{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:24:46Z","timestamp":1791764686252,"version":"4.3.4"},"reference-count":215,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100001513","name":"Breast Cancer Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001513","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008090","name":"Tufts University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.bbamem.2020.183341","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T21:55:07Z","timestamp":1589579707000},"page":"183341","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":203,"title":["Regulation and function of V-ATPases in physiology and disease"],"prefix":"10.1016","volume":"1862","author":[{"given":"Michael P.","family":"Collins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Forgac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamem.2020.183341_bb0005","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nrm729","article-title":"The vacuolar (H+)-ATPases--nature\u2019s most versatile proton pumps","volume":"3","author":"Nishi","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0010","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrm2272","article-title":"Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology","volume":"8","author":"Forgac","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0015","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10863-007-9112-z","article-title":"The long physiological reach of the yeast vacuolar H+-ATPase","volume":"39","author":"Kane","year":"2007","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.bbamem.2020.183341_bb0020","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00424-008-0458-9","article-title":"Vacuolar H(+)-ATPase-an enzyme for all seasons","volume":"457","author":"Saroussi","year":"2009","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bbamem.2020.183341_bb0025","first-page":"318","article-title":"Regulation of luminal acidification by the V-ATPase","volume":"28","author":"Breton","year":"2013","journal-title":"Physiol. Bethesda Md."},{"key":"10.1016\/j.bbamem.2020.183341_bb0030","first-page":"805","article-title":"Vacuolar-type proton pump ATPases: acidification and pathological relationships","volume":"28","author":"Sun-Wada","year":"2013","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/675430","article-title":"Vacuolar H + -ATPase: an essential multitasking enzyme in physiology and pathophysiology","volume":"2014","author":"Holliday","year":"2014","journal-title":"New J. Sci."},{"key":"10.1016\/j.bbamem.2020.183341_bb0040","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.bbabio.2014.01.018","article-title":"Eukaryotic V-ATPase: novel structural findings and functional insights","volume":"1837","author":"Marshansky","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2020.183341_bb0045","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.tibs.2015.08.005","article-title":"Recent insights into the structure, regulation, and function of the V-ATPases","volume":"40","author":"Cotter","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbamem.2020.183341_bb0050","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/pro.3147","article-title":"Breaking up and making up: the secret life of the vacuolar H+ -ATPase","volume":"26","author":"Oot","year":"2017","journal-title":"Protein Sci. Publ. Protein Soc."},{"key":"10.1016\/j.bbamem.2020.183341_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.febslet.2004.08.065","article-title":"The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+\/ATP coupling ratio","volume":"576","author":"Cross","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbamem.2020.183341_bb0060","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.bbabio.2014.03.004","article-title":"ATP synthases from archaea: the beauty of a molecular motor","volume":"1837","author":"Gr\u00fcber","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2020.183341_bb0065","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/1574-6976.12043","article-title":"Adaptations of anaerobic archaea to life under extreme energy limitation","volume":"38","author":"Mayer","year":"2014","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.bbamem.2020.183341_bb0070","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/386299a0","article-title":"Direct observation of the rotation of F1-ATPase","volume":"386","author":"Noji","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.bbamem.2020.183341_bb0075","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1073\/pnas.0436796100","article-title":"Evidence for rotation of V1-ATPase","volume":"100","author":"Imamura","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2020.183341_bb0080","doi-asserted-by":"crossref","first-page":"23714","DOI":"10.1074\/jbc.M302756200","article-title":"Subunit rotation of vacuolar-type proton pumping ATPase: relative rotation of the G and C subunits","volume":"278","author":"Hirata","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0085","doi-asserted-by":"crossref","first-page":"10939","DOI":"10.1074\/jbc.273.18.10939","article-title":"Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules","volume":"273","author":"Ludwig","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0090","doi-asserted-by":"crossref","first-page":"17372","DOI":"10.1074\/jbc.274.24.17372","article-title":"A novel insect V-ATPase subunit M9.7 is glycosylated extensively","volume":"274","author":"Merzendorfer","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0095","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.1074\/jbc.M310680200","article-title":"Genome-wide analysis of iron-dependent growth reveals a novel yeast gene required for vacuolar acidification","volume":"279","author":"Davis-Kaplan","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0100","doi-asserted-by":"crossref","first-page":"17361","DOI":"10.1074\/jbc.M314104200","article-title":"The yeast vacuolar proton-translocating ATPase contains a subunit homologous to the Manduca sexta and bovine e subunits that is essential for function","volume":"279","author":"Sambade","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0105","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nature11778","article-title":"Rotation mechanism of Enterococcus hirae V1-ATPase based on asymmetric crystal structures","volume":"493","author":"Arai","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbamem.2020.183341_bb0110","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nature14365","article-title":"Electron cryomicroscopy observation of rotational states in a eukaryotic V-ATPase","volume":"521","author":"Zhao","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bbamem.2020.183341_bb0115","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13235","article-title":"Crystal structures of the ATP-binding and ADP-release dwells of the V1 rotary motor","volume":"7","author":"Suzuki","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbamem.2020.183341_bb0120","doi-asserted-by":"crossref","first-page":"30364","DOI":"10.1016\/S0021-9258(18)43822-7","article-title":"A mechanism of proton translocation by F1F0 ATP synthases suggested by double mutants of the a subunit","volume":"269","author":"Vik","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0125","doi-asserted-by":"crossref","first-page":"41908","DOI":"10.1074\/jbc.M308026200","article-title":"Interacting helical surfaces of the transmembrane segments of subunits a and c\u2019 of the yeast V-ATPase defined by disulfide-mediated cross-linking","volume":"278","author":"Kawasaki-Nishi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0130","doi-asserted-by":"crossref","first-page":"20696","DOI":"10.1074\/jbc.M803258200","article-title":"Analysis of the membrane topology of transmembrane segments in the C-terminal hydrophobic domain of the yeast vacuolar ATPase subunit a (Vph1p) by chemical modification","volume":"283","author":"Wang","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0135","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nature19828","article-title":"Atomic model for the membrane-embedded VO motor of a eukaryotic V-ATPase","volume":"539","author":"Mazhab-Jafari","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bbamem.2020.183341_bb0140","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.molcel.2018.02.006","article-title":"The 3.5-\u00c5 CryoEM structure of nanodisc-reconstituted yeast vacuolar ATPase Vo proton channel","volume":"69","author":"Roh","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbamem.2020.183341_bb0145","doi-asserted-by":"crossref","first-page":"12397","DOI":"10.1073\/pnas.221291798","article-title":"Arg-735 of the 100-kDa subunit a of the yeast V-ATPase is essential for proton translocation","volume":"98","author":"Kawasaki-Nishi","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2020.183341_bb0150","doi-asserted-by":"crossref","first-page":"44628","DOI":"10.1074\/jbc.M407345200","article-title":"TM2 but not TM4 of subunit c\u2033 interacts with TM7 of subunit a of the yeast V-ATPase as defined by disulfide-mediated cross-linking","volume":"279","author":"Wang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0155","doi-asserted-by":"crossref","first-page":"35176","DOI":"10.1074\/jbc.M111.273409","article-title":"Definition of membrane topology and identification of residues important for transport in subunit a of the vacuolar ATPase","volume":"286","author":"Toei","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0160","doi-asserted-by":"crossref","first-page":"35983","DOI":"10.1074\/jbc.M805345200","article-title":"Structure of the yeast vacuolar ATPase","volume":"283","author":"Zhang","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0165","doi-asserted-by":"crossref","first-page":"38409","DOI":"10.1074\/jbc.M203521200","article-title":"The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase (V-ATPase) interacts with the H subunit and is required for V-ATPase function","volume":"277","author":"Lu","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0170","doi-asserted-by":"crossref","first-page":"41942","DOI":"10.1074\/jbc.M407821200","article-title":"Three-dimensional structure of the vacuolar ATPase. Localization of subunit H by difference imaging and chemical cross-linking","volume":"279","author":"Wilkens","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0175","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1021\/bi048402x","article-title":"Defined sites of interaction between subunits E (Vma4p), C (Vma5p), and G (Vma10p) within the stator structure of the vacuolar H+-ATPase","volume":"44","author":"Jones","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamem.2020.183341_bb0180","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1016\/j.febslet.2006.03.001","article-title":"Localization of subunit C (Vma5p) in the yeast vacuolar ATPase by immuno electron microscopy","volume":"580","author":"Zhang","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbamem.2020.183341_bb0185","doi-asserted-by":"crossref","first-page":"7134","DOI":"10.1073\/pnas.131192798","article-title":"Crystal structure of the regulatory subunit H of the V-type ATPase of Saccharomyces cerevisiae","volume":"98","author":"Sagermann","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2020.183341_bb0190","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/sj.embor.7400294","article-title":"Crystal structure of yeast V-ATPase subunit C reveals its stator function","volume":"5","author":"Drory","year":"2004","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbamem.2020.183341_bb0195","doi-asserted-by":"crossref","first-page":"24654","DOI":"10.1074\/jbc.M110.136960","article-title":"Domain characterization and interaction of the yeast vacuolar ATPase subunit C with the peripheral stator stalk subunits E and G","volume":"285","author":"Oot","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0200","doi-asserted-by":"crossref","first-page":"13396","DOI":"10.1074\/jbc.M112.343962","article-title":"Subunit interactions at the V1-Vo interface in yeast vacuolar ATPase","volume":"287","author":"Oot","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0205","doi-asserted-by":"crossref","first-page":"27959","DOI":"10.1074\/jbc.M115.662494","article-title":"Affinity purification and structural features of the yeast vacuolar ATPase Vo membrane sector","volume":"290","author":"Couoh-Cardel","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0210","doi-asserted-by":"crossref","first-page":"21761","DOI":"10.1074\/jbc.M002305200","article-title":"The H subunit (Vma13p) of the yeast V-ATPase inhibits the ATPase activity of cytosolic V1 complexes","volume":"275","author":"Parra","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0215","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1074\/jbc.M707144200","article-title":"Subunit H of the vacuolar (H+) ATPase inhibits ATP hydrolysis by the free V1 domain by interaction with the rotary subunit F","volume":"283","author":"Jefferies","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0220","doi-asserted-by":"crossref","first-page":"13316","DOI":"10.1074\/jbc.M900475200","article-title":"Subunit interactions and requirements for inhibition of the yeast V1-ATPase","volume":"284","author":"Diab","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0225","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.15252\/embj.201593447","article-title":"Crystal structure of yeast V1-ATPase in the autoinhibited state","volume":"35","author":"Oot","year":"2016","journal-title":"EMBO J."},{"key":"10.1016\/j.bbamem.2020.183341_bb0235","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.1091\/mbc.e08-06-0629","article-title":"Voa1p functions in V-ATPase assembly in the yeast endoplasmic reticulum","volume":"19","author":"Ryan","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbamem.2020.183341_bb0240","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11600","article-title":"ATP6AP1 deficiency causes an immunodeficiency with hepatopathy, cognitive impairment and abnormal protein glycosylation","volume":"7","author":"Jansen","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbamem.2020.183341_bb0245","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1091\/mbc.E18-04-0234","article-title":"ATP6AP2 functions as a V-ATPase assembly factor in the endoplasmic reticulum","volume":"29","author":"Guida","year":"2018","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbamem.2020.183341_bb0250","doi-asserted-by":"crossref","first-page":"24102","DOI":"10.1016\/S0021-9258(19)51053-5","article-title":"A novel accessory subunit for vacuolar H(+)-ATPase from chromaffin granules","volume":"269","author":"Supek","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0255","doi-asserted-by":"crossref","first-page":"13194","DOI":"10.1074\/jbc.M709712200","article-title":"Cytoplasmic terminus of vacuolar type proton pump accessory subunit Ac45 is required for proper interaction with V(0) domain subunits and efficient osteoclastic bone resorption","volume":"283","author":"Feng","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0260","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1126\/science.1179802","article-title":"Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling","volume":"327","author":"Cruciat","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.bbamem.2020.183341_bb0265","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm1315","article-title":"Endocytic recycling","volume":"5","author":"Maxfield","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0270","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nrm1050","article-title":"Mannose 6-phosphate receptors: new twists in the tale","volume":"4","author":"Ghosh","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0275","doi-asserted-by":"crossref","first-page":"8154","DOI":"10.1074\/jbc.275.11.8154","article-title":"ARF1 regulates pH-dependent COP functions in the early endocytic pathway","volume":"275","author":"Gu","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0280","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1083\/jcb.201108131","article-title":"The cell biology of receptor-mediated virus entry","volume":"195","author":"Grove","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0285","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nrm1959","article-title":"Mechanisms of pathogen entry through the endosomal compartments","volume":"7","author":"Gruenberg","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0290","doi-asserted-by":"crossref","first-page":"10712","DOI":"10.1016\/S0021-9258(18)61022-1","article-title":"Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump","volume":"262","author":"Rhodes","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0295","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1146\/annurev.immunol.22.012703.104538","article-title":"Cell biology of antigen processing in vitro and in vivo","volume":"23","author":"Trombetta","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0300","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1126\/science.aad8142","article-title":"Single-vesicle imaging reveals different transport mechanisms between glutamatergic and GABAergic vesicles","volume":"351","author":"Farsi","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.bbamem.2020.183341_bb0305","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev-physiol-021014-071649","article-title":"Lysosomal physiology","volume":"77","author":"Xu","year":"2015","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0310","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev-physiol-012110-142317","article-title":"Lysosomal acidification mechanisms","volume":"74","author":"Mindell","year":"2012","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0315","doi-asserted-by":"crossref","first-page":"295","DOI":"10.4161\/auto.4144","article-title":"Chaperone-mediated autophagy","volume":"3","author":"Dice","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.bbamem.2020.183341_bb0320","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nrm2708","article-title":"Dynamics and diversity in autophagy mechanisms: lessons from yeast","volume":"10","author":"Nakatogawa","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0325","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/cr.2013.168","article-title":"The machinery of macroautophagy","volume":"24","author":"Feng","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.bbamem.2020.183341_bb0330","doi-asserted-by":"crossref","first-page":"17707","DOI":"10.1016\/S0021-9258(19)47429-2","article-title":"Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells","volume":"266","author":"Yoshimori","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0335","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1247\/csf.23.33","article-title":"Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells","volume":"23","author":"Yamamoto","year":"1998","journal-title":"Cell Struct. Funct."},{"key":"10.1016\/j.bbamem.2020.183341_bb0340","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4161\/auto.3634","article-title":"Autophagosome-lysosome fusion depends on the pH in acidic compartments in CHO cells","volume":"3","author":"Kawai","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.bbamem.2020.183341_bb0345","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nrd.2017.22","article-title":"Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles","volume":"16","author":"Galluzzi","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbamem.2020.183341_bb0350","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bbamem.2020.183341_bb0355","doi-asserted-by":"crossref","first-page":"8760","DOI":"10.1074\/jbc.275.12.8760","article-title":"Three subunit a isoforms of mouse vacuolar H(+)-ATPase. Preferential expression of the a3 isoform during osteoclast differentiation","volume":"275","author":"Toyomura","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0360","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/77131","article-title":"Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis","volume":"25","author":"Frattini","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbamem.2020.183341_bb0365","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1242\/jeb.028803","article-title":"Regulation of the V-ATPase in kidney epithelial cells: dual role in acid-base homeostasis and vesicle trafficking","volume":"212","author":"Brown","year":"2009","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0370","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/79208","article-title":"Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116-kD subunit, cause recessive distal renal tubular acidosis with preserved hearing","volume":"26","author":"Smith","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbamem.2020.183341_bb0375","doi-asserted-by":"crossref","first-page":"40050","DOI":"10.1074\/jbc.M106488200","article-title":"a4, a unique kidney-specific isoform of mouse vacuolar H+-ATPase subunit a","volume":"276","author":"Oka","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0380","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1242\/jeb.027284","article-title":"Regulation of luminal acidification in the male reproductive tract via cell-cell crosstalk","volume":"212","author":"Shum","year":"2009","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0385","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1038\/sj.emboj.7601272","article-title":"Epididymal expression of the forkhead transcription factor Foxi1 is required for male fertility","volume":"25","author":"Blomqvist","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.bbamem.2020.183341_bb0390","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1152\/physrev.00035.2015","article-title":"The function of V-ATPases in cancer","volume":"96","author":"Stransky","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbamem.2020.183341_bb0395","doi-asserted-by":"crossref","first-page":"14836","DOI":"10.1016\/S0021-9258(18)77190-1","article-title":"Functional reassembly of the coated vesicle proton pump","volume":"265","author":"Puopolo","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0400","doi-asserted-by":"crossref","first-page":"9773","DOI":"10.1016\/S0021-9258(19)50159-4","article-title":"Characterization of the V0 domain of the coated vesicle (H+)-ATPase","volume":"267","author":"Zhang","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0405","doi-asserted-by":"crossref","first-page":"19592","DOI":"10.1074\/jbc.271.32.19592","article-title":"Wild-type and mutant vacuolar membranes support pH-dependent reassembly of the yeast vacuolar H+-ATPase in vitro","volume":"271","author":"Parra","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0410","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2174\/138920312800493142","article-title":"Targeting reversible disassembly as a mechanism of controlling V-ATPase activity","volume":"13","author":"M. Kane","year":"2012","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.bbamem.2020.183341_bb0415","doi-asserted-by":"crossref","first-page":"17025","DOI":"10.1016\/S0021-9258(17)46944-4","article-title":"Disassembly and reassembly of the yeast vacuolar H(+)-ATPase in vivo","volume":"270","author":"Kane","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0420","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1074\/jbc.270.10.5649","article-title":"Regulation of plasma membrane V-ATPase activity by dissociation of peripheral subunits","volume":"270","author":"Sumner","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0425","doi-asserted-by":"crossref","first-page":"7064","DOI":"10.1128\/MCB.18.12.7064","article-title":"Reversible association between the V1 and V0 domains of yeast vacuolar H+-ATPase is an unconventional glucose-induced effect","volume":"18","author":"Parra","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0430","doi-asserted-by":"crossref","first-page":"17941","DOI":"10.1074\/jbc.M010790200","article-title":"Yeast V-ATPase complexes containing different isoforms of the 100-kDa a-subunit differ in coupling efficiency and in vivo dissociation","volume":"276","author":"Kawasaki-Nishi","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0435","doi-asserted-by":"crossref","first-page":"36513","DOI":"10.1074\/jbc.M805232200","article-title":"The Ras\/cAMP\/protein kinase a pathway regulates glucose-dependent assembly of the vacuolar (H+)-ATPase in yeast","volume":"283","author":"Bond","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0440","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1038\/emboj.2010.138","article-title":"Cytosolic pH is a second messenger for glucose and regulates the PKA pathway through V-ATPase","volume":"29","author":"Dechant","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.bbamem.2020.183341_bb0445","doi-asserted-by":"crossref","first-page":"23771","DOI":"10.1074\/jbc.M110.110122","article-title":"Regulation of vacuolar proton-translocating ATPase activity and assembly by extracellular pH","volume":"285","author":"Diakov","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0450","doi-asserted-by":"crossref","first-page":"48663","DOI":"10.1074\/jbc.M408278200","article-title":"Involvement of the nonhomologous region of subunit A of the yeast V-ATPase in coupling and in vivo dissociation","volume":"279","author":"Shao","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0455","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1073\/pnas.0600011103","article-title":"cAMP regulates plasma membrane vacuolar-type H+-ATPase assembly and activity in blowfly salivary glands","volume":"103","author":"Dames","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2020.183341_bb0460","doi-asserted-by":"crossref","first-page":"33735","DOI":"10.1074\/jbc.M703368200","article-title":"Stimulus-induced phosphorylation of vacuolar H(+)-ATPase by protein kinase a","volume":"282","author":"Voss","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0465","doi-asserted-by":"crossref","first-page":"C56","DOI":"10.1152\/ajpcell.00041.2007","article-title":"Hormone-induced assembly and activation of V-ATPase in blowfly salivary glands is mediated by protein kinase A","volume":"294","author":"Rein","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0470","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1042\/BJ20131293","article-title":"Reversible disassembly of the yeast V-ATPase revisited under in vivo conditions","volume":"462","author":"Tabke","year":"2014","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbamem.2020.183341_bb0475","doi-asserted-by":"crossref","first-page":"9102","DOI":"10.1016\/S0021-9258(19)76514-4","article-title":"The cDNA sequence of the 69-kDa subunit of the carrot vacuolar H+-ATPase. Homology to the beta-chain of F0F1-ATPases","volume":"263","author":"Zimniak","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0480","doi-asserted-by":"crossref","first-page":"12985","DOI":"10.1074\/jbc.M212096200","article-title":"Mutational analysis of the non-homologous region of subunit a of the yeast V-ATPase","volume":"278","author":"Shao","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0485","doi-asserted-by":"crossref","first-page":"24855","DOI":"10.1074\/jbc.M100637200","article-title":"Microtubules are involved in glucose-dependent dissociation of the yeast vacuolar [H+]-ATPase in vivo","volume":"276","author":"Xu","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0490","doi-asserted-by":"crossref","first-page":"10938","DOI":"10.1021\/bi9608065","article-title":"Mutational analysis of the catalytic subunit of the yeast vacuolar proton-translocating ATPase","volume":"35","author":"Liu","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamem.2020.183341_bb0495","doi-asserted-by":"crossref","first-page":"32869","DOI":"10.1074\/jbc.274.46.32869","article-title":"Photoaffinity labeling of wild-type and mutant forms of the yeast V-ATPase a subunit by 2-azido-[(32)P]ADP","volume":"274","author":"MacLeod","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0500","doi-asserted-by":"crossref","first-page":"24495","DOI":"10.1074\/jbc.M702598200","article-title":"Physical interaction between aldolase and vacuolar H+-ATPase is essential for the assembly and activity of the proton pump","volume":"282","author":"Lu","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0505","doi-asserted-by":"crossref","first-page":"19448","DOI":"10.1074\/jbc.M114.569855","article-title":"Yeast phosphofructokinase-1 subunit Pfk2p is necessary for pH homeostasis and glucose-dependent vacuolar ATPase reassembly","volume":"289","author":"Chan","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0510","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/35070067","article-title":"Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly","volume":"3","author":"Seol","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0515","doi-asserted-by":"crossref","first-page":"13831","DOI":"10.1074\/jbc.M200682200","article-title":"The RAVE complex is essential for stable assembly of the yeast V-ATPase","volume":"277","author":"Smardon","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0520","doi-asserted-by":"crossref","first-page":"26185","DOI":"10.1074\/jbc.M703627200","article-title":"RAVE is essential for the efficient assembly of the C subunit with the vacuolar H(+)-ATPase","volume":"282","author":"Smardon","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0525","doi-asserted-by":"crossref","first-page":"27511","DOI":"10.1074\/jbc.M115.667634","article-title":"Molecular interactions and cellular itinerary of the yeast RAVE (regulator of the H+-ATPase of vacuolar and endosomal membranes) complex","volume":"290","author":"Smardon","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0530","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1091\/mbc.e13-05-0231","article-title":"The RAVE complex is an isoform-specific V-ATPase assembly factor in yeast","volume":"25","author":"Smardon","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbamem.2020.183341_bb0535","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.devcel.2009.07.001","article-title":"The vacuolar proton pump, V-ATPase, is required for notch signaling and endosomal trafficking in Drosophila","volume":"17","author":"Yan","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbamem.2020.183341_bb0540","doi-asserted-by":"crossref","first-page":"34757","DOI":"10.1074\/jbc.M110.158634","article-title":"Rabconnectin-3 is a functional regulator of mammalian Notch signaling","volume":"285","author":"Sethi","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0545","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1091\/mbc.e13-10-0563","article-title":"The signaling lipid PI(3,5)P\u2082 stabilizes V\u2081-V(o) sector interactions and activates the V-ATPase","volume":"25","author":"Li","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbamem.2020.183341_bb0550","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-3-319-25304-6_3","article-title":"Proton transport and pH control in Fungi","volume":"892","author":"Kane","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0555","doi-asserted-by":"crossref","first-page":"9161","DOI":"10.1074\/jbc.RA119.008552","article-title":"Interaction of the late endo-lysosomal lipid PI(3,5)P2 with the Vph1 isoform of yeast V-ATPase increases its activity and cellular stress tolerance","volume":"294","author":"Banerjee","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0560","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1091\/mbc.e17-05-0316","article-title":"Direct interaction of the Golgi V-ATPase a-subunit isoform with PI(4)P drives localization of Golgi V-ATPases in yeast","volume":"28","author":"Banerjee","year":"2017","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbamem.2020.183341_bb0565","doi-asserted-by":"crossref","first-page":"C97","DOI":"10.1152\/ajpcell.00469.2003","article-title":"Glucose activates H(+)-ATPase in kidney epithelial cells","volume":"287","author":"Nakamura","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0570","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1128\/MCB.25.2.575-589.2005","article-title":"Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells","volume":"25","author":"Sautin","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0575","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1462-5822.2010.01556.x","article-title":"Influenza a virus-induced early activation of ERK and PI3K mediates V-ATPase-dependent intracellular pH change required for fusion","volume":"13","author":"Marjuki","year":"2011","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0580","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006820","article-title":"Activation of PI3K, Akt, and ERK during early rotavirus infection leads to V-ATPase-dependent endosomal acidification required for uncoating","volume":"14","author":"Soliman","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bbamem.2020.183341_bb0585","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1126\/science.1080106","article-title":"Activation of lysosomal function during dendritic cell maturation","volume":"299","author":"Trombetta","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bbamem.2020.183341_bb0590","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1074\/jbc.M113.524561","article-title":"Regulated assembly of vacuolar ATPase is increased during cluster disruption-induced maturation of dendritic cells through a phosphatidylinositol 3-kinase\/mTOR-dependent pathway","volume":"289","author":"Liberman","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0595","doi-asserted-by":"crossref","first-page":"26409","DOI":"10.1074\/jbc.M112.352229","article-title":"Epidermal growth factor-induced vacuolar (H+)-atpase assembly: a role in signaling via mTORC1 activation","volume":"287","author":"Xu","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0600","doi-asserted-by":"crossref","first-page":"9113","DOI":"10.1074\/jbc.RA117.001327","article-title":"Glucose starvation increases V-ATPase assembly and activity in mammalian cells through AMP kinase and phosphatidylinositide 3-kinase\/Akt signaling","volume":"293","author":"McGuire","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0605","doi-asserted-by":"crossref","first-page":"27360","DOI":"10.1074\/jbc.M115.659128","article-title":"Amino acid availability modulates vacuolar H+-ATPase assembly","volume":"290","author":"Stransky","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0610","first-page":"881","article-title":"Protein kinase A-dependent and -independent activation of the V-ATPase in Malpighian tubules of Aedes aegypti","volume":"216","author":"Tiburcy","year":"2013","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0615","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.2337\/db16-0727","article-title":"Palmitate-induced vacuolar-type H+-ATPase inhibition feeds forward into insulin resistance and contractile dysfunction","volume":"66","author":"Liu","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.bbamem.2020.183341_bb0620","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.celrep.2017.07.040","article-title":"The presynaptic v-ATPase reversibly disassembles and thereby modulates exocytosis but is not part of the fusion machinery","volume":"20","author":"Bodz\u0119ta","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbamem.2020.183341_bb0625","doi-asserted-by":"crossref","first-page":"14294","DOI":"10.1016\/S0021-9258(19)49711-1","article-title":"The VPH1 gene encodes a 95-kDa integral membrane polypeptide required for in vivo assembly and activity of the yeast vacuolar H(+)-ATPase","volume":"267","author":"Manolson","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0630","doi-asserted-by":"crossref","first-page":"14064","DOI":"10.1016\/S0021-9258(17)36755-8","article-title":"STV1 gene encodes functional homologue of 95-kDa yeast vacuolar H(+)-ATPase subunit Vph1p","volume":"269","author":"Manolson","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0635","doi-asserted-by":"crossref","first-page":"47411","DOI":"10.1074\/jbc.M108310200","article-title":"The amino-terminal domain of the vacuolar proton-translocating ATPase a subunit controls targeting and in vivo dissociation, and the carboxyl-terminal domain affects coupling of proton transport and ATP hydrolysis","volume":"276","author":"Kawasaki-Nishi","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0640","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009531","article-title":"An extended nomenclature for mammalian V-ATPase subunit genes and splice variants","volume":"5","author":"Miranda","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbamem.2020.183341_bb0645","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/ncb1348","article-title":"V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway","volume":"8","author":"Hurtado-Lorenzo","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0650","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.1242\/jcs.00791","article-title":"Specific sorting of the a1 isoform of the V-H+ATPase a subunit to nerve terminals where it associates with both synaptic vesicles and the presynaptic plasma membrane","volume":"116","author":"Morel","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamem.2020.183341_bb0655","doi-asserted-by":"crossref","first-page":"22023","DOI":"10.1074\/jbc.M302436200","article-title":"From lysosomes to the plasma membrane: localization of vacuolar-type H+ -ATPase with the a3 isoform during osteoclast differentiation","volume":"278","author":"Toyomura","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0660","doi-asserted-by":"crossref","first-page":"6701","DOI":"10.1038\/s41598-018-24918-7","article-title":"Essential role of the a3 isoform of V-ATPase in secretory lysosome trafficking via Rab7 recruitment","volume":"8","author":"Matsumoto","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbamem.2020.183341_bb0665","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1091\/mbc.e11-02-0155","article-title":"Vacuolar H(+)-ATPase subunits Voa1 and Voa2 cooperatively regulate secretory vesicle acidification, transmitter uptake, and storage","volume":"22","author":"Saw","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbamem.2020.183341_bb0670","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1242\/jcs.050443","article-title":"Direct recruitment of H+-ATPase from lysosomes for phagosomal acidification","volume":"122","author":"Sun-Wada","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbamem.2020.183341_bb0675","doi-asserted-by":"crossref","first-page":"6824","DOI":"10.1074\/jbc.275.10.6824","article-title":"Molecular cloning and expression of three isoforms of the 100-kDa a subunit of the mouse vacuolar proton-translocating ATPase","volume":"275","author":"Nishi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0680","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1095\/biolreprod.105.043752","article-title":"Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis","volume":"74","author":"Pietrement","year":"2006","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bbamem.2020.183341_bb0685","doi-asserted-by":"crossref","first-page":"C488","DOI":"10.1152\/ajpcell.00537.2007","article-title":"Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells","volume":"294","author":"Pastor-Soler","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0690","doi-asserted-by":"crossref","first-page":"24676","DOI":"10.1074\/jbc.M110.106278","article-title":"PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells","volume":"285","author":"Alzamora","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0695","doi-asserted-by":"crossref","first-page":"F643","DOI":"10.1152\/ajprenal.00584.2009","article-title":"cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells","volume":"298","author":"P\u0103unescu","year":"2010","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0700","doi-asserted-by":"crossref","first-page":"C672","DOI":"10.1152\/ajpcell.00004.2009","article-title":"AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells","volume":"296","author":"Hallows","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0705","doi-asserted-by":"crossref","first-page":"F943","DOI":"10.1152\/ajprenal.00303.2013","article-title":"AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney","volume":"305","author":"Alzamora","year":"2013","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0710","doi-asserted-by":"crossref","first-page":"5817","DOI":"10.1016\/S0021-9258(18)42626-9","article-title":"Cysteine 254 of the 73-kDa a subunit is responsible for inhibition of the coated vesicle (H+)-ATPase upon modification by sulfhydryl reagents","volume":"267","author":"Feng","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0715","doi-asserted-by":"crossref","first-page":"13224","DOI":"10.1016\/S0021-9258(17)36822-9","article-title":"Inhibition of vacuolar H(+)-ATPase by disulfide bond formation between cysteine 254 and cysteine 532 in subunit A","volume":"269","author":"Feng","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0720","doi-asserted-by":"crossref","first-page":"19769","DOI":"10.1016\/S0021-9258(19)88619-2","article-title":"A novel mechanism for regulation of vacuolar acidification","volume":"267","author":"Feng","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0230","doi-asserted-by":"crossref","first-page":"7272","DOI":"10.1073\/pnas.1814818116","article-title":"Structural comparison of the vacuolar and Golgi V-ATPases from Saccharomyces cerevisiae","volume":"116","author":"Vasanthakumar","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2020.183341_bb0725","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.abb.2008.03.025","article-title":"Function, structure and regulation of the vacuolar (H+)-ATPases","volume":"476","author":"Jefferies","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbamem.2020.183341_bb0730","doi-asserted-by":"crossref","first-page":"8075","DOI":"10.1073\/pnas.95.14.8075","article-title":"ClC-5, the chloride channel mutated in Dent\u2019s disease, colocalizes with the proton pump in endocytotically active kidney cells","volume":"95","author":"G\u00fcnther","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbamem.2020.183341_bb0735","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1091\/mbc.e10-09-0745","article-title":"Degradation of Alzheimer\u2019s amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes","volume":"22","author":"Majumdar","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbamem.2020.183341_bb0740","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(01)00206-9","article-title":"Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man","volume":"104","author":"Kornak","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.bbamem.2020.183341_bb0745","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrc3110","article-title":"Dysregulated pH: a perfect storm for cancer progression","volume":"11","author":"Webb","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbamem.2020.183341_bb0750","doi-asserted-by":"crossref","first-page":"902","DOI":"10.3389\/fphys.2018.00902","article-title":"Regulation of V-ATPase assembly in nutrient sensing and function of V-ATPases in breast Cancer metastasis","volume":"9","author":"Collins","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0755","doi-asserted-by":"crossref","first-page":"46142","DOI":"10.18632\/oncotarget.10063","article-title":"The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer","volume":"7","author":"Cotter","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbamem.2020.183341_bb0760","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/1746-1596-8-145","article-title":"The expression of V-ATPase is associated with drug resistance and pathology of non-small-cell lung cancer","volume":"8","author":"Lu","year":"2013","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0765","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.bbadis.2013.04.003","article-title":"V-ATPase is a candidate therapeutic target for Ewing sarcoma","volume":"1832","author":"Avnet","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2020.183341_bb0770","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1158\/1541-7786.MCR-10-0449","article-title":"The a3 isoform vacuolar type H+-ATPase promotes distant metastasis in the mouse B16 melanoma cells","volume":"9","author":"Nishisho","year":"2011","journal-title":"Mol. Cancer Res. MCR."},{"key":"10.1016\/j.bbamem.2020.183341_bb0775","doi-asserted-by":"crossref","first-page":"C1443","DOI":"10.1152\/ajpcell.00407.2003","article-title":"Vacuolar H+-ATPase in human breast cancer cells with distinct metastatic potential: distribution and functional activity","volume":"286","author":"Sennoune","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0780","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1093\/carcin\/bgs277","article-title":"Expression and functional role of vacuolar H(+)-ATPase in human hepatocellular carcinoma","volume":"33","author":"Xu","year":"2012","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbamem.2020.183341_bb0785","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/labinvest.2011.8","article-title":"The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer","volume":"91","author":"Chung","year":"2011","journal-title":"Lab. Investig. J. Tech. Methods Pathol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0790","doi-asserted-by":"crossref","first-page":"8500","DOI":"10.1074\/jbc.M116.723395","article-title":"Extracellular and luminal pH regulation by vacuolar H+-ATPase isoform expression and targeting to the plasma membrane and endosomes","volume":"291","author":"Smith","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0795","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.18632\/oncotarget.2902","article-title":"Vacuolar ATPase \u201ca2\u201d isoform exhibits distinct cell surface accumulation and modulates matrix metalloproteinase activity in ovarian cancer","volume":"6","author":"Kulshrestha","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbamem.2020.183341_bb0800","first-page":"1194","article-title":"Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer","volume":"56","author":"Gerweck","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamem.2020.183341_bb0805","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1074\/jbc.M112.412007","article-title":"Mode of cell death induction by pharmacological vacuolar H+-ATPase (V-ATPase) inhibition","volume":"288","author":"von Schwarzenberg","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0810","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1158\/1535-7163.MCT-13-0484","article-title":"V-ATPase inhibition regulates anoikis resistance and metastasis of cancer cells","volume":"13","author":"Schempp","year":"2014","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bbamem.2020.183341_bb0815","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.3892\/etm.2015.2758","article-title":"Bafilomycin A1 inhibits the growth and metastatic potential of the BEL-7402 liver cancer and HO-8910 ovarian cancer cell lines and induces alterations in their microRNA expression","volume":"10","author":"Lu","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bbamem.2020.183341_bb0820","doi-asserted-by":"crossref","first-page":"43508","DOI":"10.18632\/oncotarget.6180","article-title":"Anti-leukemic effects of the V-ATPase inhibitor Archazolid a","volume":"6","author":"Zhang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbamem.2020.183341_bb0825","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1021\/mp200292c","article-title":"Drug resistance and cellular adaptation to tumor acidic pH microenvironment","volume":"8","author":"Wojtkowiak","year":"2011","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bbamem.2020.183341_bb0830","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/bjc.1997.201","article-title":"Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan","volume":"75","author":"Vukovic","year":"1997","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbamem.2020.183341_bb0835","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/sj.bjc.6690455","article-title":"Enhancement of chemotherapy by manipulation of tumour pH","volume":"80","author":"Raghunand","year":"1999","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbamem.2020.183341_bb0840","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/S0006-2952(03)00467-2","article-title":"Tumor acidity, ion trapping and chemotherapeutics. I. Acid pH affects the distribution of chemotherapeutic agents in vitro","volume":"66","author":"Mahoney","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0845","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0006-2952(99)00022-2","article-title":"pH and drug resistance. I. Functional expression of plasmalemmal V-type H+-ATPase in drug-resistant human breast carcinoma cell lines","volume":"57","author":"Mart\u00ednez-Zaguil\u00e1n","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0850","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0006-2952(99)00021-0","article-title":"pH and drug resistance. II. Turnover of acidic vesicles and resistance to weakly basic chemotherapeutic drugs","volume":"57","author":"Raghunand","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0855","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1093\/jnci\/83.15.1098","article-title":"Involvement of vacuolar H(+)-adenosine triphosphatase activity in multidrug resistance in HL60 cells","volume":"83","author":"Marquardt","year":"1991","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bbamem.2020.183341_bb0860","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1042\/bj20021411","article-title":"Inhibitors of vacuolar H+-ATPase impair the preferential accumulation of daunomycin in lysosomes and reverse the resistance to anthracyclines in drug-resistant renal epithelial cells","volume":"370","author":"Ouar","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbamem.2020.183341_bb0865","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1093\/jnci\/djh305","article-title":"Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs","volume":"96","author":"Luciani","year":"2004","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bbamem.2020.183341_bb0870","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2343876","article-title":"Targeting V-ATPase isoform restores cisplatin activity in resistant ovarian cancer: inhibition of autophagy, endosome function, and ERK\/MEK pathway","volume":"2019","author":"Kulshrestha","year":"2019","journal-title":"J. Oncol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0875","doi-asserted-by":"crossref","first-page":"28921","DOI":"10.18632\/oncotarget.25641","article-title":"V-ATPase-dependent repression of androgen receptor in prostate cancer cells","volume":"9","author":"Licon-Munoz","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbamem.2020.183341_bb0880","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrc.2016.25","article-title":"Targeting metastasis","volume":"16","author":"Steeg","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbamem.2020.183341_bb0885","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.cell.2016.11.037","article-title":"Emerging biological principles of metastasis","volume":"168","author":"Lambert","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.bbamem.2020.183341_bb0890","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/nrc1949","article-title":"Cysteine cathepsins: multifunctional enzymes in cancer","volume":"6","author":"Mohamed","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbamem.2020.183341_bb0895","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.1158\/0008-5472.CAN-05-4463","article-title":"Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer","volume":"66","author":"Vasiljeva","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamem.2020.183341_bb0900","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1158\/0008-5472.CAN-11-2759","article-title":"Cathepsin B inhibition limits bone metastasis in breast cancer","volume":"72","author":"Withana","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamem.2020.183341_bb0905","first-page":"C1015","article-title":"Vacuolar-type H(+)-ATPases are functionally expressed in plasma membranes of human tumor cells","volume":"265","author":"Martinez-Zaguilan","year":"1993","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.bbamem.2020.183341_bb0910","doi-asserted-by":"crossref","first-page":"16400","DOI":"10.1074\/jbc.M901201200","article-title":"Function of a subunit isoforms of the V-ATPase in pH homeostasis and in vitro invasion of MDA-MB231 human breast cancer cells","volume":"284","author":"Hinton","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0915","doi-asserted-by":"crossref","first-page":"32731","DOI":"10.1074\/jbc.M113.503771","article-title":"The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells","volume":"288","author":"Capecci","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0920","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1074\/jbc.M114.611210","article-title":"Activity of plasma membrane V-ATPases is critical for the invasion of MDA-MB231 breast cancer cells","volume":"290","author":"Cotter","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0925","doi-asserted-by":"crossref","first-page":"11248","DOI":"10.1074\/jbc.RA119.007713","article-title":"Isoform-specific gene disruptions reveal a role for the V-ATPase subunit a4 isoform in the invasiveness of 4T1-12B breast cancer cells","volume":"294","author":"McGuire","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0930","doi-asserted-by":"crossref","first-page":"5976","DOI":"10.1158\/0008-5472.CAN-12-1772","article-title":"The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1","volume":"72","author":"Wiedmann","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbamem.2020.183341_bb0935","first-page":"1734","article-title":"F-actin reorganization by V-ATPase inhibition in prostate cancer","volume":"6","author":"Licon-Munoz","year":"2017","journal-title":"Biol. Open."},{"key":"10.1016\/j.bbamem.2020.183341_bb0940","doi-asserted-by":"crossref","first-page":"32331","DOI":"10.1074\/jbc.M004795200","article-title":"The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site","volume":"275","author":"Holliday","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0945","doi-asserted-by":"crossref","first-page":"18499","DOI":"10.1074\/jbc.M212844200","article-title":"A novel role for subunit C in mediating binding of the H+-V-ATPase to the actin cytoskeleton","volume":"278","author":"Vitavska","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb0950","doi-asserted-by":"crossref","first-page":"H1147","DOI":"10.1152\/ajpheart.00166.2006","article-title":"Vacuolar-type H+-ATPases at the plasma membrane regulate pH and cell migration in microvascular endothelial cells","volume":"291","author":"Rojas","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbamem.2020.183341_bb0955","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1248\/bpb.b14-00548","article-title":"Iejimalide C is a potent V-ATPase inhibitor, and induces actin disorganization","volume":"37","author":"Kazami","year":"2014","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bbamem.2020.183341_bb0960","article-title":"Atp6v1c1 may regulate filament actin arrangement in breast cancer cells","volume":"9","author":"Cai","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbamem.2020.183341_bb0965","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s00424-009-0677-8","article-title":"Protons make tumor cells move like clockwork","volume":"458","author":"Stock","year":"2009","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bbamem.2020.183341_bb0970","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2015.56","article-title":"Alzheimer\u2019s disease","volume":"1","author":"Masters","year":"2015","journal-title":"Nat. Rev. Dis. Primer."},{"key":"10.1016\/j.bbamem.2020.183341_bb0975","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.cell.2010.05.008","article-title":"Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations","volume":"141","author":"Lee","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bbamem.2020.183341_bb0980","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.celrep.2015.07.050","article-title":"Presenilin 1 maintains lysosomal Ca(2+) homeostasis via TRPML1 by regulating vATPase-mediated lysosome acidification","volume":"12","author":"Lee","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbamem.2020.183341_bb0985","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Primer."},{"key":"10.1016\/j.bbamem.2020.183341_bb0990","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1093\/hmg\/ddt180","article-title":"Altered splicing of ATP6AP2 causes X-linked parkinsonism with spasticity (XPDS)","volume":"22","author":"Korvatska","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbamem.2020.183341_bb0995","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.arr.2016.05.004","article-title":"Disorders of lysosomal acidification-the emerging role of v-ATPase in aging and neurodegenerative disease","volume":"32","author":"Colacurcio","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bbamem.2020.183341_bb1000","doi-asserted-by":"crossref","first-page":"26829","DOI":"10.1074\/jbc.M112.345702","article-title":"Osteopetrosis mutation R444L causes endoplasmic reticulum retention and misprocessing of vacuolar H+-ATPase a3 subunit","volume":"287","author":"Bhargava","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb1005","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/5022","article-title":"Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness","volume":"21","author":"Karet","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbamem.2020.183341_bb1010","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1136\/jmg.39.11.796","article-title":"Novel ATP6V1B1 and ATP6V0A4 mutations in autosomal recessive distal renal tubular acidosis with new evidence for hearing loss","volume":"39","author":"Stover","year":"2002","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.bbamem.2020.183341_bb1015","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1074\/jbc.M117.818872","article-title":"Molecular mechanisms of cutis laxa- and distal renal tubular acidosis-causing mutations in V-ATPase a subunits, ATP6V0A2 and ATP6V0A4","volume":"293","author":"Esmail","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2020.183341_bb1020","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/ng.2007.45","article-title":"Impaired glycosylation and cutis laxa caused by mutations in the vesicular H+-ATPase subunit ATP6V0A2","volume":"40","author":"Kornak","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbamem.2020.183341_bb1025","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1126\/science.1157535","article-title":"The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1","volume":"320","author":"Sancak","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.bbamem.2020.183341_bb1030","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cell.2010.02.024","article-title":"Ragulator-rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids","volume":"141","author":"Sancak","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bbamem.2020.183341_bb1035","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.cell.2012.07.032","article-title":"Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1","volume":"150","author":"Bar-Peled","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bbamem.2020.183341_bb1040","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","article-title":"AKT\/PKB signaling: navigating the network","volume":"169","author":"Manning","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.bbamem.2020.183341_bb1045","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ncb839","article-title":"TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling","volume":"4","author":"Inoki","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbamem.2020.183341_bb1050","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/ncb999","article-title":"Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins","volume":"5","author":"Zhang","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbamem.2020.183341_bb1055","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/ncb2763","article-title":"Signal integration by mTORC1 coordinates nutrient input with biosynthetic output","volume":"15","author":"Dibble","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbamem.2020.183341_bb1060","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.1207056","article-title":"mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase","volume":"334","author":"Zoncu","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bbamem.2020.183341_bb1065","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cmet.2017.10.009","article-title":"AMPK: sensing glucose as well as cellular energy status","volume":"27","author":"Lin","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbamem.2020.183341_bb1070","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.cmet.2014.06.014","article-title":"The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism","volume":"20","author":"Zhang","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbamem.2020.183341_bb1075","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature23275","article-title":"Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK","volume":"548","author":"Zhang","year":"2017","journal-title":"Nature"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273620301814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273620301814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T08:55:01Z","timestamp":1757753701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0005273620301814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":215,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S0005273620301814"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamem.2020.183341","relation":{},"ISSN":["0005-2736"],"issn-type":[{"value":"0005-2736","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation and function of V-ATPases in physiology and disease","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Biomembranes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamem.2020.183341","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"183341"}}