{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T02:11:53Z","timestamp":1776651113696,"version":"3.51.2"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T00:00:00Z","timestamp":1421798400000},"content-version":"vor","delay-in-days":326,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2012\/ 50191-4"],"award-info":[{"award-number":["2012\/ 50191-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.bbapap.2013.12.014","type":"journal-article","created":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T20:50:59Z","timestamp":1388782259000},"page":"545-552","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["P-I class metalloproteinase from Bothrops moojeni venom is a post-proline cleaving peptidase with kininogenase activity: Insights into substrate selectivity and kinetic behavior"],"prefix":"10.1016","volume":"1844","author":[{"given":"D\u00e9bora N.","family":"Okamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia Y.","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian C.G.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo V.","family":"Honorato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia M.","family":"Zanphorlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika A.","family":"Coronado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana S.","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guacyara","family":"da Motta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila L.","family":"Veronez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila S.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo S.L.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghuvir K.","family":"Arni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelia C.O.","family":"Cintra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suely V.","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Juliano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz","family":"Juliano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rio T.","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iuri E.","family":"Gouvea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbapap.2013.12.014_bb0005","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.toxicon.2005.02.012","article-title":"Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases","volume":"45","author":"Fox","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.bbapap.2013.12.014_bb0010","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0041-0101(96)00017-7","article-title":"Insights into the mechanism of haemorrhage caused by snake venom metalloproteinases","volume":"34","author":"Kamiguti","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.bbapap.2013.12.014_bb0015","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1590\/S0100-879X1998000700001","article-title":"Snake venom metalloproteinases and disintegrins: interactions with cells","volume":"31","author":"Kamiguti","year":"1998","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.bbapap.2013.12.014_bb0020","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1111\/j.1742-4658.2008.06466.x","article-title":"Insights into and speculations about snake venom metalloproteinase (SVMP) synthesis, folding and disulfide bond formation and their contribution to venom complexity","volume":"275","author":"Fox","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.bbapap.2013.12.014_bb0025","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.toxicon.2009.01.039","article-title":"Experimental pathophysiology of systemic alterations induced by Bothrops asper snake venom","volume":"54","author":"Gutierrez","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.bbapap.2013.12.014_bb0030","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.toxicon.2005.02.029","article-title":"Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage","volume":"45","author":"Gutierrez","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.bbapap.2013.12.014_bb0035","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.toxicon.2009.08.013","article-title":"Structural studies of BmooMP alpha-I, a non-hemorrhagic metalloproteinase from Bothrops moojeni venom","volume":"55","author":"Akao","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.bbapap.2013.12.014_bb0040","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jprot.2009.01.015","article-title":"Timeline of key events in snake venom metalloproteinase research","volume":"72","author":"Fox","year":"2009","journal-title":"J. Proteome"},{"key":"10.1016\/j.bbapap.2013.12.014_bb0045","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.toxicon.2007.11.017","article-title":"Isolation and structural characterization of a new fibrin(ogen)olytic metalloproteinase from Bothrops moojeni snake venom","volume":"51","author":"Bernardes","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.bbapap.2013.12.014_bb0050","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during assembly of head of bacteriophage-T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.bbapap.2013.12.014_bb0055","series-title":"The Proteomics Protocols Handbook","first-page":"571","author":"Gasteiger","year":"2005"},{"key":"10.1016\/j.bbapap.2013.12.014_bb0060","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/nprot.2008.63","article-title":"Measuring elastase, proteinase 3 and cathepsin G activities at the surface of human neutrophils with fluorescence resonance energy transfer substrates","volume":"3","author":"Korkmaz","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbapap.2013.12.014_bb0065","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ab.2011.10.025","article-title":"Internally quenched fluorescent peptide libraries with randomized sequences designed to detect endopeptidases","volume":"421","author":"Oliveira","year":"2012","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbapap.2013.12.014_bb0070","doi-asserted-by":"crossref","first-page":"8519","DOI":"10.1021\/bi9928905","article-title":"Peptidase specificity characterization of C- and N-terminal catalytic sites of angiotensin I-converting enzyme","volume":"39","author":"Araujo","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbapap.2013.12.014_bb0075","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/S1567-5769(02)00145-5","article-title":"Glycosaminoglycans affect the action of human plasma kallikrein on kininogen hydrolysis and inflammation","volume":"2","author":"Andrezza","year":"2002","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbapap.2013.12.014_bb0080","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1128\/JB.183.12.3742-3751.2001","volume":"183","author":"Shimamoto","year":"2001","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbapap.2013.12.014_bb0085","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.1021\/bi9002315","article-title":"High-resolution crystal structure of the snake venom metalloproteinase BaP1 complexed with a peptidomimetic: insight into inhibitor binding","volume":"48","author":"Lingott","year":"2009","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbapap.2013.12.014_bb0090","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/prot.10104","article-title":"Increasing the precision of comparative models with YASARA NOVA \u2014 a self-parameterizing force field","volume":"47","author":"Krieger","year":"2002","journal-title":"Proteins Struct. Funct. Genet."},{"key":"10.1016\/j.bbapap.2013.12.014_bb0095","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/prot.20251","article-title":"Making optimal use of empirical energy functions: force-field parameterization in crystal space","volume":"57","author":"Krieger","year":"2004","journal-title":"Proteins Struct. Funct. Genet."},{"key":"10.1016\/j.bbapap.2013.12.014_bb0100","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1515\/bc.2010.145","article-title":"The increase of SARS-CoV 3CL peptidase activity due to macromolecular crowding effects in the milieu composition","volume":"391","author":"Okamoto","year":"2010","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bbapap.2013.12.014_bb0105","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nrd2092","article-title":"Targeting proteases: successes, failures and future prospects","volume":"5","author":"Turk","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbapap.2013.12.014_bb0110","series-title":"Chemistry and Biology of the Kallikrein Kinin System in Health and Disease","author":"Nagasawa","year":"1974"},{"key":"10.1016\/j.bbapap.2013.12.014_bb0115","doi-asserted-by":"crossref","first-page":"6433","DOI":"10.1016\/S0021-9258(18)43757-X","article-title":"Human high molecular-weight kininogen \u2014 effects of cleavage by kallikrein on protein-structure and procoagulant activity","volume":"255","author":"Schiffman","year":"1980","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2013.12.014_bb0120","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1096\/fasebj.14.2.231","article-title":"The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains","volume":"14","author":"Kay","year":"2000","journal-title":"FASEB J."},{"key":"10.1016\/j.bbapap.2013.12.014_bb0125","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.cca.2006.09.001","article-title":"Suggested functions for prolyl oligopeptidase: a puzzling paradox","volume":"377","author":"Brandt","year":"2007","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.bbapap.2013.12.014_bb0130","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jprot.2010.12.002","article-title":"High resolution analysis of snake venom metalloproteinase (SVMP) peptide bond cleavage specificity using proteome based peptide libraries and mass spectrometry","volume":"74","author":"Paes Leme","year":"2011","journal-title":"J. Proteomics"},{"key":"10.1016\/j.bbapap.2013.12.014_bb0135","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0167-4838(99)00268-X","article-title":"Snake venom proteases affecting hemostasis and thrombosis","volume":"1477","author":"Matsui","year":"2000","journal-title":"Biochim. Biophys. Acta Protein Struct. Mol. Enzymol."},{"key":"10.1016\/j.bbapap.2013.12.014_bb0140","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1055\/s-0037-1615236","article-title":"Purification and characterization of kaouthiagin, a von Willebrand factor-binding and -cleaving metalloproteinase from Naja kaouthia cobra venom","volume":"80","author":"Hamako","year":"1998","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.bbapap.2013.12.014_bb0145","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/S1567-5769(02)00145-5","article-title":"Glycosaminoglycans affect the action of human plasma kallikrein on kininogen hydrolysis and inflammation","volume":"2","author":"Gozzo","year":"2002","journal-title":"Int. Immunopharmacol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570963913004378?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570963913004378?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T12:38:53Z","timestamp":1647866333000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570963913004378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S1570963913004378"],"URL":"https:\/\/doi.org\/10.1016\/j.bbapap.2013.12.014","relation":{},"ISSN":["1570-9639"],"issn-type":[{"value":"1570-9639","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"P-I class metalloproteinase from Bothrops moojeni venom is a post-proline cleaving peptidase with kininogenase activity: Insights into substrate selectivity and kinetic behavior","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbapap.2013.12.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}