{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:19:55Z","timestamp":1787649595498,"version":"build-2736575974"},"reference-count":69,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,6,11]],"date-time":"2027-06-11T00:00:00Z","timestamp":1812672000000},"content-version":"am","delay-in-days":253,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01HL076586"],"award-info":[{"award-number":["R01HL076586"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000152","name":"National Science Foundation Division of Molecular and Cellular Biosciences","doi-asserted-by":"publisher","award":["1329467"],"award-info":[{"award-number":["1329467"]}],"id":[{"id":"10.13039\/100000152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000152","name":"National Science Foundation Division of Molecular and Cellular Biosciences","doi-asserted-by":"publisher","award":["MCB1715384"],"award-info":[{"award-number":["MCB1715384"]}],"id":[{"id":"10.13039\/100000152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM077232"],"award-info":[{"award-number":["R01GM077232"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbamem.2026.184547","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:43:02Z","timestamp":1780555382000},"page":"184547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fluorescence readouts of KL4-induced changes in lipid order and fluidity in surfactant-like bilayers relevant to ARDS and COVID-19 lung injury"],"prefix":"10.1016","volume":"1868","author":[{"given":"Otonye","family":"Braide-Moncoeur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhi","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna R.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail E.","family":"Fanucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbamem.2026.184547_bb0005","first-page":"1015","article-title":"Isolation and properties of type II alveolar cells from rat lung","volume":"115","author":"Mason","year":"1977","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.bbamem.2026.184547_bb0010","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1542\/peds.2004-2231","article-title":"A multicenter, randomized, controlled trial of lucinactant versus poractant alfa among very premature infants at high risk for respiratory distress syndrome","volume":"115","author":"Sinha","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.bbamem.2026.184547_bb0015","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1164\/ajrccm.160.4.9808118","article-title":"Bronchopulmonary segmental lavage with Surfaxin (KL(4)-surfactant) for acute respiratory distress syndrome","volume":"160","author":"Wiswell","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbamem.2026.184547_bb0020","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/s41390-020-0750-8","article-title":"Surfactant replacement therapy: from biological basis to current clinical practice","volume":"88","author":"Hentschel","year":"2020","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbamem.2026.184547_bb0025","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1203\/00006450-199604000-00025","article-title":"Efficacy of synthetic peptide-containing surfactant in the treatment of respiratory distress syndrome in preterm infant rhesus monkeys","volume":"39","author":"Revak","year":"1996","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbamem.2026.184547_bb0030","article-title":"The role of pulmonary surfactants in the treatment of acute respiratory distress syndrome in COVID-19","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbamem.2026.184547_bb0035","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1159\/000084879","article-title":"History of surfactant from 1980","volume":"87","author":"Halliday","year":"2005","journal-title":"Biol. Neonate"},{"key":"10.1016\/j.bbamem.2026.184547_bb0040","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1159\/000084878","article-title":"History of surfactant up to 1980","volume":"87","author":"Obladen","year":"2005","journal-title":"Biol. Neonate"},{"key":"10.1016\/j.bbamem.2026.184547_bb0045","doi-asserted-by":"crossref","first-page":"7794","DOI":"10.1073\/pnas.92.17.7794","article-title":"Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice","volume":"92","author":"Clark","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbamem.2026.184547_bb0050","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1172\/JCI117173","article-title":"A mutation in the surfactant protein B gene responsible for fatal neonatal respiratory disease in multiple kindreds","volume":"93","author":"Nogee","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbamem.2026.184547_bb0055","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cbpa.2016.02.012","article-title":"Peptide-based synthetic pulmonary surfactant for the treatment of respiratory distress disorders","volume":"32","author":"Braide-Moncoeur","year":"2016","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.bbamem.2026.184547_bb0060","series-title":"Comparison of Synthetic Amphipathic Peptides with Recombinant Human SP-C in Their Ability to Promote the Activity of Artificial Lung Surfactants","first-page":"178","author":"Voelter","year":"1996"},{"key":"10.1016\/j.bbamem.2026.184547_bb0065","doi-asserted-by":"crossref","first-page":"6795","DOI":"10.1038\/s41598-018-25009-3","article-title":"Effective in vivo treatment of acute lung injury with helical, amphipathic peptoid mimics of pulmonary surfactant proteins","volume":"8","author":"Czyzewski","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbamem.2026.184547_bb0070","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1038\/s41598-020-58248-4","article-title":"In vitro functional and structural characterization of a synthetic clinical pulmonary surfactant with enhanced resistance to inhibition","volume":"10","author":"Echaide","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbamem.2026.184547_bb0075","doi-asserted-by":"crossref","first-page":"F497","DOI":"10.1136\/archdischild-2017-312722","article-title":"A first-in-human clinical study of a new SP-B and SP-C enriched synthetic surfactant (CHF5633) in preterm babies with respiratory distress syndrome","volume":"102","author":"Sweet","year":"2017","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"10.1016\/j.bbamem.2026.184547_bb0080","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.1021\/acs.langmuir.2c03349","article-title":"Surfactant proteins SP-B and SP-C in pulmonary surfactant monolayers: physical properties controlled by specific protein-lipid interactions","volume":"39","author":"Liekkinen","year":"2023","journal-title":"Langmuir"},{"key":"10.1016\/j.bbamem.2026.184547_bb0085","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1016\/j.jmb.2020.02.028","article-title":"Pulmonary surfactant lipid reorganization induced by the adsorption of the oligomeric surfactant protein B complex","volume":"432","author":"Liekkinen","year":"2020","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbamem.2026.184547_bb0090","doi-asserted-by":"crossref","first-page":"20946","DOI":"10.1038\/s41598-023-47672-x","article-title":"A randomized controlled trial of nebulized surfactant for the treatment of severe COVID-19 in adults (COVSurf trial)","volume":"13","author":"Dushianthan","year":"2023","journal-title":"Sci. Rep-Uk"},{"key":"10.1016\/j.bbamem.2026.184547_bb0095","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20230504","article-title":"Surfactant replacement therapy as promising treatment for COVID-19: an updated narrative review","volume":"43","author":"Khudadah","year":"2023","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.bbamem.2026.184547_bb0100","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0014-5793(96)00290-6","article-title":"The 21-residue surfactant peptide (LysLeu4)4Lys(KL4) is a transmembrane alpha-helix with a mixed nonpolar\/polar surface","volume":"384","author":"Gustafsson","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbamem.2026.184547_bb0105","first-page":"206","article-title":"Lucinactant: new and approved, but is it an improvement?","volume":"17","author":"Garner","year":"2012","journal-title":"J. Pediatr. Pharmacol. Ther."},{"key":"10.1016\/j.bbamem.2026.184547_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.mehy.2020.109976","article-title":"Deceiving SARS-CoV-2 molecular-tropism clues - a combinational contemporary strategy","volume":"144","author":"Balaji","year":"2020","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.bbamem.2026.184547_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.mehy.2020.110081","article-title":"Surfactant-based prophylaxis and therapy against COVID-19: a possibility","volume":"143","author":"Pramod","year":"2020","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.bbamem.2026.184547_bb0120","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3389\/fmed.2020.00254","article-title":"Lung surfactant for pulmonary barrier restoration in patients with COVID-19 pneumonia","volume":"7","author":"Mirastschijski","year":"2020","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.bbamem.2026.184547_bb0125","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1126\/science.1948032","article-title":"Pulmonary surfactant protein B (SP-B): structure-function relationships","volume":"254","author":"Cochrane","year":"1991","journal-title":"Science (Washington, D. C., 1883)"},{"key":"10.1016\/j.bbamem.2026.184547_bb0130","series-title":"Reconstituted Surfactants Having Improved Properties","first-page":"29","author":"Johansson","year":"2008"},{"key":"10.1016\/j.bbamem.2026.184547_bb0135","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.bbamem.2009.08.020","article-title":"Partitioning, dynamics, and orientation of lung surfactant peptide KL4 in phospholipid bilayers","volume":"1798","author":"Long","year":"2010","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.bbamem.2026.184547_bb0140","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1016\/j.bbamem.2014.09.006","article-title":"Residue specific partitioning of KL4 into phospholipid bilayers","volume":"1838","author":"Turner","year":"2014","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.bbamem.2026.184547_bb0145","doi-asserted-by":"crossref","first-page":"8292","DOI":"10.1021\/bi702551c","article-title":"The helical structure of surfactant peptide KL4 when bound to POPC: POPG lipid vesicles","volume":"47","author":"Mills","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamem.2026.184547_bb0150","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1111\/j.1742-4658.2006.05258.x","article-title":"Physical properties and surface activity of surfactant-like membranes containing the cationic and hydrophobic peptide KL4","volume":"273","author":"Saenz","year":"2006","journal-title":"FEBS J."},{"key":"10.1016\/j.bbamem.2026.184547_bb0155","doi-asserted-by":"crossref","first-page":"8228","DOI":"10.1021\/bi00083a025","article-title":"Interactions of model human pulmonary surfactants with a mixed phospholipid bilayer assembly: Raman spectroscopic studies","volume":"32","author":"Vincent","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamem.2026.184547_bb0160","doi-asserted-by":"crossref","first-page":"8395","DOI":"10.1021\/bi00098a017","article-title":"Raman spectroscopic studies of model human pulmonary surfactant systems: phospholipid interactions with peptide paradigms for the surfactant protein SP-B","volume":"30","author":"Vincent","year":"1991","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbamem.2026.184547_bb0165","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.1016\/j.bpj.2008.12.3966","article-title":"Penetration depth of surfactant peptide KL4 into membranes is determined by fatty acid saturation","volume":"96","author":"Antharam","year":"2009","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbamem.2026.184547_bb0170","doi-asserted-by":"crossref","first-page":"9102","DOI":"10.1021\/acs.jpcb.7b06538","article-title":"Entropic anomaly observed in lipid polymorphisms induced by surfactant peptide SP-B(1-25)","volume":"121","author":"Tran","year":"2017","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.bbamem.2026.184547_bb0175","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bbamem.2014.05.012","article-title":"Delineation of the dynamic properties of individual lipid species in native and synthetic pulmonary surfactants","volume":"1848","author":"Farver","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbamem.2026.184547_bb0180","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1021\/acs.jpcb.5c07807","article-title":"Improving the estimation of pK(a) values for all titratable amino acids at the water\/membrane interface","volume":"130","author":"Oliveira","year":"2026","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.bbamem.2026.184547_bb0185","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1529\/biophysj.106.090217","article-title":"Effect of surfactant protein A on the physical properties and surface activity of KL4-surfactant","volume":"92","author":"Saenz","year":"2007","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbamem.2026.184547_bb0190","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1021\/mp700123p","article-title":"Characterization of the in situ structural and interfacial properties of the cationic hydrophobic heteropolypeptide, KL4, in lung surfactant bilayer and monolayer models at the air-water interface: implications for pulmonary surfactant delivery","volume":"5","author":"Mansour","year":"2008","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bbamem.2026.184547_bb0195","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1089\/nat.2020.0855","article-title":"Modification of KL4 peptide revealed the importance of alpha-helical structure for efficient small interfering RNA delivery","volume":"31","author":"Qiu","year":"2021","journal-title":"Nucleic Acid Ther."},{"key":"10.1016\/j.bbamem.2026.184547_bb0200","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jconrel.2019.10.026","article-title":"Effective mRNA pulmonary delivery by dry powder formulation of PEGylated synthetic KL4 peptide","volume":"314","author":"Qiu","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bbamem.2026.184547_bb0205","doi-asserted-by":"crossref","DOI":"10.4028\/b-wjQRP6","article-title":"Recent progress in nucleic acid pulmonary delivery toward overcoming physiological barriers and improving transfection efficiency","volume":"11","author":"Wang","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bbamem.2026.184547_bb0210","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00408-024-00689-z","article-title":"The synthetic surfactant CHF5633 restores lung function and lung architecture in severe acute respiratory distress syndrome in adult rabbits","volume":"202","author":"Mikolka","year":"2024","journal-title":"Lung"},{"key":"10.1016\/j.bbamem.2026.184547_bb0215","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4236\/ojbiphy.2015.53007","article-title":"Free volume in membranes: viscosity or tension?","volume":"5","author":"Markin","year":"2015","journal-title":"Open J. Biophys."},{"key":"10.1016\/j.bbamem.2026.184547_bb0220","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.chemphyslip.2012.02.007","article-title":"The photophysics of a rhodamine head labeled phospholipid in the identification and characterization of membrane lipid phases","volume":"165","author":"Castro","year":"2012","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.bbamem.2026.184547_bb0225","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.chemphyslip.2004.08.004","article-title":"Intermolecular interactions of lysobisphosphatidic acid with phosphatidylcholine in mixed bilayers","volume":"133","author":"Holopainen","year":"2005","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.bbamem.2026.184547_bb0230","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0009-3084(80)90036-5","article-title":"Excimer-forming lipids in membrane research","volume":"27","author":"Galla","year":"1980","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.bbamem.2026.184547_bb0235","article-title":"In situ light-driven pH modulation for NMR studies","volume":"64","author":"Barde","year":"2025","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.bbamem.2026.184547_bb0240","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bbrc.2010.02.180","article-title":"Bis(monoacylglycero)phosphate and ganglioside GM1 spontaneously form small homogeneous vesicles at specific concentrations","volume":"394","author":"Chebukati","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbamem.2026.184547_bb0245","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0009-3084(02)00020-8","article-title":"Pyrene-labeled lipids as tools in membrane biophysics and cell biology","volume":"116","author":"Somerharju","year":"2002","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.bbamem.2026.184547_bb0250","doi-asserted-by":"crossref","first-page":"8749","DOI":"10.1021\/la000512r","article-title":"Molecular dynamics of monopyrenyl lipids in liposomes from global analysis of time-resolved fluorescence of pyrene monomer and excimer emission","volume":"16","author":"Novikov","year":"2000","journal-title":"Langmuir"},{"key":"10.1016\/j.bbamem.2026.184547_bb0255","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.bbamem.2012.12.014","article-title":"Sensing hydration and behavior of pyrene in POPC and POPC\/cholesterol bilayers: a molecular dynamics study","volume":"1828","author":"Loura","year":"2013","journal-title":"Bba-Biomembranes"},{"key":"10.1016\/j.bbamem.2026.184547_bb0260","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S0006-3495(98)77563-0","article-title":"Phospholipid component volumes: determination and application to bilayer structure calculations","volume":"75","author":"Armen","year":"1998","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbamem.2026.184547_bb0265","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1021\/acsabm.3c00824","article-title":"Unraveling the effects of cationic peptides on vesicle structures: insights into peptide-membrane interactions","volume":"7","author":"Alfred","year":"2024","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.bbamem.2026.184547_bb0270","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1529\/biophysj.106.090860","article-title":"Differential detection of phospholipid fluidity, order, and spacing by fluorescence spectroscopy of bis-pyrene, prodan, nystatin, and merocyanine 540","volume":"91","author":"Wilson-Ashworth","year":"2006","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbamem.2026.184547_bb0275","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1177\/108705710000500501","article-title":"Fluorescence polarization and anisotropy in high throughput screening: perspectives and primer","volume":"5","author":"Owicki","year":"2000","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.bbamem.2026.184547_bb0280","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.addr.2018.01.019","article-title":"Fluorescence anisotropy imaging in drug discovery","volume":"151-152","author":"Vinegoni","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bbamem.2026.184547_bb0285","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.coph.2010.09.013","article-title":"Fluorescence anisotropy and resonance energy transfer: powerful tools for measuring real time protein dynamics in a physiological environment","volume":"10","author":"Yengo","year":"2010","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.bbamem.2026.184547_bb0290","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.saa.2013.10.062","article-title":"Fluorescence spectroscopy of Rhodamine 6G: concentration and solvent effects","volume":"121","author":"Zehentbauer","year":"2014","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.bbamem.2026.184547_bb0295","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.chemphyslip.2007.06.210","article-title":"The role of phospholipid headgroups in mediating bilayer organization: perturbations induced by the presence of a tethered chromophore","volume":"150","author":"Lapinski","year":"2007","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.bbamem.2026.184547_bb0300","doi-asserted-by":"crossref","first-page":"14637","DOI":"10.1039\/D4CP00030G","article-title":"Computation of Overhauser dynamic nuclear polarization processes reveals fundamental correlation between water dynamics, structure, and solvent restructuring entropy","volume":"26","author":"Robinson Brown","year":"2024","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.bbamem.2026.184547_bb0305","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/bs.mie.2018.09.024","article-title":"Overhauser dynamic nuclear polarization for the study of hydration dynamics, explained","volume":"615","author":"Franck","year":"2019","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbamem.2026.184547_bb0310","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.pnmrs.2013.06.001","article-title":"Quantitative cw Overhauser effect dynamic nuclear polarization for the analysis of local water dynamics","volume":"74","author":"Franck","year":"2013","journal-title":"Prog. Nucl. Magn. Reson. Spectrosc."},{"key":"10.1016\/j.bbamem.2026.184547_bb0315","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.micromeso.2013.04.019","article-title":"Overhauser dynamic nuclear polarization-enhanced NMR relaxometry","volume":"178","author":"Franck","year":"2013","journal-title":"Microporous Mesoporous Mater."},{"key":"10.1016\/j.bbamem.2026.184547_bb0320","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1021\/acs.jpcb.4c00405","article-title":"Hydrophobic clusters regulate surface hydration dynamics of Bacillus subtilis lipase a","volume":"128","author":"Jaufer","year":"2024","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.bbamem.2026.184547_bb0325","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222011113","article-title":"Photophysical properties of BADAN revealed in the study of GGBP structural transitions","volume":"22","author":"Fonin","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbamem.2026.184547_bb0330","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0241594","article-title":"BADAN-conjugated beta-lactamases as biosensors for beta-lactam antibiotic detection","volume":"15","author":"Au","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.bbamem.2026.184547_bb0335","doi-asserted-by":"crossref","first-page":"10085","DOI":"10.1021\/jp504625d","article-title":"Fluorescence quenching of (dimethylamino)naphthalene dyes Badan and Prodan by tryptophan in cytochromes P450 and micelles","volume":"118","author":"Pospisil","year":"2014","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.bbamem.2026.184547_bb0340","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.275","article-title":"Spectral characteristics of the mutant form GGBP\/H152C of D-glucose\/D-galactose-binding protein labeled with fluorescent dye BADAN: influence of external factors","volume":"2","author":"Fonin","year":"2014","journal-title":"PeerJ"},{"key":"10.1016\/j.bbamem.2026.184547_bb0345","doi-asserted-by":"crossref","first-page":"8766","DOI":"10.1021\/bi0495735","article-title":"Phosphorylation and binding interactions of CheY studied by use of Badan-labeled protein","volume":"43","author":"Stewart","year":"2004","journal-title":"Biochemistry"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Biomembranes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273626000507?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0005273626000507?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:30:47Z","timestamp":1787646647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0005273626000507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0005273626000507"],"URL":"https:\/\/doi.org\/10.1016\/j.bbamem.2026.184547","relation":{},"ISSN":["0005-2736"],"issn-type":[{"value":"0005-2736","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fluorescence readouts of KL4-induced changes in lipid order and fluidity in surfactant-like bilayers relevant to ARDS and COVID-19 lung injury","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Biomembranes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbamem.2026.184547","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"184547"}}