{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:20:37Z","timestamp":1793910037394,"version":"4.8.0"},"reference-count":103,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.bbcan.2023.189032","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T11:50:52Z","timestamp":1701172252000},"page":"189032","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Tumor microenvironment crosstalk between tumors and the nervous system in pancreatic cancer: Molecular mechanisms and clinical perspectives"],"prefix":"10.1016","volume":"1879","author":[{"given":"Wenchao","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhou","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbcan.2023.189032_bb0005","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ccell.2017.02.005","article-title":"Nerve dependence: from regeneration to cancer","volume":"31","author":"Boilly","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2023.189032_bb0010","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1097\/SLA.0000000000000968","article-title":"The impact of neural invasion severity in gastrointestinal malignancies: a clinicopathological study","volume":"260","author":"Liebl","year":"2014","journal-title":"Ann. Surg."},{"key":"10.1016\/j.bbcan.2023.189032_bb0015","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/SLA.0000000000004464","article-title":"Implications of perineural invasion on disease recurrence and survival after pancreatectomy for pancreatic head ductal adenocarcinoma","volume":"276","author":"Crippa","year":"2022","journal-title":"Ann. Surg."},{"key":"10.1016\/j.bbcan.2023.189032_bb0020","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54095","article-title":"Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer","volume":"9","author":"Burfeind","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.bbcan.2023.189032_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13184594","article-title":"Perineural invasion and associated pain transmission in pancreatic cancer","volume":"13","author":"Wang","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbcan.2023.189032_bb0030","article-title":"Relationship between neural alteration and perineural invasion in pancreatic cancer patients with hyperglycemia","volume":"6","author":"Li","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2023.189032_bb0035","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13046-018-0674-x","article-title":"Role of the nervous system in cancer metastasis","volume":"37","author":"Kuol","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2023.189032_bb0040","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nature11547","article-title":"Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes","volume":"491","author":"Biankin","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2023.189032_bb0045","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.cell.2020.10.016","article-title":"Neurons release serine to support mRNA translation in pancreatic cancer","volume":"183","author":"Banh","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2023.189032_bb0050","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41586-022-05374-w","article-title":"Nociceptor neurons affect cancer immunosurveillance","volume":"611","author":"Balood","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2023.189032_bb0055","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ccell.2017.11.007","article-title":"\u03b22 adrenergic-neurotrophin feedforward loop promotes pancreatic cancer","volume":"33","author":"Renz","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2023.189032_bb0060","doi-asserted-by":"crossref","first-page":"22501","DOI":"10.18632\/oncotarget.15019","article-title":"Subdiaphragmatic vagotomy promotes tumor growth and reduces survival via TNF\u03b1 in a murine pancreatic cancer model","volume":"8","author":"Partecke","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbcan.2023.189032_bb0065","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1073\/pnas.1512603113","article-title":"Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer","volume":"113","author":"Saloman","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbcan.2023.189032_bb0070","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1038\/s41467-022-29659-w","article-title":"Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer","volume":"13","author":"Guillot","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2023.189032_bb0075","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1158\/0008-5472.CAN-19-2689","article-title":"Perineural invasion reprograms the immune microenvironment through cholinergic signaling in pancreatic ductal adenocarcinoma","volume":"80","author":"Yang","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2023.189032_bb0080","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1097\/SLA.0000000000002234","article-title":"Patterns, timing, and predictors of recurrence following pancreatectomy for pancreatic ductal adenocarcinoma","volume":"267","author":"Groot","year":"2018","journal-title":"Ann. Surg."},{"key":"10.1016\/j.bbcan.2023.189032_bb0085","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.ccell.2020.08.004","article-title":"Challenges and opportunities for pancreatic cancer immunotherapy","volume":"38","author":"Bear","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2023.189032_bb0090","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1001\/jamaoncol.2022.3829","article-title":"Five-year outcomes of FOLFIRINOX vs gemcitabine as adjuvant therapy for pancreatic cancer: a randomized clinical trial","volume":"8","author":"Conroy","year":"2022","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.bbcan.2023.189032_bb0095","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.1158\/0008-5472.CAN-17-0108","article-title":"Beta-blocker drug use and survival among patients with pancreatic adenocarcinoma","volume":"77","author":"Udumyan","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2023.189032_bb0100","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1016\/S1470-2045(21)00596-9","article-title":"Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities","volume":"23","author":"Shi","year":"2022","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.bbcan.2023.189032_bb0105","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1053\/j.gastro.2008.09.029","article-title":"Pancreatic neuropathy and neuropathic pain \u2013 a comprehensive pathomorphological study of 546 cases","volume":"136","author":"Ceyhan","year":"2009","journal-title":"Gastroenterology"},{"issue":"Suppl","key":"10.1016\/j.bbcan.2023.189032_bb0110","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1016\/j.bbi.2012.06.005","article-title":"Neuroendocrine influences on cancer progression","volume":"30","author":"Armaiz-Pena","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbcan.2023.189032_bb0115","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/1099-1611(200101\/02)10:1<19::AID-PON501>3.0.CO;2-6","article-title":"The prevalence of psychological distress by cancer site","volume":"10","author":"Zabora","year":"2001","journal-title":"Psychooncology"},{"key":"10.1016\/j.bbcan.2023.189032_bb0120","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/cncr.23231","article-title":"GABA B receptor is a novel drug target for pancreatic cancer","volume":"112","author":"Schuller","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.bbcan.2023.189032_bb0125","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1158\/1535-7163.MCT-12-0809","article-title":"Interaction of the sympathetic nerve with pancreatic cancer cells promotes perineural invasion through the activation of STAT3 signaling","volume":"12","author":"Guo","year":"2013","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bbcan.2023.189032_bb0130","first-page":"3015","article-title":"Norepinephrine enhances cell viability and invasion, and inhibits apoptosis of pancreatic cancer cells in a Notch-1-dependent manner","volume":"40","author":"Qian","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bbcan.2023.189032_bb0135","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1158\/0008-5472.CAN-16-2143","article-title":"Enriching the housing environment for mice enhances their NK cell antitumor immunity via sympathetic nerve-dependent regulation of NKG2D and CCR5","volume":"77","author":"Song","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2023.189032_bb0140","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.canep.2015.11.007","article-title":"Vagal nerve activity predicts overall survival in metastatic pancreatic cancer, mediated by inflammation","volume":"40","author":"De Couck","year":"2016","journal-title":"Cancer Epidemiol."},{"key":"10.1016\/j.bbcan.2023.189032_bb0145","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1158\/2159-8290.CD-18-0046","article-title":"Cholinergic signaling via muscarinic receptors directly and indirectly suppresses pancreatic tumorigenesis and cancer stemness","volume":"8","author":"Renz","year":"2018","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bbcan.2023.189032_bb0150","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s13046-020-01796-4","article-title":"Indirect cholinergic activation slows down pancreatic cancer growth and tumor-associated inflammation","volume":"39","author":"Pfitzinger","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2023.189032_bb0155","doi-asserted-by":"crossref","first-page":"180","DOI":"10.21147\/j.issn.1000-9604.2016.02.05","article-title":"Parasympathetic neurogenesis is strongly associated with tumor budding and correlates with an adverse prognosis in pancreatic ductal adenocarcinoma","volume":"28","author":"Zhang","year":"2016","journal-title":"Chin. J. Cancer Res."},{"key":"10.1016\/j.bbcan.2023.189032_bb0160","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1158\/0008-5472.CAN-13-2050","article-title":"Neuroplastic changes occur early in the development of pancreatic ductal adenocarcinoma","volume":"74","author":"Stopczynski","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2023.189032_bb0165","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1158\/0008-5472.CAN-16-0899","article-title":"PanIN neuroendocrine cells promote tumorigenesis via neuronal cross-talk","volume":"77","author":"Sinha","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2023.189032_bb0170","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1053\/j.gastro.2020.04.037","article-title":"CXCL10 and CCL21 promote migration of pancreatic cancer cells toward sensory neurons and neural remodeling in tumors in mice, associated with pain in patients","volume":"159","author":"Hirth","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2023.189032_bb0175","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1053\/j.gastro.2017.03.008","article-title":"Increased serotonin signaling contributes to the Warburg effect in pancreatic tumor cells under metabolic stress and promotes growth of pancreatic tumors in mice","volume":"153","author":"Jiang","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2023.189032_bb0180","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1007\/s00262-020-02816-0","article-title":"Dopamine improves chemotherapeutic efficacy for pancreatic cancer by regulating macrophage-derived inflammations","volume":"70","author":"Liu","year":"2021","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.bbcan.2023.189032_bb0185","doi-asserted-by":"crossref","first-page":"11083","DOI":"10.2147\/OTT.S221844","article-title":"Extrapancreatic neuropathy correlates with early liver metastasis in pancreatic head adenocarcinoma","volume":"12","author":"Lu","year":"2019","journal-title":"Onco. Targets. Ther."},{"key":"10.1016\/j.bbcan.2023.189032_bb0190","article-title":"Association between age at diabetes onset or diabetes duration and subsequent risk of pancreatic cancer: results from a longitudinal cohort and mendelian randomization study","volume":"30","author":"Shen","year":"2023","journal-title":"Lancet Reg. Health West Pac."},{"key":"10.1016\/j.bbcan.2023.189032_bb0195","doi-asserted-by":"crossref","first-page":"1236361","DOI":"10.1126\/science.1236361","article-title":"Autonomic nerve development contributes to prostate cancer progression","volume":"341","author":"Magnon","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.bbcan.2023.189032_bb0200","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1097\/SLA.0b013e3181d974d4","article-title":"Nerve growth factor and artemin are paracrine mediators of pancreatic neuropathy in pancreatic adenocarcinoma","volume":"251","author":"Ceyhan","year":"2010","journal-title":"Ann. Surg."},{"key":"10.1016\/j.bbcan.2023.189032_bb0205","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1111\/cas.13975","article-title":"Reduction of intrapancreatic neural density in cancer tissue predicts poorer outcome in pancreatic ductal carcinoma","volume":"110","author":"Iwasaki","year":"2019","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bbcan.2023.189032_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119848","article-title":"Pan-cancer analysis reveals that neurotrophin signaling correlates positively with anti-tumor immunity, clinical outcomes, and response to targeted therapies and immunotherapies in cancer","volume":"282","author":"Feng","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.bbcan.2023.189032_bb0215","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrc.2016.38","article-title":"Mechanisms of cancer dissemination along nerves","volume":"16","author":"Amit","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2023.189032_bb0220","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1097\/j.pain.0000000000000956","article-title":"A mouse model for pain and neuroplastic changes associated with pancreatic ductal adenocarcinoma","volume":"158","author":"Selvaraj","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.bbcan.2023.189032_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165586","article-title":"Blocking nerve growth factor signaling reduces the neural invasion potential of pancreatic Cancer cells","volume":"11","author":"Bapat","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2023.189032_bb0230","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/nrc3131","article-title":"Perineural invasion and associated pain in pancreatic cancer","volume":"11","author":"Bapat","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2023.189032_bb0235","doi-asserted-by":"crossref","first-page":"8588","DOI":"10.1523\/JNEUROSCI.1726-06.2006","article-title":"Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo","volume":"26","author":"Malin","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbcan.2023.189032_bb0240","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1053\/j.gastro.2011.03.046","article-title":"Nerve growth factor modulates TRPV1 expression and function and mediates pain in chronic pancreatitis","volume":"141","author":"Zhu","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2023.189032_bb0245","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.4103\/0366-6999.191777","article-title":"Continuous low-dose-rate irradiation of Iodine-125 seeds inhibiting perineural invasion in pancreatic cancer","volume":"129","author":"Lu","year":"2016","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.bbcan.2023.189032_bb0250","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.bbrc.2018.09.147","article-title":"MiR-429 suppresses neurotrophin-3 to alleviate perineural invasion of pancreatic cancer","volume":"505","author":"Liu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbcan.2023.189032_bb0255","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1007\/s12031-020-01607-7","article-title":"MicroRNA-330 directs downregulation of the GABA(B)R2 in the pathogenesis of pancreatic cancer pain","volume":"70","author":"Zhu","year":"2020","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.bbcan.2023.189032_bb0260","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1002\/bjs.9892","article-title":"Meta-analysis of radical resection rates and margin assessment in pancreatic cancer","volume":"102","author":"Chandrasegaram","year":"2015","journal-title":"Br. J. Surg."},{"key":"10.1016\/j.bbcan.2023.189032_bb0265","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s12943-018-0858-1","article-title":"Tumor microenvironment participates in metastasis of pancreatic cancer","volume":"17","author":"Ren","year":"2018","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbcan.2023.189032_bb0270","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1080\/15384047.2015.1040952","article-title":"Hyperglycemic tumor microenvironment induces perineural invasion in pancreatic cancer","volume":"16","author":"Li","year":"2015","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.bbcan.2023.189032_bb0275","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1053\/j.gastro.2019.05.065","article-title":"Axon guidance molecules promote perineural invasion and metastasis of orthotopic pancreatic tumors in mice","volume":"157","author":"Jurcak","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2023.189032_bb0280","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.cell.2011.11.060","article-title":"Computational modeling of pancreatic cancer reveals kinetics of metastasis suggesting optimum treatment strategies","volume":"148","author":"Haeno","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2023.189032_bb0285","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.pan.2016.09.005","article-title":"Nerve growth factor regulates CD133 function to promote tumor cell migration and invasion via activating ERK1\/2 signaling in pancreatic cancer","volume":"16","author":"Xin","year":"2016","journal-title":"Pancreatology"},{"key":"10.1016\/j.bbcan.2023.189032_bb0290","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1158\/1078-0432.440.11.2","article-title":"Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells","volume":"11","author":"Sclabas","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2023.189032_bb0295","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.pharmthera.2019.04.010","article-title":"Signaling in the microenvironment of pancreatic cancer: transmitting along the nerve","volume":"200","author":"Jurcak","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbcan.2023.189032_bb0300","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/dju184","article-title":"Investigation of Schwann cells at neoplastic cell sites before the onset of cancer invasion","volume":"106","author":"Demir","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bbcan.2023.189032_bb0305","doi-asserted-by":"crossref","first-page":"10222","DOI":"10.1158\/0008-5472.CAN-06-2483","article-title":"MUC1 is a counter-receptor for myelin-associated glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion","volume":"67","author":"Swanson","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2023.189032_bb0310","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13046-021-02198-w","article-title":"Autophagic Schwann cells promote perineural invasion mediated by the NGF\/ATG7 paracrine pathway in pancreatic cancer","volume":"41","author":"Zhang","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2023.189032_bb0315","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1158\/0008-5472.CAN-20-3326","article-title":"Peripheral nerve resident macrophages and Schwann cells mediate cancer-induced pain","volume":"81","author":"De Logu","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2023.189032_bb0320","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1038\/s41467-017-01739-2","article-title":"Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice","volume":"8","author":"De Logu","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2023.189032_bb0325","doi-asserted-by":"crossref","first-page":"E85","DOI":"10.1073\/pnas.1606909114","article-title":"Early pancreatic cancer lesions suppress pain through CXCL12-mediated chemoattraction of Schwann cells","volume":"114","author":"Demir","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbcan.2023.189032_bb0330","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1136\/gutjnl-2015-309784","article-title":"Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia","volume":"65","author":"Demir","year":"2016","journal-title":"Gut"},{"issue":"480\u201390","key":"10.1016\/j.bbcan.2023.189032_bb0335","first-page":"e112","article-title":"The microenvironment in chronic pancreatitis and pancreatic cancer induces neuronal plasticity","volume":"22","author":"Demir","year":"2010","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.bbcan.2023.189032_bb0340","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1177\/0963689719851772","article-title":"Pancreatic stellate cells facilitate perineural invasion of pancreatic cancer via HGF\/c-met pathway","volume":"28","author":"Nan","year":"2019","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bbcan.2023.189032_bb0345","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1126\/science.2492115","article-title":"Perineurium originates from fibroblasts: demonstration in vitro with a retroviral marker","volume":"243","author":"Bunge","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.bbcan.2023.189032_bb0350","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.557","article-title":"Stromal SLIT2 impacts on pancreatic cancer-associated neural remodeling","volume":"6","author":"Secq","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbcan.2023.189032_bb0355","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.1158\/0008-5472.CAN-12-0764","article-title":"Endoneurial macrophages induce perineural invasion of pancreatic cancer cells by secretion of GDNF and activation of RET tyrosine kinase receptor","volume":"72","author":"Cavel","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2023.189032_bb0360","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.conb.2019.11.006","article-title":"Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons","volume":"62","author":"Chen","year":"2020","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.bbcan.2023.189032_bb0365","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1213\/ANE.0000000000002803","article-title":"Neural invasion spreads macrophage-related allodynia via neural root in pancreatic cancer","volume":"126","author":"Miura","year":"2018","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.bbcan.2023.189032_bb0370","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41419-022-04799-5","article-title":"HGF\/c-met pathway facilitates the perineural invasion of pancreatic cancer by activating the mTOR\/NGF axis","volume":"13","author":"Qin","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbcan.2023.189032_bb0375","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/jnci\/djp456","article-title":"Paracrine regulation of pancreatic cancer cell invasion by peripheral nerves","volume":"102","author":"Gil","year":"2010","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bbcan.2023.189032_bb0380","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/carcin\/bgt312","article-title":"The neurotrophic factor neurturin contributes toward an aggressive cancer cell phenotype, neuropathic pain and neuronal plasticity in pancreatic cancer","volume":"35","author":"Wang","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbcan.2023.189032_bb0385","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bbi.2014.02.019","article-title":"Chronic stress accelerates pancreatic cancer growth and invasion: a critical role for beta-adrenergic signaling in the pancreatic microenvironment","volume":"40","author":"Kim-Fuchs","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbcan.2023.189032_bb0390","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1136\/gutjnl-2018-317479","article-title":"GABRP regulates chemokine signalling, macrophage recruitment and tumour progression in pancreatic cancer through tuning KCNN4-mediated Ca(2+) signalling in a GABA-independent manner","volume":"68","author":"Jiang","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.bbcan.2023.189032_bb0395","doi-asserted-by":"crossref","first-page":"9704","DOI":"10.1158\/0008-5472.CAN-07-2099","article-title":"Gamma-aminobutyric acid (GABA) stimulates pancreatic cancer growth through overexpressing GABAA receptor pi subunit","volume":"67","author":"Takehara","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2023.189032_bb0400","doi-asserted-by":"crossref","first-page":"eabc8188","DOI":"10.1126\/scitranslmed.abc8188","article-title":"Attenuation of peripheral serotonin inhibits tumor growth and enhances immune checkpoint blockade therapy in murine tumor models","volume":"13","author":"Schneider","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbcan.2023.189032_bb0405","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1172\/JCI82658","article-title":"Schwann cells induce cancer cell dispersion and invasion","volume":"126","author":"Deborde","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2023.189032_bb0410","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0304-3835(98)00359-0","article-title":"Expression of highly polysialylated neural cell adhesion molecule in pancreatic cancer neural invasive lesion","volume":"137","author":"Kameda","year":"1999","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbcan.2023.189032_bb0415","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/s41388-018-0458-y","article-title":"L1CAM induces perineural invasion of pancreas cancer cells by upregulation of metalloproteinase expression","volume":"38","author":"Na'ara","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2023.189032_bb0420","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/ijc.25104","article-title":"Nerve invasion distance is dependent on laminin gamma2 in tumors of pancreatic cancer","volume":"127","author":"Mitsunaga","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbcan.2023.189032_bb0425","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.canlet.2019.03.036","article-title":"HIF-1\u03b1 mediates tumor-nerve interactions through the up-regulation of GM-CSF in pancreatic ductal adenocarcinoma","volume":"453","author":"Wang","year":"2019","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbcan.2023.189032_bb0430","doi-asserted-by":"crossref","first-page":"9060","DOI":"10.1158\/0008-5472.CAN-08-1810","article-title":"The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma","volume":"68","author":"Marchesi","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2023.189032_bb0435","doi-asserted-by":"crossref","first-page":"6400","DOI":"10.1158\/0008-5472.CAN-17-1612","article-title":"Inflammatory monocytes promote perineural invasion via CCL2-mediated recruitment and cathepsin B expression","volume":"77","author":"Bakst","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2023.189032_bb0440","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/s41598-018-19643-0","article-title":"CCR5\/CCL5 axis interaction promotes migratory and invasiveness of pancreatic cancer cells","volume":"8","author":"Singh","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2023.189032_bb0445","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1200\/jco.2015.33.3_suppl.302","article-title":"Effect of coadministered beta blocker and COX-2 inhibitor to patients with pancreatic cancer prior to receiving albumin-bound (Nab) paclitaxel","volume":"33","author":"Bhattacharyya","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2023.189032_bb0450","first-page":"1924","article-title":"The neurotrophin-trk receptor axes are critical for the growth and progression of human prostatic carcinoma and pancreatic ductal adenocarcinoma xenografts in nude mice","volume":"8","author":"Miknyoczki","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2023.189032_bb0455","doi-asserted-by":"crossref","first-page":"15130","DOI":"10.1038\/ncomms15130","article-title":"Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer","volume":"8","author":"Lei","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2023.189032_bb0460","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41584-020-00528-4","article-title":"The evolution of nerve growth factor inhibition in clinical medicine","volume":"17","author":"Wise","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bbcan.2023.189032_bb0465","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1007\/s40265-017-0781-6","article-title":"Nerve growth factor antagonists: is the future of monoclonal antibodies becoming clearer?","volume":"77","author":"Bannwarth","year":"2017","journal-title":"Drugs"},{"key":"10.1016\/j.bbcan.2023.189032_bb0470","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1053\/j.gastro.2016.08.040","article-title":"Expression of DRD2 is increased in human pancreatic ductal adenocarcinoma and inhibitors slow tumor growth in mice","volume":"151","author":"Jandaghi","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2023.189032_bb0475","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/jama.291.9.1092","article-title":"Effect of neurolytic celiac plexus block on pain relief, quality of life, and survival in patients with unresectable pancreatic cancer: a randomized controlled trial","volume":"291","author":"Wong","year":"2004","journal-title":"Jama"},{"key":"10.1016\/j.bbcan.2023.189032_bb0480","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/ALN.0000000000003936","article-title":"Neurolytic splanchnic nerve block and pain relief, survival, and quality of life in unresectable pancreatic Cancer: a randomized controlled trial","volume":"135","author":"Dong","year":"2021","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bbcan.2023.189032_bb0485","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1200\/JCO.2010.32.2750","article-title":"Randomized, double-blind, controlled trial of early endoscopic ultrasound-guided celiac plexus neurolysis to prevent pain progression in patients with newly diagnosed, painful, inoperable pancreatic cancer","volume":"29","author":"Wyse","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2023.189032_bb0490","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.gie.2014.12.036","article-title":"Impact of celiac neurolysis on survival in patients with pancreatic cancer","volume":"82","author":"Fujii-Lau","year":"2015","journal-title":"Gastrointest. Endosc."},{"key":"10.1016\/j.bbcan.2023.189032_bb0495","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.3892\/ijo.2015.3190","article-title":"The concept and controversy of retroperitoneal nerve dissection in pancreatic head carcinoma (Review)","volume":"47","author":"Wang","year":"2015","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbcan.2023.189032_bb0500","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/(SICI)1097-0142(19960215)77:4<640::AID-CNCR9>3.0.CO;2-K","article-title":"Results of extensive surgery for pancreatic carcinoma","volume":"77","author":"Nagakawa","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/j.bbcan.2023.189032_bb0505","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1097\/00029330-200806020-00018","article-title":"Radical pancreatoduodenectomy combined with retroperitoneal nerve, lymph, and soft-tissue dissection in pancreatic head cancer","volume":"121","author":"Shao","year":"2008","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.bbcan.2023.189032_bb0510","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/cr.2016.151","article-title":"Regulatory T cells in cancer immunotherapy","volume":"27","author":"Tanaka","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.bbcan.2023.189032_bb0515","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41593-019-0430-3","article-title":"Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression","volume":"22","author":"Kamiya","year":"2019","journal-title":"Nat. Neurosci."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X23001816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X23001816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T04:45:35Z","timestamp":1759639535000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304419X23001816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":103,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S0304419X23001816"],"URL":"https:\/\/doi.org\/10.1016\/j.bbcan.2023.189032","relation":{},"ISSN":["0304-419X"],"issn-type":[{"value":"0304-419X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tumor microenvironment crosstalk between tumors and the nervous system in pancreatic cancer: Molecular mechanisms and clinical perspectives","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbcan.2023.189032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"189032"}}