"Eur. Biophys. J."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0315","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.1021\/ct300675z","article-title":"Lipid bilayers: the effect of force field on ordering and dynamics","volume":"8","author":"Poger","year":"2012","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0320","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/jcc.21396","article-title":"A new force field for simulating phosphatidylcholine bilayers","volume":"31","author":"Poger","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0325","first-page":"331","article-title":"Interaction models for water in relation to protein hydration","volume":"14","author":"Berendsen","year":"1981"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0330","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1063\/1.469273","article-title":"A generalized reaction field method for molecular dynamics simulations","volume":"102","author":"Tironi","year":"1995","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0335","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/jcc.540130805","article-title":"Settle-analytical version of the shake and rattle algorithm for rigid water models","volume":"13","author":"Miyamoto","year":"1992","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0340","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1063\/1.448118","article-title":"Molecular dynamics with coupling to an external bath","volume":"81","author":"Berendsen","year":"1984","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0345","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD\u2014visual molecular dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0350","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1002\/jcc.21787","article-title":"MDAnalysis: a toolkit for the analysis of molecular dynamics simulations","volume":"32","author":"Michaud-Agrawal","year":"2011","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0355","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1039\/qr9591300183","article-title":"Molecular quadrupole moments","volume":"13","author":"Buckingham","year":"1959","journal-title":"Q. Rev. Chem. Soc."},{"key":"10.1016\/j.bbamem.2016.02.002_bb0360","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0041-0101(00)00160-4","article-title":"The cystine knot motif in toxins and implications for drug design","volume":"39","author":"Craik","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.bbamem.2016.02.002_bb0365","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1002\/pro.5560031022","article-title":"A common structural motif incorporating a cystine knot and a triple-stranded beta-sheet in toxic and inhibitory polypeptides","volume":"3","author":"Pallaghy","year":"1994","journal-title":"Prot. Sci."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273616300323?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273616300323?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T16:02:06Z","timestamp":1537027326000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0005273616300323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":73,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0005273616300323"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamem.2016.02.002","relation":{},"ISSN":["0005-2736"],"issn-type":[{"value":"0005-2736","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Membrane-binding properties of gating modifier and pore-blocking toxins: Membrane interaction is not a prerequisite for modification of channel gating","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Biomembranes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamem.2016.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}