{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T11:28:16Z","timestamp":1769081296121,"version":"3.49.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003947","name":"National University of La Plata","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006668","name":"Fund for Scientific and Technological Research","doi-asserted-by":"publisher","award":["PICT 2016-0915"],"award-info":[{"award-number":["PICT 2016-0915"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006668","name":"Fund for Scientific and Technological Research","doi-asserted-by":"publisher","award":["PICT 201-0613"],"award-info":[{"award-number":["PICT 201-0613"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006668","name":"Fund for Scientific and Technological Research","doi-asserted-by":"publisher","award":["PICT 2020-A-01702"],"award-info":[{"award-number":["PICT 2020-A-01702"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"National Scientific and Technical Research Council","doi-asserted-by":"publisher","award":["PUE 22920160100002"],"award-info":[{"award-number":["PUE 22920160100002"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"National Scientific and Technical Research Council","doi-asserted-by":"publisher","award":["PIP 0800"],"award-info":[{"award-number":["PIP 0800"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.bbapap.2025.141093","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T15:09:42Z","timestamp":1754492982000},"page":"141093","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Self-association of Apolipoprotein A-I studied with multiple-association models: A pyrene multiparametric analysis"],"prefix":"10.1016","volume":"1873","author":[{"given":"Wilson A.","family":"T\u00e1rraga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisandro J.","family":"Falomir-Lockhart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horacio A.","family":"Garda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina C.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbapap.2025.141093_bb0005","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-030-41769-7_16","article-title":"High-density lipoproteins and apolipoprotein A1","volume":"94","author":"van der Vorst","year":"2020","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.bbapap.2025.141093_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113634","article-title":"Leveraging knowledge of HDLs major protein ApoA1: structure, function, mutations, and potential therapeutics","volume":"154","author":"Bhale","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbapap.2025.141093_bb0015","doi-asserted-by":"crossref","DOI":"10.1172\/JCI30163","article-title":"Molecular regulation of HDL metabolism and function: implications for novel therapies","author":"Rader","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbapap.2025.141093_bb0020","article-title":"Cardiovascular disease risk reduction by raising HDL cholesterol \u2013 current therapies and future opportunities","volume":"167","author":"Mahdy Ali","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbapap.2025.141093_bb0025","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1194\/jlr.M034785","article-title":"Comparison of apoA-I helical structure and stability in discoidal and spherical HDL particles by HX and mass spectrometry","volume":"54","author":"Chetty","year":"2013","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbapap.2025.141093_bb0030","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nsb931","article-title":"The C-terminal domain of apolipoprotein A-I contains a lipid-sensitive conformational trigger","volume":"10","author":"Oda","year":"2003","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbapap.2025.141093_bb0035","doi-asserted-by":"crossref","first-page":"9143","DOI":"10.1074\/jbc.M608717200","article-title":"Electron paramagnetic resonance spectroscopy of site-directed spin labels reveals the structural heterogeneity in the N-terminal domain of apoA-I in solution","volume":"282","author":"Lagerstedt","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2025.141093_bb0040","article-title":"Leveraging knowledge of HDLs major protein ApoA1: structure, function, mutations, and potential therapeutics","volume":"154","author":"Sudam Bhale","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbapap.2025.141093_bb0045","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/nsmb.3501","article-title":"A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state","volume":"24","author":"Melchior","year":"2017","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbapap.2025.141093_bb0050","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0021-9258(17)33810-3","article-title":"Studies on human serum high density lipoproteins. Self-association of apolipoprotein A-I in aqueous solutions","volume":"251","author":"Vitello","year":"1976","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2025.141093_bb0055","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1021\/bi1009634","article-title":"Membrane insertion topology of the central apolipoprotein A-I region. Fluorescence studies using single tryptophan mutants","volume":"50","author":"Prieto","year":"2011","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbapap.2025.141093_bb0060","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1021\/acs.jpcb.5b12397","article-title":"Self-Association of Apo A-1 studied with dynamic and static light scattering","volume":"120","author":"Sch\u00f6nfeld","year":"2016","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.bbapap.2025.141093_bb0065","doi-asserted-by":"crossref","first-page":"8116","DOI":"10.1021\/bi00399a015","article-title":"Self-association of human apolipoproteins A-I and A-II and interactions of apolipoprotein A-I with bile salts: quasi-elastic light scattering studies","volume":"26","author":"Donovan","year":"1987","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbapap.2025.141093_bb0070","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1021\/bi2013799","article-title":"Thermodynamics of protein self-association and unfolding. The case of apolipoprotein A-I","volume":"51","author":"Zehender","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbapap.2025.141093_bb0075","doi-asserted-by":"crossref","first-page":"13605","DOI":"10.1073\/pnas.93.24.13605","article-title":"The role of apolipoprotein AI domains in lipid binding","volume":"93","author":"Davidson","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbapap.2025.141093_bb0080","doi-asserted-by":"crossref","first-page":"9645","DOI":"10.1074\/jbc.M107883200","article-title":"Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distribution","volume":"277","author":"Reschly","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2025.141093_bb0085","doi-asserted-by":"crossref","first-page":"35610","DOI":"10.1074\/jbc.M111.262485","article-title":"Impact of self-association on function of apolipoprotein A-I","volume":"286","author":"Jayaraman","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2025.141093_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108748","article-title":"Analysis of pyrene-labelled apolipoprotein A-I oligomerization in solution: spectra deconvolution and changes in P-value and excimer formation","volume":"699","author":"T\u00e1rraga","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbapap.2025.141093_bb0095","first-page":"3149","article-title":"Methionine oxidized apolipoprotein A-I at the crossroads of HDL biogenesis and amyloid formation","volume":"36","author":"Witkowski","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.bbapap.2025.141093_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.dib.2021.106829","volume":"35","author":"T\u00e1rraga","year":"2021","journal-title":"Data Brief"},{"key":"10.1016\/j.bbapap.2025.141093_bb0105","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s10930-012-9448-z","article-title":"Characterization of a human apolipoprotein a-I construct expressed in a bacterial system","volume":"31","author":"Prieto","year":"2012","journal-title":"Protein J."},{"key":"10.1016\/j.bbapap.2025.141093_bb0110","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1002\/elps.11501601159","article-title":"A silver stain protocol for proteins yielding high resolution and transparent background in sodium dodecyl sulphate-polyacrylamide gels","volume":"16","author":"Swain","year":"1995","journal-title":"Electrophoresis"},{"key":"10.1016\/j.bbapap.2025.141093_bb0115","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0076-6879(97)78015-7","article-title":"Intramolecular pyrene excimer fluorescence: a probe of proximity and protein conformational change","volume":"278","author":"Lehrer","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbapap.2025.141093_bb0120","doi-asserted-by":"crossref","first-page":"8045","DOI":"10.1016\/S0021-9258(19)40813-2","article-title":"High density serum lipoproteins the self-association of the apo-Gln-I and apo-Gln-II polypeptides of human high density serum lipoproteins","volume":"250","author":"Stone","year":"1975","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2025.141093_bb0125","doi-asserted-by":"crossref","first-page":"8634","DOI":"10.1016\/S0021-9258(19)75268-5","article-title":"An ultracentrifugal study of the self-association apolipoprotein A-I in solution of canine","volume":"252","author":"Ta-Lee Teng","year":"1977","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2025.141093_bb0130","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S0021-9258(17)38212-1","article-title":"Effect of pressure and ionic strength on the self-association of Apo-A-I from the human high density lipoprotein complex","volume":"253","author":"Formisano","year":"1978","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2025.141093_bb0135","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/biot.201000221","article-title":"Apolipoprotein A-I(Milano) anion exchange chromatography: self association and adsorption equilibrium","volume":"5","author":"Bankston","year":"2010","journal-title":"Biotechnol. J."},{"issue":"2","key":"10.1016\/j.bbapap.2025.141093_bb0140","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1071\/WR99107","article-title":"Kullback-Leibler information as a basis for strong inference in ecological studies","volume":"28","author":"Burnham","year":"2001","journal-title":"Wildl. Res."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570963925000317?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570963925000317?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T17:30:42Z","timestamp":1758043842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570963925000317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S1570963925000317"],"URL":"https:\/\/doi.org\/10.1016\/j.bbapap.2025.141093","relation":{},"ISSN":["1570-9639"],"issn-type":[{"value":"1570-9639","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Self-association of Apolipoprotein A-I studied with multiple-association models: A pyrene multiparametric analysis","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbapap.2025.141093","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"141093"}}