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Physiol."},{"key":"10.1016\/j.bbamem.2017.03.015_bb0375","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039392","article-title":"SP-B and SP-C containing new synthetic surfactant for treatment of extremely immature lamb lung","volume":"7","author":"Sato","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbamem.2017.03.015_bb0380","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047631","article-title":"New surfactant with SP-B and C analogs gives survival benefit after inactivation in preterm lambs","volume":"7","author":"Seehase","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbamem.2017.03.015_bb0385","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1056-8719(99)00025-8","article-title":"A rat model of acute respiratory distress syndrome (ARDS) Part 2, influence of lavage volume, lavage repetition, and therapeutic treatment with rSP-C surfactant","volume":"41","author":"H\u00e4fner","year":"1999","journal-title":"J. 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Res."},{"issue":"Pt 2","key":"10.1016\/j.bbamem.2017.03.015_bb0670","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1042\/bj3000519","article-title":"Surface-area cycling of different surfactant preparations: SP-A and SP-B are essential for large-aggregate integrity","volume":"300","author":"Veldhuizen","year":"1994","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbamem.2017.03.015_bb0675","doi-asserted-by":"crossref","first-page":"464","DOI":"10.4049\/jimmunol.174.1.464","article-title":"Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor","volume":"174","author":"Granata","year":"2005","journal-title":"J. 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