{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:35:15Z","timestamp":1790886915616,"version":"4.1.0"},"reference-count":199,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.bbcan.2010.09.002","type":"journal-article","created":{"date-parts":[[2010,10,2]],"date-time":"2010-10-02T08:41:49Z","timestamp":1286008909000},"page":"44-64","source":"Crossref","is-referenced-by-count":28,"title":["Current status of molecular markers for early detection of sporadic pancreatic cancer"],"prefix":"10.1016","volume":"1815","author":[{"given":"Subhankar","family":"Chakraborty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Baine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron R.","family":"Sasson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surinder K.","family":"Batra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbcan.2010.09.002_bb0005","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1242\/dev.121.6.1569","article-title":"Developmental biology of the pancreas","volume":"121","author":"Slack","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0010","series-title":"National Diabetes Statistics, 2007 Fact Sheet, U.S. Department of Health and Human Services, National Institutes of Health, Bethesda, MD","year":"2008"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0015","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3322\/caac.20006","article-title":"Cancer statistics, 2009","volume":"59","author":"Jemal","year":"2009","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1476-4598-2-13","article-title":"What is the origin of pancreatic adenocarcinoma?","volume":"2","author":"Pour","year":"2003","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0025","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ccr.2007.02.020","article-title":"A case of mistaken identity? Nonductal origins of pancreatic \u201cductal\u201d cancers","volume":"11","author":"Murtaugh","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0030","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000178874","article-title":"Pancreatic intraepithelial neoplasia revisited and updated","volume":"9","author":"Sipos","year":"2009","journal-title":"Pancreatology"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0035","doi-asserted-by":"crossref","first-page":"375","DOI":"10.5858\/133.3.375","article-title":"Pancreatic intraepithelial neoplasia and pancreatic tumorigenesis: of mice and men","volume":"133","author":"Ottenhof","year":"2009","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0040","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1097\/01.sla.0000128306.90650.aa","article-title":"Intraductal papillary mucinous neoplasms of the pancreas: an updated experience","volume":"239","author":"Sohn","year":"2004","journal-title":"Ann. Surg."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0045","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00534-006-1165-6","article-title":"Current understanding of precursors to pancreatic cancer","volume":"14","author":"Takaori","year":"2007","journal-title":"J. Hepatobiliary-Pancreat. Surg."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0050","series-title":"Surgical Pathology of the GI tract, Liver, Biliary Tract and Pancreas","first-page":"765","article-title":"Biliary tract and pancreas tissue processing techniques","author":"Crawford","year":"2009"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0055","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1136\/jcp.2007.049361","article-title":"Intraductal papillary mucinous neoplasms of the pancreas: clinical and pathological features and diagnostic approach","volume":"61","author":"Katabi","year":"2008","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0060","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/00000658-200002000-00009","article-title":"Clinical and pathologic correlation of 84 mucinous cystic neoplasms of the pancreas: can one reliably differentiate benign from malignant (or premalignant) neoplasms?","volume":"231","author":"Sarr","year":"2000","journal-title":"Ann. Surg."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0065","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000142947","article-title":"Serous cystic tumors of the pancreas: when to observe and when to operate: a single-center experience","volume":"25","author":"Zanini","year":"2008","journal-title":"Dig. Surg."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0070","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1136\/gut.2006.103333","article-title":"Biology and management of pancreatic cancer","volume":"84","author":"Ghaneh","year":"2008","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0075","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/1471-2407-8-192","article-title":"Gemcitabine based combination chemotherapy in advanced pancreatic cancer-indirect comparison","volume":"8","author":"Sultana","year":"2008","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0080","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/ncponc0925","article-title":"Surgery insight: surgical management of pancreatic cancer","volume":"4","author":"Michalski","year":"2007","journal-title":"Nat. Clin. Pract. Oncol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0085","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/gcc.20337","article-title":"Pancreatic adenocarcinoma \u2014 genetic portrait from chromosomes to microarrays","volume":"45","author":"Karhu","year":"2006","journal-title":"Genes Chromosom. Cancer"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0090","first-page":"S11","article-title":"Pancreatic adenocarcinoma: new strategies for success","volume":"3","author":"O'Reilly","year":"2009","journal-title":"Gastrointest. Cancer Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0095","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2353\/jmoldx.2008.070115","article-title":"Molecular genetics of pancreatic ductal adenocarcinomas and recent implications for translational efforts","volume":"10","author":"Feldmann","year":"2008","journal-title":"J. Mol. Diagn."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0100","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1056\/NEJM199305203282001","article-title":"Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group","volume":"328","author":"Lowenfels","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0105","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S1542-3565(04)00171-5","article-title":"Signs and symptoms of pancreatic cancer: a population-based case\u2013control study in the San Francisco Bay area","volume":"2","author":"Holly","year":"2004","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0110","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF02712816","article-title":"Exocrine pancreatic cancer: symptoms at presentation and their relation to tumour site and stage","volume":"7","author":"Porta","year":"2005","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0115","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/sj.bjc.6601140","article-title":"A meta-analysis of obesity and the risk of pancreatic cancer","volume":"89","author":"Berrington de","year":"2003","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0120","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1158\/1055-9965.EPI-04-0583","article-title":"Obesity, recreational physical activity, and risk of pancreatic cancer in a large U.S. Cohort","volume":"14","author":"Patel","year":"2005","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0125","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s10552-009-9303-5","article-title":"Lifestyle, dietary, and medical history factors associated with pancreatic cancer risk in Ontario, Canada","volume":"20","author":"Anderson","year":"2009","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0130","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/BF03403631","article-title":"Environmental tobacco smoke and the risk of pancreatic cancer: findings from a Canadian population-based case\u2013control study","volume":"95","author":"Villeneuve","year":"2004","journal-title":"Can. J. Public Health"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0135","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/ijc.1446","article-title":"Physical activity, anthropometric factors and risk of pancreatic cancer: results from the Canadian enhanced cancer surveillance system","volume":"94","author":"Hanley","year":"2001","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0140","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00008469-200002000-00007","article-title":"Alcohol, tobacco and coffee consumption and the risk of pancreatic cancer: results from the Canadian Enhanced Surveillance System case\u2013control project. Canadian Cancer Registries Epidemiology Research Group","volume":"9","author":"Villeneuve","year":"2000","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0145","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cdp.2007.10.002","article-title":"Allergies, variants in IL-4 and IL-4R alpha genes, and risk of pancreatic cancer","volume":"31","author":"Olson","year":"2007","journal-title":"Cancer Detect. Prev."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0150","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/00006676-200308000-00007","article-title":"Exocrine pancreatic cancer, cigarette smoking, and diabetes mellitus: a case\u2013control study in northern Italy","volume":"27","author":"Bonelli","year":"2003","journal-title":"Pancreas"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0155","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1136\/gut.48.2.143","article-title":"Inherited predisposition to pancreatic cancer","volume":"48","author":"Efthimiou","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0160","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/S0016-5085(03)00272-5","article-title":"Risk factors for the development of pancreatic cancer in familial pancreatic cancer kindreds","volume":"124","author":"Rulyak","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0165","doi-asserted-by":"crossref","first-page":"4928","DOI":"10.1158\/0008-5472.CAN-07-5539","article-title":"Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk","volume":"68","author":"McWilliams","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0170","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1023\/A:1026580131793","article-title":"Predictors of pancreatic cancer mortality among a large cohort of United States adults","volume":"11","author":"Coughlin","year":"2000","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0175","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/sj.bjc.6605636","article-title":"Non-steroidal anti-inflammatory drugs and pancreatic cancer risk: a nested case\u2013control study","volume":"102","author":"Bradley","year":"2010","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0180","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.mrrev.2008.12.001","article-title":"Genetic predisposition and environmental risk factors to pancreatic cancer: a review of the literature","volume":"681","author":"Landi","year":"2009","journal-title":"Mutat. Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0185","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1136\/gut.2006.108456","article-title":"Advances in counselling and surveillance of patients at risk for pancreatic cancer","volume":"56","author":"Brand","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0190","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bpg.2009.02.001","article-title":"Hereditary pancreatic cancer: a clinical perspective","volume":"23","author":"Greer","year":"2009","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0195_1","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/jnci\/94.18.1365","article-title":"Cancer risk estimates for BRCA1 mutation carriers identified in a risk evaluation program","volume":"94","author":"Brose","year":"2002","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0195_2","first-page":"1731","article-title":"Tumor-suppressive pathways in pancreatic carcinoma","volume":"57","author":"Rozenblum","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0200","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1093\/jnci\/92.15.1260","article-title":"High frequency of multiple melanomas and breast and pancreas carcinomas in CDKN2A mutation-positive melanoma families","volume":"92","author":"Borg","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0205","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1097\/00000658-200212000-00005","article-title":"CDKN2A germline mutations in familial pancreatic cancer","volume":"236","author":"Bartsch","year":"2002","journal-title":"Ann. Surg."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0210","first-page":"738","article-title":"Increased risk of incident pancreatic cancer among first-degree relatives of patients with familial pancreatic cancer","volume":"7","author":"Tersmette","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0215","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.molcel.2006.05.022","article-title":"Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2","volume":"22","author":"Xia","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0220","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/ng1947","article-title":"Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer","volume":"39","author":"Reid","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0225","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1158\/1078-0432.CCR-08-3128","article-title":"The breast cancer susceptibility mutation PALB2 1592delT is associated with an aggressive tumor phenotype","volume":"15","author":"Heikkinen","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0230","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.1171202","article-title":"Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene","volume":"324","author":"Jones","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0235","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/ng1959","article-title":"PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene","volume":"39","author":"Rahman","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0240","doi-asserted-by":"crossref","first-page":"e516","DOI":"10.1371\/journal.pmed.0030516","article-title":"Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism","volume":"3","author":"Pogue-Geile","year":"2006","journal-title":"PLoS. Med."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0245","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1158\/1055-9965.EPI-09-0056","article-title":"Absence of deleterious palladin mutations in patients with familial pancreatic cancer","volume":"18","author":"Klein","year":"2009","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0250","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1371\/journal.pmed.0040164","article-title":"Palladin mutation causes familial pancreatic cancer: absence in European families","volume":"4","author":"Slater","year":"2007","journal-title":"PLoS Med."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0255","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00439-007-0361-z","article-title":"The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer","volume":"121","author":"Zogopoulos","year":"2007","journal-title":"Hum. Genet."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0260","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1158\/1055-9965.EPI-06-0376","article-title":"Evaluation of the 4q32\u201334 locus in European familial pancreatic cancer","volume":"15","author":"Earl","year":"2006","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0265","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1159\/000201553","article-title":"Identification of a novel kindred with familial pancreatitis and pancreatic cancer","volume":"9","author":"LaFemina","year":"2009","journal-title":"Pancreatology"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0270","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/jnci\/djp020","article-title":"ABO blood group and the risk of pancreatic cancer","volume":"101","author":"Wolpin","year":"2009","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0275","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/1097-0142(19880715)62:2<451::AID-CNCR2820620234>3.0.CO;2-D","article-title":"Allergy and risk of cancer. A prospective study using NHANESI follow up data","volume":"62","author":"McWhorter","year":"1988","journal-title":"Cancer"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0280","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/oxfordjournals.aje.a114087","article-title":"Allergy-related diseases and cancer: an inverse association","volume":"122","author":"Vena","year":"1985","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0285","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/aje\/kwi193","article-title":"Cancer mortality among US men and women with asthma and hay fever","volume":"162","author":"Turner","year":"2005","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0290","first-page":"263","article-title":"Phenotypic CYP2A6 variation and the risk of pancreatic cancer","volume":"10","author":"Kadlubar","year":"2009","journal-title":"JOP"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0295","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1158\/1055-9965.EPI-07-0119","article-title":"Mitochondrial genetic polymorphisms and pancreatic cancer risk","volume":"16","author":"Wang","year":"2007","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0300","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1158\/1055-9965.EPI-08-0460","article-title":"Mitochondrial genetic polymorphisms do not predict survival in patients with pancreatic cancer","volume":"17","author":"Halfdanarson","year":"2008","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0305","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000236023","article-title":"Pooling-based genome-wide association study implicates gamma-glutamyltransferase 1 (GGT1) gene in pancreatic carcinogenesis","volume":"10","author":"Diergaarde","year":"2010","journal-title":"Pancreatology"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0310","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/ng.522","article-title":"A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33","volume":"42","author":"Petersen","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0315","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1572-0241.2007.01615.x","article-title":"XRCC2 and XRCC3 gene polymorphism and risk of pancreatic cancer","volume":"103","author":"Jiao","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0320","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.canlet.2005.12.026","article-title":"The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk","volume":"245","author":"Jiao","year":"2007","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0325","first-page":"17","article-title":"Chronic pancreatitis","volume":"5","author":"Tsirambidis","year":"2003","journal-title":"MedGenMed."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0330","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1053\/gast.2001.22586","article-title":"Chronic pancreatitis: diagnosis, classification, and new genetic developments","volume":"120","author":"Etemad","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0335","first-page":"17","article-title":"Chronic pancreatitis: relation to acute pancreatitis and pancreatic cancer","volume":"71","author":"Uomo","year":"2000","journal-title":"Ann. Ital. Chir."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0340","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.3748\/wjg.v11.i11.1634","article-title":"A Thai family with hereditary pancreatitis and increased cancer risk due to a mutation in PRSS1 gene","volume":"11","author":"Pho-Iam","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0345","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cll.2004.12.004","article-title":"Cationic trypsinogen mutations and pancreatitis","volume":"25","author":"Howes","year":"2005","journal-title":"Clin. Lab. Med."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0350","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bpg.2007.11.007","article-title":"Chronic inflammation and pancreatic cancer","volume":"22","author":"McKay","year":"2008","journal-title":"Best. Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0355","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.cgh.2006.02.005","article-title":"Screening for early pancreatic neoplasia in high-risk individuals: a prospective controlled study","volume":"4","author":"Canto","year":"2006","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0360","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/labinvest.2009.19","article-title":"Mechanisms of parenchymal injury and signaling pathways in ectatic ducts of chronic pancreatitis: implications for pancreatic carcinogenesis","volume":"89","author":"Bhanot","year":"2009","journal-title":"Lab. Invest."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0365","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.bpg.2010.02.007","article-title":"Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detection","volume":"24","author":"Raimondi","year":"2010","journal-title":"Best. Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0370","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1053\/j.gastro.2008.06.078","article-title":"Overexpression of interleukin-1beta in the murine pancreas results in chronic pancreatitis","volume":"135","author":"Marrache","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0375","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/ncpgasthep0881","article-title":"Mechanisms of disease: chronic inflammation and cancer in the pancreas\u2014a potential role for pancreatic stellate cells?","volume":"4","author":"Algul","year":"2007","journal-title":"Nat. Clin. Pract. Gastroenterol. Hepatol."},{"issue":"Suppl 17","key":"10.1016\/j.bbcan.2010.09.002_bb0380","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s00535-006-1922-y","article-title":"Classification and diagnosis of chronic pancreatitis","volume":"42","author":"Banks","year":"2007","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0385","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1159\/000201553","article-title":"Identification of a novel kindred with familial pancreatitis and pancreatic cancer","volume":"9","author":"LaFemina","year":"2009","journal-title":"Pancreatology"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0390","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.bbrc.2009.03.068","article-title":"Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras","volume":"382","author":"Carriere","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0395","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1080\/13651820310017804","article-title":"Detection of oncogenes in chronic pancreatitis","volume":"5","author":"Paramythiotis","year":"2003","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0400","first-page":"2649","article-title":"Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer","volume":"63","author":"Logsdon","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0405","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/MPA.0b013e31802f2483","article-title":"Plasma proteomic analysis of pancreatic cancer by 2-dimensional gel electrophoresis","volume":"34","author":"Deng","year":"2007","journal-title":"Pancreas"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0410","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/ijc.22487","article-title":"Accurate discrimination of pancreatic ductal adenocarcinoma and chronic pancreatitis using multimarker expression data and samples obtained by minimally invasive fine needle aspiration","volume":"120","author":"Chen","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0415","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/01.pai.0000203037.25791.21","article-title":"Maspin is useful in the distinction of pancreatic adenocarcinoma from chronic pancreatitis: a tissue microarray based study","volume":"15","author":"Nash","year":"2007","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0420","doi-asserted-by":"crossref","first-page":"556","DOI":"10.5858\/2007-131-556-DISWPI","article-title":"Double immunohistochemical staining with MUC4\/p53 is useful in the distinction of pancreatic adenocarcinoma from chronic pancreatitis: a tissue microarray-based study","volume":"131","author":"Bhardwaj","year":"2007","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0425","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1074\/mcp.M700072-MCP200","article-title":"Quantitative proteomics analysis reveals that proteins differentially expressed in chronic pancreatitis are also frequently involved in pancreatic cancer","volume":"6","author":"Chen","year":"2007","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0430","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1053\/j.gastro.2005.08.012","article-title":"Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma","volume":"129","author":"Crnogorac-Jurcevic","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0435","first-page":"15","article-title":"Family history of diabetes and pancreatic cancer","volume":"30","author":"Egawa","year":"2005","journal-title":"Pancreas"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0440","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.gastro.2005.05.007","article-title":"Probability of pancreatic cancer following diabetes: a population-based study","volume":"129","author":"Chari","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0445","series-title":"Incidentally Discovered Pancreatic Cysts: What Evaluation is Useful?","first-page":"466","author":"Correa-Gallego","year":"2008"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0450","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.gie.2005.06.051","article-title":"Yield of EUS-guided FNA of pancreatic masses in the presence or the absence of chronic pancreatitis","volume":"62","author":"Varadarajulu","year":"2005","journal-title":"Gastrointest. Endosc."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0455","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1067\/mge.2000.107910","article-title":"EUS to detect evidence of pancreatic disease in patients with persistent or nonspecific dyspepsia","volume":"52","author":"Sahai","year":"2000","journal-title":"Gastrointest. Endosc."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0460","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.gie.2005.06.051","article-title":"Yield of EUS-guided FNA of pancreatic masses in the presence or the absence of chronic pancreatitis","volume":"62","author":"Varadarajulu","year":"2005","journal-title":"Gastrointest. Endosc."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0465","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0016-5107(03)02863-3","article-title":"Optimal number of EUS-guided fine needle passes needed to obtain a correct diagnosis","volume":"59","author":"LeBlanc","year":"2004","journal-title":"Gastrointest. Endosc."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0470","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.gie.2010.02.056","article-title":"Combined contrast-enhanced power Doppler and real-time sonoelastography performed during EUS, used in the differential diagnosis of focal pancreatic masses (with videos)","volume":"72","author":"Saftoiu","year":"2010","journal-title":"Gastrointest. Endosc."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0475","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/S0016-5107(05)00364-0","article-title":"Pancreatic FNA in 1000 cases: a comparison of imaging modalities","volume":"61","author":"Volmar","year":"2005","journal-title":"Gastrointest. Endosc."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0480","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/145749690909800105","article-title":"Intraductal papillary mucinous tumor of the pancreas (IPMT): follow-up of twelve cases","volume":"98","author":"Khalid","year":"2009","journal-title":"Scand. J. Surg."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0485","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0002-9440(10)61121-2","article-title":"Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas","volume":"160","author":"Terris","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0490","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1055\/s-0028-1098791","article-title":"Carcinoma of the pancreas at the site of an intraductal papillary mucinous neoplasia","volume":"134","author":"Fieger","year":"2009","journal-title":"Zentralbl. Chir."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0495","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1001\/archsurg.2009.36","article-title":"Current trends in pancreatic cystic neoplasms","volume":"144","author":"Ferrone","year":"2009","journal-title":"Arch. Surg."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0500","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1440-1746.2007.05117.x","article-title":"Radiology of pancreatic adenocarcinoma: current status of imaging","volume":"23","author":"Sahani","year":"2008","journal-title":"J Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0505","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.suc.2009.12.003","article-title":"Evidence-based imaging of pancreatic malignancies","volume":"90","author":"Kinney","year":"2010","journal-title":"Surg. Clin. N. Am."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0510","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1053\/j.gastro.2009.02.040","article-title":"A multivariable model using advanced cytologic methods for the evaluation of indeterminate pancreatobiliary strictures","volume":"136","author":"Fritcher","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0515","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1021\/nn8008933","article-title":"Imaging pancreatic cancer using bioconjugated InP quantum dots","volume":"3","author":"Yong","year":"2009","journal-title":"ACS Nano"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0520","series-title":"Plectin-1 as a Novel Imaging Marker in Pancreatic Cancer","first-page":"462","author":"Bausch","year":"2008"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0525","doi-asserted-by":"crossref","first-page":"15102","DOI":"10.1088\/0957-4484\/20\/1\/015102","article-title":"Mn-doped near-infrared quantum dots as multimodal targeted probes for pancreatic cancer imaging","volume":"20","author":"Yong","year":"2009","journal-title":"Nanotechnology"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0530","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1155\/2008\/958214","article-title":"Investigating population risk factors of pancreatic cancer by evaluation of optical markers in the duodenal mucosa","volume":"25","author":"Turzhitsky","year":"2008","journal-title":"Dis. Markers"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0535","doi-asserted-by":"crossref","first-page":"6626","DOI":"10.1038\/sj.onc.1208804","article-title":"Transcriptome analysis of microdissected pancreatic intraepithelial neoplastic lesions","volume":"24","author":"Buchholz","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0540","doi-asserted-by":"crossref","first-page":"7380","DOI":"10.1158\/1078-0432.CCR-07-1488","article-title":"PAM4-reactive MUC1 is a biomarker for early pancreatic adenocarcinoma","volume":"13","author":"Gold","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0545","first-page":"427","article-title":"Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies","volume":"140","author":"Moll","year":"1992","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0550","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/01.sla.0000154455.86404.e9","article-title":"CEACAM6 is a novel biomarker in pancreatic adenocarcinoma and PanIN lesions","volume":"241","author":"Duxbury","year":"2005","journal-title":"Ann. Surg."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0555","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1365-2559.2007.02792.x","article-title":"Class III beta-tubulin, a marker of resistance to paclitaxel, is overexpressed in pancreatic ductal adenocarcinoma and intraepithelial neoplasia","volume":"51","author":"Lee","year":"2007","journal-title":"Histopathology"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0560","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1021\/pr800890j","article-title":"Analysis of the pancreatic tumor progression by a quantitative proteomic approach and immunohistochemical validation","volume":"8","author":"Sitek","year":"2009","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0565","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1002\/elps.200800752","article-title":"Quantitative proteomics investigation of pancreatic intraepithelial neoplasia","volume":"30","author":"Pan","year":"2009","journal-title":"Electrophoresis"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0570","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1365-2559.2007.02792.x","article-title":"Class III beta-tubulin, a marker of resistance to paclitaxel, is overexpressed in pancreatic ductal adenocarcinoma and intraepithelial neoplasia","volume":"51","author":"Lee","year":"2007","journal-title":"Histopathology"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0575","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/PAS.0b013e31815701f3","article-title":"New markers of pancreatic cancer identified through differential gene expression analyses: claudin 18 and annexin A8","volume":"32","author":"Karanjawala","year":"2008","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0580","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.gie.2006.02.009","article-title":"Serous cystadenoma causing biliary obstruction with synchronous pancreatic intraepithelial neoplasia","volume":"64","author":"Kwan","year":"2006","journal-title":"Gastrointest. Endosc."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0585","series-title":"Progression of Pancreatic Intraepithelial Neoplasia to Invasive Adenocarcinoma in Chronic Pancreatitis Patients","first-page":"461","author":"Barbu","year":"2008"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0590","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1159\/000107268","article-title":"Distribution of intraductal lesions in small invasive ductal carcinoma of the pancreas","volume":"7","author":"Hisa","year":"2007","journal-title":"Pancreatology"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0595","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/mpa.0b013e31805d0190","article-title":"Hypothetical progression model of pancreatic cancer with origin in the centroacinar\u2013acinar compartment","volume":"35","author":"Esposito","year":"2007","journal-title":"Pancreas"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0600","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1053\/j.gastro.2008.12.066","article-title":"Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia","volume":"136","author":"Shi","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0605","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1021\/pr0600374","article-title":"Proteins associated with disease and clinical course in pancreas cancer: a proteomic analysis of plasma in surgical patients","volume":"5","author":"Lin","year":"2006","journal-title":"J. Proteome. Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0610","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1471-230X-10-68","article-title":"Proteomics analysis of serum protein profiling in pancreatic cancer patients by DIGE: up-regulation of mannose-binding lectin 2 and myosin light chain kinase 2","volume":"10","author":"Rong","year":"2010","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0615","doi-asserted-by":"crossref","first-page":"11193","DOI":"10.1158\/0008-5472.CAN-05-1436","article-title":"Antibody microarray profiling reveals individual and combined serum proteins associated with pancreatic cancer","volume":"65","author":"Orchekowski","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0620","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/sj.bjc.6605734","article-title":"Increased circulating cell signalling phosphoproteins in sera are useful for the detection of pancreatic cancer","volume":"103","author":"Takano","year":"2010","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0625","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1074\/mcp.M500178-MCP200","article-title":"Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach","volume":"5","author":"Gronborg","year":"2006","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0630","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1593\/neo.04262","article-title":"Diagnosis of pancreatic cancer using serum proteomic profiling","volume":"6","author":"Bhattacharyya","year":"2004","journal-title":"Neoplasia"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0635","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1158\/0008-5472.CAN-05-3659","article-title":"Fibrinogen gamma overexpression in pancreatic cancer identified by large-scale proteomic analysis of serum samples","volume":"66","author":"Bloomston","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0640","doi-asserted-by":"crossref","first-page":"10613","DOI":"10.1158\/0008-5472.CAN-05-1851","article-title":"Possible detection of pancreatic cancer by plasma protein profiling","volume":"65","author":"Honda","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0645","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1515\/CCLM.2009.158","article-title":"Pancreatic cancer biomarkers discovery by surface-enhanced laser desorption and ionization time-of-flight mass spectrometry","volume":"47","author":"Navaglia","year":"2009","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0650","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1200\/JCO.2005.02.8282","article-title":"New MUC1 serum immunoassay differentiates pancreatic cancer from pancreatitis","volume":"24","author":"Gold","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0655","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.3748\/wjg.v10.i11.1675","article-title":"Serum level of TSGF, CA242 and CA19-9 in pancreatic cancer","volume":"10","author":"Jiang","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0660","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1158\/1078-0432.CCR-05-0564","article-title":"Serum markers in patients with resectable pancreatic adenocarcinoma: macrophage inhibitory cytokine 1 versus CA19-9","volume":"12","author":"Koopmann","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0665","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1002\/pmic.200500702","article-title":"Quantitative proteomic profiling of pancreatic cancer juice","volume":"6","author":"Chen","year":"2006","journal-title":"Proteomics"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0670","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/01.mpa.0000240615.20474.fd","article-title":"Comparison of pancreas juice proteins from cancer versus pancreatitis using quantitative proteomic analysis","volume":"34","author":"Chen","year":"2007","journal-title":"Pancreas"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0675","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1158\/1055-9965.EPI-07-0332","article-title":"Distinctive heavy metal composition of pancreatic juice in patients with pancreatic carcinoma","volume":"16","author":"Carrigan","year":"2007","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0680","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1349-7006.2003.tb01431.x","article-title":"Screening of genes specifically activated in the pancreatic juice ductal cells from the patients with pancreatic ductal carcinoma","volume":"94","author":"Yoshida","year":"2003","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0685","first-page":"1868","article-title":"Identification of hepatocarcinoma\u2013intestine\u2013pancreas\/pancreatitis-associated protein I as a biomarker for pancreatic ductal adenocarcinoma by protein biochip technology","volume":"62","author":"Rosty","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0690","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/1476-4598-9-149","article-title":"Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia","volume":"9","author":"Chen","year":"2010","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0695","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.4161\/cbt.5.10.3323","article-title":"Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs","volume":"5","author":"Rogers","year":"2006","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0700","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/MPA.0b013e3181a16d28","article-title":"Usefulness of human telomerase reverse transcriptase in pancreatic juice as a biomarker of pancreatic malignancy","volume":"38","author":"Nakashima","year":"2009","journal-title":"Pancreas"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0705","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10620-007-9823-3","article-title":"Proteome analysis of human pancreatic ductal adenocarcinoma tissue using two-dimensional gel electrophoresis and tandem mass spectrometry for identification of disease-related proteins","volume":"53","author":"Tian","year":"2008","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0710","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/pmic.200600086","article-title":"Comparative proteomic analysis of human pancreatic juice: methodological study","volume":"7","author":"Zhou","year":"2007","journal-title":"Proteomics"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0715","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1021\/pr800451h","article-title":"Confounding effect of obstructive jaundice in the interpretation of proteomic plasma profiling data for pancreatic cancer","volume":"8","author":"Yan","year":"2009","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0720","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1002\/prca.200780164","article-title":"Analysis of the urine proteome in patients with pancreatic ductal adenocarcinoma","volume":"2","author":"Mark E.","year":"2008","journal-title":"Proteomics Clin. Applic."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0725","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1021\/pr8004925","article-title":"Proteomic analysis of human bile from malignant biliary stenosis induced by pancreatic cancer","volume":"8","author":"Farina","year":"2009","journal-title":"J. Proteome. Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0730","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/sj.bjc.6604329","article-title":"Early diagnosis of pancreatic cancer: neutrophil gelatinase-associated lipocalin as a marker of pancreatic intraepithelial neoplasia","volume":"98","author":"Moniaux","year":"2008","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0735","doi-asserted-by":"crossref","first-page":"6458","DOI":"10.3748\/wjg.14.6458","article-title":"Cholangiocarcinoma: a compact review of the literature","volume":"14","author":"Ustundag","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0740","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2217\/bmm.10.6","article-title":"Human bile as a rich source of biomarkers for hepatopancreatobiliary cancers","volume":"4","author":"Gowda","year":"2010","journal-title":"Biomark. Med."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0745","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/abbs\/gmp023","article-title":"Genetic variation of miRNA sequence in pancreatic cancer","volume":"41","author":"Zhu","year":"2009","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0750","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1056\/NEJMoa050995","article-title":"A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia","volume":"353","author":"Calin","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0755","series-title":"MicroRNA Mir-155 Is a Biomarker of Early Pancreatic Neoplasia","first-page":"473","author":"Habbe","year":"2008"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0760","series-title":"Identification of Protein-coding and Noncoding Gene Expression Signatures Correlated with Malignant Transformation and Metastases in Pancreatic Cancer","first-page":"497","author":"Tahira","year":"2008"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0765","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1073\/pnas.0510565103","article-title":"A microRNA expression signature of human solid tumors defines cancer gene targets","volume":"103","author":"Volinia","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0770","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/ijc.22394","article-title":"Expression profiling identifies microRNA signature in pancreatic cancer","volume":"120","author":"Lee","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0775","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1200\/JCO.2005.05.5194","article-title":"MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior","volume":"24","author":"Roldo","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0780","doi-asserted-by":"crossref","DOI":"10.1158\/1535-7163.MCT-08-0592","article-title":"MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance","author":"Moriyama","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0785","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1261\/rna.1034808","article-title":"MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis","volume":"14","author":"Yan","year":"2008","journal-title":"RNA"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0790","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.1038\/sj.onc.1210228","article-title":"MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma","volume":"26","author":"Szafranska","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0795","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1373\/clinchem.2008.109603","article-title":"Analysis of microRNAs in pancreatic fine-needle aspirates can classify benign and malignant tissues","volume":"54","author":"Szafranska","year":"2008","journal-title":"Clin. Chem."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0800","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.297.17.1901","article-title":"MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis","volume":"297","author":"Bloomston","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0805","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1007\/s11605-008-0584-x","article-title":"MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survival","volume":"12","author":"Dillhoff","year":"2008","journal-title":"J. Gastrointest. Surg."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0810","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/nbt0806-905","article-title":"Cancer biomarkers: a systems approach","volume":"24","author":"Hartwell","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0815","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1158\/0008-5472.CAN-03-3823","article-title":"Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds","volume":"64","author":"Klein","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0820","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1136\/gut.2006.108456","article-title":"Advances in counselling and surveillance of patients at risk for pancreatic cancer","volume":"56","author":"Brand","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0825","first-page":"99","article-title":"Epidemiology of pancreatic cancer","volume":"59","author":"Michaud","year":"2004","journal-title":"Minerva Chir."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0830","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1136\/gut.34.10.1394","article-title":"Increased risk of thyroid and pancreatic carcinoma in familial adenomatous polyposis","volume":"34","author":"Giardiello","year":"1993","journal-title":"Gut"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0835","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1159\/000159214","article-title":"International registries of families at high risk of pancreatic cancer","volume":"8","author":"Greenhalf","year":"2008","journal-title":"Pancreatology"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0840","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/jnci\/95.3.214","article-title":"BRCA2 germline mutations in familial pancreatic carcinoma","volume":"95","author":"Hahn","year":"2003","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0845","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1097\/MCG.0b013e3181981123","article-title":"Atypical familial presentation of FAMMM syndrome with a high incidence of pancreatic cancer: case finding of asymptomatic individuals by EUS surveillance","volume":"43","author":"Kluijt","year":"2009","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0850","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1067\/mge.2003.28","article-title":"Cost-effectiveness of pancreatic cancer screening in familial pancreatic cancer kindreds","volume":"57","author":"Rulyak","year":"2003","journal-title":"Gastrointest. Endosc."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0855","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00000478-199802000-00003","article-title":"Progression of pancreatic intraductal neoplasias to infiltrating adenocarcinoma of the pancreas","volume":"22","author":"Brat","year":"1998","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0860","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJM199202133260706","article-title":"Pancreatic carcinoma","volume":"326","author":"Warshaw","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0865","first-page":"5360","article-title":"Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas","volume":"56","author":"Goggins","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0870","first-page":"3789","article-title":"Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%","volume":"62","author":"Murphy","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0875","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1158\/1055-9965.EPI-06-0783","article-title":"The prevalence of BRCA2 mutations in familial pancreatic cancer","volume":"16","author":"Couch","year":"2007","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0880","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000142947","article-title":"Serous cystic tumors of the pancreas: when to observe and when to operate: a single-center experience","volume":"25","author":"Zanini","year":"2008","journal-title":"Dig. Surg."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0885","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.gie.2008.01.026","article-title":"EUS and\/or EUS-guided FNA in patients with CT and\/or magnetic resonance imaging findings of enlarged pancreatic head or dilated pancreatic duct with or without a dilated common bile duct","volume":"68","author":"Agarwal","year":"2008","journal-title":"Gastrointest. Endosc."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0890","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S1542-3565(05)00859-1","article-title":"A single-center experience of endoscopic ultrasonography for enlarged pancreas on computed tomography","volume":"4","author":"Ho","year":"2006","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0895","doi-asserted-by":"crossref","first-page":"365","DOI":"10.5858\/133.3.365","article-title":"Familial pancreatic cancer","volume":"133","author":"Shi","year":"2009","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0900","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1136\/gut.48.2.143","article-title":"Inherited predisposition to pancreatic cancer","volume":"48","author":"Efthimiou","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0905","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.gie.2006.09.018","article-title":"Interobserver agreement for EUS findings in familial pancreatic-cancer kindreds","volume":"66","author":"Topazian","year":"2007","journal-title":"Gastrointest. Endosc."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0910","doi-asserted-by":"crossref","DOI":"10.1016\/S0025-7125(05)70255-8","article-title":"Pancreatic cancer surveillance in a high-risk cohort. Is it worth the cost?","volume":"84","author":"Martin","year":"2000","journal-title":"Med. Clin. N. Am."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0915","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1016\/S0016-5107(02)70092-8","article-title":"Screening and surveillance for hereditary pancreatic cancer","volume":"56","author":"Kimmey","year":"2002","journal-title":"Gastrointest. Endosc."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0920","series-title":"Factors Associated with Screening Behavior of Stomach Cancer based on Socio-Ecological Model: Korean National Study","author":"Jo","year":"2005"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0925","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1159\/000212082","article-title":"A web-based platform for mining pancreatic expression datasets","volume":"9","author":"Chelala","year":"2009","journal-title":"Pancreatology"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0930","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.2214\/ajr.180.5.1801311","article-title":"Diagnosis, staging, and surveillance of pancreatic cancer","volume":"180","author":"Tamm","year":"2003","journal-title":"AJR Am. J. Roentgenol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0935","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.bbapap.2007.04.001","article-title":"Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers","volume":"1774","author":"Sun","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0940","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S1542-3565(05)00489-1","article-title":"Folate and methylenetetrahydrofolate reductase polymorphisms: new nutritional and genetic risk factors for pancreatic cancer?","volume":"3","author":"Kim","year":"2005","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0945","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1111\/j.1349-7006.2008.00841.x","article-title":"Role of the WWOX gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cells","volume":"99","author":"Nakayama","year":"2008","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0950","doi-asserted-by":"crossref","first-page":"7785","DOI":"10.1158\/1078-0432.CCR-05-0714","article-title":"The role of S100A6 in pancreatic cancer development and its clinical implication as a diagnostic marker and therapeutic target","volume":"11","author":"Ohuchida","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0955","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1097\/01.pas.0000126675.59108.80","article-title":"An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms","volume":"28","author":"Hruban","year":"2004","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0960","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/modpathol.3800991","article-title":"CpG island methylation profile of pancreatic intraepithelial neoplasia","volume":"21","author":"Sato","year":"2008","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0965","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/01.mpa.0000278692.78683.7c","article-title":"Immunohistochemical analyses in intraductal gradually transitional components is useful for evaluation of stepwise progression of pancreatic intraepithelial neoplasia","volume":"35","author":"Sanada","year":"2007","journal-title":"Pancreas"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0970","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/modpathol.3800772","article-title":"Prognostic significance of maspin in pancreatic ductal adenocarcinoma: tissue microarray analysis of 223 surgically resected cases","volume":"20","author":"Cao","year":"2007","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0975","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1136\/gut.2007.143941","article-title":"The chemokine receptor CXCR4 is expressed in pancreatic intraepithelial neoplasia","volume":"57","author":"Thomas","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.bbcan.2010.09.002_bb0980","doi-asserted-by":"crossref","first-page":"6075","DOI":"10.1158\/0008-5472.CAN-06-4128","article-title":"The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression","volume":"67","author":"Thomas","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0985","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1349-7006.2005.00071.x","article-title":"Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas","volume":"96","author":"Peng","year":"2005","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bbcan.2010.09.002_bb0990","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1053\/j.gastro.2005.08.012","article-title":"Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma","volume":"129","author":"Crnogorac-Jurcevic","year":"2005","journal-title":"Gastroenterology"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X10000636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X10000636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:39:22Z","timestamp":1636591162000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304419X10000636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":199,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0304419X10000636"],"URL":"https:\/\/doi.org\/10.1016\/j.bbcan.2010.09.002","relation":{},"ISSN":["0304-419X"],"issn-type":[{"value":"0304-419X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}