{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:33:03Z","timestamp":1790400783605,"version":"4.1.0"},"reference-count":158,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.bbcan.2017.11.003","type":"journal-article","created":{"date-parts":[[2017,11,25]],"date-time":"2017-11-25T03:15:30Z","timestamp":1511579730000},"page":"42-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"title":["Genetic host factors in Helicobacter pylori -induced carcinogenesis: Emerging new paradigms"],"prefix":"10.1016","volume":"1869","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7269-5364","authenticated-orcid":false,"given":"Michiel C.","family":"Mommersteeg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maikel P.","family":"Peppelenbosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9221-4855","authenticated-orcid":false,"given":"Gwenny M.","family":"Fuhler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbcan.2017.11.003_bb0005","series-title":"I. A. for R. on C. W. World Cancer Report 2014","author":"C.P.","year":"2014"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0010","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s00423-004-0482-y","article-title":"Survival after surgical treatment of early gastric cancer, surgical techniques, and long-term survival","volume":"390","author":"Yuasa","year":"2005","journal-title":"Langenbeck's Arch. Surg."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0015","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4143\/crt.2006.38.1.13","article-title":"Prognostic factors for advanced gastric cancer: stage-stratified analysis of patients who underwent curative resection","volume":"38","author":"Park","year":"2006","journal-title":"Cancer Res. Treat."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0020","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1056\/NEJMoa001999","article-title":"Helicobacter pylori infection and the development of gastric cancer","volume":"345","author":"Uemura","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0025","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1002\/ijc.21731","article-title":"The global health burden of infection-associated cancers in the year 2002","volume":"118","author":"Parkin","year":"2006","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0030","first-page":"121","article-title":"Schistosomes, liver flukes and Helicobacter pylori","volume":"61","author":"Iarc","year":"1994","journal-title":"IARC Monogr. Eval. Carcinog. Risk Hum."},{"issue":"Suppl. 1","key":"10.1016\/j.bbcan.2017.11.003_bb0035","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1365-2036.1999.00002.x","article-title":"Review article: exploring the link between Helicobacter pylori and gastric cancer","volume":"13","author":"Kuipers","year":"1999","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0040","doi-asserted-by":"crossref","first-page":"982","DOI":"10.7326\/0003-4819-120-12-199406150-00002","article-title":"Helicobacter pylori infection: genetic and environmental influences. A study of twins","volume":"120","author":"Malaty","year":"1994","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0045","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1001\/jama.2013.4350","article-title":"Identification of genetic loci associated with Helicobacter pylori serologic status","volume":"309","author":"Mayerle","year":"2013","journal-title":"JAMA J. Am. Med. Assoc."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098899","article-title":"The NOD-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer: a case-control study and gene expression analyses","volume":"9","author":"Casta\u00f1o-Rodr\u00edguez","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0055","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/hel.12211","article-title":"Autophagy in Helicobacter pylori infection and related gastric cancer","author":"Casta\u00f1o-Rodr\u00edguez","year":"2015","journal-title":"Helicobacter"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0060","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.humimm.2014.06.001","article-title":"Genetic polymorphisms in the Toll-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer","volume":"75","author":"Casta\u00f1o-Rodr\u00edguez","year":"2014","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0065","first-page":"317","article-title":"ATG16L1 T300A polymorphism is correlated with gastric cancer susceptibility","author":"Burada","year":"2015","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0070","first-page":"6735","article-title":"Human gastric carcinogenesis: a multistep and multifactorial process - first American cancer society award lecture on cancer epidemiology and prevention","volume":"52","author":"Correa","year":"1992","journal-title":"Cancer Res."},{"issue":"Suppl. 1","key":"10.1016\/j.bbcan.2017.11.003_bb0075","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.1365-2036.1996.22164006.x","article-title":"The role of Helicobacter pylori urease in the pathogenesis of gastritis and peptic ulceration","volume":"10","author":"Mobley","year":"1996","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0080","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1111\/j.1462-5822.2008.01156.x","article-title":"Role of type IV secretion in Helicobacter pylori pathogenesis","volume":"10","author":"Backert","year":"2008","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0085","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1099\/jmm.0.2008\/001818-0","article-title":"Differences in Helicobacter pylori CagA tyrosine phosphorylation motif patterns between western and East Asian strains, and influences on interleukin-8 secretion","volume":"57","author":"Argent","year":"2008","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0090","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/0140-6736(91)90477-7","article-title":"Mucosal IgA recognition of Helicobacter pylori 120kDa protein, peptic ulceration, and gastric pathology","volume":"338","author":"Crabtree","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0095","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1172\/JCI61143","article-title":"c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains","volume":"122","author":"Mueller","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0100","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1126\/science.1067147","article-title":"SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein","volume":"295","author":"Higashi","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004621","article-title":"A specific A\/T polymorphism in Western tyrosine phosphorylation B-motifs regulates helicobacter pylori CagA epithelial cell interactions","volume":"11","author":"Zhang","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0110","doi-asserted-by":"crossref","DOI":"10.1038\/srep15749","article-title":"Dramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: its implications in gastric carcinogenesis","volume":"5","author":"Nagase","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0115","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/1753425916681077","article-title":"Inflammatory signaling pathways induced by Helicobacter pylori in primary human gastric epithelial cells","volume":"23","author":"Tran","year":"2017","journal-title":"Innate Immun."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0120","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1158\/0008-5472.CAN-15-3089","article-title":"Stomach-specific activation of oncogenic KRAS and STAT3-dependent inflammation cooperatively promote gastric tumorigenesis in a preclinical model","volume":"76","author":"Thiem","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0125","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1053\/j.gastro.2006.07.018","article-title":"STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis","volume":"131","author":"Judd","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0130","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.1038\/sj.onc.1210251","article-title":"Helicobacter pylori CagA interacts with E-cadherin and deregulates the \u03b2-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells","volume":"26","author":"Murata-Kamiya","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0135","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1136\/jmg.2009.074237","article-title":"Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research","volume":"47","author":"Fitzgerald","year":"2010","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0140","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1590\/S0004-28032010000100002","article-title":"Methylation status of CDH1 gene in samples of gastric mucous from Brazilian patients with chronic gastritis infected by Helicobacter pylori","volume":"47","author":"Kague","year":"2010","journal-title":"Arq. Gastroenterol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0145","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4166\/kjg.2016.68.5.253","article-title":"Helicobacter pylori eradication modulates aberrant CpG island hypermethylation in gastric carcinogenesis","volume":"68","author":"Choi","year":"2016","journal-title":"Korean J. Gastroenterol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0150","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.tim.2008.01.001","article-title":"Sticky socks: Helicobacter pylori VacA takes shape","volume":"16","author":"Sewald","year":"2008","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0155","doi-asserted-by":"crossref","first-page":"19183","DOI":"10.1074\/jbc.M300117200","article-title":"Protein-tyrosine phosphatase alpha, RPTP alpha, is a Helicobacter pylori VacA receptor","volume":"278","author":"Yahiro","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0160","doi-asserted-by":"crossref","first-page":"6571","DOI":"10.1128\/IAI.00356-06","article-title":"Clustering of Helicobacter pylori VacA in lipid rafts, mediated by its receptor, receptor-like protein tyrosine phosphatase beta, is required for intoxication in AZ-521 cells","volume":"74","author":"Nakayama","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0165","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1096\/fj.14-259366","article-title":"Phosphorylation of tyrosine 285 of PAK1 facilitates PIX\/GIT1 binding and adhesion turnover","volume":"29","author":"Hammer","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0170","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1620\/tjem.220.3","article-title":"Pleiotropic actions of Helicobacter pylori vacuolating cytotoxin, VacA","volume":"220","author":"Isomoto","year":"2010","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0175","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1242\/dmm.004879","article-title":"Helicobacter pylori CagA inhibits endocytosis of cytotoxin VacA in host cells","volume":"3","author":"Akada","year":"2010","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0180","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1099\/jmm.0.47465-0","article-title":"Functional association between the Helicobacter pylori virulence factors VacA and CagA","volume":"57","author":"Argent","year":"2008","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0185","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1128\/JCM.01501-09","article-title":"Epidemiological link between gastric disease and polymorphisms in VacA and CagA","volume":"48","author":"Jang","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0190","doi-asserted-by":"crossref","first-page":"C450","DOI":"10.1152\/ajpcell.00319.2004","article-title":"Helicobacter pylori lipopolysaccharide activates Rac1 and transcription of NADPH oxidase Nox1 and its organizer NOXO1 in guinea pig gastric mucosal cells","volume":"288","author":"Kawahara","year":"2005","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41021-016-0055-7","article-title":"Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells","volume":"38","author":"Kawanishi","year":"2016","journal-title":"Genes Environ."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0200","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1097\/MOG.0b013e328365efc7","article-title":"Gastric secretion","volume":"29","author":"Chu","year":"2013","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0205","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1159\/000332213","article-title":"The intriguing relationship of Helicobacter pylori infection and acid secretion in peptic ulcer disease and gastric cancer","volume":"29","author":"Malfertheiner","year":"2011","journal-title":"Dig. Dis."},{"issue":"e10","key":"10.1016\/j.bbcan.2017.11.003_bb0210","article-title":"Progastrin stimulates colonic cell proliferation via CCK2R- and \u03b2-arrestin-dependent suppression of BMP2","volume":"145","author":"Jin","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0215","doi-asserted-by":"crossref","first-page":"14605","DOI":"10.18632\/oncotarget.7522","article-title":"Assessment of cholecystokinin 2 receptor (CCK2R) in neoplastic tissue","volume":"7","author":"Roy","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0220","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jcmgh.2017.03.004","article-title":"Gastrin and gastric cancer","volume":"4","author":"Smith","year":"2017","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0225","first-page":"G135","article-title":"Gastric mucosal cell proliferation during development in rats and effects of pentagastrin","volume":"242","author":"Majumdar","year":"1982","journal-title":"Am. J. Phys."},{"issue":"Suppl. 180","key":"10.1016\/j.bbcan.2017.11.003_bb0230","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3109\/00365529109093190","article-title":"Trophic effects of gastrin","author":"H\u00e5kanson","year":"1991","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0235","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0167-0115(00)00176-2","article-title":"Gastrin as a growth factor in the gastrointestinal tract","volume":"93","author":"Koh","year":"2000","journal-title":"Regul. Pept."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0240","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1136\/gut.51.5.628","article-title":"Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract","volume":"51","author":"van den Brink","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0245","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0016-5085(98)70581-5","article-title":"Mice lacking secretory phospholipase A2 show altered apoptosis and differentiation with Helicobacter felis infection","volume":"114","author":"Wang","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0250","doi-asserted-by":"crossref","first-page":"G362","DOI":"10.1152\/ajpgi.00160.2004","article-title":"Alterations in gastric mucosal lineages induced by acute oxyntic atrophy in wild-type and gastrin-deficient mice","volume":"288","author":"Nomura","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0255","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/S0016-5085(00)70361-1","article-title":"Reversible drug-induced oxyntic atrophy in rats","volume":"118","author":"Goldenring","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0260","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4291\/wjgp.v5.i3.133","article-title":"Role of Toll-like receptors in Helicobacter pylori infection and immunity","volume":"5","author":"Smith","year":"2014","journal-title":"World J. Gastrointest. Pathophysiol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0265","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/35074106","article-title":"The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5","volume":"410","author":"Hayashi","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0270","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/35047123","article-title":"A Toll-like receptor recognizes bacterial DNA","volume":"408","author":"Hemmi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0275","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1093\/infdis\/jiv270","article-title":"Toll-like receptor 10 in Helicobacter pylori infection","volume":"212","author":"Nagashima","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0280","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1074-7613(00)80119-3","article-title":"Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components","volume":"11","author":"Takeuchi","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0285","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","article-title":"Mechanisms and functions of inflammasomes","volume":"157","author":"Lamkanfi","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0290","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1462-5822.2005.00482.x","article-title":"Lipopolysaccharides from Helicobacter pylori can act as antagonists for Toll-like receptor 4","volume":"7","author":"Lepper","year":"2005","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0295","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1128\/IAI.00903-09","article-title":"Helicobacter pylori lipopolysaccharides upregulate toll-like receptor 4 expression and proliferation of gastric epithelial cells via the MEK1\/2-ERK1\/2 mitogen-activated protein kinase pathway","volume":"78","author":"Yokota","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0300","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1086\/386289","article-title":"Helicobacter pylori flagellin evades toll-like receptor 5\u2013mediated innate immunity","volume":"189","author":"Gewirtz","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0305","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/gene.2015.33","article-title":"Association of 4p14 TLR locus with antibodies to Helicobacter pylori","volume":"16","author":"Sung","year":"2015","journal-title":"Genes Immun."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0310","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.humimm.2016.12.002","article-title":"Genetic variants of TLR4 and TLR9 are risk factors for chronic Helicobacter pylori infection in South Indian Tamils","volume":"78","author":"Loganathan","year":"2017","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0315","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.meegid.2015.02.005","article-title":"Toll-like receptor 1 and 10 polymorphisms, Helicobacter pylori susceptibility and risk of gastric lesions in a high-risk Chinese population","volume":"31","author":"Tang","year":"2015","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0320","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/hel.12001","article-title":"A frequent toll-like receptor 1 gene polymorphism affects NK- and T-cell IFN-\u03b3 production and is associated with Helicobacter pylori - induced gastric disease","volume":"18","author":"Yang","year":"2013","journal-title":"Helicobacter"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141865","article-title":"Polymorphisms at locus 4p14 of Toll-like receptors TLR-1 and TLR-10 confer susceptibility to gastric carcinoma in Helicobacter pylori infection","volume":"10","author":"Ravishankar Ram","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0330","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.2147\/OTT.S95807","article-title":"Association between CD14 SNP-159 C\/T and gastric cancer: an independent case\u2013control study and an updated meta-analysis","volume":"9","author":"Wang","year":"2016","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0335","first-page":"336","article-title":"Pattern-recognition receptors and gastric cancer","volume":"5","author":"Casta\u00f1o-Rodr\u00edguez","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0340","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1158\/1940-6207.CAPR-15-0315","article-title":"Myeloid differentiation factor 88 signaling in bone marrow-derived cells promotes gastric tumorigenesis by generation of inflammatory microenvironment","volume":"9","author":"Maeda","year":"2016","journal-title":"Cancer Prev. Res."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0345","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ijmm.2005.02.009","article-title":"Toll-like receptors TLR4, TLR5 and TLR9 on gastric carcinoma cells: an implication for interaction with Helicobacter pylori","volume":"295","author":"Schmau\u00dfer","year":"2005","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0350","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s12253-011-9368-9","article-title":"Increased expression of toll-like receptors (TLR) 2, 4 and 5 in gastric dysplasia","volume":"17","author":"Pimentel-Nunes","year":"2011","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0355","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.3748\/wjg.v18.i17.2112","article-title":"Association of NOD1 and NOD2 genes polymorphisms with Helicobacter pylori related gastric cancer in a Chinese population","volume":"18","author":"Wang","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0360","first-page":"757","article-title":"Gene polymorphisms of the NOD-2\/CARD-15 gene and the risk of gastric cancer in Germany","volume":"28","author":"Wex","year":"2008","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0365","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.humimm.2009.04.026","article-title":"NOD2\/CARD15 polymorphisms impair innate immunity and increase susceptibility to gastric cancer in an Italian population","volume":"70","author":"Angeletti","year":"2009","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0370","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrd2783","article-title":"Unleashing the therapeutic potential of NOD-like receptors","volume":"8","author":"Geddes","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0375","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1152\/physrev.00009.2014","article-title":"NOD-like receptors: versatile cytosolic sentinels","volume":"95","author":"Motta","year":"2015","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0380","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3349\/ymj.2016.57.1.5","article-title":"NOD-like receptors in infection, immunity, and diseases","volume":"57","author":"Kim","year":"2016","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0385","doi-asserted-by":"crossref","first-page":"8099","DOI":"10.4049\/jimmunol.0900664","article-title":"Helicobacter pylori induces MAPK phosphorylation and AP-1 activation via a NOD1-dependent mechanism","volume":"183","author":"Allison","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0390","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/ni1131","article-title":"Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island","volume":"5","author":"Viala","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0395","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1172\/JCI39481","article-title":"NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway","volume":"120","author":"Watanabe","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0400","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.4049\/jimmunol.1200591","article-title":"Nucleotide oligomerization domain 1 enhances IFN-signaling in gastric epithelial cells during Helicobacter pylori infection and exacerbates disease severity","volume":"190","author":"Allison","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0405","first-page":"358","article-title":"Nucleotide binding oligomerization domain 1 is an essential signal transducer in human epithelial cells infected with Helicobacter pylori that induces the transepithelial migration of neutrophils","volume":"9","author":"Kim","year":"2015","journal-title":"Gut Liver"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0410","first-page":"355","article-title":"Association of nucleotide-binding oligomerization domain receptors with peptic ulcer and gastric cancer","volume":"15","author":"Mohammadian Amiri","year":"2016","journal-title":"Iran. J. Allergy Asthma Immunol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0415","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1158\/0008-5472.CAN-15-2272","article-title":"Cdx2 expression and intestinal metaplasia induced by H. pylori infection of gastric cells is regulated by NOD1-mediated innate immune responses","volume":"76","author":"Asano","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0420","article-title":"NOD1 and NOD2 genetic variants in association with risk of gastric cancer and its precursors in a Chinese population","volume":"10","author":"Li","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0425","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/ijc.28357","article-title":"Polymorphisms of Helicobacter pylori signaling pathway genes and gastric cancer risk in the European prospective investigation into cancer-eurgast cohort","volume":"134","author":"Companioni","year":"2014","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0430","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.yexmp.2010.03.003","article-title":"Association of c. 802C> T polymorphism of NOD2\/CARD15 gene with the chronic gastritis and predisposition to cancer in H. pylori infected patients","volume":"88","author":"Hnatyszyn","year":"2010","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0435","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/ibd.20390","article-title":"Monocyte-derived dendritic cells from Crohn patients show differential NOD2\/CARD15-dependent immune responses to bacteria","volume":"14","author":"Salucci","year":"2008","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0440","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1111\/j.1462-5822.2006.00701.x","article-title":"Influence of polymorphisms in the NOD1\/CARD4 and NOD2\/CARD15 genes on the clinical outcome of Helicobacter pylori infection","volume":"8","author":"Rosenstiel","year":"2006","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0445","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1136\/gut.2009.199679","article-title":"New IBD genetics: common pathways with other diseases","volume":"60","author":"Lees","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0450","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1073\/pnas.1417945112","article-title":"Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5","volume":"112","author":"Matusiak","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0455","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1574-695X.2007.00288.x","article-title":"Highly-purified Helicobacter pylori LPS preparations induce weak inflammatory reactions and utilize Toll-like receptor 2 complex but not Toll-like receptor 4 complex","volume":"51","author":"Yokota","year":"2007","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0460","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/1753425915619475","article-title":"Activation of NLRP3 inflammasome in human neutrophils by Helicobacter pylori infection","volume":"22","author":"P\u00e9rez-Figueroa","year":"2016","journal-title":"Innate Immun."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0465","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.1400362","article-title":"Helicobacter pylori\u2013induced IL-1\u03b2 secretion in innate immune cells is regulated by the NLRP3 inflammasome and requires the cag pathogenicity island","volume":"193","author":"Semper","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0470","first-page":"3594","article-title":"Caspase-1 has both proinflammatory and caspase-1 has both proinflammatory and regulatory properties in helicobacter infections, which are differentially mediated by its substrates IL-1b and IL-18","volume":"188","author":"Koch","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0475","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1053\/j.gastro.2009.10.043","article-title":"Interleukin-1\u03b2 promotes gastric atrophy through suppression of Sonic Hedgehog","volume":"138","author":"Waghray","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0480","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1053\/gast.1996.v110.pm8536851","article-title":"Gastrin secretion from primary cultures of rabbit antral G cells: stimulation by inflammatory cytokines","volume":"110","author":"Weigert","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0485","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.ccr.2008.10.011","article-title":"Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice","volume":"14","author":"Tu","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0490","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.canlet.2013.07.034","article-title":"Interleukin-1\u03b2 induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis","volume":"340","author":"Shigematsu","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0495","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1038\/sj.onc.1209926","article-title":"Interleukin-18 is a critical factor for vascular endothelial growth factor-enhanced migration in human gastric cancer cell lines","volume":"26","author":"Kim","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0500","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1093\/carcin\/bgp158","article-title":"Interleukin-18 increases metastasis and immune escape of stomach cancer via the downregulation of CD70 and maintenance of CD44","volume":"30","author":"Kang","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0505","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1111\/j.1440-1746.2009.05791.x","article-title":"IL-18 serum level and IL-18 promoter gene polymorphism in Iranian patients with gastrointestinal cancers","volume":"24","author":"Haghshenas","year":"2009","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0510","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1053\/gast.2002.37043","article-title":"Effect of interleukin 1 polymorphisms on gastric mucosal interleukin 1\u03b2 production in Helicobacter pylori infection","volume":"123","author":"Hwang","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0515","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0016-5085(03)00157-4","article-title":"Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms","volume":"124","author":"El-Omar","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0520","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/35006081","article-title":"Interleukin-1 polymorphisms associated with increased risk of gastric cancer","volume":"404","author":"El-Omar","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0525","doi-asserted-by":"crossref","first-page":"44069","DOI":"10.1074\/jbc.M107373200","article-title":"CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways","volume":"276","author":"Bouchier-Hayes","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0530","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1101\/gad.1599207","article-title":"Autophagy: process and function","volume":"21","author":"Mizushima","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0535","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nrm3696","article-title":"The autophagosome: origins unknown, biogenesis complex","volume":"14","author":"Lamb","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0540","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ni.3273","article-title":"Autophagy and autophagy-related proteins in the immune system","volume":"16","author":"Shibutani","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0545","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.molcel.2015.03.020","article-title":"IRGM governs the core autophagy machinery to conduct antimicrobial defense","volume":"58","author":"Chauhan","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0550","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.cell.2004.11.038","article-title":"Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages","volume":"119","author":"Gutierrez","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0555","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1046\/j.1462-5822.2003.00292.x","article-title":"Cytoplasmic bacteria can be targets for autophagy","volume":"5","author":"Rich","year":"2003","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0560","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1053\/j.gastro.2010.07.006","article-title":"ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis","volume":"139","author":"Homer","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0565","doi-asserted-by":"crossref","first-page":"370","DOI":"10.4161\/auto.5.3.7663","article-title":"Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells","volume":"5","author":"Terebiznik","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0570","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.chom.2012.10.014","article-title":"Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells","volume":"12","author":"Tsugawa","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0575","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1053\/j.gastro.2012.01.043","article-title":"Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote helicobacter pylori infection in humans","volume":"142","author":"Raju","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0580","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.4161\/auto.20159","article-title":"Compromised autophagy by MIR30B benefits the intracellular survival of Helicobacter pylori","volume":"8","author":"Tang","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0585","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.3748\/wjg.v22.i15.3978","article-title":"Mir-30d increases intracellular survival of Helicobacter pylori through inhibition of autophagy pathway","volume":"22","author":"Yang","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0590","doi-asserted-by":"crossref","DOI":"10.1111\/hel.12376","article-title":"Autophagy-related genes in Helicobacter pylori infection","volume":"22","author":"Tanaka","year":"2017","journal-title":"Helicobacter"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0595","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.1128\/IAI.00524-10","article-title":"Invasion and multiplication of Helicobacter pylori in gastric epithelial cells and implications for antibiotic resistance","volume":"78","author":"Chu","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0600","doi-asserted-by":"crossref","first-page":"639","DOI":"10.4161\/auto.23782","article-title":"The impact of autophagic processes on the intracellular fate of Helicobacter pylori: more tricks from an enigmatic pathogen?","volume":"9","author":"Deen","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0605","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2010.00115","article-title":"A tale of two toxins: Helicobacter pylori CagA and VacA modulate host pathways that impact disease","volume":"1","author":"Jones","year":"2010","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0610","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.4081\/ejh.2015.2489","article-title":"Infection with CagA-positive Helicobacter pylori strain containing three EPIYA C phosphorylation sites is associated with more severe gastric lesions in experimentally infected Mongolian gerbils (Meriones unguiculatus)","volume":"59","author":"Ferreira J\u00fanior","year":"2015","journal-title":"Eur. J. Histochem."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0615","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nm.2069","article-title":"NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation","volume":"16","author":"Cooney","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0620","doi-asserted-by":"crossref","first-page":"7741","DOI":"10.1073\/pnas.1407001111","article-title":"Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense","volume":"111","author":"Lassen","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0625","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003391","article-title":"Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant","volume":"3","author":"Kuballa","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0630","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1136\/gutjnl-2012-303527","article-title":"Genomic ATG16L1 risk allele-restricted Paneth cell ER stress in quiescent Crohn's disease","volume":"63","author":"Deuring","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0635","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.4161\/auto.21007","article-title":"Crohn disease ATG16L1 polymorphism increases susceptibility to infection with Helicobacter pylori in humans","volume":"8","author":"Raju","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0640","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nrc2254","article-title":"Role of autophagy in cancer","volume":"7","author":"Mathew","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0645","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1158\/1078-0432.CCR-13-2438","article-title":"Molecular pathways: autophagy in cancer--a matter of timing and context","volume":"21","author":"Cicchini","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0655","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1751-2980.2012.00602.x","article-title":"IRGM gene polymorphisms and risk of gastric cancer","volume":"13","author":"Burada","year":"2012","journal-title":"J. Dig. Dis."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0660","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1007\/s13277-015-3229-1","article-title":"Elevated expression of immunity-related GTPase family M in gastric cancer","volume":"36","author":"Song","year":"2015","journal-title":"Tumour Biol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0665","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s10753-013-9773-1","article-title":"Autophagy gene polymorphism is associated with susceptibility to leprosy by affecting inflammatory cytokines","volume":"37","author":"Yang","year":"2014","journal-title":"Inflammation"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0670","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0675","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1089\/ars.2010.3485","article-title":"Autophagy shapes inflammation","volume":"14","author":"F\u00e9s\u00fcs","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0680","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4049\/jimmunol.1102108","article-title":"Autophagy: an emerging immunological paradigm","volume":"189","author":"Deretic","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0685","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature09782","article-title":"Autophagy in immunity and inflammation","volume":"469","author":"Levine","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0690","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/ni.2215","article-title":"Activation of autophagy by inflammatory signals limits IL-1\u03b2 production by targeting ubiquitinated inflammasomes for destruction","volume":"13","author":"Shi","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0695","doi-asserted-by":"crossref","DOI":"10.1038\/nature07383","article-title":"Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1 beta production","volume":"456","author":"Saitoh","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0700","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1084\/jem.20160791","article-title":"Defective ATG16L1-mediated removal of IRE1\u03b1 drives Crohn's disease-like ileitis","volume":"214","author":"Tschurtschenthaler","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0705","doi-asserted-by":"crossref","first-page":"7683","DOI":"10.1093\/nar\/gkt563","article-title":"The eIF2\u03b1\/ATF4 pathway is essential for stress-induced autophagy gene expression","volume":"41","author":"B'chir","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0710","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1007\/s00018-012-1173-4","article-title":"Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress","volume":"70","author":"Deegan","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0715","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tibs.2015.01.002","article-title":"UPR autophagy, and mitochondria crosstalk underlies the ER stress response","volume":"40","author":"Senft","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0720","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/sj.embor.7400687","article-title":"Tumour necrosis factor receptor 1 mediates endoplasmic reticulum stress-induced activation of the MAP kinase JNK","volume":"7","author":"Yang","year":"2006","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0725","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045362","article-title":"Violacein induces death of resistant leukaemia cells via kinome reprogramming, endoplasmic reticulum stress and Golgi apparatus collapse","volume":"7","author":"Queiroz","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0730","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/onc.2015.108","article-title":"The evolving paradigm of cell-nonautonomous UPR-based regulation of immunity by cancer cells","volume":"35","author":"Zanetti","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0735","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1158\/1535-7163.MCT-15-0774","article-title":"Expression of GRP78, master regulator of the unfolded protein response, increases chemoresistance in pancreatic ductal adenocarcinoma","volume":"15","author":"Gifford","year":"2016","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0740","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.humpath.2007.11.009","article-title":"Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas","volume":"39","author":"Zheng","year":"2008","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0745","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s10585-006-9051-9","article-title":"Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer","volume":"23","author":"Zhang","year":"2006","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0750","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/labinvest.2012.131","article-title":"The unfolded protein response is activated in Helicobacter-induced gastric carcinogenesis in a non-cell autonomous manner","volume":"93","author":"Baird","year":"2012","journal-title":"Lab. Investig."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0755","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082322","article-title":"Endoplasmic reticulum stress contributes to Helicobacter pylori VacA-induced apoptosis","volume":"8","author":"Akazawa","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0760","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/jgh.12663","article-title":"Helicobacter pylori vacuolating cytotoxin induces apoptosis via activation of endoplasmic reticulum stress in dendritic cells","volume":"30","author":"Kim","year":"2015","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0765","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/cmi.12396","article-title":"The secreted antigen, HP0175, of Helicobacter pylori links the unfolded protein response (UPR) to autophagy in gastric epithelial cells","volume":"17","author":"Halder","year":"2015","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0770","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1038\/emboj.2013.233","article-title":"Autophagy proteins control goblet cell function by potentiating reactive oxygen species production","volume":"32","author":"Patel","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0775","doi-asserted-by":"crossref","first-page":"0440","DOI":"10.1371\/journal.pmed.0050054","article-title":"Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis","volume":"5","author":"Heazlewood","year":"2008","journal-title":"PLoS Med."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0780","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1042\/BJ20101569","article-title":"Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting","volume":"434","author":"Ni","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbcan.2017.11.003_bb0785","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0790","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10552-012-0114-8","article-title":"Gastric cancer incidence and mortality is associated with altitude in the mountainous regions of Pacific Latin America","volume":"24","author":"Torres","year":"2013","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.bbcan.2017.11.003_bb0795","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s12664-010-0024-1","article-title":"The enigma of Helicobacter pylori infection and gastric cancer","volume":"29","author":"Ghoshal","year":"2010","journal-title":"Indian J. Gastroenterol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X17301580?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X17301580?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T20:33:37Z","timestamp":1603398817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304419X17301580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":158,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0304419X17301580"],"URL":"https:\/\/doi.org\/10.1016\/j.bbcan.2017.11.003","relation":{},"ISSN":["0304-419X"],"issn-type":[{"value":"0304-419X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic host factors in Helicobacter pylori-induced carcinogenesis: Emerging new paradigms","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbcan.2017.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}