{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:27:52Z","timestamp":1792182472707,"version":"4.4.0"},"reference-count":175,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173341"],"award-info":[{"award-number":["82173341"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["kp2208362"],"award-info":[{"award-number":["kp2208362"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2022"],"award-info":[{"award-number":["2022"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.bbcan.2025.189265","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T01:08:34Z","timestamp":1736730514000},"page":"189265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Programmed cell death in nasopharyngeal carcinoma: Mechanisms and therapeutic targets"],"prefix":"10.1016","volume":"1880","author":[{"given":"Shen'er","family":"Qian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuozhong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0005","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s41392-022-01110-y","article-title":"Regulated cell death (RCD) in cancer: key pathways and targeted therapies","volume":"7","author":"Peng","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"5","key":"10.1016\/j.bbcan.2025.189265_bb0010","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","article-title":"The molecular machinery of regulated cell death","volume":"29","author":"Tang","year":"2019","journal-title":"Cell Res."},{"issue":"10192","key":"10.1016\/j.bbcan.2025.189265_bb0015","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(19)30956-0","article-title":"Nasopharyngeal carcinoma","volume":"394","author":"Chen","year":"2019","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.bbcan.2025.189265_bb0020","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41571-021-00524-x","article-title":"Nasopharyngeal carcinoma: an evolving paradigm","volume":"18","author":"Wong","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.bbcan.2025.189265_bb0025","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/bjc.1972.33","article-title":"Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics","volume":"26","author":"Kerr","year":"1972","journal-title":"Br. J. Cancer"},{"issue":"3","key":"10.1016\/j.bbcan.2025.189265_bb0030","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S0008-6363(99)00384-3","article-title":"Morphologic and biochemical hallmarks of apoptosis","volume":"45","author":"Saraste","year":"2000","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0035","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s004410000193","article-title":"The morphology of apoptosis","volume":"301","author":"H\u00e4cker","year":"2000","journal-title":"Cell Tissue Res."},{"issue":"5","key":"10.1016\/j.bbcan.2025.189265_bb0040","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","article-title":"Necroptosis, pyroptosis and apoptosis: an intricate game of cell death","volume":"18","author":"Bertheloot","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0045","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s40364-022-00397-x","article-title":"Small biomarkers with massive impacts: PI3K\/AKT\/mTOR signalling and microRNA crosstalk regulate nasopharyngeal carcinoma","volume":"10","author":"Li","year":"2022","journal-title":"Biomark. Res."},{"issue":"11","key":"10.1016\/j.bbcan.2025.189265_bb0050","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1002\/ptr.6158","article-title":"Curcumol induces cell cycle arrest and apoptosis by inhibiting IGF-1R\/PI3K\/Akt signaling pathway in human nasopharyngeal carcinoma CNE-2 cells","volume":"32","author":"Li","year":"2018","journal-title":"Phytother. Res."},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0055","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s12967-022-03446-z","article-title":"C2orf40 inhibits metastasis and regulates chemo-resistance and radio-resistance of nasopharyngeal carcinoma cells by influencing cell cycle and activating the PI3K\/AKT\/mTOR signaling pathway","volume":"20","author":"Xie","year":"2022","journal-title":"J. Transl. Med."},{"issue":"18","key":"10.1016\/j.bbcan.2025.189265_bb0060","first-page":"7935","article-title":"MiR-155 promotes proliferation and inhibits apoptosis of nasopharyngeal carcinoma cells through targeting PTEN-PI3K\/AKT pathway","volume":"23","author":"Zuo","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"4","key":"10.1016\/j.bbcan.2025.189265_bb0065","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1158\/1078-0432.CCR-08-0144","article-title":"Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy","volume":"15","author":"Kang","year":"2009","journal-title":"Clin. Cancer Res."},{"issue":"5\u20136","key":"10.1016\/j.bbcan.2025.189265_bb0070","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cca.2009.12.010","article-title":"Expression of bcl-2 correlates with poor prognosis and modulates migration of nasopharyngeal carcinoma cells","volume":"411","author":"Chen","year":"2010","journal-title":"Clin. Chim. Acta"},{"issue":"9","key":"10.1016\/j.bbcan.2025.189265_bb0075","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1158\/0008-5472.CAN-07-5836","article-title":"ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor","volume":"68","author":"Tse","year":"2008","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.bbcan.2025.189265_bb0080","first-page":"1","article-title":"Single agent and synergistic activity of Maritoclax with ABT-263 in nasopharyngeal carcinoma (NPC) cell lines","volume":"31","author":"Xiang","year":"2020","journal-title":"Trop Life Sci. Res."},{"issue":"2","key":"10.1016\/j.bbcan.2025.189265_bb0085","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a041053","article-title":"The Death Receptor Pathway of Apoptosis","volume":"vol. 14","author":"Green","year":"2022","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"2","key":"10.1016\/j.bbcan.2025.189265_bb0090","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/(SICI)1097-0215(20000415)86:2<229::AID-IJC12>3.0.CO;2-1","article-title":"Radiation-induced expression of functional Fas ligand in EBV-positive human nasopharyngeal carcinoma cells","volume":"86","author":"Abdulkarim","year":"2000","journal-title":"Int. J. Cancer"},{"issue":"3","key":"10.1016\/j.bbcan.2025.189265_bb0095","first-page":"257","article-title":"Photodynamic therapy induced Fas-mediated apoptosis in human carcinoma cells","volume":"9","author":"Ali","year":"2002","journal-title":"Int. J. Mol. Med."},{"issue":"11","key":"10.1016\/j.bbcan.2025.189265_bb0100","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/hed.20090","article-title":"Prognostic implications of Fas-ligand expression in nasopharyngeal carcinoma","volume":"26","author":"Ho","year":"2004","journal-title":"Head Neck"},{"issue":"2","key":"10.1016\/j.bbcan.2025.189265_bb0105","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003832","article-title":"Exosomes derived from \u03b3\u03b4-T cells synergize with radiotherapy and preserve antitumor activities against nasopharyngeal carcinoma in immunosuppressive microenvironment","volume":"10","author":"Wang","year":"2022","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0110","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1142\/S0192415X19500125","article-title":"Bufalin induces apoptotic cell death in human nasopharyngeal carcinoma cells through mitochondrial ROS and TRAIL pathways","volume":"47","author":"Su","year":"2019","journal-title":"Am. J. Chin. Med."},{"issue":"2\u20133","key":"10.1016\/j.bbcan.2025.189265_bb0115","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0031-6865(99)00038-2","article-title":"Apoptosis induced by death receptors","volume":"74","author":"Schneider","year":"2000","journal-title":"Pharm. Acta Helv."},{"issue":"12","key":"10.1016\/j.bbcan.2025.189265_bb0120","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1016\/j.humpath.2014.08.010","article-title":"Fatty acid synthase-associated protein with death domain: a prognostic factor for survival in patients with nasopharyngeal carcinoma","volume":"45","author":"Li","year":"2014","journal-title":"Hum. Pathol."},{"issue":"2","key":"10.1016\/j.bbcan.2025.189265_bb0125","first-page":"223","article-title":"FADD and TRADD expression and apoptosis in primary hepatocellular carcinoma","volume":"6","author":"Sun","year":"2000","journal-title":"World J. Gastroenterol."},{"issue":"7","key":"10.1016\/j.bbcan.2025.189265_bb0130","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/modpathol.3800398","article-title":"Absence of caspase 3 activation in neoplastic cells of nasopharyngeal carcinoma biopsies predicts rapid fatal outcome","volume":"18","author":"Oudejans","year":"2005","journal-title":"Mod. Pathol."},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0135","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1080\/21691401.2019.1667815","article-title":"Junduqing extractive promotes the apoptosis of nasopharyngeal carcinoma cells through down-regulating Mcl-1 and Bcl-xL and up-regulating Caspase-3, Caspase-8 and Caspase-9","volume":"47","author":"Zhao","year":"2019","journal-title":"Artif Cells Nanomed Biotechnol."},{"issue":"23","key":"10.1016\/j.bbcan.2025.189265_bb0140","doi-asserted-by":"crossref","first-page":"6914","DOI":"10.1093\/emboj\/16.23.6914","article-title":"The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases","volume":"16","author":"Roy","year":"1997","journal-title":"EMBO J."},{"issue":"3","key":"10.1016\/j.bbcan.2025.189265_bb0145","first-page":"640","article-title":"IAP-1 promoted cisplatin resistance in nasopharyngeal carcinoma via inhibition of caspase-3-mediated apoptosis","volume":"11","author":"Miao","year":"2021","journal-title":"Am. J. Cancer Res."},{"issue":"2","key":"10.1016\/j.bbcan.2025.189265_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016748","article-title":"Functional polymorphism -31C\/G in the promoter of BIRC5 gene and risk of nasopharyngeal carcinoma among chinese","volume":"6","author":"Ma","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0155","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.pharmthera.2014.05.007","article-title":"Small-molecule SMAC mimetics as new cancer therapeutics","volume":"144","author":"Bai","year":"2014","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.bbcan.2025.189265_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/cells9030663","article-title":"Targeting XIAP for promoting Cancer cell death-the story of ARTS and SMAC","volume":"9","author":"Abbas","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0165","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.canlet.2016.07.008","article-title":"A novel Smac mimetic APG-1387 demonstrates potent antitumor activity in nasopharyngeal carcinoma cells by inducing apoptosis","volume":"381","author":"Li","year":"2016","journal-title":"Cancer Lett."},{"issue":"9","key":"10.1016\/j.bbcan.2025.189265_bb0170","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1158\/1535-7163.MCT-13-0017","article-title":"Smac mimetics in combination with TRAIL selectively target cancer stem cells in nasopharyngeal carcinoma","volume":"12","author":"Wu","year":"2013","journal-title":"Mol. Cancer Ther."},{"issue":"2","key":"10.1016\/j.bbcan.2025.189265_bb0175","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.biocel.2009.11.015","article-title":"Cellular FLICE-inhibitory protein (c-FLIP) signalling: a key regulator of receptor-mediated apoptosis in physiologic context and in cancer","volume":"42","author":"Bagnoli","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"9","key":"10.1016\/j.bbcan.2025.189265_bb0180","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1038\/cdd.2010.24","article-title":"The antiapoptotic protein, FLIP, is regulated by heterogeneous nuclear ribonucleoprotein K and correlates with poor overall survival of nasopharyngeal carcinoma patients","volume":"17","author":"Chen","year":"2010","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0185","doi-asserted-by":"crossref","first-page":"74","DOI":"10.4149\/neo_2017_109","article-title":"EGCG sensitizes human nasopharyngeal carcinoma cells to TRAIL-mediated apoptosis by activation NF-\u03baB","volume":"64","author":"Li","year":"2017","journal-title":"Neoplasma"},{"issue":"4","key":"10.1016\/j.bbcan.2025.189265_bb0190","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.bbcan.2025.189265_bb0195","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1089\/ars.2013.5371","article-title":"An overview of autophagy: morphology, mechanism, and regulation","volume":"20","author":"Parzych","year":"2014","journal-title":"Antioxid. Redox Signal."},{"issue":"11","key":"10.1016\/j.bbcan.2025.189265_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113466","article-title":"The roles of autophagy in Cancer","volume":"19","author":"Yun","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.bbcan.2025.189265_bb0205","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s00280-018-3669-6","article-title":"Autophagy modulation: a prudent approach in cancer treatment?","volume":"82","author":"Bishop","year":"2018","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"19","key":"10.1016\/j.bbcan.2025.189265_bb0210","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1101\/gad.17558811","article-title":"The dynamic nature of autophagy in cancer","volume":"25","author":"Kimmelman","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbcan.2025.189265_bb0215","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ejps.2019.04.011","article-title":"Autophagy as a molecular target for cancer treatment","volume":"134","author":"Kocaturk","year":"2019","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.bbcan.2025.189265_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120297","article-title":"Preclinical efficacy and involvement of mTOR signaling in the mechanism of Orf virus against nasopharyngeal carcinoma cells","volume":"291","author":"Huang","year":"2022","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.bbcan.2025.189265_bb0225","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.cmet.2020.01.015","article-title":"AMPK and TOR: the Yin and Yang of cellular nutrient sensing and growth control","volume":"31","author":"Gonz\u00e1lez","year":"2020","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.bbcan.2025.189265_bb0230","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41419-019-1369-8","article-title":"Downregulation of G2\/mitotic-specific cyclinB1 triggers autophagy via AMPK-ULK1-dependent signal pathway in nasopharyngeal carcinoma cells","volume":"10","author":"Xie","year":"2019","journal-title":"Cell Death Dis."},{"issue":"16","key":"10.1016\/j.bbcan.2025.189265_bb0235","doi-asserted-by":"crossref","first-page":"9135","DOI":"10.1111\/jcmm.15550","article-title":"TIPE1-mediated autophagy suppression promotes nasopharyngeal carcinoma cell proliferation via the AMPK\/mTOR signalling pathway","volume":"24","author":"Liu","year":"2020","journal-title":"J. Cell. Mol. Med."},{"issue":"5","key":"10.1016\/j.bbcan.2025.189265_bb0240","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1158\/0008-5472.CAN-21-2342","article-title":"AMPK-mTOR-mediated activation of autophagy promotes formation of dormant Polyploid Giant Cancer cells","volume":"82","author":"You","year":"2022","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.bbcan.2025.189265_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22031407","article-title":"lncRNA CASC19 contributes to Radioresistance of nasopharyngeal carcinoma by promoting autophagy via AMPK-mTOR pathway","volume":"22","author":"Liu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2025.189265_bb0250","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3389\/fcell.2020.00232","article-title":"ANXA6 contributes to Radioresistance by promoting autophagy via inhibiting the PI3K\/AKT\/mTOR signaling pathway in nasopharyngeal carcinoma","volume":"8","author":"Chen","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0255","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1080\/21691401.2019.1640233","article-title":"Upregulation of lncRNA HAGLROS enhances the development of nasopharyngeal carcinoma via modulating miR-100\/ATG14 axis-mediated PI3K\/AKT\/mTOR signals","volume":"47","author":"Zhang","year":"2019","journal-title":"Artif Cells Nanomed Biotechnol."},{"key":"10.1016\/j.bbcan.2025.189265_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154833","article-title":"RNA-binding domain 2 of nucleolin is important for the autophagy induction of curcumol in nasopharyngeal carcinoma cells","volume":"115","author":"Liu","year":"2023","journal-title":"Phytomedicine"},{"issue":"14","key":"10.1016\/j.bbcan.2025.189265_bb0265","doi-asserted-by":"crossref","first-page":"7778","DOI":"10.1111\/jcmm.15409","article-title":"Plac8-mediated autophagy regulates nasopharyngeal carcinoma cell function via AKT\/mTOR pathway","volume":"24","author":"Huang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"issue":"6","key":"10.1016\/j.bbcan.2025.189265_bb0270","doi-asserted-by":"crossref","DOI":"10.3390\/cells10061522","article-title":"BECLIN1: protein structure, function and regulation","volume":"10","author":"Tran","year":"2021","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.bbcan.2025.189265_bb0275","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/aps.2010.118","article-title":"Autophagic pathways as new targets for cancer drug development","volume":"31","author":"Liu","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0280","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4161\/auto.8.1.16645","article-title":"Beclin1: a role in membrane dynamics and beyond","volume":"8","author":"Wirawan","year":"2012","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.bbcan.2025.189265_bb0285","doi-asserted-by":"crossref","first-page":"395","DOI":"10.4161\/auto.6.3.11303","article-title":"Elevated Beclin 1 expression is correlated with HIF-1alpha in predicting poor prognosis of nasopharyngeal carcinoma","volume":"6","author":"Wan","year":"2010","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.bbcan.2025.189265_bb0290","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.3892\/ijo.2014.2497","article-title":"Apogossypolone, a small-molecule inhibitor of Bcl-2, induces radiosensitization of nasopharyngeal carcinoma cells by stimulating autophagy","volume":"45","author":"He","year":"2014","journal-title":"Int. J. Oncol."},{"issue":"6","key":"10.1016\/j.bbcan.2025.189265_bb0295","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2005.07.002","article-title":"Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy","volume":"122","author":"Pattingre","year":"2005","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.bbcan.2025.189265_bb0300","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.7150\/jca.71526","article-title":"Wnt5a-mediated autophagy promotes radiation resistance of nasopharyngeal carcinoma","volume":"13","author":"Lu","year":"2022","journal-title":"J. Cancer"},{"key":"10.1016\/j.bbcan.2025.189265_bb0305","doi-asserted-by":"crossref","first-page":"5661","DOI":"10.2147\/OTT.S207810","article-title":"LAPTM4B knockdown increases the radiosensitivity of EGFR-overexpressing radioresistant nasopharyngeal cancer cells by inhibiting autophagy","volume":"12","author":"Chu","year":"2019","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.bbcan.2025.189265_bb0310","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.canlet.2022.01.019","article-title":"Let-7i-5p promotes a malignant phenotype in nasopharyngeal carcinoma via inhibiting tumor-suppressive autophagy","volume":"531","author":"You","year":"2022","journal-title":"Cancer Lett."},{"issue":"17","key":"10.1016\/j.bbcan.2025.189265_bb0315","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1038\/s41388-021-01768-8","article-title":"Protein tyrosine phosphatase receptor type D gene promotes radiosensitivity via STAT3 dephosphorylation in nasopharyngeal carcinoma","volume":"40","author":"Lin","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2025.189265_bb0320","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/1479-5876-9-161","article-title":"C-Jun NH2-terminal kinase activation is essential for up-regulation of LC3 during ceramide-induced autophagy in human nasopharyngeal carcinoma cells","volume":"9","author":"Sun","year":"2011","journal-title":"J. Transl. Med."},{"issue":"8","key":"10.1016\/j.bbcan.2025.189265_bb0325","article-title":"Inhibition of autophagy potentiated the antitumor effect of Nedaplatin in cisplatin-resistant nasopharyngeal carcinoma cells","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bbcan.2025.189265_bb0330","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41580-022-00542-2","article-title":"The mechanisms and roles of selective autophagy in mammals","volume":"24","author":"Vargas","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.bbcan.2025.189265_bb0335","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020104705","article-title":"Molecular mechanisms and physiological functions of mitophagy","volume":"40","author":"Onishi","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.bbcan.2025.189265_bb0340","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.canlet.2021.07.019","article-title":"LACTB2 renders radioresistance by activating PINK1\/Parkin-dependent mitophagy in nasopharyngeal carcinoma","volume":"518","author":"Chen","year":"2021","journal-title":"Cancer Lett."},{"issue":"6","key":"10.1016\/j.bbcan.2025.189265_bb0345","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1042\/EBC20170035","article-title":"Regulation of selective autophagy: the p62\/SQSTM1 paradigm","volume":"61","author":"Lamark","year":"2017","journal-title":"Essays Biochem."},{"issue":"3","key":"10.1016\/j.bbcan.2025.189265_bb0350","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1158\/1078-0432.CCR-17-1963","article-title":"A prognostic bio-model based on SQSTM1 and N-stage identifies nasopharyngeal carcinoma patients at high risk of metastasis for additional induction chemotherapy","volume":"24","author":"Yang","year":"2018","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0355","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/s41420-021-00783-8","article-title":"CRISPR\/Cas9 genome-wide screening identifies LUC7L2 that promotes radioresistance via autophagy in nasopharyngeal carcinoma cells","volume":"7","author":"Shen","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbcan.2025.189265_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109576","article-title":"Casticin elicits inflammasome-induced pyroptosis through activating PKR\/JNK\/NF-\u03baB signal in 5-8F cells","volume":"123","author":"Jiang","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"12","key":"10.1016\/j.bbcan.2025.189265_bb0365","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1002\/emmm.201201569","article-title":"Tumour inflammasome-derived IL-1\u03b2 recruits neutrophils and improves local recurrence-free survival in EBV-induced nasopharyngeal carcinoma","volume":"4","author":"Chen","year":"2012","journal-title":"EMBO Mol. Med."},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0370","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1074\/mcp.RA119.001808","article-title":"Mitochondrial oxidative phosphorylation complex regulates NLRP3 Inflammasome activation and predicts patient survival in nasopharyngeal carcinoma","volume":"19","author":"Chung","year":"2020","journal-title":"Mol. Cell. Proteomics"},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0375","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s13046-021-01995-7","article-title":"Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-\u0399\u0399","volume":"40","author":"Cai","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"5","key":"10.1016\/j.bbcan.2025.189265_bb0380","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2021.12010","article-title":"Tanshinone IIA regulates microRNA-125b\/foxp3\/caspase-1 signaling and inhibits cell viability of nasopharyngeal carcinoma","volume":"23","author":"Wang","year":"2021","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0385","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/s13046-022-02533-9","article-title":"OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis","volume":"41","author":"Di","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"5","key":"10.1016\/j.bbcan.2025.189265_bb0390","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s10565-020-09514-8","article-title":"The role of Caspase-1\/GSDMD-mediated pyroptosis in Taxol-induced cell death and a Taxol-resistant phenotype in nasopharyngeal carcinoma regulated by autophagy","volume":"36","author":"Wang","year":"2020","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.bbcan.2025.189265_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114023","article-title":"Lobaplatin induces pyroptosis through regulating cIAP1\/2, Ripoptosome and ROS in nasopharyngeal carcinoma","volume":"177","author":"Chen","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"9","key":"10.1016\/j.bbcan.2025.189265_bb0400","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/s41422-021-00506-9","article-title":"The metabolite \u03b1-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8","volume":"31","author":"Zhang","year":"2021","journal-title":"Cell Res."},{"issue":"6","key":"10.1016\/j.bbcan.2025.189265_bb0405","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1007\/s10565-023-09799-5","article-title":"Role of GSDM family members in airway epithelial cells of lung diseases: a systematic and comprehensive transcriptomic analysis","volume":"39","author":"Liu","year":"2023","journal-title":"Cell Biol. Toxicol."},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0410","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1186\/s12967-022-03632-z","article-title":"System analysis based on the pyroptosis-related genes identifies GSDMC as a novel therapy target for pancreatic adenocarcinoma","volume":"20","author":"Yan","year":"2022","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0415","doi-asserted-by":"crossref","DOI":"10.1172\/JCI166841","article-title":"Gasdermin C sensitizes tumor cells to PARP inhibitor therapy in cancer models","volume":"134","author":"Wang","year":"2024","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.bbcan.2025.189265_bb0420","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/s41556-020-0575-z","article-title":"PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis","volume":"22","author":"Hou","year":"2020","journal-title":"Nat. Cell Biol."},{"issue":"5","key":"10.1016\/j.bbcan.2025.189265_bb0425","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nchembio.83","article-title":"Identification of RIP1 kinase as a specific cellular target of necrostatins","volume":"4","author":"Degterev","year":"2008","journal-title":"Nat. Chem. Biol."},{"issue":"5","key":"10.1016\/j.bbcan.2025.189265_bb0430","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1101\/gad.1756509","article-title":"Tumor suppressors and cell metabolism: a recipe for cancer growth","volume":"23","author":"Jones","year":"2009","journal-title":"Genes Dev."},{"issue":"5","key":"10.1016\/j.bbcan.2025.189265_bb0435","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.149","article-title":"Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells","volume":"4","author":"Huang","year":"2013","journal-title":"Cell Death Dis."},{"issue":"9","key":"10.1016\/j.bbcan.2025.189265_bb0440","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.324","article-title":"Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K\/Akt signaling pathway","volume":"4","author":"Deng","year":"2013","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.bbcan.2025.189265_bb0445","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41568-021-00435-0","article-title":"The role of ROS in tumour development and progression","volume":"22","author":"Cheung","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2025.189265_bb0450","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.2147\/OTT.S200740","article-title":"Shikonin-induced necroptosis in nasopharyngeal carcinoma cells via ROS overproduction and upregulation of RIPK1\/RIPK3\/MLKL expression","volume":"12","author":"Liu","year":"2019","journal-title":"Onco Targets Ther"},{"issue":"3","key":"10.1016\/j.bbcan.2025.189265_bb0455","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s10863-017-9714-z","article-title":"Shikonin induces necroptosis by reactive oxygen species activation in nasopharyngeal carcinoma cell line CNE-2Z","volume":"49","author":"Zhang","year":"2017","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.bbcan.2025.189265_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112940","article-title":"Discovery and development of selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors","volume":"209","author":"Li","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"14","key":"10.1016\/j.bbcan.2025.189265_bb0465","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.7150\/jca.77914","article-title":"Targeting ALDH1A1 to induce necroptosis in nasopharyngeal carcinoma","volume":"13","author":"Wang","year":"2022","journal-title":"J. Cancer"},{"issue":"11","key":"10.1016\/j.bbcan.2025.189265_bb0470","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1002\/cncr.31318","article-title":"Salvage treatment using carbon ion radiation in patients with locoregionally recurrent nasopharyngeal carcinoma: initial results","volume":"124","author":"Hu","year":"2018","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.bbcan.2025.189265_bb0475","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.7150\/jca.46316","article-title":"Carbon ion triggered immunogenic necroptosis of nasopharyngeal carcinoma cells involving necroptotic inhibitor BCL-x","volume":"12","author":"Bao","year":"2021","journal-title":"J. Cancer"},{"issue":"23","key":"10.1016\/j.bbcan.2025.189265_bb0480","doi-asserted-by":"crossref","first-page":"741","DOI":"10.21037\/atm.2019.11.104","article-title":"Depletion of MLKL inhibits invasion of radioresistant nasopharyngeal carcinoma cells by suppressing epithelial-mesenchymal transition","volume":"7","author":"Dong","year":"2019","journal-title":"Ann. Transl. Med."},{"issue":"2","key":"10.1016\/j.bbcan.2025.189265_bb0485","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41419-023-05691-6","article-title":"The double-edged functions of necroptosis","volume":"14","author":"Ye","year":"2023","journal-title":"Cell Death Dis."},{"issue":"7598","key":"10.1016\/j.bbcan.2025.189265_bb0490","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nature17403","article-title":"The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression","volume":"532","author":"Seifert","year":"2016","journal-title":"Nature"},{"issue":"7615","key":"10.1016\/j.bbcan.2025.189265_bb0495","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nature19076","article-title":"Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis","volume":"536","author":"Strilic","year":"2016","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bbcan.2025.189265_bb0500","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.bbcan.2025.189265_bb0505","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.7150\/thno.54113","article-title":"Ferroptosis as a novel therapeutic target for cardiovascular disease","volume":"11","author":"Wu","year":"2021","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0510","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1038\/s41598-023-28897-2","article-title":"The ferroptosis signature predicts the prognosis and immune microenvironment of nasopharyngeal carcinoma","volume":"13","author":"Zhou","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2025.189265_bb0515","doi-asserted-by":"crossref","first-page":"1006535","DOI":"10.3389\/fbioe.2022.1006535","article-title":"Ferroptosis-related gene ATG5 is a novel prognostic biomarker in nasopharyngeal carcinoma and head and neck squamous cell carcinoma","volume":"10","author":"Shi","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"4","key":"10.1016\/j.bbcan.2025.189265_bb0520","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1080\/08923973.2022.2072328","article-title":"Lupeol triggers oxidative stress, ferroptosis, apoptosis and restrains inflammation in nasopharyngeal carcinoma via AMPK\/NF-\u03baB pathway","volume":"44","author":"Zhou","year":"2022","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"9","key":"10.1016\/j.bbcan.2025.189265_bb0525","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.bbcan.2025.189265_bb0530","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death Nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.bbcan.2025.189265_bb0535","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.tibs.2021.07.003","article-title":"The lysosome as a master regulator of iron metabolism","volume":"46","author":"Rizzollo","year":"2021","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbcan.2025.189265_bb0540","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.freeradbiomed.2014.12.007","article-title":"Ferritin-stimulated lipid peroxidation, lysosomal leak, and macroautophagy promote lysosomal \u201cmetastability\u201d in primary hepatocytes determining in vitro cell survival","volume":"80","author":"Krenn","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.bbcan.2025.189265_bb0545","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/tox.23031","article-title":"Itraconazole attenuates the stemness of nasopharyngeal carcinoma cells via triggering ferroptosis","volume":"36","author":"Xu","year":"2021","journal-title":"Environ. Toxicol."},{"issue":"10","key":"10.1016\/j.bbcan.2025.189265_bb0550","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/nchem.2778","article-title":"Salinomycin kills cancer stem cells by sequestering iron in lysosomes","volume":"9","author":"Mai","year":"2017","journal-title":"Nat. Chem."},{"key":"10.1016\/j.bbcan.2025.189265_bb0555","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.791187","article-title":"Exosomal MIF derived from nasopharyngeal carcinoma promotes metastasis by repressing Ferroptosis of macrophages","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0560","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13045-019-0720-y","article-title":"Ferroptosis, a new form of cell death: opportunities and challenges in cancer","volume":"12","author":"Mou","year":"2019","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0565","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12943-022-01530-y","article-title":"Ferroptosis in cancer therapy: a novel approach to reversing drug resistance","volume":"21","author":"Zhang","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbcan.2025.189265_bb0570","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2018.09.014","article-title":"Role of GPX4 in ferroptosis and its pharmacological implication","volume":"133","author":"Seibt","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbcan.2025.189265_bb0575","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.bbcan.2025.189265_bb0580","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41419-021-03516-y","article-title":"Induction of ferroptosis in human nasopharyngeal cancer cells by cucurbitacin B: molecular mechanism and therapeutic potential","volume":"12","author":"Huang","year":"2021","journal-title":"Cell Death Dis."},{"issue":"16","key":"10.1016\/j.bbcan.2025.189265_bb0585","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23169014","article-title":"Combination RSL3 treatment sensitizes Ferroptosis- and EGFR-inhibition-resistant HNSCCs to Cetuximab","volume":"23","author":"Liu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.bbcan.2025.189265_bb0590","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell"},{"issue":"8","key":"10.1016\/j.bbcan.2025.189265_bb0595","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1158\/0008-5472.CAN-18-3037","article-title":"The Deubiquitylase OTUB1 mediates Ferroptosis via stabilization of SLC7A11","volume":"79","author":"Liu","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2025.189265_bb0600","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2022.101576","article-title":"m6A demethylase FTO renders radioresistance of nasopharyngeal carcinoma via promoting OTUB1-mediated anti-ferroptosis","volume":"27","author":"Huang","year":"2023","journal-title":"Transl. Oncol."},{"issue":"7545","key":"10.1016\/j.bbcan.2025.189265_bb0605","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature14344","article-title":"Ferroptosis as a p53-mediated activity during tumour suppression","volume":"520","author":"Jiang","year":"2015","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0610","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12010138","article-title":"Disulfiram\/copper induces antitumor activity against both nasopharyngeal Cancer cells and Cancer-associated fibroblasts through ROS\/MAPK and Ferroptosis pathways","volume":"12","author":"Li","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"15","key":"10.1016\/j.bbcan.2025.189265_bb0615","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.7150\/ijbs.76162","article-title":"Platelet-derived extracellular vesicles inhibit ferroptosis and promote distant metastasis of nasopharyngeal carcinoma by upregulating ITGB3","volume":"18","author":"Li","year":"2022","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0620","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ccell.2018.03.022","article-title":"NRF2 and the hallmarks of Cancer","volume":"34","author":"Rojo de la Vega","year":"2018","journal-title":"Cancer Cell"},{"issue":"8","key":"10.1016\/j.bbcan.2025.189265_bb0625","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1038\/s41418-022-00939-8","article-title":"EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma","volume":"29","author":"Yuan","year":"2022","journal-title":"Cell Death Differ."},{"issue":"6","key":"10.1016\/j.bbcan.2025.189265_bb0630","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","article-title":"The metabolic underpinnings of Ferroptosis","volume":"32","author":"Zheng","year":"2020","journal-title":"Cell Metab."},{"issue":"11","key":"10.1016\/j.bbcan.2025.189265_bb0635","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/nrc.2016.76","article-title":"The interplay between cell signalling and the mevalonate pathway in cancer","volume":"16","author":"Mullen","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2025.189265_bb0640","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110609","article-title":"P4HA1 activates HMGCS1 to promote nasopharyngeal carcinoma ferroptosis resistance and progression","volume":"105","author":"Zhou","year":"2023","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbcan.2025.189265_bb0645","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.931749","article-title":"CAPRIN2 upregulation by LINC00941 promotes nasopharyngeal carcinoma ferroptosis resistance and metastatic colonization through HMGCR","volume":"12","author":"Qiu","year":"2022","journal-title":"Front. Oncol."},{"issue":"7860","key":"10.1016\/j.bbcan.2025.189265_bb0650","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41586-021-03539-7","article-title":"DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer","volume":"593","author":"Mao","year":"2021","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0655","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","article-title":"GTP Cyclohydrolase 1\/tetrahydrobiopterin counteract Ferroptosis through lipid remodeling","volume":"6","author":"Kraft","year":"2020","journal-title":"ACS Cent. Sci."},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0660","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12885-022-10465-y","article-title":"Depletion of SOD2 enhances nasopharyngeal carcinoma cell radiosensitivity via ferroptosis induction modulated by DHODH inhibition","volume":"23","author":"Amos","year":"2023","journal-title":"BMC Cancer"},{"issue":"9","key":"10.1016\/j.bbcan.2025.189265_bb0665","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrm2239","article-title":"Self-eating and self-killing: crosstalk between autophagy and apoptosis","volume":"8","author":"Maiuri","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"12","key":"10.1016\/j.bbcan.2025.189265_bb0670","doi-asserted-by":"crossref","first-page":"7004","DOI":"10.1002\/ptr.7321","article-title":"Curcumol simultaneously induces both apoptosis and autophagy in human nasopharyngeal carcinoma cells","volume":"35","author":"Wang","year":"2021","journal-title":"Phytother. Res."},{"issue":"9","key":"10.1016\/j.bbcan.2025.189265_bb0675","first-page":"1922","article-title":"A low dose of AZD8055 enhances radiosensitivity of nasopharyngeal carcinoma cells by activating autophagy and apoptosis","volume":"9","author":"Chang","year":"2019","journal-title":"Am. J. Cancer Res."},{"issue":"9\u201310","key":"10.1016\/j.bbcan.2025.189265_bb0680","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s10495-021-01687-9","article-title":"Mechanism of interaction between autophagy and apoptosis in cancer","volume":"26","author":"Das","year":"2021","journal-title":"Apoptosis"},{"issue":"11","key":"10.1016\/j.bbcan.2025.189265_bb0685","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1002\/jcb.24224","article-title":"Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells","volume":"113","author":"Chow","year":"2012","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbcan.2025.189265_bb0690","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.freeradbiomed.2017.08.020","article-title":"Elimination of dysfunctional mitochondria through mitophagy suppresses benzo[a]pyrene-induced apoptosis","volume":"112","author":"Das","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"15","key":"10.1016\/j.bbcan.2025.189265_bb0695","doi-asserted-by":"crossref","first-page":"12455","DOI":"10.1074\/jbc.M111.309104","article-title":"Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis","volume":"287","author":"Young","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bbcan.2025.189265_bb0700","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/cdd.2010.191","article-title":"The Beclin 1 network regulates autophagy and apoptosis","volume":"18","author":"Kang","year":"2011","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0705","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41418-018-0212-6","article-title":"Pyroptosis versus necroptosis: similarities, differences, and crosstalk","volume":"26","author":"Frank","year":"2019","journal-title":"Cell Death Differ."},{"issue":"9","key":"10.1016\/j.bbcan.2025.189265_bb0710","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s41573-023-00749-8","article-title":"The therapeutic potential of targeting regulated non-apoptotic cell death","volume":"22","author":"Hadian","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"issue":"14","key":"10.1016\/j.bbcan.2025.189265_bb0715","doi-asserted-by":"crossref","first-page":"5322","DOI":"10.1073\/pnas.1200012109","article-title":"Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis","volume":"109","author":"Zhao","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7575","key":"10.1016\/j.bbcan.2025.189265_bb0720","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bbcan.2025.189265_bb0725","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020106700","article-title":"Cell death pathways: intricate connections and disease implications","volume":"40","author":"Kist","year":"2021","journal-title":"EMBO J."},{"issue":"7","key":"10.1016\/j.bbcan.2025.189265_bb0730","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1002\/ijc.33698","article-title":"Caspase-8: a key protein of cross-talk signal way in \u201cPANoptosis\u201d in cancer","volume":"149","author":"Jiang","year":"2021","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbcan.2025.189265_bb0735","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3389\/fcimb.2019.00406","article-title":"ZBP1 and TAK1: master regulators of NLRP3 Inflammasome\/Pyroptosis, apoptosis, and necroptosis (PAN-optosis)","volume":"9","author":"Malireddi","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"7784","key":"10.1016\/j.bbcan.2025.189265_bb0740","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41586-019-1770-6","article-title":"Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis","volume":"575","author":"Fritsch","year":"2019","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bbcan.2025.189265_bb0745","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.chembiol.2020.02.005","article-title":"Autophagy-dependent Ferroptosis: machinery and regulation","volume":"27","author":"Liu","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.bbcan.2025.189265_bb0750","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121390","article-title":"Arsenic induces pancreatic dysfunction and ferroptosis via mitochondrial ROS-autophagy-lysosomal pathway","volume":"384","author":"Wei","year":"2020","journal-title":"J. Hazard. Mater."},{"issue":"8","key":"10.1016\/j.bbcan.2025.189265_bb0755","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1080\/15548627.2019.1687985","article-title":"RNA-binding protein ZFP36\/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells","volume":"16","author":"Zhang","year":"2020","journal-title":"Autophagy"},{"issue":"8","key":"10.1016\/j.bbcan.2025.189265_bb0760","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1080\/15548627.2016.1187366","article-title":"Autophagy promotes ferroptosis by degradation of ferritin","volume":"12","author":"Hou","year":"2016","journal-title":"Autophagy"},{"issue":"12","key":"10.1016\/j.bbcan.2025.189265_bb0765","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1080\/15548627.2021.1911016","article-title":"Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells","volume":"17","author":"Qin","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.bbcan.2025.189265_bb0770","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.freeradbiomed.2020.08.009","article-title":"Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury","volume":"160","author":"Li","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.bbcan.2025.189265_bb0775","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.bbrc.2018.12.039","article-title":"Lipid storage and lipophagy regulates ferroptosis","volume":"508","author":"Bai","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0780","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1186\/s13046-021-02168-2","article-title":"PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells","volume":"40","author":"You","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"8","key":"10.1016\/j.bbcan.2025.189265_bb0785","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1158\/0008-5472.CAN-16-1979","article-title":"HSPA5 regulates Ferroptotic cell death in Cancer cells","volume":"77","author":"Zhu","year":"2017","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.bbcan.2025.189265_bb0790","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1158\/0008-5472.CAN-22-3169","article-title":"HBx-induced HSPA8 stimulates HBV replication and suppresses Ferroptosis to support liver Cancer progression","volume":"83","author":"Wang","year":"2023","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.bbcan.2025.189265_bb0795","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1073\/pnas.1819728116","article-title":"Chaperone-mediated autophagy is involved in the execution of ferroptosis","volume":"116","author":"Wu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"12","key":"10.1016\/j.bbcan.2025.189265_bb0800","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1080\/15548627.2018.1513758","article-title":"BECN1 is a new driver of ferroptosis","volume":"14","author":"Kang","year":"2018","journal-title":"Autophagy"},{"issue":"15","key":"10.1016\/j.bbcan.2025.189265_bb0805","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2018.05.094","article-title":"AMPK-mediated BECN1 phosphorylation promotes Ferroptosis by directly blocking system X(c)(\u2212) activity","volume":"28","author":"Song","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbcan.2025.189265_bb0810","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cois.2017.07.001","article-title":"The essential roles of metal ions in insect homeostasis and physiology","volume":"23","author":"Dow","year":"2017","journal-title":"Curr. Opin. Insect. Sci."},{"issue":"37","key":"10.1016\/j.bbcan.2025.189265_bb0815","doi-asserted-by":"crossref","first-page":"12234","DOI":"10.1039\/D1SC03516A","article-title":"Cancer therapeutic strategies based on metal ions","volume":"12","author":"Liu","year":"2021","journal-title":"Chem. Sci."},{"issue":"6586","key":"10.1016\/j.bbcan.2025.189265_bb0820","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.bbcan.2025.189265_bb0825","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.989286","article-title":"Cuproptosis related genes associated with Jab1 shapes tumor microenvironment and pharmacological profile in nasopharyngeal carcinoma","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.bbcan.2025.189265_bb0830","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10495-022-01790-5","article-title":"Cuproptosis-related LncRNA signatures as a prognostic model for head and neck squamous cell carcinoma","volume":"28","author":"Sun","year":"2023","journal-title":"Apoptosis"},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0835","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00432-022-04471-7","article-title":"A novel cuproptosis-related gene signature of prognosis and immune microenvironment in head and neck squamous cell carcinoma cancer","volume":"149","author":"Jiang","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2025.189265_bb0840","article-title":"Cuproptosis-related lncRNAs are biomarkers of prognosis and immune microenvironment in head and neck squamous cell carcinoma","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Genet."},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0845","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s13046-023-02720-2","article-title":"Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in primary liver cancer","volume":"42","author":"Wang","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"22","key":"10.1016\/j.bbcan.2025.189265_bb0850","article-title":"Cuproptosis induced by ROS responsive nanoparticles with Elesclomol and copper combined with \u03b1PD-L1 for enhanced Cancer immunotherapy","volume":"35","author":"Guo","year":"2023","journal-title":"Adv. Mater."},{"issue":"4","key":"10.1016\/j.bbcan.2025.189265_bb0855","article-title":"Calcification-based Cancer diagnosis and therapy","volume":"17","author":"Shou","year":"2022","journal-title":"ChemMedChem"},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0860","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/nyas.12885","article-title":"Calcium signaling as a mediator of cell energy demand and a trigger to cell death","volume":"1350","author":"Bhosale","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"12","key":"10.1016\/j.bbcan.2025.189265_bb0865","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202202424","article-title":"A self-reinforcing Nanoplatform for highly effective synergistic targeted Combinatary calcium-overload and photodynamic therapy of Cancer","volume":"12","author":"Guo","year":"2023","journal-title":"Adv. Healthc. Mater."},{"issue":"9","key":"10.1016\/j.bbcan.2025.189265_bb0870","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202200447","article-title":"Calcicoptosis induced by purple sweet potato anthocyanins through the nonosmotic regulation of the NFAT5\/S100A4-S100A9 pathway in acute lymphoblastic leukemia","volume":"19","author":"Guo","year":"2022","journal-title":"Chem. Biodivers."},{"issue":"1","key":"10.1016\/j.bbcan.2025.189265_bb0875","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s40820-022-00894-6","article-title":"Connecting calcium-based nanomaterials and Cancer: from diagnosis to therapy","volume":"14","author":"Bai","year":"2022","journal-title":"Nano Lett."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X25000071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X25000071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:39:43Z","timestamp":1778510383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304419X25000071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":175,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S0304419X25000071"],"URL":"https:\/\/doi.org\/10.1016\/j.bbcan.2025.189265","relation":{},"ISSN":["0304-419X"],"issn-type":[{"value":"0304-419X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Programmed cell death in nasopharyngeal carcinoma: Mechanisms and therapeutic targets","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbcan.2025.189265","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"189265"}}