{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:15:28Z","timestamp":1789143328791,"version":"build-2803163510"},"reference-count":76,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.bbcan.2023.188962","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T11:29:49Z","timestamp":1690975789000},"page":"188962","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Intratumoral lipid metabolic reprogramming as a pro-tumoral regulator in the tumor milieu"],"prefix":"10.1016","volume":"1878","author":[{"given":"Runtian","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiang","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bbcan.2023.188962_bb0005","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41590-019-0589-5","article-title":"CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors","volume":"21","author":"Wang","year":"2020","journal-title":"Nat. Immunol."},{"issue":"11","key":"10.1016\/j.bbcan.2023.188962_bb0010","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201910698","article-title":"Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages","volume":"11","author":"Wu","year":"2019","journal-title":"EMBO Mol. Med."},{"issue":"9","key":"10.1016\/j.bbcan.2023.188962_bb0015","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/s41568-020-0273-y","article-title":"Metabolism of immune cells in cancer","volume":"20","author":"Leone","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2023.188962_bb0020","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.canlet.2017.10.037","article-title":"Metabolic changes in tumor cells and tumor-associated macrophages: a mutual relationship","volume":"413","author":"Netea-Maier","year":"2018","journal-title":"Cancer Lett."},{"issue":"6","key":"10.1016\/j.bbcan.2023.188962_bb0025","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1085\/jgp.8.6.519","article-title":"The metabolism of tumors in the body","volume":"8","author":"Warburg","year":"1927","journal-title":"J. Gen. Physiol."},{"issue":"8","key":"10.1016\/j.bbcan.2023.188962_bb0030","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1172\/JCI127201","article-title":"Adipocyte and lipid metabolism in cancer drug resistance","volume":"129","author":"Cao","year":"2019","journal-title":"J. Clin. Invest."},{"issue":"17","key":"10.1016\/j.bbcan.2023.188962_bb0035","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1038\/s41388-017-0093-z","article-title":"Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis","volume":"37","author":"Ladanyi","year":"2018","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.bbcan.2023.188962_bb0040","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1002\/art.42456","article-title":"Reduction of pro-inflammatory effector functions through remodeling of fatty acid metabolism in CD8(+) T-cells from rheumatoid arthritis patients","volume":"75","author":"Kraus","year":"2023","journal-title":"Arthrit. Rheumatol. (Hoboken, N.J.)"},{"key":"10.1016\/j.bbcan.2023.188962_bb0045","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.semcdb.2015.08.004","article-title":"Pyruvate kinase: function, regulation and role in cancer","volume":"43","author":"Israelsen","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"issue":"6","key":"10.1016\/j.bbcan.2023.188962_bb0050","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.cmet.2021.03.023","article-title":"Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment","volume":"33","author":"Poznanski","year":"2021","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.bbcan.2023.188962_bb0055","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cell.2016.12.039","article-title":"Understanding the intersections between metabolism and Cancer biology","volume":"168","author":"Vander Heiden","year":"2017","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.bbcan.2023.188962_bb0060","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/s41416-020-0759-0","article-title":"Dual metabolic reprogramming by ONC201\/TIC10 and 2-Deoxyglucose induces energy depletion and synergistic anti-cancer activity in glioblastoma","volume":"122","author":"Pruss","year":"2020","journal-title":"Br. J. Cancer"},{"issue":"9","key":"10.1016\/j.bbcan.2023.188962_bb0065","doi-asserted-by":"crossref","DOI":"10.1172\/JCI167442","article-title":"Persistent fasting lipogenesis links impaired ketogenesis with citrate synthesis in humans with non-alcoholic fatty liver","volume":"133","author":"Fu","year":"2023","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.bbcan.2023.188962_bb0070","first-page":"175","article-title":"The pro-tumorigenic effects of metabolic alterations in glioblastoma including brain tumor initiating cells, Biochimica et biophysica acta","volume":"1869","author":"Libby","year":"2018","journal-title":"Rev. Cancer"},{"key":"10.1016\/j.bbcan.2023.188962_bb0075","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.canlet.2020.02.034","article-title":"The metabolic landscape of urological cancers: new therapeutic perspectives","volume":"477","author":"Miranda-Gon\u00e7alves","year":"2020","journal-title":"Cancer Lett."},{"issue":"21","key":"10.1016\/j.bbcan.2023.188962_bb0080","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.1158\/1078-0432.CCR-18-1040","article-title":"Metabolic reprogramming by dual AKT\/ERK inhibition through Imipridones elicits unique vulnerabilities in glioblastoma","volume":"24","author":"Ishida","year":"2018","journal-title":"Clin. Cancer Res.: Off. J. Am. Assoc. Cancer Res."},{"issue":"20","key":"10.1016\/j.bbcan.2023.188962_bb0085","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1182\/blood-2013-03-493163","article-title":"Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia","volume":"122","author":"Willems","year":"2013","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.bbcan.2023.188962_bb0090","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.ccr.2012.09.021","article-title":"ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation","volume":"22","author":"Qing","year":"2012","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.bbcan.2023.188962_bb0095","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cmet.2016.01.007","article-title":"Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer","volume":"23","author":"Davidson","year":"2016","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.bbcan.2023.188962_bb0100","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.cmet.2019.08.013","article-title":"Mechanisms and implications of metabolic heterogeneity in Cancer","volume":"30","author":"Kim","year":"2019","journal-title":"Cell Metab."},{"issue":"6","key":"10.1016\/j.bbcan.2023.188962_bb0105","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41419-021-03842-1","article-title":"HDAC6 regulates primordial follicle activation through mTOR signaling pathway","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.bbcan.2023.188962_bb0110","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/ncb3124","article-title":"Metabolic pathways promoting cancer cell survival and growth","volume":"17","author":"Boroughs","year":"2015","journal-title":"Nat. Cell Biol."},{"issue":"7578","key":"10.1016\/j.bbcan.2023.188962_bb0115","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nature15529","article-title":"Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis","volume":"527","author":"Rabinovich","year":"2015","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bbcan.2023.188962_bb0120","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.cmet.2017.10.013","article-title":"Resistance is futile: targeting mitochondrial energetics and metabolism to overcome drug resistance in cancer treatment","volume":"26","author":"Bosc","year":"2017","journal-title":"Cell Metab."},{"issue":"7","key":"10.1016\/j.bbcan.2023.188962_bb0125","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1158\/2159-8290.CD-16-0441","article-title":"Chemotherapy-resistant human acute myeloid leukemia cells are not enriched for leukemic stem cells but require oxidative metabolism","volume":"7","author":"Farge","year":"2017","journal-title":"Cancer Discov."},{"issue":"8","key":"10.1016\/j.bbcan.2023.188962_bb0130","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.bbabio.2017.01.012","article-title":"Mitochondria and cancer chemoresistance, Biochimica et biophysica acta","volume":"1858","author":"Guerra","year":"2017","journal-title":"Bioenergetics"},{"issue":"3","key":"10.1016\/j.bbcan.2023.188962_bb0135","first-page":"1055","article-title":"ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cells","volume":"53","author":"Xu","year":"2018","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbcan.2023.188962_bb0140","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.freeradbiomed.2019.03.009","article-title":"Cisplatin resistance involves a metabolic reprogramming through ROS and PGC-1\u03b1 in NSCLC which can be overcome by OXPHOS inhibition","volume":"135","author":"Cruz-Berm\u00fadez","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbcan.2023.188962_bb0145","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fonc.2020.00005","article-title":"Metabolic Symbiosis in Chemoresistance: refocusing the role of aerobic glycolysis","volume":"10","author":"Ma","year":"2020","journal-title":"Front. Oncol."},{"issue":"9","key":"10.1016\/j.bbcan.2023.188962_bb0150","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.chembiol.2017.08.028","article-title":"Targeting metabolism for Cancer therapy","volume":"24","author":"Luengo","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.bbcan.2023.188962_bb0155","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1146\/annurev-pathol-012615-044329","article-title":"Metabolic reprogramming in brain tumors","volume":"12","author":"Venneti","year":"2017","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.bbcan.2023.188962_bb0160","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jbior.2018.09.006","article-title":"Role of FABP7 in tumor cell signaling","volume":"71","author":"Kagawa","year":"2019","journal-title":"Adv. Biol. Reg."},{"issue":"1","key":"10.1016\/j.bbcan.2023.188962_bb0165","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41416-019-0650-z","article-title":"Reprogramming of fatty acid metabolism in cancer","volume":"122","author":"Koundouros","year":"2020","journal-title":"Br. J. Cancer"},{"issue":"17","key":"10.1016\/j.bbcan.2023.188962_bb0170","doi-asserted-by":"crossref","first-page":"29487","DOI":"10.18632\/oncotarget.15494","article-title":"Fatty acid metabolism in breast cancer subtypes","volume":"8","author":"Monaco","year":"2017","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.bbcan.2023.188962_bb0175","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41580-018-0085-z","article-title":"Dynamics and functions of lipid droplets","volume":"20","author":"Olzmann","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"8","key":"10.1016\/j.bbcan.2023.188962_bb0180","article-title":"Lipid droplets in cancer: guardians of fat in a stressful world","volume":"23","author":"Petan","year":"2018","journal-title":"Mol. (Basel, Switzerl.)"},{"issue":"12","key":"10.1016\/j.bbcan.2023.188962_bb0185","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/s41568-021-00388-4","article-title":"Tumour fatty acid metabolism in the context of therapy resistance and obesity","volume":"21","author":"Hoy","year":"2021","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.bbcan.2023.188962_bb0190","first-page":"27","article-title":"Lipid metabolism reprogramming and its potential targets in cancer","volume":"38","author":"Cheng","year":"2018","journal-title":"Cancer Commun. (Lond., Engl.)"},{"issue":"4","key":"10.1016\/j.bbcan.2023.188962_bb0195","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ccr.2005.09.008","article-title":"ATP citrate lyase inhibition can suppress tumor cell growth","volume":"8","author":"Hatzivassiliou","year":"2005","journal-title":"Cancer Cell"},{"issue":"5","key":"10.1016\/j.bbcan.2023.188962_bb0200","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ccell.2016.04.003","article-title":"Loss of chromosome 8p governs tumor progression and drug response by altering lipid metabolism","volume":"29","author":"Cai","year":"2016","journal-title":"Cancer Cell"},{"issue":"10","key":"10.1016\/j.bbcan.2023.188962_bb0205","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1101\/gad.1987211","article-title":"Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress","volume":"25","author":"Zaugg","year":"2011","journal-title":"Genes Dev."},{"issue":"46","key":"10.1016\/j.bbcan.2023.188962_bb0210","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.1038\/s41388-018-0384-z","article-title":"CPT1A-mediated fatty acid oxidation promotes colorectal cancer cell metastasis by inhibiting anoikis","volume":"37","author":"Wang","year":"2018","journal-title":"Oncogene"},{"issue":"9","key":"10.1016\/j.bbcan.2023.188962_bb0215","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.7150\/thno.21451","article-title":"Targeting CPT1A-mediated fatty acid oxidation sensitizes nasopharyngeal carcinoma to radiation therapy","volume":"8","author":"Tan","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.bbcan.2023.188962_bb0220","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.plipres.2015.11.004","article-title":"Carnitine palmitoyltransferase 1C: From cognition to cancer","volume":"61","author":"Casals","year":"2016","journal-title":"Prog. Lipid Res."},{"issue":"5","key":"10.1016\/j.bbcan.2023.188962_bb0225","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.cell.2015.05.001","article-title":"Integrative clinical genomics of advanced prostate cancer","volume":"161","author":"Robinson","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2023.188962_bb0230","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3389\/fonc.2020.00155","article-title":"Fatty acid metabolism, bone marrow adipocytes, and AML","volume":"10","author":"Tabe","year":"2020","journal-title":"Front. Oncol."},{"issue":"2","key":"10.1016\/j.bbcan.2023.188962_bb0235","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nrm2335","article-title":"Lipid signalling in disease","volume":"9","author":"Wymann","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.bbcan.2023.188962_bb0240","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.cmet.2011.12.018","article-title":"FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling","volume":"15","author":"Zechner","year":"2012","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.bbcan.2023.188962_bb0245","first-page":"221","article-title":"Adipose triglyceride lipase regulation: an overview","volume":"19","author":"Cerk","year":"2018","journal-title":"Curr. Protein Pept. Sci."},{"issue":"1","key":"10.1016\/j.bbcan.2023.188962_bb0250","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1038\/s41598-017-02963-y","article-title":"Lipid droplet-associated hydrolase promotes lipid droplet fusion and enhances ATGL degradation and triglyceride accumulation","volume":"7","author":"Goo","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.bbcan.2023.188962_bb0255","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41419-018-0345-z","article-title":"Hints on ATGL implications in cancer: beyond bioenergetic clues","volume":"9","author":"Vegliante","year":"2018","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.bbcan.2023.188962_bb0260","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1016\/j.cmet.2022.11.003","article-title":"Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells","volume":"34","author":"Gong","year":"2022","journal-title":"Cell Metab."},{"issue":"7","key":"10.1016\/j.bbcan.2023.188962_bb0265","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.chembiol.2011.05.009","article-title":"Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer","volume":"18","author":"Nomura","year":"2011","journal-title":"Chem. Biol."},{"issue":"1","key":"10.1016\/j.bbcan.2023.188962_bb0270","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13046-021-02223-y","article-title":"Adiponectin triggers breast cancer cell death via fatty acid metabolic reprogramming","volume":"41","author":"Pham","year":"2022","journal-title":"J. Exper. Clin. Cancer Re.: CR"},{"issue":"1","key":"10.1016\/j.bbcan.2023.188962_bb0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.immuni.2013.07.012","article-title":"Oncology meets immunology: the cancer-immunity cycle","volume":"39","author":"Chen","year":"2013","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.bbcan.2023.188962_bb0280","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/sj.pcan.4500879","article-title":"Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer","volume":"9","author":"Liu","year":"2006","journal-title":"Prostate Cancer Prostatic Dis."},{"issue":"3","key":"10.1016\/j.bbcan.2023.188962_bb0285","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019102525","article-title":"Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells","volume":"39","author":"Clement","year":"2020","journal-title":"EMBO J."},{"issue":"7251","key":"10.1016\/j.bbcan.2023.188962_bb0290","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature08097","article-title":"Enhancing CD8 T-cell memory by modulating fatty acid metabolism","volume":"460","author":"Pearce","year":"2009","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bbcan.2023.188962_bb0295","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ccell.2017.08.004","article-title":"Enhancing CD8(+) T cell fatty acid catabolism within a metabolically challenging tumor microenvironment increases the efficacy of melanoma immunotherapy","volume":"32","author":"Zhang","year":"2017","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.bbcan.2023.188962_bb0300","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.cmet.2019.10.013","article-title":"STAT3 activation-induced fatty acid oxidation in CD8(+) T effector cells is critical for obesity-promoted breast tumor growth","volume":"31","author":"Zhang","year":"2020","journal-title":"Cell Metab."},{"issue":"28","key":"10.1016\/j.bbcan.2023.188962_bb0305","doi-asserted-by":"crossref","first-page":"E6546","DOI":"10.1073\/pnas.1720113115","article-title":"Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth","volume":"115","author":"Pacella","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.bbcan.2023.188962_bb0310","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.celrep.2018.03.084","article-title":"Differential reliance on lipid metabolism as a salvage pathway underlies functional differences of T cell subsets in poor nutrient environments","volume":"23","author":"Ecker","year":"2018","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.bbcan.2023.188962_bb0315","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001536","article-title":"Tumor-derived ILT4 induces T cell senescence and suppresses tumor immunity","volume":"9","author":"Gao","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"8","key":"10.1016\/j.bbcan.2023.188962_bb0320","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20191920","article-title":"Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells","volume":"217","author":"Manzo","year":"2020","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.bbcan.2023.188962_bb0325","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1038\/s41467-021-24331-1","article-title":"Microbial short-chain fatty acids modulate CD8(+) T cell responses and improve adoptive immunotherapy for cancer","volume":"12","author":"Luu","year":"2021","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.bbcan.2023.188962_bb0330","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-002138","article-title":"N-cadherin inhibitor creates a microenvironment that protect TILs from immune checkpoints and Treg cells","volume":"9","author":"Sun","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.bbcan.2023.188962_bb0335","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.immuni.2020.06.016","article-title":"An oncogenic alteration creates a microenvironment that promotes tumor progression by conferring a metabolic advantage to regulatory T cells","volume":"53","author":"Kumagai","year":"2020","journal-title":"Immunity"},{"issue":"7849","key":"10.1016\/j.bbcan.2023.188962_bb0340","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41586-021-03235-6","article-title":"Lipid signalling enforces functional specialization of T(reg) cells in tumours","volume":"591","author":"Lim","year":"2021","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bbcan.2023.188962_bb0345","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.molmed.2018.03.006","article-title":"Macrophages: the road less traveled, changing anticancer therapy","volume":"24","author":"Guerriero","year":"2018","journal-title":"Trends Mol. Med."},{"issue":"6","key":"10.1016\/j.bbcan.2023.188962_bb0350","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-002548","article-title":"S100A4 enhances protumor macrophage polarization by control of PPAR-\u03b3-dependent induction of fatty acid oxidation","volume":"9","author":"Liu","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"9","key":"10.1016\/j.bbcan.2023.188962_bb0355","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1158\/0008-5472.CAN-17-2465","article-title":"Expression of adipocyte\/macrophage fatty acid-binding protein in tumor-associated macrophages promotes breast Cancer progression","volume":"78","author":"Hao","year":"2018","journal-title":"Cancer Res."},{"issue":"26","key":"10.1016\/j.bbcan.2023.188962_bb0360","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1182\/blood.2020005602","article-title":"Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment","volume":"136","author":"Kobayashi","year":"2020","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.bbcan.2023.188962_bb0365","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1053\/j.gastro.2020.01.028","article-title":"High serum levels of cholesterol increase antitumor functions of nature killer cells and reduce growth of liver tumors in mice","volume":"158","author":"Qin","year":"2020","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.bbcan.2023.188962_bb0370","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/s41423-022-00872-3","article-title":"Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver","volume":"19","author":"Tang","year":"2022","journal-title":"Cell. Mol. Immunol."},{"issue":"7754","key":"10.1016\/j.bbcan.2023.188962_bb0375","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-019-1118-2","article-title":"Fatty acid transport protein 2 reprograms neutrophils in cancer","volume":"569","author":"Veglia","year":"2019","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.bbcan.2023.188962_bb0380","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1172\/JCI97570","article-title":"Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity","volume":"128","author":"Chen","year":"2018","journal-title":"J. Clin. Invest."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X23001117?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X23001117?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T04:53:37Z","timestamp":1759640017000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304419X23001117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":76,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S0304419X23001117"],"URL":"https:\/\/doi.org\/10.1016\/j.bbcan.2023.188962","relation":{},"ISSN":["0304-419X"],"issn-type":[{"value":"0304-419X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intratumoral lipid metabolic reprogramming as a pro-tumoral regulator in the tumor milieu","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbcan.2023.188962","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"188962"}}