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Immunol."},{"key":"10.1016\/j.bbcan.2025.189320_bb0600","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12935-023-02902-0","article-title":"Cancer immunotherapy with immune checkpoint inhibitors (ICIs): potential, mechanisms of resistance, and strategies for reinvigorating T cell responsiveness when resistance is acquired","volume":"23","author":"Marei","year":"2023","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.bbcan.2025.189320_bb0610","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s00262-019-02384-y","article-title":"Tumor-induced peripheral immunosuppression promotes brain metastasis in patients with non-small cell lung cancer","volume":"68","author":"Li","year":"2019","journal-title":"Cancer Immunol. Immunother. CII"},{"key":"10.1016\/j.bbcan.2025.189320_bb0615","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1056\/NEJMoa1112824","article-title":"Immunologic correlates of the abscopal effect in a patient with melanoma","volume":"366","author":"Postow","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2025.189320_bb0635","doi-asserted-by":"crossref","first-page":"924","DOI":"10.3389\/fimmu.2020.00924","article-title":"Dendritic Cells and their role in immunotherapy","volume":"11","author":"Gardner","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2025.189320_bb0640","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.omtm.2019.12.017","article-title":"Manufacturing dendritic Cells for immunotherapy: monocyte enrichment","volume":"16","author":"Hopewell","year":"2020","journal-title":"Mol. Ther. Methods Clin. 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J. Radiol."},{"key":"10.1016\/j.bbcan.2025.189320_bb0680","doi-asserted-by":"crossref","first-page":"17937","DOI":"10.18632\/oncotarget.24788","article-title":"Phytochemicals as modulators of M1-M2 macrophages in inflammation","volume":"9","author":"Saqib","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbcan.2025.189320_bb0690","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.ijrobp.2003.09.012","article-title":"Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated","volume":"58","author":"Demaria","year":"2004","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.bbcan.2025.189320_bb0695","article-title":"Abscopal effect after radiosurgery for solitary brain metastasis from non-small cell lung Cancer","volume":"10","author":"Hamilton","year":"2018","journal-title":"Cureus"},{"key":"10.1016\/j.bbcan.2025.189320_bb0700","first-page":"176","article-title":"The evolving landscape of brain metastasis, trends","volume":"4","author":"Valiente","year":"2018","journal-title":"Cancer"},{"key":"10.1016\/j.bbcan.2025.189320_bb0705","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1136\/gutjnl-2022-329147","article-title":"Targeting MS4A4A on tumour-associated macrophages restores CD8+ T-cell-mediated antitumour immunity","volume":"72","author":"Li","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.bbcan.2025.189320_bb0710","article-title":"A meta-analysis for the efficacy and safety of icotinib combined with radiotherapy in treating brain metastases of non-small cell lung cancer","volume":"102","author":"Zhang","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.bbcan.2025.189320_bb0715","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41568-020-0246-1","article-title":"Inflammatory microenvironment remodelling by tumour cells after radiotherapy","volume":"20","author":"McLaughlin","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2025.189320_bb0720","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2016.1239005","article-title":"LAG-3 confers poor prognosis and its blockade reshapes antitumor response in head and neck squamous cell carcinoma","volume":"5","author":"Deng","year":"2016","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.bbcan.2025.189320_bb0725","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13045-022-01325-0","article-title":"Immune checkpoint modulators in cancer immunotherapy: recent advances and emerging concepts, J. Hematol. Oncol","volume":"15","author":"Wang","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bbcan.2025.189320_bb0730","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2217\/imt-2022-0172","article-title":"Relatlimab and nivolumab in untreated advanced melanoma: insight into RELATIVITY","volume":"15","author":"Raschi","year":"2023","journal-title":"Immunotherapy"},{"key":"10.1016\/j.bbcan.2025.189320_bb0735","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cllc.2020.10.014","article-title":"Combined immunotherapy and stereotactic radiotherapy improves neurologic outcomes in patients with non-small-cell lung Cancer brain metastases","volume":"22","author":"Enright","year":"2021","journal-title":"Clin. 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