{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:40:04Z","timestamp":1771476004203,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2022\/06394-0"],"award-info":[{"award-number":["2022\/06394-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2019\/27813-8"],"award-info":[{"award-number":["2019\/27813-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2021\/01503-2"],"award-info":[{"award-number":["2021\/01503-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.bbapap.2025.141090","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T23:30:11Z","timestamp":1753745411000},"page":"141090","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Role of N-terminal of metacaspase of Candida albicans in calcium binding."],"prefix":"10.1016","volume":"1873","author":[{"given":"Taiz dos Reis","family":"Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Nascimento Romero","family":"Trujilho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Pedro Martins Silva","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurade Azevedo Maffeis","family":"Dalzoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ane Caroline Moreira","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolaine Stella Siqueirade Moraes","family":"Valdivia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana J\u00faliade Oliveira","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vit\u00f3ria Caroline Domingues","family":"Rios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiane Faustino de","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wagner Alves de Souza","family":"Judice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Ferreira","family":"Marcondes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maur\u00edcio Ferreira Marcondes","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbapap.2025.141090_bb0005","article-title":"Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma","author":"Uren","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbapap.2025.141090_bb0010","doi-asserted-by":"crossref","DOI":"10.1038\/cdd.2011.66","article-title":"Metacaspases","author":"Tsiatsiani","year":"2011","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbapap.2025.141090_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/S1471-4922(03)00038-2","article-title":"Clan CD cysteine peptidases of parasitic protozoa","author":"Mottram","year":"2003","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.bbapap.2025.141090_bb0020","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M406329200","article-title":"Type II metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana cleave substrates after arginine and lysine","author":"Vercammen","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2025.141090_bb0025","doi-asserted-by":"crossref","DOI":"10.1111\/febs.12248","article-title":"Substrate specificity and the effect of calcium on Trypanosoma brucei metacaspase 2","volume":"280","author":"Machado","year":"2013","journal-title":"FEBS J."},{"key":"10.1016\/j.bbapap.2025.141090_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2019.12.020","article-title":"Classification and nomenclature of Metacaspases and paracaspases: no more confusion with caspases","author":"Minina","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbapap.2025.141090_bb0035","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.1016\/j.febslet.2007.11.009","article-title":"Metacaspase 2 of Trypanosoma brucei is a calcium-dependent cysteine peptidase active without processing","volume":"581","author":"Moss","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbapap.2025.141090_bb0040","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1200885109","article-title":"Crystal structure of a Trypanosoma brucei metacaspase","author":"McLuskey","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbapap.2025.141090_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbapap.2017.01.002","article-title":"Processing of metacaspase 2 from Trypanosoma brucei (TbMCA2) broadens its substrate specificity","volume":"1865","author":"Gilio","year":"2017","journal-title":"Biochim. Biophys. Acta, Proteins Proteomics"},{"key":"10.1016\/j.bbapap.2025.141090_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/bies.201400208","article-title":"The dual role of a yeast metacaspase: what doesn\u2019t kill you makes you stronger","author":"Hill","year":"2015","journal-title":"BioEssays"},{"key":"10.1016\/j.bbapap.2025.141090_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002956","article-title":"A non-death role of the yeast metacaspase: Yca1p alters cell cycle dynamics","author":"Lee","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.bbapap.2025.141090_bb0060","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1006610107","article-title":"Metacaspase Yca1 is required for clearance of insoluble protein aggregates","author":"Lee","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbapap.2025.141090_bb0065","doi-asserted-by":"crossref","first-page":"149185","DOI":"10.1016\/j.bbrc.2023.149185","article-title":"Metacaspase of Saccharomyces cerevisiae (ScMCA-Ia) presents different catalytic cysteine in a processed and non-processed form","author":"Dalzoto","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbapap.2025.141090_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.fgb.2008.11.001","article-title":"Candida albicans cells lacking CaMCA1-encoded metacaspase show resistance to oxidative stress-induced death and change in energy metabolism","author":"Cao","year":"2009","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/j.bbapap.2025.141090_bb0075","article-title":"Hsp90 is involved in apoptosis of Candida albicans by regulating the Calcineurin-caspase apoptotic pathway","volume":"7","author":"Di Dai","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbapap.2025.141090_bb0080","article-title":"Lack of trehalose accelerates H2O2-induced Candida albicans apoptosis through regulating Ca2+ signaling pathway and caspase activity","author":"Lu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbapap.2025.141090_bb0085","doi-asserted-by":"crossref","first-page":"14327","DOI":"10.1073\/pnas.2332326100","article-title":"Apoptosis induced by environmental stresses and amphotericin B in Candida albicans","volume":"100","author":"Phillips","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbapap.2025.141090_bb0090","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1073\/pnas.0506405103","article-title":"Ras pathway signaling accelerates programmed cell death in the pathogenic fungus Candida albicans","volume":"103","author":"Phillips","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbapap.2025.141090_bb0095","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.fgb.2016.10.007","article-title":"Mutational analysis of metacaspase CaMca1 and decapping activator Edc3 in the pathogenicity of Candida albicans","volume":"97","author":"Jeong","year":"2016","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/j.bbapap.2025.141090_bb0100","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01366-12","article-title":"Caspofungin kills Candida albicans by causing both cellular apoptosis and necrosis","author":"Hao","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbapap.2025.141090_bb0105","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2015.1027479","article-title":"Micafungin triggers caspase-dependent apoptosis in Candida albicans and Candida parapsilosis biofilms, including caspofungin non-susceptible isolates","author":"Shirazi","year":"2015","journal-title":"Virulence"},{"key":"10.1016\/j.bbapap.2025.141090_bb0110","series-title":"Antifungal Effects and Potential Mechanisms of Benserazide Hydrochloride Alone and in Combination with Fluconazole Against Candida albicans","author":"Chen","year":"2021"},{"key":"10.1016\/j.bbapap.2025.141090_bb0115","article-title":"The metacaspase gene family of Vitis vinifera L.: characterization and differential expression during ovule abortion in stenospermocarpic seedless grapes","author":"Zhang","year":"2013","journal-title":"Gene"},{"key":"10.1016\/j.bbapap.2025.141090_bb0120","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-022-04091-4","article-title":"Structural and molecular determinants of Candida glabrata metacaspase maturation and activation by calcium","volume":"5","author":"Conchou","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bbapap.2025.141090_bb0125","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0378-1119(89)90358-2","article-title":"Site-directed mutagenesis by overlap extension using the polymerase chain reaction","volume":"77","author":"Ho","year":"1989","journal-title":"Gene"},{"key":"10.1016\/j.bbapap.2025.141090_bb0130","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gky1169","article-title":"T5 exonuclease-dependent assembly offers a low-cost method for efficient cloning and site-directed mutagenesis","volume":"47","author":"Xia","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbapap.2025.141090_bb0135","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-313X.2011.04554.x","article-title":"Arabidopsis metacaspase 2d is a positive mediator of cell death induced during biotic and abiotic stresses","author":"Watanabe","year":"2011","journal-title":"Plant J."},{"key":"10.1016\/j.bbapap.2025.141090_bb0140","article-title":"Crystal structure of the yeast metacaspase Yca1","author":"Wong","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2025.141090_bb0145","doi-asserted-by":"crossref","DOI":"10.1111\/nph.14660","article-title":"Type III metacaspases: calcium-dependent activity proposes new function for the p10 domain","author":"Klemen\u010di\u010d","year":"2018","journal-title":"New Phytol."},{"key":"10.1016\/j.bbapap.2025.141090_bb0150","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0506948102","article-title":"Cysteine protease mcII-pa executes programmed cell death during plant embryogenesis","author":"Bozhkov","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbapap.2025.141090_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009929","article-title":"Extra N-terminal residues have a profound effect on the aggregation properties of the potential yeast prion protein Mca1","author":"Erhardt","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbapap.2025.141090_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpara.2006.10.004","article-title":"Leishmania major metacaspase can replace yeast metacaspase in programmed cell death and has arginine-specific cysteine peptidase activity","author":"Gonz\u00e1lez","year":"2007","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.bbapap.2025.141090_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/S1097-2765(02)00501-4","article-title":"A caspase-related protease regulates apoptosis in yeast","author":"Madeo","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbapap.2025.141090_bb0170","doi-asserted-by":"crossref","DOI":"10.1038\/cdd.2017.18","article-title":"Metacaspases versus caspases in development and cell fate regulation","author":"Minina","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbapap.2025.141090_bb0175","doi-asserted-by":"crossref","DOI":"10.1093\/jxb\/erz082","article-title":"Evolution and structural diversity of metacaspases","author":"Klemen\u010di\u010d","year":"2019","journal-title":"J. Exp. Bot."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570963925000287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570963925000287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T17:30:35Z","timestamp":1758043835000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570963925000287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S1570963925000287"],"URL":"https:\/\/doi.org\/10.1016\/j.bbapap.2025.141090","relation":{},"ISSN":["1570-9639"],"issn-type":[{"value":"1570-9639","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of N-terminal of metacaspase of Candida albicans in calcium binding.","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbapap.2025.141090","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"141090"}}