{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:53:02Z","timestamp":1791067982260,"version":"4.1.0"},"reference-count":92,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"UKRI Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00025"],"award-info":[{"award-number":["MC_UU_00025"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bbapap.2026.141180","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:51:57Z","timestamp":1790135517000},"page":"141180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["From proteome definition to modern proteomics: Mass spectrometry and emerging affinity-based platforms including SomaScan, Olink PEA, and Nautilus voyager\u2122"],"prefix":"10.1016","volume":"1875","author":[{"given":"Dimitra","family":"Papatziamou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aman","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehul V.","family":"Makwana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip K.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbapap.2026.141180_bb0005","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1042\/EBC20200108","article-title":"Uncovering protein function: from classification to complexes","volume":"66","author":"Morris","year":"2022","journal-title":"Essays Biochem."},{"key":"10.1016\/j.bbapap.2026.141180_bb0010","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nature19949","article-title":"Mass-spectrometric exploration of proteome structure and function","volume":"537","author":"Aebersold","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bbapap.2026.141180_bb0015","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cell.2016.03.014","article-title":"On the dependency of cellular protein levels on mRNA abundance","volume":"165","author":"Liu","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.bbapap.2026.141180_bb0020","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1002\/elps.11501601185","article-title":"Progress with gene-product mapping of the Mollicutes: mycoplasma genitalium","volume":"16","author":"Wasinger","year":"1995","journal-title":"Electrophoresis"},{"key":"10.1016\/j.bbapap.2026.141180_bb0025","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1586\/epr.09.81","article-title":"Proteomics data mining","volume":"6","author":"Wilkins","year":"2009","journal-title":"Expert Rev. Proteomics"},{"key":"10.1016\/j.bbapap.2026.141180_bb0030","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41586-024-08477-8","article-title":"SARS-CoV-2 evolution on a dynamic immune landscape","volume":"639","author":"Raharinirina","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.bbapap.2026.141180_bb0035","doi-asserted-by":"crossref","unstructured":"T. Guo, J.A. Steen, M. Mann, Mass-spectrometry-based proteomics: from single cells to clinical applications, Nature 2025 638:8052 901\u2013911. doi:https:\/\/doi.org\/10.1038\/s41586-025-08584-0.","DOI":"10.1038\/s41586-025-08584-0"},{"key":"10.1016\/j.bbapap.2026.141180_bb0040","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41586-023-06592-6","article-title":"Plasma proteomic associations with genetics and health in the UK biobank","volume":"622","author":"Sun","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.bbapap.2026.141180_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015004","article-title":"Aptamer-based multiplexed proteomic technology for biomarker discovery","volume":"5","author":"Gold","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbapap.2026.141180_bb0050","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkr424","article-title":"Homogeneous antibody-based proximity extension assays provide sensitive and specific detection of low-abundant proteins in human blood","volume":"39","author":"Lundberg","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbapap.2026.141180_bb0055","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1146\/annurev-anchem-071015-041550","article-title":"Progress in top-down proteomics and the analysis of Proteoforms","volume":"9","author":"Toby","year":"2016","journal-title":"Annu Rev Anal Chem (Palo Alto, Calif)"},{"key":"10.1016\/j.bbapap.2026.141180_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026332","article-title":"From SOMAmer-based biomarker discovery to diagnostic and clinical applications: a SOMAmer-based, streamlined multiplex proteomic assay","volume":"6","author":"Kraemer","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbapap.2026.141180_bb0065","doi-asserted-by":"crossref","DOI":"10.1038\/mtna.2014.49","article-title":"Nucleic acid ligands with protein-like side chains: modified aptamers and their use as diagnostic and therapeutic agents","volume":"3","author":"Rohloff","year":"2014","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.bbapap.2026.141180_bb0070","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nbt0502-473","article-title":"Protein detection using proximity-dependent DNA ligation assays","volume":"20","author":"Fredriksson","year":"2002","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbapap.2026.141180_bb0075","article-title":"A theoretical framework for proteome-scale single-molecule protein identification using multi-affinity protein binding reagents","author":"Egertson","year":"2021","journal-title":"BioRxiv"},{"key":"10.1016\/j.bbapap.2026.141180_bb0080","article-title":"High-density and scalable protein arrays for single-molecule proteomic studies","author":"Aksel","year":"2022","journal-title":"BioRxiv"},{"key":"10.1016\/j.bbapap.2026.141180_bb0085","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","article-title":"Initial sequencing and analysis of the human genome","volume":"409","author":"Lander","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bbapap.2026.141180_bb0090","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nmeth.2369","article-title":"Proteoform: a single term describing protein complexity","volume":"10","author":"Smith","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbapap.2026.141180_bb0095","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaq1327","article-title":"Co-regulatory networks of human serum proteins link genetics to disease","volume":"361","author":"Emilsson","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.bbapap.2026.141180_bb0100","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1038\/s41591-019-0665-2","article-title":"Plasma protein patterns as comprehensive indicators of health","volume":"25","author":"Williams","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbapap.2026.141180_bb0105","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1016\/S0021-9258(19)41496-8","article-title":"High resolution two dimensional electrophoresis of proteins","volume":"250","author":"O\u2019Farrell","year":"1975","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbapap.2026.141180_bb0110","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/j.jprot.2011.05.040","article-title":"Two-dimensional gel electrophoresis in proteomics: a tutorial","volume":"74","author":"Rabilloud","year":"2011","journal-title":"J. Proteome"},{"key":"10.1016\/j.bbapap.2026.141180_bb0115","doi-asserted-by":"crossref","first-page":"9390","DOI":"10.1073\/pnas.160270797","article-title":"Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology","volume":"97","author":"Gygi","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbapap.2026.141180_bb0120","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1126\/science.2675315","article-title":"Electrospray ionization for mass spectrometry of large biomolecules","volume":"246","author":"Fenn","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.bbapap.2026.141180_bb0125","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/rcm.1290020802","article-title":"Protein and polymer analyses up to m\/z 100 000 by laser ionization time-of-flight mass spectrometry","volume":"2","author":"Tanaka","year":"1988","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.bbapap.2026.141180_bb0130","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1006\/bbrc.1993.1990","article-title":"Identification of ionizable groups essential for the enzyme catalysis on glutathione S-transferase P","volume":"194","author":"Nishihira","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbapap.2026.141180_bb0135","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1146\/annurev.biochem.70.1.437","article-title":"Analysis of proteins and proteomes by mass spectrometry","volume":"70","author":"Mann","year":"2001","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bbapap.2026.141180_bb0140","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1021\/ac0262560","article-title":"Tandem mass tags: a novel quantification strategy for comparative analysis of complex protein mixtures by MS\/MS","volume":"75","author":"Thompson","year":"2003","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbapap.2026.141180_bb0145","doi-asserted-by":"crossref","first-page":"7150","DOI":"10.1021\/ac502040v","article-title":"MultiNotch MS3 enables accurate, sensitive, and multiplexed detection of differential expression across cancer cell line proteomes","volume":"86","author":"McAlister","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbapap.2026.141180_bb0150","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nmeth.1714","article-title":"MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics","volume":"8","author":"Ting","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbapap.2026.141180_bb0155","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.O111.016717","article-title":"Targeted data extraction of the MS\/MS spectra generated by data-independent acquisition: a new concept for consistent and accurate proteome analysis","volume":"11","author":"Gillet","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbapap.2026.141180_bb0160","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41592-019-0638-x","article-title":"DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput","volume":"17","author":"Demichev","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbapap.2026.141180_bb0165","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1074\/mcp.RA118.001288","article-title":"Analysis of 1508 plasma samples by capillary-flow data-independent acquisition profiles proteomics of weight loss and maintenance","volume":"18","author":"Bruderer","year":"2019","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbapap.2026.141180_bb0170","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/s41587-021-00860-4","article-title":"Ultra-fast proteomics with Scanning SWATH","volume":"39","author":"Messner","year":"2021","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbapap.2026.141180_bb0175","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s13361-016-1545-3","article-title":"Native mass spectrometry: what is in the name?","volume":"28","author":"Leney","year":"2017","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.bbapap.2026.141180_bb0180","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-018-1547-5","article-title":"SCoPE-MS: mass spectrometry of single mammalian cells quantifies proteome heterogeneity during cell differentiation","volume":"19","author":"Budnik","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbapap.2026.141180_bb0185","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-021-02267-5","article-title":"Single-cell proteomic and transcriptomic analysis of macrophage heterogeneity using SCoPE2","volume":"22","author":"Specht","year":"2021","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbapap.2026.141180_bb0190","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/pro.3307","article-title":"The human protein atlas: a spatial map of the human proteome","volume":"27","author":"Thul","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.bbapap.2026.141180_bb0195","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41580-018-0094-y","article-title":"Spatial proteomics: a powerful discovery tool for cell biology","volume":"20","author":"Lundberg","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbapap.2026.141180_bb0200","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41592-020-01010-5","article-title":"Deciphering molecular interactions by proximity labeling","volume":"18","author":"Qin","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbapap.2026.141180_bb0205","first-page":"1665","article-title":"Advances in spatial proteomics: mapping proteome architecture from protein complexes to subcellular localizations, cell","volume":"31","author":"Breckels","year":"2024","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bbapap.2026.141180_bb0210","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41580-026-00947-3","article-title":"Subcellular localization as a driver of protein function","volume":"27","author":"Sigaeva","year":"2026","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbapap.2026.141180_bb0215","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/s41587-022-01302-5","article-title":"Deep visual proteomics defines single-cell identity and heterogeneity","volume":"40","author":"Mund","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbapap.2026.141180_bb0220","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1016\/j.molcel.2022.05.022","article-title":"Unbiased spatial proteomics with single-cell resolution in tissues","volume":"82","author":"Mund","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbapap.2026.141180_bb0225","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1021\/jasms.1c00081","article-title":"Factorial design to optimize matrix spraying parameters for MALDI mass spectrometry imaging","volume":"32","author":"Tressler","year":"2021","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.bbapap.2026.141180_bb0230","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1074\/mcp.O115.052266","article-title":"Quantitative profiling of post-translational modifications by immunoaffinity enrichment and LC-MS\/MS in cancer serum without immunodepletion","volume":"15","author":"Gu","year":"2016","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbapap.2026.141180_bb0235","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41592-020-0781-4","article-title":"TMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples","volume":"17","author":"Li","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbapap.2026.141180_bb0240","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1074\/mcp.M114.044305","article-title":"Extending the limits of quantitative proteome profiling with data-independent acquisition and application to acetaminophen-treated three-dimensional liver microtissues","volume":"14","author":"Bruderer","year":"2015","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbapap.2026.141180_bb0245","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cell.2006.09.026","article-title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks","volume":"127","author":"Olsen","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.bbapap.2026.141180_bb0250","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature18003","article-title":"Proteogenomics connects somatic mutations to signalling in breast cancer","volume":"534","author":"Mertins","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bbapap.2026.141180_bb0255","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1126\/science.aat1884","article-title":"Proteoforms as the next proteomics currency","volume":"359","author":"Smith","year":"2018","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.bbapap.2026.141180_bb0260","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1038\/s41467-021-24030-x","article-title":"Systematic detection of functional proteoform groups from bottom-up proteomic datasets","volume":"12","author":"Bludau","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbapap.2026.141180_bb0265","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/nature10575","article-title":"Mapping intact protein isoforms in discovery mode using top-down proteomics","volume":"480","author":"Tran","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbapap.2026.141180_bb0270","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1021\/acs.chemrev.2c00600","article-title":"Ion mobility mass spectrometry (IM-MS) for structural biology: insights gained by measuring mass, charge, and collision cross section","volume":"123","author":"Christofi","year":"2023","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bbapap.2026.141180_bb0275","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.molcel.2024.12.023","article-title":"Deciphering functional tumor-immune crosstalk through highly multiplexed imaging and deep visual proteomics","volume":"85","author":"Zheng","year":"2025","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.bbapap.2026.141180_bb0280","doi-asserted-by":"crossref","first-page":"7710","DOI":"10.1038\/s41467-023-43520-8","article-title":"Deep topographic proteomics of a human brain tumour","volume":"14","author":"Davis","year":"2023","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.bbapap.2026.141180_bb0285","doi-asserted-by":"crossref","DOI":"10.15252\/msb.202110798","article-title":"Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation","volume":"18","author":"Brunner","year":"2022","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.bbapap.2026.141180_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/proteomes14020020","article-title":"Enabling next-generation mass spectrometry-based proteomics: standards, proteoform resolution, and FAIR, reproducible, and quantitative analysis","volume":"14","author":"Vitorino","year":"2026","journal-title":"Proteomes"},{"key":"10.1016\/j.bbapap.2026.141180_bb0295","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24065350","article-title":"Bottom-up proteomics: advancements in sample preparation","volume":"24","author":"Duong","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbapap.2026.141180_bb0300","article-title":"The $10 proteome: low-cost, deep and quantitative proteome profiling of limited sample amounts using the Orbitrap astral and timsTOF ultra 2 mass spectrometers","author":"Huang","year":"2025","journal-title":"BioRxiv"},{"key":"10.1016\/j.bbapap.2026.141180_bb0305","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1021\/acs.jproteome.5c00759","article-title":"The 2025 Report on the human proteome from the HUPO human proteome project","volume":"25","author":"Deutsch","year":"2026","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbapap.2026.141180_bb0310","doi-asserted-by":"crossref","first-page":"5531","DOI":"10.1021\/acs.jproteome.4c00667","article-title":"Variability of 7K and 11K SomaScan plasma proteomics assays","volume":"23","author":"Candia","year":"2024","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbapap.2026.141180_bb0315","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1021\/acs.jproteome.4c00521","article-title":"Multi-omics study reveals Nc886\/vtRNA2-1 as a positive regulator of prostate cancer cell immunity","volume":"24","author":"Oliveira-Rizzo","year":"2025","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbapap.2026.141180_bb0320","doi-asserted-by":"crossref","DOI":"10.1126\/science.abj1541","article-title":"Mapping the proteo-genomic convergence of human diseases","volume":"374","author":"Pietzner","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.bbapap.2026.141180_bb0325","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1161\/CIRCULATIONAHA.118.036823","article-title":"In aptamers they trust: the caveats of the SOMAscan biomarker discovery platform from SomaLogic","volume":"138","author":"Joshi","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.bbapap.2026.141180_bb0330","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14755-5","article-title":"Assessment of variability in the SOMAscan assay","volume":"7","author":"Candia","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbapap.2026.141180_bb0335","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/s41586-023-06563-x","article-title":"Large-scale plasma proteomics comparisons through genetics and disease associations","volume":"622","author":"Eldjarn","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.bbapap.2026.141180_bb0340","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1074\/mcp.M113.036095","article-title":"Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach","volume":"13","author":"Carr","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbapap.2026.141180_bb0345","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1038\/s41591-019-0673-2","article-title":"Undulating changes in human plasma proteome profiles across the lifespan","volume":"25","author":"Lehallier","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbapap.2026.141180_bb0350","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41586-023-06802-1","article-title":"Organ aging signatures in the plasma proteome track health and disease","volume":"624","author":"Oh","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.bbapap.2026.141180_bb0355","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/ana.26827","article-title":"Hippocampal perfusion affects motor and cognitive functions in Parkinson disease: An Early phase 18 F-FP-CIT positron emission tomography study","volume":"95","author":"Chun","year":"2024","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbapap.2026.141180_bb0360","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.jalz.2013.09.016","article-title":"Alzheimer\u2019s disease biomarker discovery using SOMAscan multiplexed protein technology","volume":"10","author":"Sattlecker","year":"2014","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.bbapap.2026.141180_bb0365","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s43587-021-00064-0","article-title":"Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk","volume":"1","author":"Walker","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.bbapap.2026.141180_bb0370","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-023-05469-8","article-title":"Insights into the mechanism of SARS-CoV-2 main protease autocatalytic maturation from model precursors","volume":"6","author":"Aniana","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bbapap.2026.141180_bb0375","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm5164","article-title":"Proteomic profiling platforms head to head: leveraging genetics and clinical traits to compare aptamer- and antibody-based methods","volume":"8","author":"Katz","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbapap.2026.141180_bb0380","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-27164-0","article-title":"Synergistic insights into human health from aptamer- and antibody-based proteomic profiling","volume":"12","author":"Pietzner","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbapap.2026.141180_bb0385","doi-asserted-by":"crossref","DOI":"10.1038\/s41592-026-03085-y","article-title":"AI proteomics: from protein identification to virtual cells","author":"Sun","year":"2026","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbapap.2026.141180_bb0390","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1038\/s41588-021-00978-w","article-title":"Large-scale integration of the plasma proteome with genetics and disease","volume":"53","author":"Ferkingstad","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbapap.2026.141180_bb0395","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095192","article-title":"Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability","volume":"9","author":"Assarsson","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbapap.2026.141180_bb0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2021.100168","article-title":"Proximity extension assay in combination with next-generation sequencing for high-throughput proteome-wide analysis","volume":"20","author":"Wik","year":"2021","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbapap.2026.141180_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110659","article-title":"Multi-omics analysis of aggregative multicellularity","volume":"27","author":"Edelbroek","year":"2024","journal-title":"IScience"},{"key":"10.1016\/j.bbapap.2026.141180_bb0410","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-018-0175-2","article-title":"Genomic atlas of the human plasma proteome","volume":"558","author":"Sun","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.bbapap.2026.141180_bb0415","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nbt1235","article-title":"Protein biomarker discovery and validation: the long and uncertain path to clinical utility","volume":"24","author":"Rifai","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbapap.2026.141180_bb0420","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-59745-450-6_1","article-title":"What is a B-cell epitope?","volume":"524","author":"Van Regenmortel","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbapap.2026.141180_bb0425","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1016\/j.jprot.2010.08.009","article-title":"A survey of computational methods and error rate estimation procedures for peptide and protein identification in shotgun proteomics","volume":"73","author":"Nesvizhskii","year":"2010","journal-title":"J. Proteome"},{"key":"10.1016\/j.bbapap.2026.141180_bb0430","doi-asserted-by":"crossref","first-page":"4728","DOI":"10.1021\/acs.analchem.4c06750","article-title":"Recent advances in mass spectrometry-based bottom-up proteomics","volume":"97","author":"Movassaghi","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbapap.2026.141180_bb0435","doi-asserted-by":"crossref","DOI":"10.1038\/s43856-025-00945-0","article-title":"Deep plasma proteomics identifies and validates an eight-protein biomarker panel that separate benign from malignant tumors in ovarian cancer","volume":"5","author":"Moskov","year":"2025","journal-title":"Commun. Med."},{"issue":"8","key":"10.1016\/j.bbapap.2026.141180_bb0440","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1038\/s41591-025-03834-0","article-title":"The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging","volume":"31","author":"Imam","year":"2025","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbapap.2026.141180_bb0445","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.bbapap.2026.141180_bb0450","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1126\/science.ade2574","article-title":"Evolutionary-scale prediction of atomic-level protein structure with a language model","volume":"379","author":"Lin","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.bbapap.2026.141180_bb0455","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-017-1215-1","article-title":"Multi-omics approaches to disease","volume":"18","author":"Hasin","year":"2017","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbapap.2026.141180_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.06.013","article-title":"Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma","volume":"182","author":"Gillette","year":"2020","journal-title":"Cell"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570963926000579?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1570963926000579?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:01:33Z","timestamp":1791064893000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1570963926000579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":92,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2027,1]]}},"alternative-id":["S1570963926000579"],"URL":"https:\/\/doi.org\/10.1016\/j.bbapap.2026.141180","relation":{},"ISSN":["1570-9639"],"issn-type":[{"value":"1570-9639","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"From proteome definition to modern proteomics: Mass spectrometry and emerging affinity-based platforms including SomaScan, Olink PEA, and Nautilus voyager\u2122","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbapap.2026.141180","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"141180"}}