{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:36:30Z","timestamp":1787067390969,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.bbamem.2025.184442","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T12:34:05Z","timestamp":1755693245000},"page":"184442","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessing the anticancer potential of spider venom peptide Latarcin Ltc2a against triple negative breast cancer"],"prefix":"10.1016","volume":"1867","author":[{"given":"Prasanjeet","family":"Kaur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srabaita","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpi","family":"Minocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Chugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamem.2025.184442_bb0005","doi-asserted-by":"crossref","first-page":"448","DOI":"10.21037\/jtd.2017.02.75","article-title":"Cancer prevention from the perspective of global cancer burden patterns","volume":"9","author":"Nagai","year":"2017","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.bbamem.2025.184442_bb0010","series-title":"Global Cancer Observatory: Cancer Today","year":"2024"},{"key":"10.1016\/j.bbamem.2025.184442_bb0015","first-page":"1","article-title":"Multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches","volume":"12","author":"Bin Emran","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbamem.2025.184442_bb0020","doi-asserted-by":"crossref","first-page":"678","DOI":"10.3892\/ijo.2020.5099","article-title":"Anticancer peptide: physicochemical property, functional aspect and trend in clinical application","volume":"57","author":"Chiangjong","year":"2020","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbamem.2025.184442_bb0025","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.3390\/molecules25184245","article-title":"Peptides with dual antimicrobial\u2013anticancer activity: strategies to overcome peptide limitations and rational design of anticancer peptides","volume":"25","author":"Liscano","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bbamem.2025.184442_bb0030","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.drudis.2014.10.003","article-title":"Peptide therapeutics: current status and future directions","volume":"20","author":"Fosgerau","year":"2015","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.bbamem.2025.184442_bb0035","first-page":"232","article-title":"Cytotoxic and anticancer effects of ICD-85 (venom derived peptides) in human breast adenocarcinoma and normal human dermal fibroblasts","volume":"18","author":"Zarandi","year":"2019","journal-title":"Iran. J. Pharm. Res."},{"key":"10.1016\/j.bbamem.2025.184442_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/toxins12040255","article-title":"Hitchhiking with nature: snake venom peptides to fight cancer and superbugs","volume":"12","author":"P\u00e9rez-Peinado","year":"2020","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.bbamem.2025.184442_bb0045","article-title":"Venom-based peptide therapy: insights into anti-cancer mechanism","volume":"8","author":"Ma","year":"2020","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbamem.2025.184442_bb0050","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10989-020-10073-z","article-title":"Venom-derived bioactive compounds as potential anticancer agents: a review","volume":"27","author":"Roy","year":"2021","journal-title":"Int. J. Pept. Res. Ther."},{"key":"10.1016\/j.bbamem.2025.184442_bb0055","doi-asserted-by":"crossref","DOI":"10.1177\/11795514211006071","article-title":"Therapeutic potential of peptides derived from animal venoms: current views and emerging drugs for diabetes","volume":"14","author":"Coulter-Parkhill","year":"2021","journal-title":"Clin. Med. Insights Endocrinol. Diabetes"},{"key":"10.1016\/j.bbamem.2025.184442_bb0060","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4331\/wjbc.v6.i2.28","article-title":"Animal venom studies: current benefits and future developments","volume":"6","author":"Utkin","year":"2015","journal-title":"World J. Biol. Chem."},{"key":"10.1016\/j.bbamem.2025.184442_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11070374","article-title":"Potential therapeutic applications of bee venom on skin disease and its mechanisms: a literature review","volume":"11","author":"Kim","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.bbamem.2025.184442_bb0070","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1016\/j.bmc.2017.09.029","article-title":"Peptide therapeutics from venom: current status and potential","volume":"26","author":"Pennington","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bbamem.2025.184442_bb0075","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.neuropharm.2017.07.002","article-title":"Venom-derived peptide inhibitors of voltage-gated potassium channels","volume":"127","author":"Norton","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbamem.2025.184442_bb0080","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neuropharm.2017.07.011","article-title":"Venom-derived peptides inhibiting Kir channels: past, present, and future","volume":"127","author":"Doupnik","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbamem.2025.184442_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114146","article-title":"The voltage-gated potassium channel KV1.3 as a therapeutic target for venom-derived peptides","volume":"181","author":"Tajti","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbamem.2025.184442_bb0090","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1111\/jcmm.13745","article-title":"Triggering of cancer cell cycle arrest by a novel scorpion venom-derived peptide\u2014Gonearrestide","volume":"22","author":"Li","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbamem.2025.184442_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2180-14-140","article-title":"Identification of natural antimicrobial agents to treat dengue infection: in vitro analysis of latarcin peptide activity against dengue virus","volume":"14","author":"Rothan","year":"2014","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.bbamem.2025.184442_bb0100","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.bbamem.2017.10.029","article-title":"Antifungal activity of Latarcin 1 derived cell-penetrating peptides against Fusarium solani","volume":"1860","author":"Budagavi","year":"2018","journal-title":"Biochim. Biophys. Acta - Biomembr."},{"key":"10.1016\/j.bbamem.2025.184442_bb0105","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejps.2018.01.015","article-title":"Antibacterial properties of Latarcin 1 derived cell-penetrating peptides","volume":"115","author":"Budagavi","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.bbamem.2025.184442_bb0110","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ijantimicag.2011.05.006","article-title":"Potent antimicrobial peptides with selectivity for bacillus anthracis over human erythrocytes","volume":"38","author":"Dawson","year":"2011","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.bbamem.2025.184442_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221810156","article-title":"Membrane interactions of latarcins: antimicrobial peptides from spider venom","volume":"22","author":"Wadhwani","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbamem.2025.184442_bb0120","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3390\/cimb44010004","article-title":"Lessons from a single amino acid substitution: anticancer and antibacterial properties of two phospholipase A2-derived peptides","volume":"44","author":"Almeida","year":"2021","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.bbamem.2025.184442_bb0125","doi-asserted-by":"crossref","first-page":"e10167","DOI":"10.1002\/btm2.10167","article-title":"The wasp venom antimicrobial peptide polybia-CP and its synthetic derivatives display antiplasmodial and anticancer properties","volume":"5","author":"Torres","year":"2020","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.bbamem.2025.184442_bb0130","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.peptides.2011.11.002","article-title":"Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells","volume":"33","author":"Slaninov\u00e1","year":"2012","journal-title":"Peptides"},{"key":"10.1016\/j.bbamem.2025.184442_bb0135","doi-asserted-by":"crossref","DOI":"10.1590\/1678-9199-jvatitd-14-63-18","article-title":"Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities","volume":"25","author":"Wu","year":"2019","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.bbamem.2025.184442_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221810156","article-title":"Membrane interactions of latarcins: antimicrobial peptides from spider venom","volume":"22","author":"Wadhwani","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbamem.2025.184442_bb0145","author":"The ASCO Post"},{"key":"10.1016\/j.bbamem.2025.184442_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cocis.2018.06.009","article-title":"Membrane interactions and cell selectivity of amphiphilic anticancer peptides","volume":"38","author":"Nystr\u00f6m","year":"2018","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"10.1016\/j.bbamem.2025.184442_bb0155","first-page":"1367","article-title":"Cancer chemotherapy and beyond: current status, drug candidates, associated risks and progress in targeted therapeutics","volume":"10","author":"Chandel","year":"2022","journal-title":"Genes Dis."},{"key":"10.1016\/j.bbamem.2025.184442_bb0160","doi-asserted-by":"crossref","DOI":"10.5812\/jjnpp-134049","article-title":"Current status of peptide medications and the position of active therapeutic peptides with scorpion venom origin","volume":"18","author":"Baradaran","year":"2023","journal-title":"Jundishapur J. Nat. Pharm. Prod."},{"key":"10.1016\/j.bbamem.2025.184442_bb0165","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.biochi.2010.09.016","article-title":"Haemolytic and cytotoxic action of latarcin Ltc2a","volume":"93","author":"Vorontsova","year":"2011","journal-title":"Biochimie"},{"key":"10.1016\/j.bbamem.2025.184442_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2013.00294","article-title":"From antimicrobial to anticancer peptides. A review","volume":"4","author":"Gaspar","year":"2013","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bbamem.2025.184442_bb0175","doi-asserted-by":"crossref","first-page":"6210","DOI":"10.1021\/ja210569f","article-title":"Anticancer \u03b2-hairpin peptides: membrane-induced folding triggers activity","volume":"134","author":"Sinthuvanich","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bbamem.2025.184442_bb0180","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.bbamem.2017.03.002","article-title":"Phosphatidylserine lipids and membrane order precisely regulate the activity of Polybia-MP1 peptide","volume":"1859","author":"Alvares","year":"2017","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.bbamem.2025.184442_bb0185","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3390\/toxins14070438","article-title":"Scorpion peptide Smp24 exhibits a potent antitumor effect on human lung cancer cells by damaging the membrane and cytoskeleton in vivo and in vitro","volume":"14","author":"Guo","year":"2022","journal-title":"Toxins"},{"key":"10.1016\/j.bbamem.2025.184442_bb0190","doi-asserted-by":"crossref","first-page":"10759","DOI":"10.1021\/bi060635w","article-title":"Spatial structure and activity mechanism of a novel spider antimicrobial peptide","volume":"45","author":"Dubovskii","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamem.2025.184442_bb0195","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s00249-011-0726-z","article-title":"Investigating the effect of a single glycine to alanine substitution on interactions of antimicrobial peptide latarcin 2a with a lipid membrane","volume":"40","author":"Idiong","year":"2011","journal-title":"Eur. Biophys. J."},{"key":"10.1016\/j.bbamem.2025.184442_bb0200","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1016\/j.bbamem.2012.07.030","article-title":"Imaging the membrane lytic activity of bioactive peptide latarcin 2a","volume":"1818","author":"Won","year":"2012","journal-title":"Biochim. Biophys. Acta - Biomembr."},{"key":"10.1016\/j.bbamem.2025.184442_bb0205","doi-asserted-by":"crossref","first-page":"678","DOI":"10.3892\/ijo.2020.5099","article-title":"Anticancer peptide: physicochemical property, functional aspect and trend in clinical application","volume":"57","author":"Chiangjong","year":"2020","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbamem.2025.184442_bb0210","doi-asserted-by":"crossref","first-page":"867","DOI":"10.3390\/microorganisms8060867","article-title":"Shorter antibacterial peptide having high selectivity for E. coli membranes and low potential for inducing resistance","volume":"8","author":"Barreto-Santamar\u00eda","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.bbamem.2025.184442_bb0215","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.bbamem.2007.11.008","article-title":"Studies on anticancer activities of antimicrobial peptides","volume":"1778","author":"Hoskin","year":"2008","journal-title":"Biochim. Biophys. Acta (BBA)-Biomembr."},{"key":"10.1016\/j.bbamem.2025.184442_bb0220","doi-asserted-by":"crossref","first-page":"487","DOI":"10.2174\/138920306779025611","article-title":"Anticancer \u03b1-helical peptides and structure\/function relationships underpinning their interactions with tumour cell membranes","volume":"7","author":"Dennison","year":"2006","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.bbamem.2025.184442_bb0225","article-title":"Peptide-based delivery of therapeutics in cancer treatment","volume":"14","author":"Samec","year":"2022","journal-title":"Mater. Today Bio."},{"key":"10.1016\/j.bbamem.2025.184442_bb0230","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.bbamem.2008.09.013","article-title":"Control of cell selectivity of antimicrobial peptides","volume":"1788","author":"Matsuzaki","year":"2009","journal-title":"Biochim. Biophys. Acta (BBA)-Biomembr."},{"key":"10.1016\/j.bbamem.2025.184442_bb0235","first-page":"7","article-title":"In vitro and MD simulation study to explore physicochemical parameters for antibacterial peptide to become potent anticancer peptide","volume":"16","author":"Ma","year":"2020","journal-title":"Mol. Ther."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273625000367?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273625000367?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:54:51Z","timestamp":1762091691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0005273625000367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0005273625000367"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamem.2025.184442","relation":{},"ISSN":["0005-2736"],"issn-type":[{"value":"0005-2736","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessing the anticancer potential of spider venom peptide Latarcin Ltc2a against triple negative breast cancer","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Biomembranes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamem.2025.184442","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"184442"}}