{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T14:40:41Z","timestamp":1775572841818,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1016\/j.bbapap.2006.03.004","type":"journal-article","created":{"date-parts":[[2006,4,10]],"date-time":"2006-04-10T16:20:11Z","timestamp":1144686011000},"page":"863-871","source":"Crossref","is-referenced-by-count":18,"title":["Isolation and characterization of cotiaractivase, a novel low molecular weight prothrombin activator from the venom of Bothrops cotiara"],"prefix":"10.1016","volume":"1764","author":[{"given":"Yotis A.","family":"Senis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul Y.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma L.J.","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngel","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sripadi","family":"Prabhakar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark C.","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Brittan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Zitzmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Wait","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Warrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve P.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aura S.","family":"Kamiguti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. David G.","family":"Theakston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Nesheim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin D.","family":"Laing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbapap.2006.03.004_bib1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1055\/s-2004-830904","article-title":"Snake venoms and the neuromuscular junction","volume":"24","author":"Lewis","year":"2004","journal-title":"Semin. Neurol."},{"key":"10.1016\/j.bbapap.2006.03.004_bib2","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1111\/j.1538-7836.2005.01358.x","article-title":"Snake venoms and hemostasis","volume":"3","author":"Lu","year":"2005","journal-title":"J. Thromb. Haemost."},{"issue":"Suppl. 1","key":"10.1016\/j.bbapap.2006.03.004_bib3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1590\/S0074-02762005000900031","article-title":"Inflammatory effects of snake venom metalloproteinases","volume":"100","author":"Teixeira Cde","year":"2005","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.bbapap.2006.03.004_bib4","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.toxicon.2005.02.025","article-title":"Snake venom probes of platelet adhesion receptors and their ligands","volume":"45","author":"Wijeyewickrema","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.bbapap.2006.03.004_bib5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/01.moh.0000155016.30296.90","article-title":"Coagulation factor V: a plethora of anticoagulant molecules","volume":"12","author":"Kalafatis","year":"2005","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.bbapap.2006.03.004_bib6","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1055\/s-2004-833481","article-title":"Platelet coagulation\u2013protein interactions","volume":"30","author":"Walsh","year":"2004","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.bbapap.2006.03.004_bib7","series-title":"Hemostasis and thrombosis: basic principles and clinical practice","first-page":"171","author":"Jenny","year":"2001"},{"key":"10.1016\/j.bbapap.2006.03.004_bib8","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1055\/s-0038-1646781","article-title":"Thrombin-like and factor X-activator components of Bothrops snake venoms","volume":"41","author":"Nahas","year":"1979","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.bbapap.2006.03.004_bib9","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/S0041-0101(99)00087-2","article-title":"Identification of bothrojaracin-like proteins in snake venoms from Bothrops species and Lachesis muta","volume":"37","author":"Castro","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.bbapap.2006.03.004_bib10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0742-8413(97)00163-1","article-title":"Bothrops sp. snake venoms: comparison of some biochemical and physicochemical properties and interference in platelet functions","volume":"119","author":"Francischetti","year":"1998","journal-title":"Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol."},{"key":"10.1016\/j.bbapap.2006.03.004_bib11","doi-asserted-by":"crossref","first-page":"6755","DOI":"10.1074\/jbc.M206413200","article-title":"Analysis of the kinetics of prothrombin activation and evidence that two equilibrating forms of prothrombinase are involved in the process","volume":"278","author":"Brufatto","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2006.03.004_bib12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/09537100400016711","article-title":"Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets","volume":"16","author":"Senis","year":"2005","journal-title":"Platelets"},{"key":"10.1016\/j.bbapap.2006.03.004_bib13","doi-asserted-by":"crossref","first-page":"12080","DOI":"10.1021\/bi970979+","article-title":"Exosites determine macromolecular substrate recognition by prothrombinase","volume":"36","author":"Krishnaswamy","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbapap.2006.03.004_bib14","doi-asserted-by":"crossref","first-page":"16948","DOI":"10.1016\/S0021-9258(17)44852-6","article-title":"The activated protein C-mediated enhancement of tissue-type plasminogen activator-induced fibrinolysis in a cell-free system","volume":"265","author":"Bajzar","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2006.03.004_bib15","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1021\/ac025529o","article-title":"Automation of nanoscale microcapillary liquid chromatography-tandem mass spectrometry with a vented column","volume":"74","author":"Licklider","year":"2002","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbapap.2006.03.004_bib16","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1182\/blood-2003-07-2392","article-title":"Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins","volume":"103","author":"Garcia","year":"2004","journal-title":"Blood"},{"issue":"Pt C","key":"10.1016\/j.bbapap.2006.03.004_bib17","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0076-6879(81)80025-0","article-title":"Prothrombin","volume":"80","author":"Mann","year":"1981","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbapap.2006.03.004_bib18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1042\/bj20020449","article-title":"A prothrombin activator from Bothrops erythromelas (jararaca-da-seca) snake venom: characterization and molecular cloning","volume":"369","author":"Silva","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbapap.2006.03.004_bib19","doi-asserted-by":"crossref","first-page":"22869","DOI":"10.1016\/S0021-9258(18)50027-2","article-title":"Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family","volume":"267","author":"Paine","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"Pt 2","key":"10.1016\/j.bbapap.2006.03.004_bib20","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1042\/bj3070411","article-title":"Molecular cloning and expression of catrocollastatin, a snake-venom protein from Crotalus atrox (western diamondback rattlesnake) which inhibits platelet adhesion to collagen","volume":"307","author":"Zhou","year":"1995","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbapap.2006.03.004_bib21","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1021\/bi00005a034","article-title":"cDNA cloning and deduced amino acid sequence of prothrombin activator (ecarin) from Kenyan Echis carinatus venom","volume":"34","author":"Nishida","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbapap.2006.03.004_bib22","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.toxicon.2005.02.012","article-title":"Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases","volume":"45","author":"Fox","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.bbapap.2006.03.004_bib23","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0300-9084(00)01163-9","article-title":"Snake venom metalloproteinases: their role in the pathogenesis of local tissue damage","volume":"82","author":"Gutierrez","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.bbapap.2006.03.004_bib24","first-page":"155","article-title":"The use of snake venom toxins as tools to study platelet receptors for collagen and von Willebrand factor","volume":"31","author":"Andrews","year":"2001","journal-title":"Haemostasis"},{"key":"10.1016\/j.bbapap.2006.03.004_bib25","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1046\/j.1538-7836.2003.00298.x","article-title":"What is all that thrombin for?","volume":"1","author":"Mann","year":"2003","journal-title":"J. Thromb. Haemost."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570963906001099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570963906001099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,25]],"date-time":"2021-07-25T14:56:51Z","timestamp":1627225011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570963906001099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S1570963906001099"],"URL":"https:\/\/doi.org\/10.1016\/j.bbapap.2006.03.004","relation":{},"ISSN":["1570-9639"],"issn-type":[{"value":"1570-9639","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}