{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:16:40Z","timestamp":1791422200985,"version":"4.3.3"},"reference-count":322,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"University Grant Commission, New Delhi","award":["42-196\/2013"],"award-info":[{"award-number":["42-196\/2013"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.bbcan.2014.05.002","type":"journal-article","created":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T17:23:13Z","timestamp":1400001793000},"page":"161-179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":99,"title":["Angiogenic factors as potential drug target: Efficacy and limitations of anti-angiogenic therapy"],"prefix":"10.1016","volume":"1846","author":[{"given":"Rajesh N.","family":"Gacche","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan J.","family":"Meshram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbcan.2014.05.002_bb0005","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1096\/fj.01-0421fje","article-title":"In vivo targeting of SF\/HGF and c-met expression via U1snRNA\/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis","volume":"16","author":"Abounader","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0010","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1215\/S1152851705000050","article-title":"Scatter factor\/hepatocyte growth factor in brain tumor growth and angiogenesis","volume":"7","author":"Abounader","year":"2005","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0015","first-page":"209","article-title":"Design and expression of chimeric U1\/ribozyme transgenes","volume":"252","author":"Abounader","year":"2004","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0020","first-page":"2749","article-title":"Placental growth factor is a survival factor for tumor endothelial cells and macrophages","volume":"62","author":"Adini","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0025","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1053\/plac.1999.0524","article-title":"Regulation of placental vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) and soluble Flt-1 by oxygen\u2014a review","volume":"21","author":"Ahmed","year":"2000","journal-title":"Placenta"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0030","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1634\/theoncologist.6-suppl_5-24","article-title":"Vascular endothelial growth factor signalling pathway as an emerging target in hematologic malignancies","volume":"6","author":"Alan","year":"2001","journal-title":"Oncologist"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0035","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1515\/CCLM.2004.230","article-title":"Bone marrow microvascular density and angiogenic growth factors in multiple myeloma","volume":"42","author":"Alexandrakis","year":"2004","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000047855","article-title":"Pericytes: cell biology and pathology","volume":"169","author":"Allt","year":"2001","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0045","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature02871","article-title":"The functions of animal microRNAs","volume":"431","author":"Ambros","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0050","first-page":"540","article-title":"Utility of vascular endothelial growth factor inhibitors in the treatment of ovarian cancer: from concept to application","author":"Amini","year":"2012","journal-title":"J. Oncol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0055","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1101\/gad.1653708","article-title":"Role of platelet-derived growth factors in physiology and medicine","volume":"22","author":"Andrae","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0060","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1161\/01.RES.0000182903.16652.d7","article-title":"Endothelial\/pericyte interactions","volume":"97","author":"Armulik","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0065","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nrm2639","article-title":"Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system","volume":"10","author":"Augustin","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0070","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/nm884","article-title":"Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1","volume":"9","author":"Autiero","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0075","first-page":"5736","article-title":"Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells","volume":"61","author":"Bachelder","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0080","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1161\/01.RES.0000125295.43813.1F","article-title":"Age-related changes in vascular endothelial growth factor dependency and angiopoietin-1-induced plasticity of adult blood vessels","volume":"94","author":"Baffert","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0085","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S1043-2760(02)00010-3","article-title":"Emerging role of endothelin-1 in tumor angiogenesis","volume":"14","author":"Bagnato","year":"2003","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0090","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1042\/CS20020314","article-title":"Gene therapy for ocular angiogenesis","volume":"104","author":"Bainbridge","year":"2003","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0095","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.cell.2010.01.033","article-title":"PlGF blockade does not inhibit angiogenesis during primary tumor growth","volume":"141","author":"Bais","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0100","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2045-824X-3-3","article-title":"Nanotechnology-mediated targeting of tumor angiogenesis","volume":"3","author":"Banerjee","year":"2011","journal-title":"Vasc. Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0105","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0110","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0115","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1056\/NEJMoa1111097","article-title":"Bevacizumab added to neoadjuvant chemotherapy for breast cancer","volume":"366","author":"Bear","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0120","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1158\/1055-9965.EPI-10-0793","article-title":"Genetic variation in VEGF family genes and breast cancer risk: a report from the Shanghai Breast Cancer Genetics Study","volume":"20","author":"Beeghly-Fadiel","year":"2011","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0125","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nrd2792","article-title":"The FGF family: biology, pathophysiology and therapy","volume":"8","author":"Beenken","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0130","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/sj.bjp.0706347","article-title":"Intracellular pathways triggered by the selective FLT-1-agonist placental growth factor in vascular smooth muscle cells exposed to hypoxia","volume":"146","author":"Bellik","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0135","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/10739680600775940","article-title":"VEGF and angiopoietin-1 stimulate different angiogenic phenotypes that combine to enhance functional neovascularization in adult tissue","volume":"13","author":"Benest","year":"2006","journal-title":"Microcirculation"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0140","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrc1093","article-title":"Tumorigenesis and the angiogenic switch","volume":"3","author":"Bergers","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0145","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nrc2442","article-title":"Modes of resistance to anti-angiogenic therapy","volume":"8","author":"Bergers","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0150","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1172\/JCI200317929","article-title":"Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors","volume":"111","author":"Bergers","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0155","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/35074588","article-title":"PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor","volume":"3","author":"Bergsten","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0160","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nrc2540","article-title":"The impact of O2 availability on human cancer","volume":"8","author":"Bertout","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0165","first-page":"115","article-title":"Role of pericytes in vascular morphogenesis","volume":"94","author":"Betsholtz","year":"2005","journal-title":"EXS"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0170","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1161\/01.RES.0000129194.61747.bf","article-title":"Blockage of VEGF-induced angiogenesis by preventing VEGF secretion","volume":"94","author":"Bjorndahl","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0175","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s10456-010-9190-0","article-title":"Placental growth factor neutralising antibodies give limited anti-angiogenic effects in an in vitro organotypic angiogenesis model","volume":"13","author":"Brave","year":"2010","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0180","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1158\/1535-7163.MCT-09-0554","article-title":"A human monoclonal anti-ANG2 antibody leads to broad antitumor activity in combination with VEGF inhibitors and chemotherapy agents in preclinical models","volume":"9","author":"Brown","year":"2010","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0185","doi-asserted-by":"crossref","first-page":"7283","DOI":"10.1158\/0008-5472.CAN-09-4125","article-title":"Enhancing tumor cell viability and angiogenesis angiopoietin-4 promotes glioblastoma progression by enhancing tumor cell viability and angiogenesis","volume":"70","author":"Brunckhorst","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0190","doi-asserted-by":"crossref","first-page":"7871","DOI":"10.1158\/1078-0432.CCR-08-0593","article-title":"VEGF as a marker for outcome among advanced breast cancer patients receiving anti-VEGF therapy with bevacizumab and vinorelbine chemotherapy","volume":"14","author":"Burstein","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0195","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1074\/jbc.M507401200","article-title":"Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1","volume":"281","author":"Cai","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0200","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.bbrc.2003.08.086","article-title":"Single chain Fv antibody against angiopoietin-2 inhibits VEGF-induced endothelial cell proliferation and migration in vitro","volume":"309","author":"Cai","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0205","doi-asserted-by":"crossref","first-page":"7443","DOI":"10.1073\/pnas.131200498","article-title":"Neutralizing monoclonal antibodies to hepatocyte growth factor\/scatter factor (HGF\/SF) display antitumor activity in animal models","volume":"98","author":"Cao","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0210","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s00109-008-0337-z","article-title":"Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways","volume":"86","author":"Cao","year":"2008","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0215","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1158\/0008-5472.CAN-11-4058","article-title":"VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression","volume":"72","author":"Cao","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0220","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.259re1","article-title":"Positive and negative modulation of angiogenesis by VEGFR1 ligands","volume":"2","author":"Cao","year":"2009","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0225","doi-asserted-by":"crossref","first-page":"26516","DOI":"10.1074\/jbc.M100282200","article-title":"Direct cell adhesion to the angiopoietins mediated by integrins","volume":"276","author":"Carlson","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0230","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/35025220","article-title":"Angiogenesis in cancer and other diseases","volume":"407","author":"Carmeliet","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0235","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0240","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/87904","article-title":"Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions","volume":"7","author":"Carmeliet","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0250","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nature04478","article-title":"Angiogenesis in life, disease and medicine","volume":"438","author":"Carmeliet","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0255","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10456-010-9163-3","article-title":"Vascular endothelial growth factor and its relationship to the prognosis and treatment of breast, ovarian, and cervical cancer","volume":"13","author":"Carpini","year":"2010","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0260","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1200\/JCO.2011.38.7621","article-title":"Targeting the angiopoietin\/Tie2 pathway: cutting tumor vessels with a double-edged sword?","volume":"30","author":"Cascone","year":"2012","journal-title":"J. Clin. Oncol."},{"issue":"1842","key":"10.1016\/j.bbcan.2014.05.002_bb0265","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.bbadis.2014.01.011","article-title":"Thromboxane synthase expression and correlation with VEGF and angiogenesis in non-small cell lung cancer","author":"Cathcart","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0270","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1182\/blood-2005-11-026823","article-title":"Enhanced natural-killer cell and erythropoietic activities in VEGF-A-overexpressing mice delay F-MuLV-induced erythroleukemia","volume":"109","author":"Cervi","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0275","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1158\/0008-5472.CAN-08-4289","article-title":"Catecholamines regulate tumor angiogenesis","volume":"69","author":"Chakroborty","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0280","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1158\/1078-0432.CCR-04-0059","article-title":"Depleted dopamine in gastric cancer tissues: dopamine treatment retards growth of gastric cancer by inhibiting angiogenesis","volume":"10","author":"Chakroborty","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0285","doi-asserted-by":"crossref","first-page":"4537","DOI":"10.1158\/0008-5472.CAN-08-4539","article-title":"VEGF-A induces angiogenesis by perturbing the cathepsin\u2013cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation","volume":"69","author":"Chang","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0290","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1021\/nn901465h","article-title":"Shape effect of carbon nanovectors on angiogenesis","volume":"4","author":"Chaudhuri","year":"2010","journal-title":"ACS Nano"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0295","doi-asserted-by":"crossref","first-page":"4869","DOI":"10.1158\/0008-5472.CAN-06-3381","article-title":"Enhanced hepatocyte growth factor signalling by type II transforming growth factor-beta receptor knockout fibroblasts promotes mammary tumorigenesis","volume":"67","author":"Cheng","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0300","doi-asserted-by":"crossref","first-page":"10382","DOI":"10.1074\/jbc.M313237200","article-title":"The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1","volume":"279","author":"Christinger","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0305","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1007\/s11605-007-0459-6","article-title":"Liver regeneration and tumor stimulation\u2014A review of cytokine and angiogenic factors","volume":"12","author":"Christophi","year":"2008","journal-title":"J. Gastrointest. Surg."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0310","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11060-007-9387-2","article-title":"Hepatocyte growth factor production is stimulated by gangliosides and TGF-beta isoforms in human glioma cells","volume":"85","author":"Chu","year":"2007","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0315","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.2353\/ajpath.2006.051314","article-title":"Placenta growth factor in diabetic wound healing altered expression and therapeutic potential","volume":"169","author":"Cianfarani","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0320","first-page":"253","article-title":"Understanding and targeting resistance to anti-angiogenic therapies","volume":"4","author":"Clarke","year":"2013","journal-title":"J. Gastrointest. Oncol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0325","first-page":"7163","article-title":"Fibroblast growth factors are required for efficient tumor angiogenesis","volume":"60","author":"Compagni","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0330","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jss.2004.06.010","article-title":"HIV-based vectors and angiogenesis following rabbit hind limb ischemia","volume":"123","author":"Conklin","year":"2005","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0335","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1023\/A:1024515517623","article-title":"Angiogenesis in psoriasis","volume":"5","author":"Creamer","year":"2002","journal-title":"Angiogenesis"},{"issue":"4","key":"10.1016\/j.bbcan.2014.05.002_bb0340","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.cell.2014.01.043","article-title":"Glycosylation-dependent lectin\u2013receptor interactions preserve angiogenesis in anti-VEGF refractory tumors","volume":"13","author":"Croci","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0345","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nrg2634","article-title":"Causes and consequences of microRNA dysregulation in cancer","volume":"10","author":"Croce","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0350","doi-asserted-by":"crossref","first-page":"15491","DOI":"10.1073\/pnas.0607538103","article-title":"Angiopietin-2 functions as an autocrine protective factor in stressed endothelial cells","volume":"103","author":"Daly","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0355","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1158\/0008-5472.CAN-09-3675","article-title":"Vascular endothelial growth factor-C induces lymphangitic carcinomatosis, an extremely aggressive form of lung metastases","volume":"70","author":"Das","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0360","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrd2614","article-title":"Nanoparticle therapeutics: an emerging treatment modality for cancer","volume":"7","author":"Davis","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0365","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S0092-8674(00)81812-7","article-title":"Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning","volume":"87","author":"Davis","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0370","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.gde.2010.10.008","article-title":"Vessel abnormalization: another hallmark of cancer? Molecular mechanisms and therapeutic implications","volume":"21","author":"De Bock","year":"2011","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0375","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3858\/emm.2012.44.1.025","article-title":"The discovery of placenta growth factor and its biological activity","volume":"44","author":"De Falco","year":"2012","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0380","doi-asserted-by":"crossref","first-page":"5226","DOI":"10.1158\/1078-0432.CCR-10-0171","article-title":"Angiopoietin-2 TIEs up macrophages in tumor angiogenesis","volume":"17","author":"De Palma","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0385","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10456-009-9152-6","article-title":"Influence of the oxygen microenvironment on the proangiogenic potential of human endothelial colony forming cells","volume":"12","author":"Decaris","year":"2009","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0390","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1182\/blood-2010-02-270819","article-title":"Identification and functional analysis of endothelial tip cell-enriched genes","volume":"116","author":"Del Toro","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0395","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1038\/sj.onc.1204368","article-title":"Paracrine and autocrine effects of fibroblast growth factor-4 in endothelial cells","volume":"20","author":"Dell'Era","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0400","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/1933719110389337","article-title":"Molecular regulation of human placental growth factor (PlGF) gene expression in placental villi and trophoblast cells is mediated via the protein kinase A pathway","volume":"18","author":"Depoix","year":"2011","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0405","doi-asserted-by":"crossref","first-page":"(a011056)","DOI":"10.1101\/cshperspect.a011056","article-title":"PlGF: a multitasking cytokine with disease-restricted activity","volume":"2","author":"Dewerchin","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0410","doi-asserted-by":"crossref","first-page":"4816","DOI":"10.1182\/blood-2002-06-1731","article-title":"HGF receptor up-regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro","volume":"101","author":"Ding","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0415","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2010.07.015","article-title":"Vascular endothelial growth factor signaling implicated in neuroprotective effects of placental growth factor in an in vitro ischemic model","volume":"1357","author":"Du","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0420","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1016\/j.febslet.2006.01.095","article-title":"Fibroblast growth factor signaling in embryonic and cancer stem cells","volume":"580","author":"Dvorak","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0425","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ccr.2009.01.021","article-title":"Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis","volume":"15","author":"Ebos","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0430","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nrclinonc.2011.21","article-title":"Antiangiogenic therapy: impact on invasion, disease progression, and metastasis","volume":"8","author":"Ebos","year":"2011","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0435","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1093\/emboj\/cdf418","article-title":"Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy","volume":"21","author":"Enge","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0440","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1096\/fj.03-0271fje","article-title":"Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms","volume":"18","author":"Erber","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0445","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1535-6108(02)00028-4","article-title":"Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1\/VEGF heterodimers","volume":"1","author":"Eriksson","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0450","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/nature04695","article-title":"Lysyl oxidase is essential for hypoxia-induced metastasis","volume":"440","author":"Erler","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0455","first-page":"2145","article-title":"Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases","volume":"61","author":"Etoh","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0460","doi-asserted-by":"crossref","first-page":"5717","DOI":"10.1158\/0008-5472.CAN-10-4635","article-title":"Angiopoietin-1 and -2 exert antagonistic functions in tumor angiogenesis, yet both induce lymphangiogenesis","volume":"71","author":"Fagiani","year":"2011","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.bbcan.2014.05.002_bb0465","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1016\/j.ajpath.2011.02.019","article-title":"Increased vascular delivery and efficacy of chemotherapy after inhibition of platelet-derived growth factor-B","volume":"178","author":"Falcon","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0470","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.2353\/ajpath.2009.090391","article-title":"Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels","volume":"175","author":"Falc\u00f3n","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0475","doi-asserted-by":"crossref","first-page":"281261","DOI":"10.1155\/2012\/281261","article-title":"Targeting the tumor microenvironment: focus on angiogenesis","volume":"2012","author":"Fan","year":"2012","journal-title":"J. Oncol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0480","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1172\/JCI58832","article-title":"Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signalling","volume":"122","author":"Felcht","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0485","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/70928","article-title":"Clinical applications of angiogenic growth factors and their inhibitors","volume":"5","author":"Ferrara","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0490","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/380439a0","article-title":"Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene","volume":"380","author":"Ferrara","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0495","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nm0603-669","article-title":"The biology of VEGF and its receptors","volume":"9","author":"Ferrara","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0500","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/0006-291X(89)92678-8","article-title":"Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells","volume":"161","author":"Ferrara","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0505","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrd1381","article-title":"Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer","volume":"3","author":"Ferrara","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0510","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cytogfr.2009.11.003","article-title":"Pathways mediating VEGF-independent tumor angiogenesis","volume":"21","author":"Ferrara","year":"2010","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0515","first-page":"209","article-title":"The role of VEGF in the regulation of physiological and pathological angiogenesis","volume":"94","author":"Ferrara","year":"2005","journal-title":"EXS"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0520","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1210\/er.2003-0027","article-title":"Vascular endothelial growth factor: basic science and clinical progress","volume":"25","author":"Ferrara","year":"2004","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0525","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.cell.2007.08.038","article-title":"Anti-PlGF inhibits growth of VEGF(R)- inhibitor-resistant tumors without affecting healthy vessels","volume":"131","author":"Fischer","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0530","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nm0195-27","article-title":"Angiogenesis in cancer, vascular, rheumatoid and other disease","volume":"1","author":"Folkman","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0535","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1056\/NEJM197111182852108","article-title":"Tumor angiogenesis: therapeutic implications","volume":"285","author":"Folkman","year":"1971","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0540","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.med.57.121304.131306","article-title":"Angiogenesis","volume":"57","author":"Folkman","year":"2006","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0545","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1053\/sonc.2002.37263","article-title":"Role of angiogenesis in tumor growth and metastasis","volume":"29","author":"Folkman","year":"2002","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0550","first-page":"3007","article-title":"Paclitaxel and Bevacizumab as first line combined treatment in patients with metastatic breast cancer, the Hellenic Cooperative Oncology Group experience with biological marker evaluation","volume":"31","author":"Fountzilas","year":"2011","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0555","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cytogfr.2004.03.007","article-title":"The PDGF family: four gene products form five dimeric isoforms","volume":"15","author":"Frederiksson","year":"2004","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0560","doi-asserted-by":"crossref","first-page":"P278","DOI":"10.1186\/1546-0096-9-S1-P278","article-title":"Differential expression of transcription factors predicted to regulate angiopoietin-1 and -2 genes is associated with specific angiopoietin signatures in RA and PsA synovial tissue","volume":"9","author":"Frleta","year":"2011","journal-title":"Pediatr. Rheumatol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0565","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nbt.1845","article-title":"Fibroblast growth factor 9 delivery during angiogenesis produces durable, vasoresponsive microvessels wrapped by smooth muscle cells","volume":"29","author":"Frontini","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0570","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbiomolbio.2013.10.001","article-title":"Targeting tumor micro-environment for design and development of novel anti-angiogenic agents arresting tumor growth","author":"Gacche","year":"2013","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0575","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejps.2009.10.008","article-title":"Effect of hydroxyl substitution of flavone on antiangiogenic and free radical scavenging activities: a structure activity relationship studies using computational tools","volume":"39","author":"Gacche","year":"2010","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0580","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s12013-011-9251-z","article-title":"Evaluation of selected flavonoids as antiangiogenic, anticancer and radical scavenging agents, an experimental and in silico analysis","volume":"61","author":"Gacche","year":"2011","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0585","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1126\/science.1150224","article-title":"Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis","volume":"319","author":"Gao","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0590","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.febslet.2008.11.032","article-title":"Breaking the VE-cadherin bonds","volume":"583","author":"Gavard","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0595","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1515\/BC.2009.144","article-title":"Chemokines in tumor-associated angiogenesis","volume":"390","author":"Gerber","year":"2009","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0600","doi-asserted-by":"crossref","first-page":"25698","DOI":"10.1074\/jbc.M702942200","article-title":"Site-directed mutagenesis in the B-neuropilin-2 domain selectively enhances its affinity to VEGF165, but not to semaphorin 3F","volume":"282","author":"Geretti","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0605","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1158\/1541-7786.MCR-10-0157","article-title":"A mutated soluble neuropilin-2 B domain antagonizes vascular endothelial growth factor bioactivity and inhibits tumor progression","volume":"8","author":"Geretti","year":"2010","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0610","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10456-004-4179-1","article-title":"Placenta growth factor is not required for exercise-induced angiogenesis","volume":"7","author":"Gigante","year":"2004","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0615","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/2040-2384-2-20","article-title":"Nano to micro delivery systems: targeting angiogenesis in brain tumors","volume":"2","author":"Gilert","year":"2010","journal-title":"J. Angiogenes. Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0620","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1152\/physrev.00038.2010","article-title":"Normalization of the vasculature for treatment of cancer and other diseases","volume":"91","author":"Goel","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0625","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/nature07424","article-title":"A role for VEGF as a negative regulator of pericyte function and vessel maturation","volume":"456","author":"Greenberg","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0630","first-page":"111","article-title":"Tumor angiogenesis: transfilter diffusion studies in the hamster by the transparant chamber technique","volume":"41","author":"Greenblatt","year":"1968","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0635","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1158\/1078-0432.CCR-12-0002","article-title":"Rapid angiogenesis onset after discontinuation of sunitinib treatment of renal cell carcinoma patients","volume":"18","author":"Griffioen","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0640","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.bbapap.2009.09.002","article-title":"Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signalling","volume":"1804","author":"Grunewald","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0645","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1136\/pgmj.2004.023309","article-title":"Angiogenesis: a curse or cure?","volume":"81","author":"Gupta","year":"2005","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0650","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0092-8674(00)80108-7","article-title":"Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis","volume":"86","author":"Hanahan","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0655","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0660","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10456-009-9154-4","article-title":"Nanoparticle-mediated targeting of phosphatidylinositol-3-kinase signaling inhibits angiogenesis","volume":"12","author":"Harfouche","year":"2009","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0665","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1158\/0008-5472.CAN-09-1977","article-title":"Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth","volume":"70","author":"Hashizume","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0670","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nm740","article-title":"Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment","volume":"8","author":"Hattori","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0675","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/S0002-9440(10)62565-5","article-title":"Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth","volume":"160","author":"Hawighorst","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0680","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1054\/bjoc.2000.1437","article-title":"Expression and function of angiopoietin-1 in breast cancer","volume":"83","author":"Hayes","year":"2000","journal-title":"Br. J. Cancer"},{"issue":"5","key":"10.1016\/j.bbcan.2014.05.002_bb0685","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/path.4324","article-title":"MicroRNA-542-3p inhibits tumour angiogenesis by targeting Angiopoietin-2","volume":"232","author":"He","year":"2014","journal-title":"J. Pathol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0690","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1006\/abbi.2001.2707","article-title":"New members of the platelet-derived growth factor family of mitogens","volume":"398","author":"Heldin","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0695","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1084\/jem.20091846","article-title":"Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma","volume":"207","author":"Helfrich","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0700","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1161\/01.ATV.0000233387.90257.9b","article-title":"Angiogenesis in atherogenesis","volume":"26","author":"Herrmann","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0705","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1158\/0008-5472.CAN-08-4654","article-title":"Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment","volume":"69","author":"Holopainen","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0710","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/jnci\/djs009","article-title":"Effects of angiopoietin-2-blocking antibody on endothelial cell\u2013cell junctions and lung metastasis","volume":"104","author":"Holopainen","year":"2012","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0715","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1172\/JCI43304","article-title":"HGF upregulation contributes to angiogenesis in mice with keratinocyte-specific Smad2 deletion","volume":"120","author":"Hoot","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0720","doi-asserted-by":"crossref","first-page":"323","DOI":"10.4155\/tde.10.13","article-title":"Nanoparticle-assisted combination therapies for effective cancer treatment","volume":"1","author":"Hu","year":"2010","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0725","first-page":"79","article-title":"Angiopoietin-1\/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade","volume":"34","author":"Huang","year":"2009","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0730","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1111\/j.1541-0420.2011.01603.x","article-title":"Comparing biomarkers as principal surrogate endpoints","volume":"67","author":"Huang","year":"2011","journal-title":"Biometrics"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0735","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1056\/NEJMoa032691","article-title":"Bevacizumab plus Irinotecan, Flouorouracil and Leucovorin for metastatic colorectal cancer","volume":"350","author":"Hurwitz","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0740","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1634\/theoncologist.2012-0339","article-title":"Analysis of early hypertension and clinical outcome with bevacizumab: results from seven phase III studies","volume":"18","author":"Hurwitz","year":"2013","journal-title":"Oncologist"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0745","first-page":"353","article-title":"Targeting angiogenesis in cancer therapy","volume":"65","author":"Ichihara","year":"2011","journal-title":"Acta Med. Okyama"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0750","doi-asserted-by":"crossref","first-page":"23779","DOI":"10.1074\/jbc.M110.130658","article-title":"Structural insights into the binding of vascular endothelial growth factor-B by VEGFR-1(D2): recognition and specificity","volume":"285","author":"Iyer","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0755","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.1104819","article-title":"Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy","volume":"307","author":"Jain","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0760","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrclinonc.2009.63","article-title":"Biomarkers of response and resistance to antiangiogenic therapy","volume":"6","author":"Jain","year":"2009","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0765","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3390\/cancers4020400","article-title":"The dynamics of developmental and tumor angiogenesis\u2014A comparison","volume":"4","author":"Jin","year":"2012","journal-title":"Cancers"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0770","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/S1470-2045(10)70232-1","article-title":"Biomarkers to predict the clinical efficacy of Bevacizumab in cancer","volume":"11","author":"Jubb","year":"2010","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0775","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1200\/JCO.2005.01.5388","article-title":"Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizumab in metastatic colorectal cancer","volume":"24","author":"Jubb","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0780","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1038\/sj.bjc.6605368","article-title":"Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer","volume":"101","author":"Jubb","year":"2009","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0785","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","article-title":"Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway","volume":"30","author":"Kaelin","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0790","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1038\/sj.bjc.6603813","article-title":"Mechanisms of adverse effects of anti-VEGF therapy for cancer","volume":"96","author":"Kamba","year":"2007","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0795","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1182\/blood-2009-01-197095","article-title":"alphaB-crystallin regulation of angiogenesis by modulation of VEGF","volume":"115","author":"Kase","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0800","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1530\/REP-11-0277","article-title":"Fibroblast growth factor 2 is a key determinant of vascular sprouting during bovine luteal angiogenesis","volume":"143","author":"Kathryn","year":"2012","journal-title":"Reproduction"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0805","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1023\/A:1013172910858","article-title":"Possible mechanisms of acquired resistance to anti-angiogenic drugs: implications for the use of combination therapy approaches","volume":"20","author":"Kerbel","year":"2001","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0810","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/carcin\/21.3.505","article-title":"Tumor angiogenesis: past, present and near future","volume":"21","author":"Kerbel","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0815","doi-asserted-by":"crossref","first-page":"7342","DOI":"10.1158\/0008-5472.CAN-07-6241","article-title":"Flt-1 signaling in macrophages promotes glioma growth in vivo","volume":"68","author":"Kerber","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0820","first-page":"151","article-title":"Hypoxia down-regulates placenta growth factor, whereas fetal growth restriction up-regulates placenta growth factor expression: molecular evidence for \u201cplacental hyperoxia\u201d in intrauterine growth restriction","volume":"79","author":"Khaliq","year":"1999","journal-title":"Lab. Invest."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0825","doi-asserted-by":"crossref","first-page":"a006593","DOI":"10.1101\/cshperspect.a006593","article-title":"The VEGF pathway in cancer and disease: responses, resistance, and the path forward","volume":"2","author":"Kieran","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0830","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1479-5876-9-104","article-title":"Fibroblast growth factor 2 orchestrates angiogenic networking in non-GIST STS patients","volume":"9","author":"Kilvaer","year":"2011","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0835","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0014-5793(99)00008-3","article-title":"Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3","volume":"443","author":"Kim","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0840","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3858\/emm.2012.44.1.023","article-title":"Role of placenta growth factor in cancer and inflammation","volume":"44","author":"Kim","year":"2012","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0845","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-1-4615-0119-0_3","article-title":"The role of neuropilin in vascular and tumor biology","volume":"515","author":"Klagsbrun","year":"2002","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0850","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ccr.2010.07.001","article-title":"Double antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakage","volume":"18","author":"Koh","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0855","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1200\/JCO.2009.24.8252","article-title":"Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistance","volume":"28","author":"Kopetz","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0860","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.molcel.2011.06.020","article-title":"FGF-2 regulates cell proliferation, migration and angiogenesis through an NDY1\/KDM2B-miR-101-EZH2 pathway","volume":"43","author":"Kottakis","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0865","doi-asserted-by":"crossref","first-page":"e17462","DOI":"10.1371\/journal.pone.0017462","article-title":"Placental growth factor contributes to micro-vascular abnormalization and blood-retinal barrier breakdown in diabetic retinopathy","volume":"6","author":"Kowalczuk","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0870","doi-asserted-by":"crossref","first-page":"8868","DOI":"10.1073\/pnas.062040199","article-title":"Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea","volume":"99","author":"Kubo","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0875","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2302\/kjm.61.47","article-title":"Tumor angiogenesis and anti-angiogenic therapy","volume":"61","author":"Kubota","year":"2012","journal-title":"Keio J. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0880","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s10456-011-9221-5","article-title":"VEGF-C differentially regulates VEGF-A expression in ocular and cancer cells; promotes angiogenesis via RhoA mediated pathway","volume":"14","author":"Kumar","year":"2011","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0885","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s10456-011-9232-2","article-title":"Bevacizumab in the treatment of high-grade gliomas: an overview","volume":"14","author":"Kunnakkat","year":"2011","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0890","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1200\/JCO.2012.46.2762","article-title":"Markers of response for the antiangiogenic agent bevacizumab","volume":"31","author":"Lambrechts","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0895","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/cvr\/cvn258","article-title":"Platelet-derived growth factor BB stimulates vasculogenesis of embryonic cell-derives endothelial cells by calcium mediated generation of reactive oxygen species","volume":"81","author":"Lange","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0900","doi-asserted-by":"crossref","first-page":"981","DOI":"10.2353\/ajpath.2010.080998","article-title":"Platelet-derived growth factor-B normalizes micromorphology and vessel function in vascular endothelial growth factor-A-induced squamous cell carcinomas","volume":"176","author":"Lederle","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0905","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1096\/fj.03-1466com","article-title":"Biological characterization of angiopoietin-3 and angiopoietin-4","volume":"18","author":"Lee","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0910","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/sj.bjc.6601611","article-title":"Tumour-derived TGF-beta1 modulates myofibroblast differentiation and promotes HGF\/SF-dependent invasion of squamous carcinoma cells","volume":"90","author":"Lewis","year":"2004","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0915","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.mvr.2004.06.002","article-title":"Angiogenic synergy of bFGF and VEGF is antagonized by angiopoietin-2 in a modified in vivo Matrigel assay","volume":"68","author":"Ley","year":"2004","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0920","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1096\/fj.05-5137fje","article-title":"VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization","volume":"20","author":"Li","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0925","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1038\/sj.onc.1206223","article-title":"PDGF-D is a potent transforming and angiogenic growth factor","volume":"22","author":"Li","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0930","doi-asserted-by":"crossref","first-page":"879623","DOI":"10.1155\/2012\/879623","article-title":"Tumor angiogenesis as a target for dietary cancer prevention","volume":"2012","author":"Li","year":"2012","journal-title":"J. Oncol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0935","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/35010579","article-title":"PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor","volume":"2","author":"Li","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0940","first-page":"3433","article-title":"Diagnostic value of 16 cellular tumor markers for metastatic thyroid cancer, an immunohistochemical study","volume":"31","author":"Liang","year":"2011","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0945","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0006-2952(00)00529-3","article-title":"Angiogenesis: regulators and clinical applications","volume":"61","author":"Liekens","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0950","doi-asserted-by":"crossref","first-page":"6130","DOI":"10.1158\/1078-0432.CCR-11-0659","article-title":"Beyond VEGF: inhibition of the fibroblast growth factor pathway and antiangiogenesis","volume":"17","author":"Lieu","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0955","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.cyto.2005.09.009","article-title":"Upregulation of neuropilin-1 by basic fibroblast growth factor enhances vascular smooth muscle cell migration in response to VEGF","volume":"32","author":"Liu","year":"2005","journal-title":"Cytokine"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0960","doi-asserted-by":"crossref","first-page":"4152","DOI":"10.1016\/S0021-9258(17)41756-X","article-title":"Structural and functional characterization of the mouse hepatocyte growth factor gene promoter","volume":"269","author":"Liu","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0965","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ccr.2010.06.016","article-title":"Regulation of tumor angiogenesis by EZH2","volume":"18","author":"Lu","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0970","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0006-291X(02)00677-0","article-title":"Loss of placental growth factor protects mice against vascular permeability in pathological conditions","volume":"295","author":"Luttun","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0975","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.ecl.2010.08.006","article-title":"The role of angiogenesis in neuroendocrine tumors","volume":"39","author":"Lyons","year":"2010","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0980","first-page":"925","article-title":"Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14","volume":"8","author":"Maglione","year":"1993","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0985","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1161\/01.ATV.0000282198.60701.94","article-title":"Platelet derived growth factor receptor-beta constitutive activity promotes angiogenesis in vivo and in vitro","volume":"27","author":"Magnusson","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb0990","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.277.5322.55","article-title":"Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis","volume":"277","author":"Maisonpierre","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.bbcan.2014.05.002_bb0995","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1155\/MI.2005.293","article-title":"Vascular endothelial growth factor and placenta growth factor in intrauterine growth-restricted fetuses and neonates","volume":"5","author":"Malamitsi-Puchner","year":"2005","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.bbcan.2014.05.002_bb1000","doi-asserted-by":"crossref","first-page":"24818","DOI":"10.1074\/jbc.M200730200","article-title":"Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain","volume":"277","author":"Mamluk","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2014.05.002_bb1005","doi-asserted-by":"crossref","first-page":"643","DOI":"10.2353\/ajpath.2006.051041","article-title":"Increased melanoma growth and metastasis spreading in mice over expressing placenta growth factor","volume":"169","author":"Marcellini","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb1010","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.clinthera.2011.08.007","article-title":"Monoclonal antibody TB-403: a first-in-human, Phase I, double-blind, dose escalation study directed against placental growth factor in healthy male subjects","volume":"33","author":"Martinsson-Niskanen","year":"2011","journal-title":"Clin. Ther."},{"key":"10.1016\/j.bbcan.2014.05.002_bb1015","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.ccr.2011.02.005","article-title":"Targeting the ANG2\/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells","volume":"19","author":"Mazzieri","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb1020","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006577","article-title":"Anti-VEGF therapies in the clinic","volume":"2","author":"Meadows","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb1025","first-page":"233","article-title":"Neuropilin-1 mediates collapsin-1\/semaphoring III inhibition of endothelial cell motility: functional competition of collapsin-1 and vascular endothelial growth factor-165","volume":"146","author":"Miao","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb1030","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/ijc.25389","article-title":"Emergence of potential biomarkers of response to anti-angiogenic anti-tumour agents","volume":"127","author":"Michael","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbcan.2014.05.002_bb1035","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ccr.2004.05.032","article-title":"Targeting the tumor and its microenvironment by a dual-function decoy Met receptor","volume":"6","author":"Michieli","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb1040","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1200\/JCO.2010.30.2794","article-title":"Disease course patterns after discontinuation of bevacizumab: pooled analysis of randomized phase III trials","volume":"29","author":"Miles","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb1045","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3390\/cancers2010190","article-title":"Cancer biomarkers: are we ready for the prime time?","volume":"2","author":"Mishra","year":"2010","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbcan.2014.05.002_bb1050","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.stem.2010.07.007","article-title":"Oxygen in stem cell biology: a critical component of the stem cell niche","volume":"7","author":"Mohyeldin","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb1055","doi-asserted-by":"crossref","first-page":"8211","DOI":"10.1158\/0008-5472.CAN-10-0202","article-title":"Vascular endothelial growth factor receptor-1 signaling promotes mobilization of macrophage lineage cells from bone marrow and stimulates solid tumor growth","volume":"70","author":"Muramatsu","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb1060","first-page":"a006544","article-title":"Vascular hyperpermeability, angiogenesis, and stroma generation","volume":"4","author":"Nagy","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb1065","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1158\/0008-5472.CAN-08-3030","article-title":"Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth","volume":"69","author":"Nasarre","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb1070","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s10555-006-9011-5","article-title":"Pro-angiogenic cytokines and their role in tumor angiogenesis","volume":"25","author":"Neufeld","year":"2006","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.bbcan.2014.05.002_bb1075","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.1172\/JCI67752","article-title":"Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis","volume":"123","author":"Nie","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2014.05.002_bb1080","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1172\/JCI32479","article-title":"Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis","volume":"117","author":"Nissen","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2014.05.002_bb1085","doi-asserted-by":"crossref","first-page":"132641","DOI":"10.1155\/2010\/132641","article-title":"Tumor angiogenesis: insights and innovations","volume":"2010","author":"Nussenbaum","year":"2010","journal-title":"J. Oncol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb1090","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1158\/0008-5472.CAN-04-2427","article-title":"Endogenous inhibitors of angiogenesis","volume":"65","author":"Nyberg","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb1095","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1242\/jcs.115.12.2559","article-title":"Mice overexpressing placenta growth factor exhibit increased vascularisation and vessel permeability","volume":"115","author":"Odorisio","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbcan.2014.05.002_bb2000","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.jvir.2010.08.009","article-title":"Angiogenesis and current antiangiogenic strategies for the treatment of cancer","volume":"21","author":"Oklu","year":"2010","journal-title":"J. Vasc. Interv. Radiol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb2005","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.ejca.2008.03.006","article-title":"Prognostic versus predictive value of biomarkers in oncology","volume":"44","author":"Oldenhuis","year":"2008","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.bbcan.2014.05.002_bb2010","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.ccr.2004.09.030","article-title":"Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2","volume":"6","author":"Oliner","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb2015","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.2741\/3007","article-title":"The heparanome and regulation of cell function: structures, functions and challenges","volume":"13","author":"Ori","year":"2008","journal-title":"Front. Biosci."},{"key":"10.1016\/j.bbcan.2014.05.002_bb2020","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cytogfr.2004.03.002","article-title":"PDGF receptors\u2014mediators of autocrine tumor growth and regulators of tumor vasculature and stroma","volume":"15","author":"Ostman","year":"2004","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bbcan.2014.05.002_bb2025","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1182\/blood-2002-05-1516","article-title":"A critical role of placental growth factor in the induction of inflammation and edema formation","volume":"101","author":"Oura","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bbcan.2014.05.002_bb2030","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1023\/A:1009229508096","article-title":"Angiogenesis in arthritis: role in disease pathogenesis and as a potential therapeutic target","volume":"2","author":"Paleolog","year":"1998","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbcan.2014.05.002_bb2035","first-page":"11","article-title":"Angiotensin II upregulates the expression of placental growth factor in human vascular endothelial cells and smooth muscle cells","volume":"26","author":"Pan","year":"2010","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb2040","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10456-011-9249-6","article-title":"Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab","volume":"15","author":"Papadopoulos","year":"2012","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbcan.2014.05.002_bb2045","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1182\/blood-2007-12-130567","article-title":"Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1a","volume":"112","author":"Patel","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bbcan.2014.05.002_bb2050","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10456-008-9119-z","article-title":"Circulating and imaging markers for angiogenesis","volume":"11","author":"Pathak","year":"2008","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbcan.2014.05.002_bb2055","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1038\/ncomms3427","article-title":"Tumour angiogenesis regulation by the miR-200 family","volume":"4","author":"Pecot","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2014.05.002_bb2060","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nnano.2007.387","article-title":"Nanocarriers as an emerging platform for cancer therapy","volume":"2","author":"Peer","year":"2007","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb2065","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1535-6108(03)00085-0","article-title":"Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene","volume":"3","author":"Pennacchietti","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb2070","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/0006-291X(92)92277-5","article-title":"Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro","volume":"189","author":"Pepper","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbcan.2014.05.002_bb2075","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1158\/1078-0432.CCR-06-0818","article-title":"Targeting the c-Met signaling pathway in cancer","volume":"12","author":"Peruzzi","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb2080","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1161\/01.RES.0000057997.77714.72","article-title":"VEGFR-1-selective VEGF homologue PlGF is arteriogenic: evidence for a monocytemediated mechanism","volume":"92","author":"Pipp","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb2085","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1074\/jbc.270.2.830","article-title":"Characterization of the scatter factor\/hepatocyte growth factor gene promoter. Positive and negative regulatory elements direct gene expression to mesenchymal cells","volume":"270","author":"Plaschke-Schl\u00fctter","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2014.05.002_bb2090","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.placenta.2014.02.002","article-title":"The interplay of human chorionic gonadotropin (hCG) with basic fibroblast growth factor and adipokines on angiogenesis in vitro","volume":"35","author":"Polec","year":"2014","journal-title":"Placenta"},{"key":"10.1016\/j.bbcan.2014.05.002_bb2095","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2011.08.039","article-title":"Basic and therapeutic aspects of angiogenesis","volume":"146","author":"Potente","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb3000","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cytogfr.2005.01.004","article-title":"Fibroblast growth factor\/fibroblast growth factor receptor system in angiogenesis","volume":"16","author":"Presta","year":"2005","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bbcan.2014.05.002_bb3005","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ccr.2009.01.027","article-title":"Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis","volume":"15","author":"P\u00e0ez-Ribes","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb3010","doi-asserted-by":"crossref","first-page":"572","DOI":"10.3390\/ph3030572","article-title":"Platelet-derived growth factor (PDGF)\/PDGF receptors (PDGFR) axis as target for antitumor and antiangiogenic therapy","volume":"3","author":"Raica","year":"2010","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bbcan.2014.05.002_bb3015","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1158\/1541-7786.MCR-10-0598","article-title":"Cells by suppression of SAF-1 transcription factor activity control of VEGF expression in triple-negative breast carcinoma","volume":"9","author":"Ray","year":"2011","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb3020","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1242\/jcs.00237","article-title":"Increased Sp1 phosphorylation as a mechanism of hepatocyte growth factor (HGF\/SF)-induced vascular endothelial growth factor (VEGF\/VPF) transcription","volume":"116","author":"Reisinger","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbcan.2014.05.002_bb3025","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1124\/pr.59.2.3","article-title":"Nonclassic endogenous novel regulators of angiogenesis","volume":"59","author":"Ribatti","year":"2007","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbcan.2014.05.002_bb3030","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10456-008-9114-4","article-title":"The discovery of the placental growth factor and its role in angiogenesis: a historical review","volume":"11","author":"Ribatti","year":"2008","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbcan.2014.05.002_bb3035","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0306-3623(01)00112-4","article-title":"The discovery of angiogenic factors: a historical review","volume":"35","author":"Ribattia","year":"2000","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb3040","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/386671a0","article-title":"Mechanisms of angiogenesis","volume":"386","author":"Risau","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2014.05.002_bb3045","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1089\/hum.2005.16.1422","article-title":"Adenovirus-mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via upregulation of the expression of endogenous vascular endothelial growth factor-A","volume":"16","author":"Roy","year":"2005","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.bbcan.2014.05.002_bb3050","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.actbio.2010.08.018","article-title":"Covalently immobilized platelet-derived growth factor-BB promotes angiogenesis in biomimetic poly (ethylene glycol) hydrogels","volume":"7","author":"Saik","year":"2011","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bbcan.2014.05.002_bb3055","first-page":"12","article-title":"Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung","volume":"25","author":"Sands","year":"2011","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb3060","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1158\/1078-0432.CCR-07-1778","article-title":"Dopamine increases the efficacy of anticancer drugs in breast and colon cancer preclinical models","volume":"14","author":"Sarkar","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb3065","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1073\/pnas.0308065101","article-title":"The Shc adaptor protein is critical for VEGF induction by Met\/HGF and ErbB2 receptors and for early onset of tumor angiogenesis","volume":"101","author":"Saucier","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbcan.2014.05.002_bb3070","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1242\/jcs.01653","article-title":"The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism","volume":"118","author":"Scharpfenecker","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbcan.2014.05.002_bb3075","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0022-2828(02)00304-8","article-title":"Bone marrow transplantation abolishes inhibition of arteriogenesis in placenta growth factor (PlGF) \u2212\/\u2212mice","volume":"35","author":"Scholz","year":"2003","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb3080","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1096\/fj.11-182287","article-title":"Angiopoietin-2 drives lymphatic metastasis of pancreatic cancer","volume":"25","author":"Schulz","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.bbcan.2014.05.002_bb3085","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1182\/blood-2002-11-3423","article-title":"Mechanism of monocyte activation and expression of proinflammatory cytochemokines by placenta growth factor","volume":"102","author":"Selvaraj","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bbcan.2014.05.002_bb3090","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1126\/science.6823562","article-title":"Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid","volume":"219","author":"Senger","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.bbcan.2014.05.002_bb3095","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/nature03794","article-title":"Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system","volume":"436","author":"Sengupta","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2014.05.002_bb4000","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1161\/01.ATV.0000048701.86621.D0","article-title":"Hepatocyte growth factor\/scatter factor can induce angiogenesis independently of vascular endothelial growth factor","volume":"23","author":"Sengupta","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb4005","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nrc3366","article-title":"Controlling escape from angiogenesis inhibitors","volume":"12","author":"Sennino","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2014.05.002_bb4010","first-page":"101","article-title":"Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; implications for cellular surrogate marker analysis of antiangiogenesis","volume":"7","author":"Shaked","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb4015","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000343845","article-title":"Predictive biomarkers of antiangiogenic therapy for advanced hepatocellular carcinoma: where are we?","volume":"2","author":"Shao","year":"2013","journal-title":"Liver Cancer"},{"key":"10.1016\/j.bbcan.2014.05.002_bb4020","doi-asserted-by":"crossref","first-page":"C349","DOI":"10.1152\/ajpcell.00374.2010","article-title":"Placenta growth factor expression is regulated by hydrogen peroxide in vascular smooth muscle cells","volume":"300","author":"Shaw","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb4025","doi-asserted-by":"crossref","first-page":"7059","DOI":"10.1158\/0008-5472.CAN-07-2053","article-title":"Tumor angiogenesis: cause or consequence of cancer?","volume":"67","author":"Shchors","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb4030","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1158\/1055-9965.EPI-04-0340","article-title":"Serum levels of hepatocyte growth factor in patients with breast cancer","volume":"14","author":"Sheen-Chen","year":"2005","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.bbcan.2014.05.002_bb4035","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1080\/00313020701444549","article-title":"Basic FGF augments hypoxia induced HIF-1-alpha expression and VEGF release in T47D breast cancer cells","volume":"39","author":"Shi","year":"2007","journal-title":"Pathology"},{"key":"10.1016\/j.bbcan.2014.05.002_bb4040","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1172\/JCI17808","article-title":"Selective stimulation of VEGFR-1 prevents oxygen-induced retinal vascular degeneration in retinopathy of prematurity","volume":"112","author":"Shih","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2014.05.002_bb4045","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1158\/1541-7786.MCR-07-0072","article-title":"Angiopoietin: a TIE(d) balance in tumor angiogenesis","volume":"5","author":"Shim","year":"2007","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb4050","doi-asserted-by":"crossref","first-page":"6742","DOI":"10.1073\/pnas.0902280106","article-title":"G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models","volume":"106","author":"Shojaei","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbcan.2014.05.002_bb4055","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/359843a0","article-title":"Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis","volume":"359","author":"Shweiki","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2014.05.002_bb4060","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nature07445","article-title":"Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis","volume":"456","author":"Stockmann","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2014.05.002_bb4065","first-page":"3370","article-title":"Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors","volume":"63","author":"Stoeltzing","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb4070","doi-asserted-by":"crossref","first-page":"5102","DOI":"10.1182\/blood-2009-07-230284","article-title":"Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching","volume":"115","author":"Strasser","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbcan.2014.05.002_bb4075","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0002-9440(10)65733-1","article-title":"Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis","volume":"153","author":"Stratmann","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb4080","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/labinvest.3780433","article-title":"Stable expression of angiopoietin-1 and other markers by cultured pericytes: phenotypic similarities to a subpopulation of cells in maturing vessels during later stages of angiogenesis in vivo","volume":"82","author":"Sundberg","year":"2002","journal-title":"Lab. Invest."},{"key":"10.1016\/j.bbcan.2014.05.002_bb4085","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.282.5388.468","article-title":"Increased vascularization in mice over expressing angiopoietin-1","volume":"282","author":"Suri","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.bbcan.2014.05.002_bb4090","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10456-011-9206-4","article-title":"Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo","volume":"14","author":"Tammali","year":"2011","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbcan.2014.05.002_bb4095","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1158\/0008-5472.CAN-09-2609","article-title":"A placental growth factor variant unable to recognize vascular endothelial growth factor (VEGF) receptor-1 inhibits VEGF-dependent tumor angiogenesis via heterodimerization","volume":"70","author":"Tarallo","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb5000","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1096\/fj.02-0145fje","article-title":"Reduced tumor growth, experimental metastasis formation, and angiogenesis in rats with a hyper reactive dopaminergic system","volume":"16","author":"Teunis","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.bbcan.2014.05.002_bb5005","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10456-009-9147-3","article-title":"The role of the angiopoietins in vascular morphogenesis","volume":"12","author":"Thomas","year":"2009","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbcan.2014.05.002_bb5010","doi-asserted-by":"crossref","first-page":"23842","DOI":"10.1074\/jbc.M109.097543","article-title":"Angiopoietin-2 stimulation of endothelial cells induces alphavbeta3 integrin internalization and degradation","volume":"285","author":"Thomas","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2014.05.002_bb5015","doi-asserted-by":"crossref","first-page":"a006650","DOI":"10.1101\/cshperspect.a006650","article-title":"The complex role of angiopoietin-2 in the angiopoietin-Tie signaling pathway","volume":"2","author":"Thurston","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb5020","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrc2130","article-title":"The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth","volume":"7","author":"Thurston","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2014.05.002_bb5025","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1242\/dev.01888","article-title":"Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period","volume":"132","author":"Thurston","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.bbcan.2014.05.002_bb5030","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s10456-005-9011-z","article-title":"Angiogenesis in the human heart: gene and cell therapy","volume":"8","author":"Tirziu","year":"2005","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbcan.2014.05.002_bb5035","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S1470-2045(12)70241-3","article-title":"Prognostic or predictive plasma cytokines and angiogenic factors for patients treated with pazopanib for metastatic renal-cell cancer: a retrospective analysis of phase 2 and phase 3 trials","volume":"13","author":"Tran","year":"2012","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb5040","doi-asserted-by":"crossref","first-page":"728325","DOI":"10.1155\/2012\/728325","article-title":"The role of angiogenesis in the development of proliferative diabetic retinopathy: impact of intravitreal anti-VEGF treatment","volume":"2012","author":"Tremolada","year":"2012","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb5045","doi-asserted-by":"crossref","first-page":"128608","DOI":"10.1155\/2012\/128608","article-title":"Angiogenesis in acute myeloid leukemia and opportunities for novel therapies","volume":"2012","author":"Trujillo","year":"2012","journal-title":"J. Oncol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb5050","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nrc2780","article-title":"Fibroblast growth factor signalling: from development to cancer","volume":"10","author":"Turner","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2014.05.002_bb5055","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1172\/JCI0215621","article-title":"Recombinant angiopoietin-1 restores higher order architecture of growing blood vessels in mice in the absence of mural cells","volume":"110","author":"Uemura","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2014.05.002_bb5060","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1073\/pnas.96.5.1904","article-title":"Angiopoietins 3 and 4: diverging gene counterparts in mice and humans","volume":"96","author":"Valenzuela","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbcan.2014.05.002_bb5065","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.cell.2010.02.039","article-title":"Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease","volume":"141","author":"Van de Veire","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2014.05.002_bb5070","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1158\/0008-5472.CAN-09-3592","article-title":"vascular endothelial growth factor\u2014A positive and negative regulator of tumor growth","volume":"70","author":"Vecchiarelli-Federico","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb5075","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nrc2152","article-title":"Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition","volume":"7","author":"Verheul","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2014.05.002_bb5080","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.yexcr.2005.10.019","article-title":"Pericytes and vascular stability","volume":"312","author":"Von Tell","year":"2006","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb5085","doi-asserted-by":"crossref","first-page":"21513","DOI":"10.1016\/S0021-9258(20)80571-7","article-title":"Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia","volume":"268","author":"Wang","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2014.05.002_bb5090","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1016\/j.bbagen.2014.02.005","article-title":"a-Melanocyte-stimulating hormone inhibits angiogenesis through attenuation of VEGF\/VEGFR2 signaling pathway","volume":"1840","author":"Weng","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbcan.2014.05.002_bb5095","first-page":"122","article-title":"Emerging roles of PDGF-D signaling pathway in tumor development and progression","volume":"1806","author":"Wang","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbcan.2014.05.002_bb6000","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.2174\/138161212802430468","article-title":"Target-based anti-angiogenic therapy in breast cancer","volume":"18","author":"Wehland","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bbcan.2014.05.002_bb6005","doi-asserted-by":"crossref","first-page":"9338","DOI":"10.3390\/ijms14059338","article-title":"Biomarkers for anti-angiogenic therapy in cancer","volume":"14","author":"Wehland","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2014.05.002_bb6010","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/nm.2537","article-title":"Tumor angiogenesis: molecular pathways and therapeutic targets","volume":"17","author":"Weis","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb6015","doi-asserted-by":"crossref","first-page":"8136","DOI":"10.1200\/JCO.2005.02.5635","article-title":"Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients","volume":"23","author":"Willett","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb6020","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0002-9440(10)64058-8","article-title":"Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo","volume":"158","author":"Xin","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb6025","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1158\/0008-5472.CAN-04-3085","article-title":"Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models","volume":"66","author":"Xu","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb6030","doi-asserted-by":"crossref","first-page":"6119","DOI":"10.1158\/0008-5472.CAN-04-1054","article-title":"Angiopoietin-3 inhibits pulmonary metastasis by inhibiting tumor angiogenesis","volume":"64","author":"Xu","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2014.05.002_bb6035","doi-asserted-by":"crossref","DOI":"10.1038\/cmi.2014.6","article-title":"Potent anti-angiogenesis and anti-tumor activity of a novel human anti-VEGF antibody, MIL60","author":"Yang","year":"2014","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb6040","doi-asserted-by":"crossref","DOI":"10.1002\/hep.26305","article-title":"MicroRNA-26a suppresses angiogenesis in human hepatocellular carcinoma by targeting hepatocyte growth factor-cMet pathway","author":"Yang","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.bbcan.2014.05.002_bb6045","doi-asserted-by":"crossref","first-page":"35172","DOI":"10.1074\/jbc.274.49.35172","article-title":"Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis","volume":"274","author":"Yonekura","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2014.05.002_bb6050","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/art.24289","article-title":"Role of placenta growth factor and its receptor flt-1 in rheumatoid inflammation: a link between angiogenesis and inflammation","volume":"60","author":"Yoo","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbcan.2014.05.002_bb6055","doi-asserted-by":"crossref","first-page":"833","DOI":"10.5483\/BMBRep.2008.41.12.833","article-title":"The hepatocyte growth factor\/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis","volume":"41","author":"You","year":"2008","journal-title":"BMB Rep."},{"key":"10.1016\/j.bbcan.2014.05.002_bb6060","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.ajpath.2013.01.045","article-title":"miR-101 inhibits cholangiocarcinoma angiogenesis vascular endothelial growth factor (VEGF)","volume":"182","author":"Zhang","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb6065","doi-asserted-by":"crossref","first-page":"543","DOI":"10.3892\/etm.2014.1476","article-title":"Suppression of angiogenesis and tumor growth in vitro and in vivo using an anti-angiopoietin-2 single-chain antibody","volume":"7","author":"Zhang","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bbcan.2014.05.002_bb6070","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/sj.clpt.6100400","article-title":"Nanoparticles in medicine: therapeutic applications and developments","volume":"83","author":"Zhang","year":"2008","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.bbcan.2014.05.002_bb6075","doi-asserted-by":"crossref","first-page":"12718","DOI":"10.1073\/pnas.2135113100","article-title":"Hepatocyte growth factor\/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation","volume":"100","author":"Zhang","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbcan.2014.05.002_bb6080","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/030089161109700117","article-title":"Basic fibroblast growth factor affects the expression of angiogenin and cell proliferation in A375 human melanoma cells","volume":"97","author":"Zhao","year":"2011","journal-title":"Tumori"},{"key":"10.1016\/j.bbcan.2014.05.002_bb6085","first-page":"1","article-title":"RNAi-mediated inhibition of PDGF-D leads to decreased cell growth, invasion and angiogenesis in the SGC-7901 gastric cancer xenograft model","volume":"9","author":"Zhao","year":"2009","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.bbcan.2014.05.002_bb6090","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1006\/exnr.1999.7162","article-title":"In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesis","volume":"159","author":"Zagzag","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbcan.2014.05.002_bb6095","first-page":"517","article-title":"Placenta growth factor-1 is chemotactic, mitogenic, and angiogenic","volume":"76","author":"Ziche","year":"1997","journal-title":"Lab. Invest."},{"issue":"10","key":"10.1016\/j.bbcan.2014.05.002_bb7000","first-page":"6038","article-title":"CXCL8\/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of","volume":"284","author":"Martin","year":"2009","journal-title":"VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3\/Bcl10\/Malt1) complex, J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2014.05.002_bb7005","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nsb880","article-title":"Angio poietins have distinct modular domains essential for receptor binding, dimerization and superclustering","volume":"10","author":"Davis","year":"2003","journal-title":"Nat. Struct. Biol."},{"issue":"6","key":"10.1016\/j.bbcan.2014.05.002_bb7010","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1172\/JCI0214105","article-title":"Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2, and angiopoietin-2","volume":"09","author":"Vajkoczy","year":"2002","journal-title":"J Clin Invest."},{"issue":"1","key":"10.1016\/j.bbcan.2014.05.002_bb7015","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/sj.bjc.6605483","article-title":"Biomarkers of angiogenesis and their role in the development of VEGF inhibitors","volume":"5;102","author":"Murukesh","year":"2010","journal-title":"Br J Cancer."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X1400047X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X1400047X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T04:23:18Z","timestamp":1759638198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304419X1400047X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":322,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0304419X1400047X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbcan.2014.05.002","relation":{},"ISSN":["0304-419X"],"issn-type":[{"value":"0304-419X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angiogenic factors as potential drug target: Efficacy and limitations of anti-angiogenic therapy","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbcan.2014.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}