{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:14:06Z","timestamp":1790169246576,"version":"4.1.0"},"reference-count":85,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,2]],"date-time":"2018-09-02T00:00:00Z","timestamp":1535846400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003086","name":"Basque Government","doi-asserted-by":"publisher","award":["IT975-16"],"award-info":[{"award-number":["IT975-16"]}],"id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003086","name":"Basque Government","doi-asserted-by":"publisher","award":["ELKARTEK16\/81"],"award-info":[{"award-number":["ELKARTEK16\/81"]}],"id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.bbamem.2017.05.009","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T02:03:47Z","timestamp":1495073027000},"page":"1604-1614","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"PB","title":["Imaging mass spectrometry (IMS) of cortical lipids from preclinical to severe stages of Alzheimer's disease"],"prefix":"10.1016","volume":"1859","author":[{"given":"E.","family":"G\u00f3nzalez de San Rom\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Manuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.T.","family":"Giralt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4517-5114","authenticated-orcid":false,"given":"R.","family":"Rodr\u00edguez-Puertas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamem.2017.05.009_bb0005","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","article-title":"Alzheimer's disease: genes, proteins, and therapy","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0010","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature08538","article-title":"Multimodal techniques for diagnosis and prognosis of Alzheimer's disease","volume":"461","author":"Perrin","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0015","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.bbalip.2010.05.004","article-title":"Lipids in Alzheimer's disease: A century-old story","volume":"1801","author":"Foley","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0020","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cell.2005.02.008","article-title":"Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective","volume":"120","author":"Tanzi","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0025","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrm2101","article-title":"Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide","volume":"8","author":"Haass","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0030","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nrn2194","article-title":"Tau-mediated neurodegeneration in Alzheimer's disease and related disorders","volume":"8","author":"Ballatore","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0035","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0197-4580(95)00021-6","article-title":"Staging of Alzheimer's disease-related neurofibrillary changes","volume":"16","author":"Braak","year":"1995","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0040","doi-asserted-by":"crossref","first-page":"7713","DOI":"10.1016\/j.chroma.2011.07.073","article-title":"From brain to food: analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin-plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry","volume":"1218","author":"Grimm","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0045","doi-asserted-by":"crossref","first-page":"603052","DOI":"10.4061\/2011\/603052","article-title":"Lipid rafts: linking Alzheimer's amyloid-beta production, aggregation, and toxicity at neuronal membranes","volume":"2011","author":"Rushworth","year":"2010","journal-title":"Int. J. Alzheimers Dis."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0050","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","article-title":"Membrane lipids: where they are and how they behave","volume":"9","author":"van Meer","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0055","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3233\/JAD-2006-9S326","article-title":"Tau phosphorylation and proteolysis: insights and perspectives","volume":"9","author":"Johnson","year":"2006","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0060","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1523\/JNEUROSCI.0862-09.2009","article-title":"Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity","volume":"29","author":"Nicholson","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0065","doi-asserted-by":"crossref","first-page":"20936","DOI":"10.1073\/pnas.0905654106","article-title":"Amyloid-beta42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism","volume":"106","author":"Ryan","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0070","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/nature08890","article-title":"Caspase activation precedes and leads to tangles","volume":"464","author":"de Calignon","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0075","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF00309338","article-title":"Neurofibrillary tangles in Niemann-Pick disease type C","volume":"89","author":"Suzuki","year":"1995","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0080","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/00002093-199601020-00004","article-title":"Reductions in membrane proteins and lipids in basal ganglia of classic Alzheimer disease patients","volume":"10","author":"Gottfries","year":"1996","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0085","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1023\/A:1011603916962","article-title":"Brain membrane phospholipid alterations in Alzheimer's disease","volume":"26","author":"Pettegrew","year":"2001","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0090","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1046\/j.1471-4159.2002.00997.x","article-title":"Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis","volume":"82","author":"Han","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0095","first-page":"809","article-title":"Specificity and potential mechanism of sulfatide deficiency in Alzheimer's disease: an electrospray ionization mass spectrometric study","volume":"49","author":"Cheng","year":"2003","journal-title":"Cell. Mol. Biol. (Noisy-Le-Grand)"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0100","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1073\/pnas.0305799101","article-title":"Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease","volume":"101","author":"Cutler","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0105","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.neuroscience.2004.08.056","article-title":"Astroglial expression of ceramide in Alzheimer's disease brains: a role during neuronal apoptosis","volume":"130","author":"Satoi","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0110","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.neurobiolaging.2008.05.010","article-title":"Deregulation of sphingolipid metabolism in Alzheimer's disease","volume":"31","author":"He","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0115","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neurobiolaging.2016.03.027","article-title":"Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease","volume":"43","author":"Couttas","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0120","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3233\/JAD-2012-110629","article-title":"Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer's disease","volume":"29","author":"Cunnane","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2014.01.014","article-title":"Combination of metabolomic and phospholipid-profiling approaches for the study of Alzheimer's disease","author":"Gonzalez-Dominguez","year":"2014","journal-title":"J. Proteome"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0130","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neurobiolaging.2013.08.001","article-title":"Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease","volume":"35","author":"Whiley","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0135","doi-asserted-by":"crossref","first-page":"887","DOI":"10.3233\/JAD-150948","article-title":"Plasma phospholipid and sphingolipid alterations in presenilin1 mutation carriers: a pilot study","volume":"50","author":"Chatterjee","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0140","doi-asserted-by":"crossref","DOI":"10.1038\/nm.3466","article-title":"Plasma phospholipids identify antecedent memory impairment in older adults","author":"Mapstone","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0145","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.1021\/ac970888i","article-title":"Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS","volume":"69","author":"Caprioli","year":"1997","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0150","doi-asserted-by":"crossref","first-page":"5263","DOI":"10.1021\/ac990781q","article-title":"Direct profiling of proteins in biological tissue sections by MALDI mass spectrometry","volume":"71","author":"Chaurand","year":"1999","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0155","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/86573","article-title":"Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues","volume":"7","author":"Stoeckli","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0160","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/jms.153","article-title":"Organic ion imaging of biological tissue with secondary ion mass spectrometry and matrix-assisted laser desorption\/ionization","volume":"36","author":"Todd","year":"2001","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0165","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1255\/ejms.671","article-title":"Changes of phospholipid composition within the dystrophic muscle by matrix-assisted laser desorption\/ionization mass spectrometry and mass spectrometry imaging","volume":"10","author":"Touboul","year":"2004","journal-title":"Eur. J. Mass. Spectrom. (Chichester, Eng.)"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0170","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1007\/s00216-011-4909-3","article-title":"Abnormal phospholipids distribution in the prefrontal cortex from a patient with schizophrenia revealed by matrix-assisted laser desorption\/ionization imaging mass spectrometry","volume":"400","author":"Matsumoto","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0175","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s13361-010-0024-5","article-title":"Anatomical distribution of lipids in human brain cortex by imaging mass spectrometry","volume":"22","author":"Veloso","year":"2011","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0180","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00216-011-4882-x","article-title":"Distribution of lipids in human brain","volume":"401","author":"Veloso","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0185","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/jms.505","article-title":"Direct tissue analysis using matrix-assisted laser desorption\/ionization mass spectrometry: practical aspects of sample preparation","volume":"38","author":"Schwartz","year":"2003","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0190","doi-asserted-by":"crossref","first-page":"5728","DOI":"10.1021\/ac200998a","article-title":"Matrix sublimation\/recrystallization for imaging proteins by mass spectrometry at high spatial resolution","volume":"83","author":"Yang","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0195","doi-asserted-by":"crossref","first-page":"9105","DOI":"10.1021\/ac801662n","article-title":"Profiling and imaging of lipids on brain and liver tissue by matrix-assisted laser desorption\/ionization mass spectrometry using 2-mercaptobenzothiazole as a matrix","volume":"80","author":"Astigarraga","year":"2008","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0200","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/jnc.13112","article-title":"Anatomical location of LPA1 activation and LPA phospholipid precursors in rodent and human brain","volume":"134","author":"Gonzalez de San Roman","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0205","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/s13361-013-0607-z","article-title":"MSiReader: an open-source interface to view and analyze high resolving power MS imaging files on Matlab platform","volume":"24","author":"Robichaud","year":"2013","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2017.02.011","article-title":"Lipid mapping of the rat brain for models of disease","author":"Martinez-Gardeazabal","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0215","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1194\/jlr.M300331-JLR200","article-title":"Characterization of the ceramide moieties of sphingoglycolipids from mouse brain by ESI-MS\/MS: identification of ceramides containing sphingadienine","volume":"45","author":"Colsch","year":"2004","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0220","doi-asserted-by":"crossref","first-page":"7188","DOI":"10.1002\/anie.200602449","article-title":"Tissue imaging at atmospheric pressure using desorption electrospray ionization (DESI) mass spectrometry","volume":"45","author":"Wiseman","year":"2006","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0225","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jasms.2006.08.015","article-title":"In situ structural characterization of glycerophospholipids and sulfatides in brain tissue using MALDI-MS\/MS","volume":"18","author":"Jackson","year":"2007","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0230","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1093\/jaoac\/91.5.1227","article-title":"Analysis of brain lipids by directly coupled matrix-assisted laser desorption ionization time-of-flight mass spectrometry and high-performance thin-layer chromatography","volume":"91","author":"Fuchs","year":"2008","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0235","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1194\/jlr.D004077","article-title":"Selective desorption\/ionization of sulfatides by MALDI-MS facilitated using 9-aminoacridine as matrix","volume":"51","author":"Cheng","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0240","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/jms.1707","article-title":"High-resolution tissue imaging on an orbitrap mass spectrometer by desorption electrospray ionization mass spectrometry","volume":"45","author":"Manicke","year":"2010","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0245","doi-asserted-by":"crossref","first-page":"8800","DOI":"10.1021\/ac102422b","article-title":"Ionic matrix for enhanced MALDI imaging mass spectrometry for identification of phospholipids in mouse liver and cerebellum tissue sections","volume":"82","author":"Shrivas","year":"2010","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0250","doi-asserted-by":"crossref","first-page":"6491","DOI":"10.1021\/cr200280p","article-title":"MALDI imaging of lipid biochemistry in tissues by mass spectrometry","volume":"111","author":"Berry","year":"2011","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0255","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1021\/ac050276v","article-title":"Direct profiling of lipid distribution in brain tissue using MALDI-TOFMS","volume":"77","author":"Jackson","year":"2005","journal-title":"Anal. Chem."},{"issue":"Suppl. 1","key":"10.1016\/j.bbamem.2017.05.009_bb0260","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1471-4159.2007.04715.x","article-title":"Alzheimer's disease: the lipid connection","volume":"103","author":"Hartmann","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0265","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/nrn3012","article-title":"Linking lipids to Alzheimer's disease: cholesterol and beyond","volume":"12","author":"Di Paolo","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0270","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/j.neurobiolaging.2014.02.005","article-title":"Altered lipid composition in cortical lipid rafts occurs at early stages of sporadic Alzheimer's disease and facilitates APP\/BACE1 interactions","volume":"35","author":"Fabelo","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0275","doi-asserted-by":"crossref","first-page":"10635","DOI":"10.1073\/pnas.91.22.10635","article-title":"Electrospray ionization mass spectroscopic analysis of human erythrocyte plasma membrane phospholipids","volume":"91","author":"Han","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0280","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1021\/ac00094a020","article-title":"Liquid chromatography\/mass spectrometry of phospholipids using electrospray ionization","volume":"66","author":"Kim","year":"1994","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0285","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0005-2760(94)90262-3","article-title":"Metabolic and functional aspects of sulfogalactolipids","volume":"1211","author":"Vos","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0290","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0163-7827(97)00011-8","article-title":"Chemistry and functional distribution of sulfoglycolipids","volume":"36","author":"Ishizuka","year":"1997","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0295","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1194\/jlr.R026682","article-title":"Role of sulfatide in normal and pathological cells and tissues","volume":"53","author":"Takahashi","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0300","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/glia.10327","article-title":"Sulfatide is a negative regulator of oligodendrocyte differentiation: development in sulfatide-null mice","volume":"45","author":"Hirahara","year":"2004","journal-title":"Glia"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0305","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1002\/jnr.22003","article-title":"Adult CST-null mice maintain an increased number of oligodendrocytes","volume":"87","author":"Shroff","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0310","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/glia.20292","article-title":"Sulfatide is essential for the maintenance of CNS myelin and axon structure","volume":"53","author":"Marcus","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0315","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/ana.10618","article-title":"Cerebrospinal fluid sulfatide is decreased in subjects with incipient dementia","volume":"54","author":"Han","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0320","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0325","doi-asserted-by":"crossref","first-page":"8098","DOI":"10.1073\/pnas.90.17.8098","article-title":"Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0330","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/jnc.12368","article-title":"Specific changes of sulfatide levels in individuals with pre-clinical Alzheimer's disease: an early event in disease pathogenesis","volume":"127","author":"Cheng","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0335","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.nic.2005.09.008","article-title":"The Alzheimer's disease neuroimaging initiative","volume":"15","author":"Mueller","year":"2005","journal-title":"Neuroimaging Clin. N. Am."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0340","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3233\/JAD-150916","article-title":"Cigarette smoke-induced alterations in frontal white matter lipid profiles demonstrated by MALDI-imaging mass spectrometry: relevance to Alzheimer's disease","volume":"51","author":"Nunez","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0345","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3233\/JAD-2010-1240","article-title":"Cigarette smoking is a risk factor for Alzheimer's disease: an analysis controlling for tobacco industry affiliation","volume":"19","author":"Cataldo","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0350","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.neuroscience.2011.07.045","article-title":"Hydroxylated and non-hydroxylated sulfatide are distinctly distributed in the human cerebral cortex","volume":"193","author":"Yuki","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0355","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.neurobiolaging.2007.07.024","article-title":"ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain","volume":"30","author":"Bandaru","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0360","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.nbd.2014.01.010","article-title":"Ceramides and sphingomyelinases in senile plaques","volume":"65","author":"Panchal","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chroma.2013.10.027","article-title":"A review of complementary separation methods and matrix assisted laser desorption ionization-mass spectrometry imaging: lowering sample complexity","volume":"1319","author":"Skraskova","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.bbamem.2017.05.009_bb0370","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1111\/j.1460-9568.2007.05797.x","article-title":"Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons","volume":"26","author":"Patil","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0375","doi-asserted-by":"crossref","first-page":"19777","DOI":"10.1074\/jbc.M300466200","article-title":"Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis","volume":"278","author":"Puglielli","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0380","doi-asserted-by":"crossref","first-page":"28110","DOI":"10.1074\/jbc.M414525200","article-title":"Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide","volume":"280","author":"Tamboli","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0385","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1097\/00005072-199511000-00010","article-title":"Regional variation in the distribution of apolipoprotein E and A beta in Alzheimer's disease","volume":"54","author":"Gearing","year":"1995","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0390","doi-asserted-by":"crossref","first-page":"17068","DOI":"10.1523\/JNEUROSCI.4067-10.2010","article-title":"Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration","volume":"30","author":"Liu","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0395","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1023\/A:1007509608440","article-title":"Interaction of amyloid beta-protein with anionic phospholipids: possible involvement of Lys28 and C-terminus aliphatic amino acids","volume":"25","author":"Chauhan","year":"2000","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0400","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1111\/j.1471-4159.1987.tb05619.x","article-title":"Reduced phosphoinositide concentrations in anterior temporal cortex of Alzheimer-diseased brains","volume":"48","author":"Stokes","year":"1987","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0405","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1022457605436","article-title":"Regional membrane phospholipid alterations in Alzheimer's disease","volume":"23","author":"Prasad","year":"1998","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0410","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.neulet.2012.04.019","article-title":"Elevated cerebrospinal fluid sphingomyelin levels in prodromal Alzheimer's disease","volume":"516","author":"Kosicek","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0415","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1001\/archneur.63.11.1545","article-title":"Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study","volume":"63","author":"Schaefer","year":"2006","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0420","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1038\/srep07130","article-title":"DHA-PC and PSD-95 decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer's disease","volume":"4","author":"Yuki","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbamem.2017.05.009_bb0425","doi-asserted-by":"crossref","first-page":"11169","DOI":"10.1523\/JNEUROSCI.4704-12.2013","article-title":"Palmitoylation of amyloid precursor protein regulates amyloidogenic processing in lipid rafts","volume":"33","author":"Bhattacharyya","year":"2013","journal-title":"J. Neurosci."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273617301621?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273617301621?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T05:45:44Z","timestamp":1719207944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0005273617301621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":85,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0005273617301621"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamem.2017.05.009","relation":{},"ISSN":["0005-2736"],"issn-type":[{"value":"0005-2736","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Imaging mass spectrometry (IMS) of cortical lipids from preclinical to severe stages of Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Biomembranes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamem.2017.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}