{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:32:04Z","timestamp":1784118724449,"version":"3.55.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.bbapap.2006.05.009","type":"journal-article","created":{"date-parts":[[2006,6,7]],"date-time":"2006-06-07T21:14:00Z","timestamp":1149714840000},"page":"1292-1298","source":"Crossref","is-referenced-by-count":11,"title":["Identification of chitotriosidase isoforms in plasma of Gaucher disease patients by two dimensional gel electrophoresis"],"prefix":"10.1016","volume":"1764","author":[{"given":"Luc\u00eda","family":"Quintana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Monasterio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kepa","family":"Escuredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jokin","family":"del Amo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Alfonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Elortza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Santa Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laureano","family":"Sim\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Giraldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Pocov\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Luis Castrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbapap.2006.05.009_bib1","series-title":"The Metabolic and Molecular Basis of Inherited Disease","first-page":"3635","author":"Beutler","year":"2001"},{"key":"10.1016\/j.bbapap.2006.05.009_bib2","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1172\/JCI117084","article-title":"Marked elevation of plasma chitotriosidase activity, a novel hallmark of Gaucher disease","volume":"93","author":"Hollak","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbapap.2006.05.009_bib3","doi-asserted-by":"crossref","first-page":"25680","DOI":"10.1074\/jbc.273.40.25680","article-title":"The human chitotriosidase gene, nature of inherited enzyme deficiency","volume":"273","author":"Boot","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2006.05.009_bib4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1432-1033.1997.00279.x","article-title":"Synthesis, sorting, and processing into distinct isoforms of human macrophage chitotriosidase","volume":"244","author":"Renkema","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbapap.2006.05.009_bib5","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1074\/jbc.270.5.2198","article-title":"Purification and characterization of human chitotriosidase, a novel member of the chitinase family of proteins","volume":"270","author":"Renkema","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2006.05.009_bib6","first-page":"792","article-title":"Report of the Spanish Gaucher's disease registry: clinical and genetic characteristics","volume":"85","author":"Giraldo","year":"2000","journal-title":"Haematologica"},{"key":"10.1016\/j.bbapap.2006.05.009_bib7","first-page":"158","article-title":"Leukocyte beta-glucosidase in homozygotes and heterozygotes for Gaucher disease","volume":"32","author":"Raghavan","year":"1980","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbapap.2006.05.009_bib8","first-page":"977","article-title":"Chitotriosidase genotype and plasma activity in patients with type 1 Gaucher's disease and their relatives (carriers and non-carriers)","volume":"86","author":"Giraldo","year":"2001","journal-title":"Haematologica"},{"key":"10.1016\/j.bbapap.2006.05.009_bib9","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/(SICI)1522-2683(20000401)21:6<1037::AID-ELPS1037>3.0.CO;2-V","article-title":"The current state of two-dimensional electrophoresis with immobilized pH gradients","volume":"21","author":"G\u00f6rg","year":"2000","journal-title":"Electrophoresis"},{"key":"10.1016\/j.bbapap.2006.05.009_bib10","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.bcmd.2003.10.007","article-title":"Effect of enzyme replacement therapy on gammopathies in Gaucher disease","volume":"32","author":"Brautbar","year":"2004","journal-title":"Blood Cells, Mol. Dis."},{"key":"10.1016\/j.bbapap.2006.05.009_bib11","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1021\/ac950914h","article-title":"Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels","volume":"68","author":"Sevchenko","year":"1996","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbapap.2006.05.009_bib12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/(SICI)1096-9888(199902)34:2<105::AID-JMS768>3.0.CO;2-4","article-title":"Sample purification and preparation technique based on nano-scale reversed-phase columns for the sensitive analysis of complex peptide mixtures by matrix-assisted laser desorption\/ionization mass spectrometry","volume":"34","author":"Gobom","year":"1999","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.bbapap.2006.05.009_bib13","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1002\/1615-9861(200209)2:9<1277::AID-PROT1277>3.0.CO;2-P","article-title":"Graphite powder as an alternative or supplement to reversed-phase material for desalting and concentration of peptide mixtures prior to matrix-assisted laser desorption\/ionization-mass spectrometry","volume":"2","author":"Larsen","year":"2002","journal-title":"Proteomics"},{"key":"10.1016\/j.bbapap.2006.05.009_bib14","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1093\/clinchem\/31.7.1198","article-title":"Incubation with neuraminidase and affinity electrophoresis with wheat-germ lectin compared for separating and quantifying alkaline phosphatase isoenzymes in plasma","volume":"31","author":"Rosalki","year":"1985","journal-title":"Clin. Chem."},{"key":"10.1016\/j.bbapap.2006.05.009_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/pmic.200300624","article-title":"Optimization of the first dimension for separation by two-dimensional gel electrophoresis of basic proteins from human brain tissue","volume":"4","author":"Pennington","year":"2004","journal-title":"Proteomics"},{"key":"10.1016\/j.bbapap.2006.05.009_bib16","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/pmic.200300392","article-title":"Strategies for the enrichment and identification of basic proteins in proteome projects","volume":"3","author":"Bae","year":"2003","journal-title":"Proteomics"},{"key":"10.1016\/j.bbapap.2006.05.009_bib17","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1006\/expr.1995.1083","article-title":"Structure and function of a family of chitinase isozymes from Brugian microfilariae","volume":"80","author":"Fuhrman","year":"1995","journal-title":"Exp. Parasitol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570963906002214?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570963906002214?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T09:52:12Z","timestamp":1586944332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570963906002214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S1570963906002214"],"URL":"https:\/\/doi.org\/10.1016\/j.bbapap.2006.05.009","relation":{},"ISSN":["1570-9639"],"issn-type":[{"value":"1570-9639","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}