{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:50:18Z","timestamp":1790099418796,"version":"4.0.1"},"reference-count":109,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874195"],"award-info":[{"award-number":["81874195"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173144"],"award-info":[{"award-number":["82173144"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2020JJ4769"],"award-info":[{"award-number":["2020JJ4769"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.bbcan.2022.188797","type":"journal-article","created":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T02:46:47Z","timestamp":1662864407000},"page":"188797","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Colorectal cancer: Metabolic interactions reshape the tumor microenvironment"],"prefix":"10.1016","volume":"1877","author":[{"given":"Jiawei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haodong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjian","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bbcan.2022.188797_bb0005","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bbcan.2022.188797_bb0010","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev-pathol-011110-130235","article-title":"Molecular genetics of colorectal cancer","volume":"6","author":"Fearon","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0015","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2022.188797_bb0020","doi-asserted-by":"crossref","first-page":"120558","DOI":"10.1016\/j.lfs.2022.120558","article-title":"PGC1alpha-mediated fatty acid oxidation promotes TGFbeta1-induced epithelial-mesenchymal transition and metastasis of nasopharyngeal carcinoma","volume":"300","author":"Quan","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.bbcan.2022.188797_bb0025","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.7150\/ijbs.69802","article-title":"Acyl-CoA synthetase long-chain 3-mediated fatty acid oxidation is required for TGFbeta1-induced epithelial-mesenchymal transition and metastasis of colorectal carcinoma","volume":"18","author":"Quan","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbcan.2022.188797_bb0030","first-page":"729","article-title":"RIP3 mediates TCN-induced necroptosis through activating mitochondrial metabolism and ROS production in chemotherapy-resistant cancers","volume":"11","author":"Zhao","year":"2021","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.bbcan.2022.188797_bb0035","doi-asserted-by":"crossref","first-page":"174397","DOI":"10.1016\/j.ejphar.2021.174397","article-title":"ACSL family: the regulatory mechanisms and therapeutic implications in cancer","volume":"909","author":"Quan","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0040","first-page":"4112","article-title":"Lipid droplet and its implication in cancer progression","volume":"10","author":"Li","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.bbcan.2022.188797_bb0045","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41419-018-0662-2","article-title":"DNMT1 mediates metabolic reprogramming induced by Epstein-Barr virus latent membrane protein 1 and reversed by grifolin in nasopharyngeal carcinoma","volume":"9","author":"Luo","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbcan.2022.188797_bb0050","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.semcdb.2019.05.018","article-title":"Metabolic pathways regulating colorectal cancer initiation and progression","volume":"98","author":"La Vecchia","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0055","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/nm.3967","article-title":"The consensus molecular subtypes of colorectal cancer","volume":"21","author":"Guinney","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2022.188797_bb0060","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ceb.2017.05.006","article-title":"Metabolism shapes the tumor microenvironment","volume":"48","author":"Reina-Campos","year":"2017","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0065","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nrc.2016.73","article-title":"The biology and function of fibroblasts in cancer","volume":"16","author":"Kalluri","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2022.188797_bb0070","doi-asserted-by":"crossref","first-page":"2368249","DOI":"10.1155\/2019\/2368249","article-title":"Tumour-associated macrophages (TAMs) in colon cancer and how to reeducate them","volume":"2019","author":"Yahaya","year":"2019","journal-title":"J Immunol Res"},{"key":"10.1016\/j.bbcan.2022.188797_bb0075","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/15384101.2016.1253641","article-title":"Cell proliferation downregulated by TGF-\u03b22-triggered G1\/S checkpoint in clinical CAFs","volume":"16","author":"Wu","year":"2017","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbcan.2022.188797_bb0080","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1053\/j.gastro.2016.11.049","article-title":"Mesenchymal cells in colon cancer","volume":"152","author":"Koliaraki","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2022.188797_bb0085","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nm.2328","article-title":"Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression","volume":"17","author":"Bissell","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2022.188797_bb0090","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12943-019-1019-x","article-title":"CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer","volume":"18","author":"Hu","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbcan.2022.188797_bb0095","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/15384101.2016.1252882","article-title":"Oxidative stress induced autophagy in cancer associated fibroblast enhances proliferation and metabolism of colorectal cancer cells","volume":"16","author":"Zhou","year":"2017","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbcan.2022.188797_bb0100","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"10.1016\/j.bbcan.2022.188797_bb0105","doi-asserted-by":"crossref","first-page":"3984","DOI":"10.4161\/cc.8.23.10238","article-title":"The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma","volume":"8","author":"Pavlides","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbcan.2022.188797_bb0110","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.cell.2015.03.011","article-title":"A lactate-induced response to hypoxia","volume":"161","author":"Lee","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2022.188797_bb0115","first-page":"C869","article-title":"Roles of exosomes in metastatic colorectal cancer","volume":"317","author":"Lafitte","year":"2019","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.bbcan.2022.188797_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800148","article-title":"Exosomes derived from human primary and metastatic colorectal cancer cells contribute to functional heterogeneity of activated fibroblasts by reprogramming their proteome","volume":"19","author":"Rai","year":"2019","journal-title":"Proteomics"},{"key":"10.1016\/j.bbcan.2022.188797_bb0125","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.18632\/aging.101355","article-title":"Exosomal microRNAs derived from colorectal cancer-associated fibroblasts: role in driving cancer progression","volume":"9","author":"Bhome","year":"2017","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bbcan.2022.188797_bb0130","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.febslet.2014.03.037","article-title":"miR-181a mediates metabolic shift in colon cancer cells via the PTEN\/AKT pathway","volume":"588","author":"Wei","year":"2014","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbcan.2022.188797_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12092462","article-title":"Insights into the role of microRNAs in colorectal cancer (CRC) metabolism","volume":"12","author":"Wai Hon","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbcan.2022.188797_bb0140","doi-asserted-by":"crossref","first-page":"149185","DOI":"10.1155\/2014\/149185","article-title":"Chronic inflammation and cytokines in the tumor microenvironment","volume":"2014","author":"Landskron","year":"2014","journal-title":"J Immunol Res"},{"key":"10.1016\/j.bbcan.2022.188797_bb0145","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ccr.2011.01.020","article-title":"Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth","volume":"19","author":"Quante","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2022.188797_bb0150","doi-asserted-by":"crossref","first-page":"516","DOI":"10.7150\/thno.37472","article-title":"ANKRD22, a novel tumor microenvironment-induced mitochondrial protein promotes metabolic reprogramming of colorectal cancer cells","volume":"10","author":"Pan","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.bbcan.2022.188797_bb0155","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.biocel.2011.01.023","article-title":"Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment","volume":"43","author":"Martinez-Outschoorn","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0160","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41588-020-00753-3","article-title":"The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer","volume":"53","author":"Najumudeen","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbcan.2022.188797_bb0165","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.cmet.2016.10.011","article-title":"Targeting stromal glutamine synthetase in tumors disrupts tumor microenvironment-regulated cancer cell growth","volume":"24","author":"Yang","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbcan.2022.188797_bb0170","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.tcb.2017.06.003","article-title":"Metabolic interactions in the tumor microenvironment","volume":"27","author":"Lyssiotis","year":"2017","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0175","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41419-020-2434-z","article-title":"Reprogramming of lipid metabolism in cancer-associated fibroblasts potentiates migration of colorectal cancer cells","volume":"11","author":"Gong","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbcan.2022.188797_bb0180","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nri978","article-title":"Alternative activation of macrophages","volume":"3","author":"Gordon","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0185","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"Mantovani","year":"2004","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0190","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ni.2703","article-title":"Innate and adaptive immune cells in the tumor microenvironment","volume":"14","author":"Gajewski","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0195","doi-asserted-by":"crossref","first-page":"762","DOI":"10.4049\/jimmunol.164.2.762","article-title":"Autocrine production of IL-10 mediates defective IL-12 production and NF-kappa B activation in tumor-associated macrophages","volume":"164","author":"Sica","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0200","doi-asserted-by":"crossref","first-page":"6679","DOI":"10.1002\/cam4.3315","article-title":"Metabolic dysfunction and early-onset colorectal cancer - how macrophages build the bridge","volume":"9","author":"Scheurlen","year":"2020","journal-title":"Cancer Med."},{"key":"10.1016\/j.bbcan.2022.188797_bb0205","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4103\/CJP.CJP_75_19","article-title":"Distinct patterns of interleukin-12\/23 and tumor necrosis factor \u03b1 synthesis by activated macrophages are modulated by glucose and colon cancer metabolites","volume":"63","author":"Huang","year":"2020","journal-title":"Chin. J. Phys."},{"key":"10.1016\/j.bbcan.2022.188797_bb0210","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41575-018-0084-8","article-title":"IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting","volume":"16","author":"Moschen","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0215","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/onc.2017.299","article-title":"Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells","volume":"37","author":"Diehl","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2022.188797_bb0220","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.4049\/jimmunol.172.7.4630","article-title":"Recruitment of STAT3 for production of IL-10 by colon carcinoma cells induced by macrophage-derived IL-6","volume":"172","author":"Herbeuval","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160891","article-title":"Intricate macrophage-colorectal cancer cell communication in response to radiation","volume":"11","author":"Pinto","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2022.188797_bb0230","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.radonc.2016.01.014","article-title":"Myeloid-derived suppressor cells reveal radioprotective properties through arginase-induced l-arginine depletion","volume":"119","author":"Leonard","year":"2016","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0235","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1189\/jlb.3A0114-055R","article-title":"\u03b3-Irradiated cancer cells promote tumor growth by activation of Toll-like receptor 1-mediated inducible nitric oxide synthase in macrophages","volume":"97","author":"Ryu","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0240","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201910698","article-title":"Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages","volume":"11","author":"Wu","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bbcan.2022.188797_bb0245","doi-asserted-by":"crossref","first-page":"11716","DOI":"10.1038\/ncomms11716","article-title":"Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM","volume":"7","author":"Miao","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2022.188797_bb0250","doi-asserted-by":"crossref","first-page":"7498","DOI":"10.1038\/s41598-017-07685-9","article-title":"Oleate but not stearate induces the regulatory phenotype of myeloid suppressor cells","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2022.188797_bb0255","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20191847","article-title":"Macrophage morphology correlates with single-cell diversity and prognosis in colorectal liver metastasis","volume":"217","author":"Donadon","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbcan.2022.188797_bb0260","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s10555-010-9223-6","article-title":"Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity","volume":"29","author":"DeNardo","year":"2010","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.bbcan.2022.188797_bb0265","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/14728222.2018.1451514","article-title":"FOXP3+ Treg as a therapeutic target for promoting anti-tumor immunity","volume":"22","author":"Whiteside","year":"2018","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bbcan.2022.188797_bb0270","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"O'Neill","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0275","doi-asserted-by":"crossref","first-page":"1242454","DOI":"10.1126\/science.1242454","article-title":"Fueling immunity: insights into metabolism and lymphocyte function","volume":"342","author":"Pearce","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.bbcan.2022.188797_bb0280","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1158\/0008-5472.CAN-19-0617","article-title":"Microenvironmental metabolism regulates antitumor immunity","volume":"79","author":"Ngwa","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2022.188797_bb0285","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41590-020-00829-6","article-title":"NF-\u03baB-inducing kinase maintains T cell metabolic fitness in antitumor immunity","volume":"22","author":"Gu","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0290","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/imm.12998","article-title":"Deceleration of glycometabolism impedes IgG-producing B-cell-mediated tumor elimination by targeting SATB1","volume":"156","author":"Liu","year":"2019","journal-title":"Immunology"},{"key":"10.1016\/j.bbcan.2022.188797_bb0295","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41573-019-0016-5","article-title":"Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond","volume":"18","author":"Platten","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbcan.2022.188797_bb0300","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s12307-012-0127-6","article-title":"Effector CD4 and CD8 T cells and their role in the tumor microenvironment","volume":"6","author":"Hadrup","year":"2013","journal-title":"Cancer Microenviron."},{"key":"10.1016\/j.bbcan.2022.188797_bb0305","doi-asserted-by":"crossref","DOI":"10.3390\/cells10102700","article-title":"A complex metabolic network confers immunosuppressive functions to myeloid-derived suppressor cells (MDSCs) within the tumour microenvironment","volume":"10","author":"Hofer","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bbcan.2022.188797_bb0310","doi-asserted-by":"crossref","first-page":"6752","DOI":"10.4049\/jimmunol.176.11.6752","article-title":"The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells","volume":"176","author":"Fallarino","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0315","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.jcmgh.2021.05.018","article-title":"Blockade of IDO-kynurenine-AhR axis ameliorated colitis-associated colon cancer via inhibiting immune tolerance","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0320","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fimmu.2015.00058","article-title":"The coevolution of IDO1 and AhR in the emergence of regulatory T-cells in mammals","volume":"6","author":"Grohmann","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0325","first-page":"1535","article-title":"Role of kynurenine in promoting the generation of exhausted CD8(+) T cells in colorectal cancer","volume":"13","author":"Wu","year":"2021","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.bbcan.2022.188797_bb0330","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41586-019-1325-x","article-title":"TOX transcriptionally and epigenetically programs CD8(+) T cell exhaustion","volume":"571","author":"Khan","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2022.188797_bb0335","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1038\/s41467-021-24785-3","article-title":"3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine","volume":"12","author":"Clement","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2022.188797_bb0340","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.64806","article-title":"Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism","volume":"10","author":"Zeitler","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.bbcan.2022.188797_bb0345","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1182\/blood-2006-11-010389","article-title":"Suppression of T-cell functions by human granulocyte arginase","volume":"108","author":"Munder","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.bbcan.2022.188797_bb0350","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/intimm\/dxs004","article-title":"Arginine deficiency leads to impaired cofilin dephosphorylation in activated human T lymphocytes","volume":"24","author":"Feldmeyer","year":"2012","journal-title":"Int. Immunol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0355","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/cbf.3581","article-title":"Cystine-glutamate antiporter xCT as a therapeutic target for cancer","volume":"39","author":"Liu","year":"2021","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.bbcan.2022.188797_bb0360","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2022.188797_bb0365","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/JLB.3MA1220-815RRR","article-title":"IFN\u03b3-mediated repression of system xc(\u2212) drives vulnerability to induced ferroptosis in hepatocellular carcinoma cells","volume":"110","author":"Kong","year":"2021","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0370","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.immuni.2014.04.007","article-title":"Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation","volume":"40","author":"Nakaya","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.bbcan.2022.188797_bb0375","doi-asserted-by":"crossref","first-page":"624324","DOI":"10.3389\/fimmu.2021.624324","article-title":"Targeting SLC1A5 and SLC3A2\/SLC7A5 as a potential strategy to strengthen anti-tumor immunity in the tumor microenvironment","volume":"12","author":"Nachef","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.11.009","article-title":"Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity","volume":"183","author":"Ringel","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2022.188797_bb0385","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.bbrc.2019.11.158","article-title":"High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage","volume":"522","author":"Tanaka","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbcan.2022.188797_bb0390","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.canlet.2015.04.030","article-title":"Lipid mediator lipoxin A4 inhibits tumor growth by targeting IL-10-producing regulatory B (Breg) cells","volume":"364","author":"Wang","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbcan.2022.188797_bb0395","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22158002","article-title":"Inflammation-related biomarkers for the prediction of prognosis in colorectal cancer patients","volume":"22","author":"Yamamoto","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2022.188797_bb0400","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/ijc.30071","article-title":"Nomograms for predicting prognostic value of inflammatory biomarkers in colorectal cancer patients after radical resection","volume":"139","author":"Li","year":"2016","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbcan.2022.188797_bb0405","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ccr.2009.06.017","article-title":"Polarization of tumor-associated neutrophil phenotype by TGF-beta: \"N1\" versus \"N2\" TAN","volume":"16","author":"Fridlender","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2022.188797_bb0410","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20030529","article-title":"The role of tumor-associated neutrophils in colorectal cancer","volume":"20","author":"Mizuno","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2022.188797_bb0415","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20246254","article-title":"Prostaglandin E2\/EP signaling in the tumor microenvironment of colorectal cancer","volume":"20","author":"Mizuno","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2022.188797_bb0420","doi-asserted-by":"crossref","first-page":"629","DOI":"10.33594\/000000245","article-title":"The critical role of cell metabolism for essential neutrophil functions","volume":"54","author":"Curi","year":"2020","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bbcan.2022.188797_bb0425","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.588","article-title":"Therapeutic targeting of SPIB\/SPI1-facilitated interplay of cancer cells and neutrophils inhibits aerobic glycolysis and cancer progression","volume":"11","author":"Wang","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.bbcan.2022.188797_bb0430","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14040963","article-title":"Early neutrophilia marked by aerobic glycolysis sustains host metabolism and delays cancer cachexia","volume":"14","author":"Petruzzelli","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbcan.2022.188797_bb0435","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s41416-018-0357-6","article-title":"Alterations in serum amino-acid profile in the progression of colorectal cancer: associations with systemic inflammation, tumour stage and patient survival","volume":"120","author":"Sirni\u00f6","year":"2019","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbcan.2022.188797_bb0440","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-019-1118-2","article-title":"Fatty acid transport protein 2 reprograms neutrophils in cancer","volume":"569","author":"Veglia","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2022.188797_bb0445","doi-asserted-by":"crossref","first-page":"7228","DOI":"10.1016\/S0021-9258(19)68951-9","article-title":"Release and metabolism of arachidonic acid in human neutrophils","volume":"256","author":"Walsh","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2022.188797_bb0450","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.7150\/thno.30056","article-title":"Tumor-secreted dickkopf2 accelerates aerobic glycolysis and promotes angiogenesis in colorectal cancer","volume":"9","author":"Deng","year":"2019","journal-title":"Theranostics"},{"issue":"5","key":"10.1016\/j.bbcan.2022.188797_bb0455","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1158\/1541-7786.MCR-20-0827","article-title":"Colorectal cancer-derived CAT1-positive extracellular vesicles alter nitric oxide metabolism in endothelial cells and promote angiogenesis","volume":"19","author":"Ikeda","year":"2021","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.bbcan.2022.188797_bb0460","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.21","article-title":"Adipocytes activate mitochondrial fatty acid oxidation and autophagy to promote tumor growth in colon cancer","volume":"8","author":"Wen","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbcan.2022.188797_bb0465","first-page":"C385","article-title":"ROR\u03b1 inhibits adipocyte-conditioned medium-induced colorectal cancer cell proliferation and migration and chick embryo chorioallantoic membrane angiopoiesis","volume":"308","author":"Xiao","year":"2015","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.bbcan.2022.188797_bb0470","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12944-018-0657-0","article-title":"Interleukin-6 induces fat loss in cancer cachexia by promoting white adipose tissue lipolysis and browning","volume":"17","author":"Han","year":"2018","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.bbcan.2022.188797_bb0475","doi-asserted-by":"crossref","first-page":"867880","DOI":"10.3389\/fgene.2022.867880","article-title":"Breaking the immune complexity of the tumor microenvironment using single-cell technologies","volume":"13","author":"Caligola","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.bbcan.2022.188797_bb0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.03.048","article-title":"Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer","volume":"181","author":"Zhang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2022.188797_bb0485","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41586-018-0694-x","article-title":"Lineage tracking reveals dynamic relationships of T cells in colorectal cancer","volume":"564","author":"Zhang","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2022.188797_bb0490","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.422","article-title":"Single-cell analyses reveal suppressive tumor microenvironment of human colorectal cancer","volume":"11","author":"Mei","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.bbcan.2022.188797_bb0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2017.08.014","article-title":"Exploring metabolic configurations of single cells within complex tissue microenvironments","volume":"26","author":"Miller","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbcan.2022.188797_bb0500","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nrc3483","article-title":"Cancer metabolism: fatty acid oxidation in the limelight","volume":"13","author":"Carracedo","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2022.188797_bb0505","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s40425-019-0701-2","article-title":"Colorectal cancer cell-derived CCL20 recruits regulatory T cells to promote chemoresistance via FOXO1\/CEBPB\/NF-\u03baB signaling","volume":"7","author":"Wang","year":"2019","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.bbcan.2022.188797_bb0510","doi-asserted-by":"crossref","first-page":"7375","DOI":"10.1158\/1078-0432.CCR-17-1283","article-title":"The immune-microenvironment confers chemoresistance of colorectal cancer through macrophage-derived IL6","volume":"23","author":"Yin","year":"2017","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"10.1016\/j.bbcan.2022.188797_bb0515","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature11252","article-title":"Cancer genome atlas, comprehensive molecular characterization of human colon and rectal cancer","volume":"487","author":"N.","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2022.188797_bb0520","doi-asserted-by":"crossref","first-page":"E7697","DOI":"10.1073\/pnas.1710366114","article-title":"Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC","volume":"114","author":"Satoh","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbcan.2022.188797_bb0525","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41556-018-0083-6","article-title":"Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells","volume":"20","author":"Yan","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbcan.2022.188797_bb0530","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/14712598.2020.1718095","article-title":"Pembrolizumab for the treatment of colorectal cancer","volume":"20","author":"Coupez","year":"2020","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.bbcan.2022.188797_bb0535","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1056\/NEJMoa1500596","article-title":"PD-1 blockade in tumors with mismatch-repair deficiency","volume":"372","author":"Le","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2022.188797_bb0540","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S1470-2045(19)30274-8","article-title":"Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301\/KEYNOTE-252): a phase 3, randomised, double-blind study","volume":"20","author":"Long","year":"2019","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.bbcan.2022.188797_bib541","doi-asserted-by":"crossref","unstructured":"Mondello S., Italiano D. Giacobbe M.S., Mondello P., Trimarchi G., Aloisi C., Bramanti P., Spina E. Glutamine-supplemented total parenteral nutrition improves immunological status in anorectic patients. Nutrition 26 (2010) 677-681.","DOI":"10.1016\/j.nut.2009.10.008"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X22001226?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X22001226?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T04:51:32Z","timestamp":1759639892000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304419X22001226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":109,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S0304419X22001226"],"URL":"https:\/\/doi.org\/10.1016\/j.bbcan.2022.188797","relation":{},"ISSN":["0304-419X"],"issn-type":[{"value":"0304-419X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Colorectal cancer: Metabolic interactions reshape the tumor microenvironment","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbcan.2022.188797","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"188797"}}