{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T18:28:32Z","timestamp":1793557712177,"version":"4.5.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bbapap.2026.141135","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:38:57Z","timestamp":1772498337000},"page":"141135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["DUSP15 exhibits structural and dynamical signatures inconsistent with catalytic phosphatase activity"],"prefix":"10.1016","volume":"1874","author":[{"given":"Adil R.","family":"Sarhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbapap.2026.141135_bb0005","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3892\/ijmm.2017.3036","article-title":"The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (review)","volume":"40","author":"Ardito","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbapap.2026.141135_bb0010","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aag1796","article-title":"Genomics and evolution of protein phosphatases","volume":"10","author":"Chen","year":"2017","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bbapap.2026.141135_bb0015","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1042\/BJ20082234","article-title":"Dual-specificity phosphatases: critical regulators with diverse cellular targets","volume":"418","author":"Patterson","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbapap.2026.141135_bb0020","doi-asserted-by":"crossref","first-page":"13524","DOI":"10.1039\/D2SC04135A","article-title":"Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases","volume":"13","author":"Shen","year":"2022","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bbapap.2026.141135_bb0025","article-title":"Phosphotyrosine substrate sequence motifs for dual specificity phosphatases","volume":"10","author":"Zhao","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbapap.2026.141135_bb0030","doi-asserted-by":"crossref","first-page":"4198","DOI":"10.1111\/febs.15431","article-title":"The dead phosphatases society: a review of the emerging roles of pseudophosphatases","volume":"287","author":"Reiterer","year":"2020","journal-title":"FEBS J."},{"key":"10.1016\/j.bbapap.2026.141135_bb0035","doi-asserted-by":"crossref","first-page":"32586","DOI":"10.1074\/jbc.M403442200","article-title":"VHY, a novel Myristoylated testis-restricted dual specificity protein phosphatase related to VHX","volume":"279","author":"Alonso","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2026.141135_bb0040","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1002\/glia.23044","article-title":"The dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in myelinating oligodendrocytes: Dusp15 as a common target of Sox10 and Myrf","volume":"64","author":"Muth","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.bbapap.2026.141135_bb0045","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/jnc.13911","article-title":"Dual specificity phosphatase 15 regulates Erk activation in Schwann cells","volume":"140","author":"Rodr\u00edguez-Molina","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbapap.2026.141135_bb0050","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12884","article-title":"Dual-specificity phosphatase 15 (DUSP15) in the nucleus accumbens is a novel negative regulator of morphine-associated contextual memory","volume":"26","author":"Qiao","year":"2021","journal-title":"Addict. Biol."},{"key":"10.1016\/j.bbapap.2026.141135_bb0055","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1248\/bpb.b24-00314","article-title":"The atypical dual specificity phosphatase DUSP15 regulates Jak1-mediated STAT3 activation","volume":"47","author":"Kikkawa","year":"2024","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bbapap.2026.141135_bb0060","article-title":"Integrative multi-omic profiling of the human phosphatome identifies DUSP15 as a tumour-selective regulator of immune-metabolic reprogramming in chromophobe renal cell carcinoma","author":"Sarhan","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.bbapap.2026.141135_bb0065","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"Edgar","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbapap.2026.141135_bb0070","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/prot.20642","article-title":"Crystal structure of the catalytic domain of human VHY, a dual-specificity protein phosphatase","volume":"61","author":"Yoon","year":"2005","journal-title":"Proteins"},{"key":"10.1016\/j.bbapap.2026.141135_bb0075","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1107\/S2053230X1500504X","article-title":"Structure of human dual-specificity phosphatase 7, a potential cancer drug target","volume":"71","author":"Lountos","year":"2015","journal-title":"Acta Crystallogr. F Struct. Biol. Commun."},{"key":"10.1016\/j.bbapap.2026.141135_bb0085","first-page":"82","article-title":"Pymol: an open-source molecular graphics tool","volume":"40","author":"DeLano","year":"2002","journal-title":"CCP4 Newsl. Protein Crystallogr."},{"key":"10.1016\/j.bbapap.2026.141135_bb0090","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein\u2013protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbapap.2026.141135_bb0095","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.bbapap.2026.141135_bb0100","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbamcr.2018.07.021","article-title":"The role of pseudophosphatases as signaling regulators","volume":"1866","author":"Hinton","year":"2019","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Cell Res."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570963926000129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570963926000129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:15:26Z","timestamp":1780384526000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570963926000129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S1570963926000129"],"URL":"https:\/\/doi.org\/10.1016\/j.bbapap.2026.141135","relation":{},"ISSN":["1570-9639"],"issn-type":[{"value":"1570-9639","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DUSP15 exhibits structural and dynamical signatures inconsistent with catalytic phosphatase activity","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbapap.2026.141135","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"141135"}}