{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:02:27Z","timestamp":1789736547301,"version":"4.0.1"},"reference-count":60,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.bbamem.2017.09.016","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T17:47:47Z","timestamp":1506016067000},"page":"2420-2434","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Molecular analysis of human solute carrier SLC26 anion transporter disease-causing mutations using 3-dimensional homology modeling"],"prefix":"10.1016","volume":"1859","author":[{"given":"Chloe","family":"Rapp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhart A.F.","family":"Reithmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bbamem.2017.09.016_bb0005","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.cell.2015.07.022","article-title":"A call for systematic research on solute carriers","volume":"162","author":"C\u00e9sar-Razquin","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bbamem.2017.09.016_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-800223-0.00001-3","article-title":"Structure, function, and trafficking of SLC4 and SLC26 anion transporters","volume":"73","author":"Cordat","year":"2014","journal-title":"Curr. Top. Membr."},{"issue":"2","key":"10.1016\/j.bbamem.2017.09.016_bb0015","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1152\/physiol.00037.2007","article-title":"The solute carrier 26 family of proteins in epithelial ion transport","volume":"23","author":"Dorwart","year":"2008","journal-title":"Physiology"},{"issue":"2\u20133","key":"10.1016\/j.bbamem.2017.09.016_bb0020","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.mam.2012.07.009","article-title":"The SLC26 gene family of anion transporters and channels","volume":"34","author":"Alper","year":"2013","journal-title":"Mol. Asp. Med."},{"issue":"2","key":"10.1016\/j.bbamem.2017.09.016_bb0025","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1089\/104454903321515913","article-title":"Characterization of the human sulfate anion transporter (hsat-1) protein and gene (SAT1; SLC26A1)","volume":"22","author":"Regeer","year":"2003","journal-title":"DNA Cell Biol."},{"issue":"1","key":"10.1016\/j.bbamem.2017.09.016_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00439-013-1358-4","article-title":"The Human gene mutation database: building a comprehensive mutation repository for clinical and molecular genetics, diagnostic testing and personalized genomic medicine","volume":"133","author":"Stenson","year":"2014","journal-title":"Hum. Genet."},{"issue":"19","key":"10.1016\/j.bbamem.2017.09.016_bb0035","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1093\/hmg\/ddh242","article-title":"Functional expression and cellular distribution of diastrophic dysplasia sulfate transporter (DTDST) gene mutations in HEK cells","volume":"13","author":"Karniski","year":"2004","journal-title":"Hum. Mol. Genet."},{"issue":"6","key":"10.1016\/j.bbamem.2017.09.016_bb0040","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/0092-8674(94)90281-X","article-title":"The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping","volume":"78","author":"H\u00e4stbacka","year":"1994","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.bbamem.2017.09.016_bb0045","first-page":"255","article-title":"Atelosteogenesis type II is caused by mutations in the diastrophic dysplasia sulfate-transporter gene (DTDST): evidence for a phenotypic series involving three chondrodysplasias","volume":"58","author":"H\u00e4stbacka","year":"1996","journal-title":"Am. J. Hum. Genet."},{"issue":"20","key":"10.1016\/j.bbamem.2017.09.016_bb0050","doi-asserted-by":"crossref","first-page":"12307","DOI":"10.1074\/jbc.273.20.12307","article-title":"Functional analysis of diastrophic dysplasia sulfate transporter. Its involvement in growth regulation of chondrocytes mediated by sulfated proteoglycans","volume":"273","author":"Satoh","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"21","key":"10.1016\/j.bbamem.2017.09.016_bb0055","doi-asserted-by":"crossref","first-page":"5662","DOI":"10.1093\/emboj\/cdf580","article-title":"A molecular mechanism for aberrantCFTR-dependent HCO3\u2212 transport in cystic fibrosis","volume":"21","author":"Ko","year":"2002","journal-title":"EMBO J."},{"issue":"5","key":"10.1016\/j.bbamem.2017.09.016_bb0060","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1085\/jgp.200509392","article-title":"Coupling modes and stoichiometry of Cl\/HCO3 exchange by slc26a3 and slc26a6","volume":"127","author":"Shcheynikov","year":"2006","journal-title":"J. Gen. Physiol."},{"issue":"3","key":"10.1016\/j.bbamem.2017.09.016_bb0065","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/ng1196-316","article-title":"Mutations of the Down\u2013regulated in adenoma (DRA) gene cause congenital chloride diarrhoea","volume":"14","author":"H\u00f6glund","year":"1996","journal-title":"Nat. Genet."},{"issue":"6783","key":"10.1016\/j.bbamem.2017.09.016_bb0070","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/35012009","article-title":"Prestin is the motor protein of cochlear outer hair cells","volume":"405","author":"Zheng","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbamem.2017.09.016_bb0075","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/1750-1172-8-172","article-title":"Diverse spectrum of rare deafness genes underlies early-childhood hearing loss in Japanese patients: a cross-sectional, multi-centre next-generation sequencing study","volume":"8","author":"Mutai","year":"2013","journal-title":"Orphanet J. Rare Dis."},{"issue":"4","key":"10.1016\/j.bbamem.2017.09.016_bb0085","doi-asserted-by":"crossref","first-page":"F826","DOI":"10.1152\/ajprenal.00079.2002","article-title":"Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1","volume":"283","author":"Xie","year":"2002","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"16","key":"10.1016\/j.bbamem.2017.09.016_bb0080","doi-asserted-by":"crossref","first-page":"14246","DOI":"10.1074\/jbc.M111802200","article-title":"Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9","volume":"277","author":"Lohi","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"23","key":"10.1016\/j.bbamem.2017.09.016_bb0090","doi-asserted-by":"crossref","first-page":"20309","DOI":"10.1074\/jbc.M011740200","article-title":"Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to RhoGTPase signaling","volume":"276","author":"Tour\u00e9","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bbamem.2017.09.016_bb0095","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.ajhg.2013.03.016","article-title":"Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia","volume":"92","author":"Dirami","year":"2013","journal-title":"Am. J. Hum. Genet."},{"issue":"4","key":"10.1016\/j.bbamem.2017.09.016_bb0100","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1016\/S0021-9258(17)42041-2","article-title":"Expression of rat renal sulfate transport systems in Xenopus laevis oocytes. Functional characterization and molecular identification","volume":"269","author":"Markovich","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"Pt 1","key":"10.1016\/j.bbamem.2017.09.016_bb0105","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1113\/jphysiol.2007.135855","article-title":"SLC26A9 is a Cl\u2212 channel regulated by the WNK kinases","volume":"584","author":"Dorwart","year":"2007","journal-title":"J. Physiol."},{"issue":"13","key":"10.1016\/j.bbamem.2017.09.016_bb0115","doi-asserted-by":"crossref","first-page":"8711","DOI":"10.1074\/jbc.M704328200","article-title":"Congenital chloride-losing diarrhea causing mutations in the STAS domain result in misfolding and mistrafficking of SLC26A3","volume":"283","author":"Dorwart","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.bbamem.2017.09.016_bb0120","doi-asserted-by":"crossref","first-page":"C943","DOI":"10.1152\/ajpcell.00030.2014","article-title":"N-glycosylation and topology of the human SLC26 family of anion transport membrane proteins","volume":"306","author":"Li","year":"2014","journal-title":"Am. J. Phys. Cell Phys."},{"issue":"7342","key":"10.1016\/j.bbamem.2017.09.016_bb0125","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nature09885","article-title":"Structure and mechanism of the uracil transporter UraA","volume":"472","author":"Lu","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbamem.2017.09.016_bb0130","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.1038\/ncomms4622","article-title":"Molecular architecture and the structural basis for anion interaction in prestin and SLC26 transporters","volume":"5","author":"Gorbunov","year":"2014","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.bbamem.2017.09.016_bb0135","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1016\/j.bbamem.2012.06.007","article-title":"Membrane transport metabolons","volume":"1818","author":"Moraes","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.bbamem.2017.09.016_bb0140","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1159\/000335104","article-title":"STAS domain structure and function","volume":"28","author":"Sharma","year":"2011","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem Pharmacol."},{"issue":"3","key":"10.1016\/j.bbamem.2017.09.016_bb0145","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1159\/000358638","article-title":"Molecular dynamics simulations of the STAS domains of rat prestin and human pendrin reveal conformational motions in conserved flexible regions","volume":"33","author":"Sharma","year":"2014","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.bbamem.2017.09.016_bb0150","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.bbamem.2016.01.006","article-title":"Functional characterization of solute carrier (SLC) 26\/sulfate permease (SulP) proteins in membrane mimetic systems","volume":"1858","author":"Srinivasan","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"10","key":"10.1016\/j.bbamem.2017.09.016_bb0155","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nsmb.3091","article-title":"Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family","volume":"22","author":"Geertsma","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"30","key":"10.1016\/j.bbamem.2017.09.016_bb0160","doi-asserted-by":"crossref","first-page":"27058","DOI":"10.1074\/jbc.M111.244533","article-title":"Low resolution structure of a bacterial SLC26 transporter reveals dimeric stoichiometry and mobile intracellular domains","volume":"286","author":"Compton","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"6261","key":"10.1016\/j.bbamem.2017.09.016_bb0165","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1126\/science.aaa4335","article-title":"Crystal structure of the anion exchanger domain of human erythrocyte band 3","volume":"350","author":"Arakawa","year":"2015","journal-title":"Science"},{"issue":"6869","key":"10.1016\/j.bbamem.2017.09.016_bb0170","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/415287a","article-title":"X-ray structure of a ClC chloride channel at 3.0A reveals the molecular basis of anion selectivity","volume":"415","author":"Dutzler","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbamem.2017.09.016_bb0175","article-title":"Effect of SLC26 anion transporter disease-causing mutations on the stability of the homologous STAS domain of E. coli DauA (YchM)","volume":"3","author":"Bai","year":"2015","journal-title":"Biochem. J."},{"issue":"11","key":"10.1016\/j.bbamem.2017.09.016_bb0180","first-page":"1450","article-title":"Structure of a SLC26 anion transporter STAS domain in complex with acyl carrier protein: implications for E. coli YchM in fatty acid metabolism","volume":"18","author":"Babu","year":"1993","journal-title":"Struct. Lond. Engl."},{"issue":"3","key":"10.1016\/j.bbamem.2017.09.016_bb0185","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jmb.2010.05.013","article-title":"Structure of the cytosolic portion of the motor protein prestin and functional role of the STAS domain in SLC26\/SulP anion transporters","volume":"400","author":"Pasqualetto","year":"2010","journal-title":"J. Mol. Biol."},{"issue":"Web Server issue","key":"10.1016\/j.bbamem.2017.09.016_bb0190","doi-asserted-by":"crossref","first-page":"W320","DOI":"10.1093\/nar\/gku316","article-title":"Deciphering key features in protein structures with the new ENDscript server","volume":"42","author":"Robert","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.bbamem.2017.09.016_bb0195","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nprot.2015.053","article-title":"The Phyre2 web portal for protein modeling, prediction and analysis - nprot.2015.053.pdf","volume":"10","author":"Kelley","year":"2015","journal-title":"Nat. Protoc."},{"issue":"Web Server issue","key":"10.1016\/j.bbamem.2017.09.016_bb0200","doi-asserted-by":"crossref","first-page":"W465","DOI":"10.1093\/nar\/gkn180","article-title":"Phylogeny.fr: robust phylogenetic analysis for the non-specialist","volume":"36","author":"Dereeper","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbamem.2017.09.016_bb0205","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2148-10-8","article-title":"BLAST-EXPLORER helps you building datasets for phylogenetic analysis","volume":"10","author":"Dereeper","year":"2010","journal-title":"BMC Evol. Biol."},{"issue":"9","key":"10.1016\/j.bbamem.2017.09.016_bb0210","doi-asserted-by":"crossref","first-page":"5391","DOI":"10.1074\/jbc.M114.619320","article-title":"Interplay between disulfide bonding and N-glycosylation defines SLC4 Na+-coupled transporter extracellular topography","volume":"290","author":"Zhu","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbamem.2017.09.016_bb0215","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/msb.2011.75","article-title":"Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega","volume":"7","author":"Sievers","year":"2014","journal-title":"Mol. Syst. Biol."},{"issue":"6","key":"10.1016\/j.bbamem.2017.09.016_bb0220","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/humu.10212","article-title":"Human Gene Mutation Database (HGMD): 2003 update","volume":"21","author":"Stenson","year":"2003","journal-title":"Hum. Mutat."},{"issue":"3","key":"10.1016\/j.bbamem.2017.09.016_bb0225","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1159\/000335107","article-title":"Molecular and functional characterization of human pendrin and its allelic variants","volume":"28","author":"Dossena","year":"2011","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.bbamem.2017.09.016_bb0230","first-page":"545","article-title":"A new mutation in the human pres gene and its effect on prestin function","volume":"20","author":"Toth","year":"2007","journal-title":"Int. J. Mol. Med."},{"issue":"7397","key":"10.1016\/j.bbamem.2017.09.016_bb0235","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature10945","article-title":"De novo mutations revealed by whole-exome sequencing are strongly associated with autism","volume":"485","author":"Sanders","year":"2012","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.bbamem.2017.09.016_bb0240","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1053\/j.ajkd.2008.07.041","article-title":"Phenotypic and functional analysis of human SLC26A6 variants in patients with familial hyperoxaluria and calcium oxalate nephrolithiasis","volume":"52","author":"Monico","year":"2008","journal-title":"Am. J. Kidney. Dis. Off. J. Natl. Kidney Found."},{"issue":"41","key":"10.1016\/j.bbamem.2017.09.016_bb0245","doi-asserted-by":"crossref","first-page":"28306","DOI":"10.1074\/jbc.M109.001669","article-title":"Slc26a9 is inhibited by the R-region of the cystic fibrosis transmembrane conductance regulator via the STAS domain","volume":"284","author":"Chang","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bbamem.2017.09.016_bb0250","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1210\/jcem.87.4.8435","article-title":"Mutations of the PDS gene, encoding pendrin, are associated with protein mislocalization and loss of iodide efflux: implications for thyroid dysfunction in pendred syndrome","volume":"87","author":"Taylor","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.bbamem.2017.09.016_bb0255","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/humu.20884","article-title":"Hypo-functional SLC26A4 variants associated with nonsyndromic hearing loss and enlargement of the vestibular aqueduct: genotype-phenotype correlation or coincidental polymorphisms?","volume":"30","author":"Choi","year":"2009","journal-title":"Hum. Mutat."},{"issue":"7","key":"10.1016\/j.bbamem.2017.09.016_bb0260","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/jmg.2007.054635","article-title":"Heterogeneity in the processing defect of SLC26A4 mutants","volume":"45","author":"Yoon","year":"2008","journal-title":"J. Med. Genet."},{"issue":"47","key":"10.1016\/j.bbamem.2017.09.016_bb0265","doi-asserted-by":"crossref","first-page":"18608","DOI":"10.1073\/pnas.0805831105","article-title":"Functional assessment of allelic variants in the SLC26A4 gene involved in Pendred syndrome and nonsyndromic EVA","volume":"105","author":"Pera","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.bbamem.2017.09.016_bb0270","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1152\/physiolgenomics.00047.2009","article-title":"Distinct and novel SLC26A4\/Pendrin mutations in Chinese and U.S. patients with nonsyndromic hearing loss","volume":"38","author":"Dai","year":"2009","journal-title":"Physiol. Genomics"},{"issue":"6","key":"10.1016\/j.bbamem.2017.09.016_bb0275","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1172\/JCI118917","article-title":"A delta F508 mutation in mouse cystic fibrosis transmembrane conductance regulator results in a temperature-sensitive processing defect in vivo","volume":"98","author":"French","year":"1996","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.bbamem.2017.09.016_bb0280","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1074\/jbc.274.6.3557","article-title":"Identification of residues lining the translocation pore of human AE1, plasma membrane anion exchange protein","volume":"274","author":"Tang","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"7 Pt A","key":"10.1016\/j.bbamem.2017.09.016_bb0285","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.bbamem.2016.03.030","article-title":"Band 3, the human red cell chloride\/bicarbonate anion exchanger (AE1, SLC4A1), in a structural context","volume":"1858","author":"Reithmeier","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.bbamem.2017.09.016_bb0290","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1085\/jgp.109.3.345","article-title":"Electrogenic sulfate\/chloride exchange in Xenopus oocytes mediated by murine AE1 E699Q","volume":"109","author":"Chernova","year":"1997","journal-title":"J. Gen. Physiol."},{"issue":"5","key":"10.1016\/j.bbamem.2017.09.016_bb0295","doi-asserted-by":"crossref","first-page":"C1034","DOI":"10.1152\/ajpcell.00447.2010","article-title":"Functional characterization and modified rescue of novel AE1 mutation R730C associated with overhydrated cation leak stomatocytosis","volume":"300","author":"Stewart","year":"2011","journal-title":"Am. J. Phys. Cell Phys."},{"issue":"21","key":"10.1016\/j.bbamem.2017.09.016_bb0300","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1056\/NEJMoa0909825","article-title":"Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation","volume":"363","author":"Accurso","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"44","key":"10.1016\/j.bbamem.2017.09.016_bb0305","doi-asserted-by":"crossref","first-page":"36639","DOI":"10.1074\/jbc.M112.393637","article-title":"Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner","volume":"287","author":"Eckford","year":"2012","journal-title":"J. Biol. Chem."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273617302900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273617302900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T04:47:56Z","timestamp":1659502076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0005273617302900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":60,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S0005273617302900"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamem.2017.09.016","relation":{},"ISSN":["0005-2736"],"issn-type":[{"value":"0005-2736","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular analysis of human solute carrier SLC26 anion transporter disease-causing mutations using 3-dimensional homology modeling","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Biomembranes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamem.2017.09.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}