{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:29:58Z","timestamp":1791404998916,"version":"4.3.3"},"reference-count":84,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1016\/j.bbapap.2009.02.017","type":"journal-article","created":{"date-parts":[[2009,3,14]],"date-time":"2009-03-14T10:40:06Z","timestamp":1237027206000},"page":"817-825","source":"Crossref","is-referenced-by-count":74,"title":["Assembly and transport mechanism of tripartite drug efflux systems"],"prefix":"10.1016","volume":"1794","author":[{"given":"Rajeev","family":"Misra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassiliy N.","family":"Bavro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbapap.2009.02.017_bib1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1128\/CMR.19.2.382-402.2006","article-title":"Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria","volume":"19","author":"Piddock","year":"2006","journal-title":"Clin. Microbio. Rev."},{"key":"10.1016\/j.bbapap.2009.02.017_bib2","first-page":"179","article-title":"Bacterial multidrug efflux pumps serve other functions","volume":"3","author":"Poole","year":"2008","journal-title":"Microbe"},{"key":"10.1016\/j.bbapap.2009.02.017_bib3","doi-asserted-by":"crossref","first-page":"5443","DOI":"10.1128\/JB.180.20.5443-5447.1998","article-title":"Influence of the MexAB-OprM Multidrug efflux system on quorum sensing in Pseudomonas aeruginosa","volume":"180","author":"Evans","year":"1998","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib4","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1128\/JB.184.13.3699-3703.2002","article-title":"Toxin disposal in Escherichia coli","volume":"182","author":"Helling","year":"2002","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib5","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1529\/biophysj.104.046151","article-title":"Colicin occlusion of OmpF and TolC channels: outer membrane translocons for colicin import","volume":"87","author":"Zakharov","year":"2004","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbapap.2009.02.017_bib6","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1128\/JB.01448-06","article-title":"Initial steps of colicin E1 import across the outer membrane of Escherichia coli","volume":"189","author":"Masi","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib7","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1073\/pnas.87.12.4776","article-title":"TolC, an Escherichia coli outer membrane protein required for hemolysin secretion","volume":"87","author":"Wandersman","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbapap.2009.02.017_bib8","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbamcr.2004.05.001","article-title":"Type I secretion in gram-negative bacteria","volume":"1694","author":"Delepelaire","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbapap.2009.02.017_bib9","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/j.1365-2958.2006.05549.x","article-title":"Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB","volume":"63","author":"Tikhonova","year":"2007","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib10","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1074\/jbc.M806964200","article-title":"The MacB ABC transporter is a dimer whose ATPase activity and macrolide-binding capacity are regulated by the membrane fusion protein MacA","volume":"284","author":"Lin","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2009.02.017_bib11","doi-asserted-by":"crossref","first-page":"7693","DOI":"10.1128\/JB.00853-08","article-title":"MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II","volume":"190","author":"Yamanaka","year":"2008","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrd2200","article-title":"Waltzing transporters and \u2018the dance macabre' between humans and bacteria","volume":"6","author":"Lomovskaya","year":"2007","journal-title":"Nat. Rev."},{"key":"10.1016\/j.bbapap.2009.02.017_bib13","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.sbi.2008.06.007","article-title":"Multidrug transporters, AcrB\u2212the pumping mechanism","volume":"18","author":"Murakai","year":"2008","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib14","first-page":"763","article-title":"Mechanisms of RND multidrug efflux pumps","volume":"1794","author":"Nikaido","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbapap.2009.02.017_bib15","doi-asserted-by":"crossref","first-page":"719","DOI":"10.2174\/138945008785747743","article-title":"Structure and mechanism of drug efflux machinery in Gram negative bacteria","volume":"9","author":"Pietras","year":"2008","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.bbapap.2009.02.017_bib16","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1080\/07853890701195262","article-title":"Efflux pumps as antimicrobial resistance mechanisms","volume":"39","author":"Poole","year":"2007","journal-title":"Ann. Med"},{"key":"10.1016\/j.bbapap.2009.02.017_bib17","doi-asserted-by":"crossref","first-page":"729","DOI":"10.2174\/138945008785747789","article-title":"The AcrB efflux pump: conformational cycling and peristalsis lead to multidrug resistance","volume":"9","author":"Seeger","year":"2008","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.bbapap.2009.02.017_bib18","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/35016007","article-title":"Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export","volume":"405","author":"Koronakis","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbapap.2009.02.017_bib19","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.jmb.2004.07.088","article-title":"Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug efflux protein TolC","volume":"342","author":"Higgins","year":"2004","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib20","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.molcel.2008.02.015","article-title":"Assembly and channel opening in a bacterial drug efflux machine","volume":"30","author":"Bavro","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbapap.2009.02.017_bib21","doi-asserted-by":"crossref","first-page":"52816","DOI":"10.1074\/jbc.C400445200","article-title":"Crystal structure of the drug discharge outer membrane protein, OprM, of Pseudomonas aeruginosa: dual modes of membrane anchoring and occluded cavity end","volume":"279","author":"Akama","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2009.02.017_bib22","doi-asserted-by":"crossref","first-page":"5307","DOI":"10.1074\/jbc.M500401200","article-title":"The crystal structure of the outer membrane protein VceC from the bacterial pathogen Vibrio cholerae at 1.8\u00a0A resolution","volume":"280","author":"Federici","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2009.02.017_bib23","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1006\/jmbi.2000.4320","article-title":"How to untwist an alpha-helix: structural principles of an alpha-helical barrel","volume":"305","author":"Calladine","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib24","doi-asserted-by":"crossref","first-page":"11103","DOI":"10.1073\/pnas.162039399","article-title":"Transition to the open state of the TolC periplasmic tunnel entrance","volume":"99","author":"Andersen","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbapap.2009.02.017_bib25","doi-asserted-by":"crossref","first-page":"25939","DOI":"10.1074\/jbc.C400164200","article-title":"Crystal structure of the membrane fusion protein, MexA, of the multidrug transporter in Pseudomonas aeruginosa","volume":"279","author":"Akama","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2009.02.017_bib26","doi-asserted-by":"crossref","first-page":"9994","DOI":"10.1073\/pnas.0400375101","article-title":"Structure of the periplasmic component of a bacterial drug efflux pump","volume":"101","author":"Higgins","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbapap.2009.02.017_bib27","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.str.2005.11.015","article-title":"Conformational flexibility in the multidrug efflux system protein AcrA","volume":"14","author":"Mikolosko","year":"2006","journal-title":"Structure"},{"key":"10.1016\/j.bbapap.2009.02.017_bib28","doi-asserted-by":"crossref","first-page":"5349","DOI":"10.1128\/JB.185.18.5349-5356.2003","article-title":"Chimeric analysis of AcrA function reveals the importance of its C-terminal domain in its interaction with the AcrB multidrug efflux pump","volume":"185","author":"Elkins","year":"2003","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib29","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1365-2958.2004.04158.x","article-title":"Interactions underlying assembly of the Escherichia coli AcrAB\u2013TolC multidrug efflux system","volume":"53","author":"Touze","year":"2004","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib30","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1107\/S1744309108008701","article-title":"Crystallization and preliminary X-ray crystallographic analysis of MacA from Actinobacillus actinomycetemcomitans","volume":"64","author":"Piao","year":"2008","journal-title":"Acta Crystallogr. Sect. F. Struct. Biol. Cryst. Commun."},{"key":"10.1016\/j.bbapap.2009.02.017_bib31","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nature01050","article-title":"Crystal structure of bacterial multidrug efflux transporter AcrB","volume":"419","author":"Murakami","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbapap.2009.02.017_bib32","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nature05076","article-title":"Crystal structures of a multidrug transporter reveal a functionally rotating mechanism","volume":"443","author":"Murakami","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbapap.2009.02.017_bib33","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1126\/science.1131542","article-title":"Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism","volume":"313","author":"Seeger","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.bbapap.2009.02.017_bib34","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.jsb.2006.12.004","article-title":"Crystal structure of the multidrug efflux transporter AcrB at 3.1\u00a0\u00c5 resolution reveals the N-terminal region with conserved amino acids","volume":"158","author":"Das","year":"2007","journal-title":"Struct. Biol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib35","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1371\/journal.pbio.0050007","article-title":"Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors","volume":"5","author":"Sennhauser","year":"2007","journal-title":"PloS Biol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib36","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1080\/09687680802552257","article-title":"The structure of the efflux pump AcrB in complex with bile acid","volume":"25","author":"Drew","year":"2008","journal-title":"Mol. Membr. Biol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib37","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1128\/JB.182.15.4264-4267.2000","article-title":"Cross-linked complex between oligomeric periplasmic lipoprotein AcrA and the inner-membrane-associated multidrug efflux pump AcrB from Escherichia coli","volume":"182","author":"Zgurskaya","year":"2000","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib38","doi-asserted-by":"crossref","first-page":"6487","DOI":"10.1093\/emboj\/17.22.6487","article-title":"Substrate-induced assembly of a contiguous channel for protein export from E. coli: reversible bridging of an inner-membrane translocase to an outer membrane exit pore","volume":"17","author":"Thanabalu","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.bbapap.2009.02.017_bib39","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.sbi.2004.10.003","article-title":"Three's company: component structures bring a closer view of tripartite drug efflux pumps","volume":"14","author":"Eswaran","year":"2004","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib40","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.febslet.2004.10.097","article-title":"A model of a transmembrane drug-efflux pump from Gram-negative bacteria","volume":"578","author":"Fernandez-Recio","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbapap.2009.02.017_bib41","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.1073\/pnas.0610160104","article-title":"A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug efflux pumps","volume":"104","author":"Lobedanz","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbapap.2009.02.017_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1000009","article-title":"An RND-type efflux system in Borrelia burgdorferi is involved in virulence and resistance to antimicrobial compounds","volume":"4","author":"Bunikis","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bbapap.2009.02.017_bib43","doi-asserted-by":"crossref","first-page":"10303","DOI":"10.1021\/bi060320g","article-title":"Importance of the adaptor (membrane fusion) protein hairpin domain for the functionality of multidrug efflux pumps","volume":"45","author":"Stegmeier","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbapap.2009.02.017_bib44","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/S0006-291X(03)01512-2","article-title":"Linkage of the efflux-pump expression level with substrate extrusion rate in the MexAB\u2013OprM efflux pump of Pseudomonas aeruginosa","volume":"308","author":"Narita","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbapap.2009.02.017_bib45","doi-asserted-by":"crossref","first-page":"76007609","DOI":"10.1128\/JB.00850-07","article-title":"Identification and characterization of TriABC\u2013OpmH, a triclosan efflux pump of Pseudomonas aeruginosa requiring two membrane fusion proteins","volume":"189","author":"Mima","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib46","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1365-2958.2008.06291.x","article-title":"PigZ, a TetR\/AcrR family repressor, modulates secondary metabolism via the expression of a putative four-component resistance-nodulation-cell-division efflux pump, ZrpADBC, in Serratia sp. ATCC 39006","volume":"69","author":"Gristwood","year":"2008","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib47","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1006\/jsbi.2001.4418","article-title":"2D crystals of AcrA appear to accommodate a central cavity","volume":"136","author":"Avila-Sakar","year":"2001","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib48","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00249-007-0208-5","article-title":"Organization of reconstituted lipoprotein MexA onto supported lipid membrane","volume":"36","author":"Tr\u00e9pout","year":"2007","journal-title":"Eur. Biophys. J."},{"key":"10.1016\/j.bbapap.2009.02.017_bib49","doi-asserted-by":"crossref","first-page":"11115","DOI":"10.1021\/bi050452u","article-title":"Direct interaction of multidrug efflux transporter AcrB and outer membrane channel TolC detected via site-directed disulfide cross-linking","volume":"44","author":"Tamura","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbapap.2009.02.017_bib50","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.bbrc.2004.07.140","article-title":"Role of the membrane fusion protein in the assembly of resistance-nodulation-cell division multidrug efflux pump in Pseudomonas aeruginosa","volume":"322","author":"Mokhonov","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbapap.2009.02.017_bib51","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1128\/JB.186.10.2973-2983.2004","article-title":"Assembly of the MexAB\u2013OprM multidrug efflux system of Pseudomonas aeruginosa: identification and characterization of mutations in mexA compromising MexA multimerization and interaction with MexB","volume":"186","author":"Nehme","year":"2004","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib52","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/j.1365-2958.2004.04301.x","article-title":"Genetic evidence for functional interactions between TolC and AcrA proteins of a major antibiotic efflux pump of Escherichia coli","volume":"54","author":"Gerken","year":"2004","journal-title":"Mol. Microbial."},{"key":"10.1016\/j.bbapap.2009.02.017_bib53","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1128\/AAC.49.10.4375-4378.2005","article-title":"Interaction of the MexA and MexB components of the MexAB\u2013OprM multidrug efflux system of Pseudomonas aeruginosa: identification of MexA extragenic suppressors of a T578I mutation in MexB","volume":"49","author":"Nehme","year":"2005","journal-title":"Antibicrob. Agents Chemother."},{"key":"10.1016\/j.bbapap.2009.02.017_bib54","doi-asserted-by":"crossref","first-page":"6118","DOI":"10.1128\/JB.00718-07","article-title":"Assembly of the MexAB\u2013OprM multidrug pump of Pseudomonas aeruginosa: component interactions defined by the study of pump mutant suppressors","volume":"189","author":"Nehme","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib55","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1128\/JB.00038-06","article-title":"Isolation and characterization of VceC gain-of-function mutants that can function with the AcrAB multiple-drug-resistant efflux pump of Escherichia coli","volume":"188","author":"Vediyappan","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib56","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1128\/JB.01276-07","article-title":"Fitting periplasmic membrane fusion proteins to inner membrane transporters: mutations that enable Escherichia coli AcrA to function with Pseudomonas aeruginosa MexB","volume":"190","author":"Krishnamoorthy","year":"2008","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib57","doi-asserted-by":"crossref","first-page":"5339","DOI":"10.1016\/j.febslet.2006.09.005","article-title":"Directed evolution of a bacterial efflux pump: adaptation of the E. coli TolC exit duct to the Pseudomonas MexAB translocase","volume":"580","author":"Bokma","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbapap.2009.02.017_bib58","doi-asserted-by":"crossref","first-page":"8533","DOI":"10.1128\/JB.186.24.8533-8536.2004","article-title":"Interaction between the TolC and AcrA proteins of a multidrug efflux system of Escherichia coli","volume":"186","author":"Husain","year":"2004","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib59","doi-asserted-by":"crossref","first-page":"6490","DOI":"10.1128\/JB.184.23.6490-6499.2002","article-title":"Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominately by two large periplasmic loops","volume":"184","author":"Elkins","year":"2002","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib60","doi-asserted-by":"crossref","first-page":"6499","DOI":"10.1128\/JB.184.23.6499-6507.2002","article-title":"Chimeric analysis of the multicomponent multidrug efflux transporters from gram negative bacteria","volume":"184","author":"Tikhonova","year":"2002","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib61","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1574-6968.2005.00010.x","article-title":"Assignment of the outer-membrane-subunit-selective domain of the membrane fusion protein in the tripartite xenobiotic efflux pump of Pseudomonas aeruginosa","volume":"254","author":"Eda","year":"2006","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.bbapap.2009.02.017_bib62","doi-asserted-by":"crossref","first-page":"32116","DOI":"10.1074\/jbc.M402230200","article-title":"AcrA, AcrB, and TolC of Escherichia coli form a stable intermembrane multidrug efflux complex","volume":"279","author":"Tikhonova","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2009.02.017_bib63","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1046\/j.1365-2958.2002.02898.x","article-title":"An aspartate ring at the TolC tunnel entrance determines ion selectivity and presents a target for blocking by large cations","volume":"44","author":"Andersen","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib64","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0022-2836(03)00116-5","article-title":"Locking TolC entrance helices to prevent protein translocation by the bacterial type I export apparatus","volume":"327","author":"Eswaran","year":"2003","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib65","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1128\/JB.186.6.1851-1860.2004","article-title":"Antibiotic-sensitive TolC mutants and their suppressors","volume":"186","author":"Augustus","year":"2004","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib66","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1006\/jmbi.2001.5080","article-title":"Assignment of homology to genome sequences using a library of hidden Markov models that represent all proteins of known structure","volume":"313","author":"Gough","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib67","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.1021\/bi0300074","article-title":"Function of the MexB efflux-transporter divided into two halves","volume":"42","author":"Eda","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbapap.2009.02.017_bib68","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0959-440X(03)00109-X","article-title":"Multidrug-exporting secondary transporters","volume":"13","author":"Murakami","year":"2003","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib69","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1126\/science.1083137","article-title":"Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump","volume":"300","author":"Yu","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bbapap.2009.02.017_bib70","doi-asserted-by":"crossref","first-page":"6804","DOI":"10.1128\/JB.187.19.6804-6815.2005","article-title":"A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study","volume":"187","author":"Yu","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib71","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nsmb.1379","article-title":"Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB","volume":"15","author":"Seeger","year":"2008","journal-title":"Nature Struct. Mol. Biol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib72","doi-asserted-by":"crossref","first-page":"5550","DOI":"10.1128\/JB.00471-07","article-title":"Drug-induced conformational changes in multidrug efflux transporter AcrB from Haemophilus influenzae","volume":"189","author":"Dastidar","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib73","doi-asserted-by":"crossref","first-page":"8677","DOI":"10.1128\/JB.01127-07","article-title":"Site-directed disulfide cross-linking shows that cleft flexibility in the periplasmic domain is needed for the multidrug efflux pump AcrB of Escherichia coli","volume":"189","author":"Takatsuka","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib74","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1074\/jbc.M308893200","article-title":"Extramembrane central pore of multidrug exporter AcrB in Escherichia coli plays an important role in drug transport","volume":"279","author":"Murakami","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2009.02.017_bib75","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1128\/JB.01441-08","article-title":"Covalently linked trimer of the AcrB multidrug efflux pump provides support for the functional rotating mechanism","volume":"191","author":"Takasuka","year":"2009","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib76","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/j.str.2007.09.023","article-title":"Crystal structure of AcrB in complex with a single transmembrane subunit reveals another twist","volume":"15","author":"T\u00f6rnroth-Horsefield","year":"2007","journal-title":"Structure"},{"key":"10.1016\/j.bbapap.2009.02.017_bib77","doi-asserted-by":"crossref","first-page":"7290","DOI":"10.1128\/JB.00684-06","article-title":"Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway","volume":"188","author":"Su","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib78","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1128\/JB.183.5.1734-1739.2001","article-title":"Identification of essential charged residues in transmembrane segments of the multidrug transporter MexB of Pseudomonas aeruginosa","volume":"183","author":"Guan","year":"2001","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib79","doi-asserted-by":"crossref","first-page":"7284","DOI":"10.1128\/JB.00683-06","article-title":"Threonine-978 in the transmembrane segment of the multidrug efflux pump AcrB of Escherichia coli is crucial for drug transport as a probable component of the proton relay network","volume":"188","author":"Takatsuka","year":"2006","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2009.02.017_bib80","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1093\/emboj\/16.10.2756","article-title":"Distinct catalytic roles of the SecYE, SecG and SecDFyajC subunits of preprotein translocase holoenzyme","volume":"16","author":"Doung","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.bbapap.2009.02.017_bib81","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF00301061","article-title":"Genetic analysis of SecY: additional export-defective mutations and factors affecting their phenotypes","volume":"243","author":"Taura","year":"1994","journal-title":"Mol. Gen. Genet."},{"key":"10.1016\/j.bbapap.2009.02.017_bib82","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1093\/jac\/dkl493","article-title":"Antibiotic efflux pumps in Gram-negative bacteria: the inhibitor response strategy","volume":"59","author":"Mahamoud","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.bbapap.2009.02.017_bib83","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.bbapap.2008.12.011","article-title":"Mechanisms of drug efflux and strategies to combat them: challenging the efflux pump of Gram negative bacteria","volume":"1794","author":"Pag\u00e8s","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbapap.2009.02.017_bib84","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2174\/092986709787002619","article-title":"Efflux mechanism, an attractive target to combat multidrug resistant plasmodium falciparum and Pseudomonas aeruginosa","volume":"16","author":"Alibert-Franco","year":"2009","journal-title":"Curr. Med. Chem."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570963909000491?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570963909000491?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T19:47:46Z","timestamp":1589658466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570963909000491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":84,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S1570963909000491"],"URL":"https:\/\/doi.org\/10.1016\/j.bbapap.2009.02.017","relation":{},"ISSN":["1570-9639"],"issn-type":[{"value":"1570-9639","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}