{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:37:43Z","timestamp":1790879863857,"version":"4.1.0"},"reference-count":117,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Stichting tegen Kanker","award":["G.0418.08"],"award-info":[{"award-number":["G.0418.08"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.bbcan.2011.02.001","type":"journal-article","created":{"date-parts":[[2011,2,20]],"date-time":"2011-02-20T09:23:55Z","timestamp":1298193835000},"page":"1-12","source":"Crossref","is-referenced-by-count":11,"title":["Uncovering the role of hypoxia inducible factor-1\u03b1 in skin carcinogenesis"],"prefix":"10.1016","volume":"1816","author":[{"given":"Kris","family":"Nys","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannelore","family":"Maes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra Maria","family":"Dudek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Agostinis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbcan.2011.02.001_bb0005","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10495-009-0324-z","article-title":"Cell death in the skin","volume":"14","author":"Lippens","year":"2009","journal-title":"Apoptosis"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0010","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/jcb.21204","article-title":"Microenvironmental influences in melanoma progression","volume":"101","author":"Lee","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0015","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1096\/fj.06-6649rev","article-title":"Human skin pigmentation: melanocytes modulate skin color in response to stress","volume":"21","author":"Costin","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0020","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1038\/sj.jid.5700451","article-title":"Oxygen levels in normal and previously irradiated human skin as assessed by EF5 binding","volume":"126","author":"Evans","year":"2006","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0025","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cell.2008.02.038","article-title":"Epidermal sensing of oxygen is essential for systemic hypoxic response","volume":"133","author":"Boutin","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0030","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.4161\/cc.5.12.2810","article-title":"Skin hypoxia: a promoting environmental factor in melanomagenesis","volume":"5","author":"Bedogni","year":"2006","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0035","doi-asserted-by":"crossref","first-page":"cm8","DOI":"10.1126\/stke.4072007cm8","article-title":"Hypoxia-inducible factor 1 (HIF-1) pathway","volume":"2007","author":"Semenza","year":"2007","journal-title":"Sci. STKE"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0040","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1096\/fj.02-0445fje","article-title":"Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs","volume":"17","author":"Wiesener","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0045","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s10059-010-0067-2","article-title":"HIF-1 and HIF-2 transcription factors\u2014similar but not identical","volume":"29","author":"Loboda","year":"2010","journal-title":"Mol. Cells"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0050","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2008.10.001","article-title":"Oxygen sensors at the crossroad of metabolism","volume":"9","author":"Aragones","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0055","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1172\/JCI200318181","article-title":"HIF hydroxylation and the mammalian oxygen-sensing pathway","volume":"111","author":"Safran","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0060","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","article-title":"Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway","volume":"30","author":"Kaelin","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0065","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.ceb.2009.08.005","article-title":"Mitochondrial reactive oxygen species regulate hypoxic signaling","volume":"21","author":"Hamanaka","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0070","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1755-148X.2009.00553.x","article-title":"Hypoxia, melanocytes and melanoma\u2014survival and tumor development in the permissive microenvironment of the skin","volume":"22","author":"Bedogni","year":"2009","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0075","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1158\/0008-5472.CAN-08-3643","article-title":"Hypoxia-inducible factor-1alpha suppresses squamous carcinogenic progression and epithelial\u2013mesenchymal transition","volume":"69","author":"Scortegagna","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0080","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.bbamcr.2007.11.017","article-title":"HIF-1alpha controls keratinocyte proliferation by up-regulating p21(WAF1\/Cip1)","volume":"1783","author":"Cho","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0085","doi-asserted-by":"crossref","first-page":"6976","DOI":"10.1073\/pnas.1001653107","article-title":"Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds","volume":"107","author":"Biswas","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0090","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1038\/jid.2008.27","article-title":"Critical role of HIF-1alpha in keratinocyte defense against bacterial infection","volume":"128","author":"Peyssonnaux","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0095","doi-asserted-by":"crossref","first-page":"e11576","DOI":"10.1371\/journal.pone.0011576","article-title":"Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens","volume":"5","author":"Werth","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0100","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.molcel.2008.01.001","article-title":"Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response","volume":"29","author":"Herrlich","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0105","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.mrfmmm.2004.07.019","article-title":"Photochemoprevention of ultraviolet B signaling and photocarcinogenesis","volume":"571","author":"Afaq","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0110","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1011-1344(01)00199-3","article-title":"UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer","volume":"63","author":"de Gruijl","year":"2001","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0115","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0006-2952(02)01146-2","article-title":"Independent contribution of three different pathways to ultraviolet-B-induced apoptosis","volume":"64","author":"Kulms","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0120","first-page":"90","article-title":"Ultraviolet radiation-induced apoptosis in keratinocytes: on the role of cytosolic factors","volume":"1755","author":"Assefa","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0125","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1172\/JCI13345","article-title":"Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53","volume":"108","author":"Grossman","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0130","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1562\/0031-8655(2001)074<0579:IVAIVT>2.0.CO;2","article-title":"In vitro and in vivo transfer of bcl-2 gene into keratinocytes suppresses UVB-induced apoptosis","volume":"74","author":"Takahashi","year":"2001","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0135","doi-asserted-by":"crossref","first-page":"19346","DOI":"10.1074\/jbc.M200401200","article-title":"Activation of caspase-9 is required for UV-induced apoptosis of human keratinocytes","volume":"277","author":"Sitailo","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0140","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0163-7258(01)00159-0","article-title":"The machinery of programmed cell death","volume":"92","author":"Zimmermann","year":"2001","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0145","first-page":"71","article-title":"Cellular UV damage responses\u2014functions of tumor suppressor p53","volume":"1755","author":"Latonen","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0150","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/372773a0","article-title":"Sunburn and p53 in the onset of skin cancer","volume":"372","author":"Ziegler","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0155","doi-asserted-by":"crossref","first-page":"8884","DOI":"10.1128\/MCB.24.20.8884-8894.2004","article-title":"Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389","volume":"24","author":"Bruins","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0160","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.taap.2006.12.006","article-title":"p53 and the pathogenesis of skin cancer","volume":"224","author":"Benjamin","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0165","doi-asserted-by":"crossref","first-page":"5299","DOI":"10.1038\/sj.onc.1208650","article-title":"Knockdown of p53 levels in human keratinocytes accelerates Mcl-1 and Bcl-x(L) reduction thereby enhancing UV-light induced apoptosis","volume":"24","author":"Chaturvedi","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0170","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1101\/gad.568810","article-title":"Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis","volume":"24","author":"Schafer","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0175","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.4161\/cc.9.15.12701","article-title":"Nrf2: a central regulator of UV protection in the epidermis","volume":"9","author":"Schafer","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0180","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1038\/jid.2010.93","article-title":"A p38(MAPK)\/HIF-1 pathway initiated by UVB irradiation is required to induce Noxa and apoptosis of human keratinocytes","volume":"130","author":"Nys","year":"2010","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0185","doi-asserted-by":"crossref","first-page":"16413","DOI":"10.1074\/jbc.M611397200","article-title":"Hypoxia-inducible factor-1alpha, a key factor in the keratinocyte response to UVB exposure","volume":"282","author":"Rezvani","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0190","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1083\/jcb.200608070","article-title":"Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa","volume":"176","author":"Naik","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0195","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1136\/jcp.2003.015032","article-title":"The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis","volume":"57","author":"Greijer","year":"2004","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0200","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1038\/sj.onc.1206666","article-title":"BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF","volume":"22","author":"Kothari","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0205","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1084\/jem.20030613","article-title":"BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha","volume":"199","author":"Kim","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0210","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1515\/BC.2006.167","article-title":"Redox regulation of the hypoxia-inducible factor","volume":"387","author":"Pouyssegur","year":"2006","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0215","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1600-0625.2007.00640.x","article-title":"UVB induces a biphasic response of HIF-1alpha in cultured human keratinocytes","volume":"17","author":"Wunderlich","year":"2008","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0220","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.freeradbiomed.2006.07.007","article-title":"Apoptosis signal regulating kinase-1 connects reactive oxygen species to p38 MAPK-induced mitochondrial apoptosis in UVB-irradiated human keratinocytes","volume":"41","author":"Van Laethem","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0225","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.freeradbiomed.2004.12.005","article-title":"Involvement of UVB-induced reactive oxygen species in TGF-beta biosynthesis and activation in keratinocytes","volume":"38","author":"Wang","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0230","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.biochi.2004.06.010","article-title":"NADPH oxidase and cyclooxygenase mediate the ultraviolet B-induced generation of reactive oxygen species and activation of nuclear factor-kappaB in HaCaT human keratinocytes","volume":"86","author":"Beak","year":"2004","journal-title":"Biochimie"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0235","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1096\/fj.04-2285fje","article-title":"Activation of p38 MAPK is required for Bax translocation to mitochondria, cytochrome c release and apoptosis induced by UVB irradiation in human keratinocytes","volume":"18","author":"Van Laethem","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0240","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/S0960-9822(02)01037-0","article-title":"Activation of GCN2 in UV-irradiated cells inhibits translation","volume":"12","author":"Deng","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0245","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1042\/BJ20041164","article-title":"GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiation","volume":"385","author":"Jiang","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0250","doi-asserted-by":"crossref","first-page":"18077","DOI":"10.1074\/jbc.M110164200","article-title":"Ultraviolet light inhibits translation through activation of the unfolded protein response kinase PERK in the lumen of the endoplasmic reticulum","volume":"277","author":"Wu","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0255","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/nar\/gkp1072","article-title":"Hypoxia-inducible factor-1alpha regulates the expression of nucleotide excision repair proteins in keratinocytes","volume":"38","author":"Rezvani","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0260","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s10059-009-0148-2","article-title":"Involvement of HIF-1alpha in UVB-induced epidermal hyperplasia","volume":"28","author":"Cho","year":"2009","journal-title":"Mol. Cells"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0265","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1038\/sj.emboj.7600196","article-title":"HIF-1alpha induces cell cycle arrest by functionally counteracting Myc","volume":"23","author":"Koshiji","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0270","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1083\/jcb.200501067","article-title":"Hypoxia-inducible factor 1{alpha} is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells","volume":"170","author":"Busca","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0275","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1056\/NEJMra052166","article-title":"Melanoma","volume":"355","author":"Miller","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0280","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nature03890","article-title":"BRAFE600-associated senescence-like cell cycle arrest of human naevi","volume":"436","author":"Michaloglou","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0285","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1038\/jid.2010.26","article-title":"Induction of autophagy and inhibition of melanoma growth in vitro and in vivo by hyperactivation of oncogenic BRAF","volume":"130","author":"Maddodi","year":"2010","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0290","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1158\/0008-5472.CAN-07-5867","article-title":"Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development","volume":"68","author":"Cheung","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0295","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1172\/JCI30102","article-title":"Overexpression of Akt converts radial growth melanoma to vertical growth melanoma","volume":"117","author":"Govindarajan","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0300","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/ng1586","article-title":"Use of human tissue to assess the oncogenic activity of melanoma-associated mutations","volume":"37","author":"Chudnovsky","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0305","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ccr.2005.11.005","article-title":"The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformation","volume":"8","author":"Bedogni","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0310","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1158\/0008-5472.CAN-06-3312","article-title":"Mutant V600E BRAF increases hypoxia inducible factor-1alpha expression in melanoma","volume":"67","author":"Kumar","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0315","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1172\/JCI36157","article-title":"Notch1 is an effector of Akt and hypoxia in melanoma development","volume":"118","author":"Bedogni","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0320","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.devcel.2005.09.010","article-title":"Hypoxia requires notch signaling to maintain the undifferentiated cell state","volume":"9","author":"Gustafsson","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0325","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/modpathol.3800526","article-title":"Evidence for differential expression of Notch receptors and their ligands in melanocytic nevi and cutaneous malignant melanoma","volume":"19","author":"Massi","year":"2006","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0330","doi-asserted-by":"crossref","first-page":"5312","DOI":"10.1158\/0008-5472.CAN-08-3767","article-title":"Active Notch1 confers a transformed phenotype to primary human melanocytes","volume":"69","author":"Pinnix","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0335","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/nrc2468","article-title":"Hypoxia, HIF1 and glucose metabolism in the solid tumour","volume":"8","author":"Denko","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0340","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.gde.2009.10.009","article-title":"HIF-1: upstream and downstream of cancer metabolism","volume":"20","author":"Semenza","year":"2010","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0345","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.semcancer.2008.11.010","article-title":"Is Akt the \u201cWarburg kinase\u201d?\u2014Akt-energy metabolism interactions and oncogenesis","volume":"19","author":"Robey","year":"2009","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0350","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0355","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1534-5807(04)00099-1","article-title":"Development by self-digestion: molecular mechanisms and biological functions of autophagy","volume":"6","author":"Levine","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0360","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","article-title":"Regulation mechanisms and signaling pathways of autophagy","volume":"43","author":"He","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0365","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.freeradbiomed.2007.07.001","article-title":"Reactive oxygen species and cellular oxygen sensing","volume":"43","author":"Cash","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0370","doi-asserted-by":"crossref","first-page":"10892","DOI":"10.1074\/jbc.M800102200","article-title":"Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia","volume":"283","author":"Zhang","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0375","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/embor.2009.256","article-title":"Nix is a selective autophagy receptor for mitochondrial clearance","volume":"11","author":"Novak","year":"2010","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0380","doi-asserted-by":"crossref","first-page":"27879","DOI":"10.1074\/jbc.M110.119537","article-title":"Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming","volume":"285","author":"Ding","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0385","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.1158\/1078-0432.CCR-07-5023","article-title":"The double-edged sword of autophagy modulation in cancer","volume":"15","author":"White","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0390","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.bbamcr.2009.01.006","article-title":"Anti- and pro-tumor functions of autophagy","volume":"1793","author":"Morselli","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0395","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ceb.2009.11.015","article-title":"Hypoxia-induced autophagy: cell death or cell survival?","volume":"22","author":"Mazure","year":"2010","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0400","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1128\/MCB.00166-09","article-title":"Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains","volume":"29","author":"Bellot","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0405","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ceb.2009.12.008","article-title":"Role of autophagy in suppression of inflammation and cancer","volume":"22","author":"White","year":"2010","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0410","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1101\/gad.1545107","article-title":"Autophagy suppresses tumor progression by limiting chromosomal instability","volume":"21","author":"Mathew","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0415","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.cell.2009.03.048","article-title":"Autophagy suppresses tumorigenesis through elimination of p62","volume":"137","author":"Mathew","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0420","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/sj.jid.5701074","article-title":"mTOR is activated in the majority of malignant melanomas","volume":"128","author":"Karbowniczek","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0425","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrc1187","article-title":"Targeting HIF-1 for cancer therapy","volume":"3","author":"Semenza","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0430","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ncb1691","article-title":"Direct regulation of TWIST by HIF-1alpha promotes metastasis","volume":"10","author":"Yang","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0435","doi-asserted-by":"crossref","first-page":"10238","DOI":"10.1158\/0008-5472.CAN-06-3197","article-title":"Lysyl oxidase mediates hypoxic control of metastasis","volume":"66","author":"Erler","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0440","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.cell.2009.10.027","article-title":"Matrix crosslinking forces tumor progression by enhancing integrin signaling","volume":"139","author":"Levental","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0445","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0070-2153(06)76007-0","article-title":"Regulation of angiogenesis by hypoxia and hypoxia-inducible factors","volume":"76","author":"Hickey","year":"2006","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0450","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ccr.2008.01.034","article-title":"HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion","volume":"13","author":"Du","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0455","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1128\/MCB.24.7.2875-2889.2004","article-title":"Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance","volume":"24","author":"Erler","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0460","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nature04871","article-title":"Hypoxia signalling in cancer and approaches to enforce tumour regression","volume":"441","author":"Pouyssegur","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0465","first-page":"5830","article-title":"Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases","volume":"59","author":"Zhong","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0470","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/jcb.22214","article-title":"Role of hypoxia in the hallmarks of human cancer","volume":"107","author":"Ruan","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0475","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1053\/j.seminoncol.2007.09.008","article-title":"Management of metastatic melanoma","volume":"34","author":"Tawbi","year":"2007","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0480","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/978-0-387-77574-6_23","article-title":"Treatment of melanoma and nonmelanoma skin cancer","volume":"624","author":"Rass","year":"2008","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0485","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0490","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/onc.2009.320","article-title":"c-Kit mutants require hypoxia-inducible factor 1alpha to transform melanocytes","volume":"29","author":"Monsel","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0495","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jconrel.2006.09.002","article-title":"Suppression of tumor growth by intratumoral injection of short hairpin RNA-expressing plasmid DNA targeting beta-catenin or hypoxia-inducible factor 1alpha","volume":"116","author":"Takahashi","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0500","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/00008390-200310000-00008","article-title":"Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin","volume":"13","author":"Giatromanolaki","year":"2003","journal-title":"Melanoma Res."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0505","doi-asserted-by":"crossref","first-page":"e11772","DOI":"10.1371\/journal.pone.0011772","article-title":"Bcl-2 regulates HIF-1alpha protein stabilization in hypoxic melanoma cells via the molecular chaperone HSP90","volume":"5","author":"Trisciuoglio","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0510","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/CCO.0b013e328331a7a4","article-title":"Targeting the Bcl-2","volume":"21","author":"Patel","year":"2009","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0515","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/00001622-200311000-00003","article-title":"Heat shock protein 90","volume":"15","author":"Neckers","year":"2003","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0520","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2004.06.001","article-title":"Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia","volume":"117","author":"Nakayama","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0525","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1158\/1541-7786.MCR-08-0458","article-title":"The ubiquitin ligase Siah2 and the hypoxia response","volume":"7","author":"Nakayama","year":"2009","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0530","doi-asserted-by":"crossref","first-page":"16713","DOI":"10.1073\/pnas.0804063105","article-title":"The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways","volume":"105","author":"Qi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0535","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1476-4598-8-104","article-title":"Expression and function of hypoxia inducible factor-1 alpha in human melanoma under non-hypoxic conditions","volume":"8","author":"Mills","year":"2009","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0540","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.ejca.2010.01.031","article-title":"Constitutive HIF-1 activity in malignant melanoma","volume":"46","author":"Kuphal","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0545","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3109\/10715761003667554","article-title":"Reactive oxygen species in cancer","volume":"44","author":"Liou","year":"2010","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0550","first-page":"6189","article-title":"Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing","volume":"60","author":"Elson","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0555","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jdermsci.2009.07.005","article-title":"Expression of hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha with progression of keratinocytic neoplasms","volume":"56","author":"Lining","year":"2009","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0560","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1038\/jid.2009.79","article-title":"PTEN: new insights into its regulation and function in skin cancer","volume":"129","author":"Ming","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0565","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jdermsci.2007.05.017","article-title":"Notch signaling: its role in epidermal homeostasis and in the pathogenesis of skin diseases","volume":"49","author":"Okuyama","year":"2008","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0570","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.4161\/cbt.8.21.9921","article-title":"Emerging role of Notch signaling in epidermal differentiation and skin cancer","volume":"8","author":"Panelos","year":"2009","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0575","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1038\/onc.2008.225","article-title":"Notch tumor suppressor function","volume":"27","author":"Dotto","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2011.02.001_bb0580","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/ng1099","article-title":"Notch1 functions as a tumor suppressor in mouse skin","volume":"33","author":"Nicolas","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbcan.2011.02.001_bb0585","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1177\/154411130201300603","article-title":"P21Waf1 control of epithelial cell cycle and cell fate","volume":"13","author":"Weinberg","year":"2002","journal-title":"Crit. Rev. Oral Biol. Med."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X11000047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X11000047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T22:06:47Z","timestamp":1588802807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304419X11000047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":117,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0304419X11000047"],"URL":"https:\/\/doi.org\/10.1016\/j.bbcan.2011.02.001","relation":{},"ISSN":["0304-419X"],"issn-type":[{"value":"0304-419X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}