{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T21:24:39Z","timestamp":1762291479573,"version":"build-2065373602"},"reference-count":72,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State","doi-asserted-by":"publisher","award":["E-26\/204.227\/2024"],"award-info":[{"award-number":["E-26\/204.227\/2024"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["310982\/2023-5"],"award-info":[{"award-number":["310982\/2023-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bbcan.2025.189376","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T18:58:27Z","timestamp":1750359507000},"page":"189376","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Meet PRC2: A new player in T-cell acute lymphoblastic leukemia"],"prefix":"10.1016","volume":"1880","author":[{"given":"Raquel Monteiro de Barros","family":"Lemos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Chianello Nicolau","family":"Fagundes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Luiza Tardem","family":"Maciel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Emerenciano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbcan.2025.189376_bb0005","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1056\/NEJMra052603","article-title":"Treatment of acute lymphoblastic leukemia","volume":"354","author":"Pui","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2025.189376_bb0010","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/S0140-6736(08)60457-2","article-title":"Acute lymphoblastic leukaemia","volume":"371","author":"Pui","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.bbcan.2025.189376_bb0015","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nature10725","article-title":"The genetic basis of early T-cell precursor acute lymphoblastic leukaemia","volume":"481","author":"Zhang","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2025.189376_bb0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13148-021-01052-2","article-title":"Integrative study of EZH2 mutational status, copy number, protein expression and H3K27 trimethylation in AML\/MDS patients","volume":"13","author":"Stomper","year":"2021","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.bbcan.2025.189376_bb0025","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nm.4247","article-title":"Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia","volume":"23","author":"G\u00f6llner","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2025.189376_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010074","article-title":"Pathogenic impacts of dysregulated polycomb repressive complex function in hematological malignancies","volume":"22","author":"Kaito","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2025.189376_bb0035","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nri2304","article-title":"Molecular pathogenesis of T-cell leukaemia and lymphoma","volume":"8","author":"Aifantis","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbcan.2025.189376_bb0040","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.1102160","article-title":"Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia","volume":"306","author":"Weng","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.bbcan.2025.189376_bb0045","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1470-2045(08)70314-0","article-title":"Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia","volume":"10","author":"Coustan-Smith","year":"2009","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.bbcan.2025.189376_bb0050","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.cell.2012.01.056","article-title":"Dynamic transformations of genome-wide epigenetic marking and transcriptional control establish T cell identity","volume":"149","author":"Zhang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2025.189376_bb0055","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bbcan.2019.06.001","article-title":"FLT3 overexpression in acute leukaemias: New insights into the search for molecular mechanisms","volume":"1872","author":"Poubel","year":"2019","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.bbcan.2025.189376_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2018.01.006","article-title":"Ezh2 and Runx1 mutations collaborate to initiate lympho-myeloid leukemia in early thymic progenitors","volume":"33","author":"Booth","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2025.189376_bb0065","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/ng.3909","article-title":"The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia","volume":"49","author":"Liu","year":"2017","journal-title":"Nat. Genet."},{"issue":"7","key":"10.1016\/j.bbcan.2025.189376_bb0070","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/gcc.23036","article-title":"CRLF2 overexpression defines an immature-like subgroup which is rescued through restoration of the PRC2 function in T-cell precursor acute lymphoblastic leukemia","volume":"61","author":"Maciel","year":"2022","journal-title":"Genes Chromosom. Cancer"},{"issue":"19","key":"10.1016\/j.bbcan.2025.189376_bb0075","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1182\/blood.2021012677","article-title":"BETter insight into PRC2-mutated T-ALL","volume":"138","author":"Bock","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.bbcan.2025.189376_bb0080","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/276565a0","article-title":"A gene complex controlling segmentation in Drosophila","volume":"276","author":"Lewis","year":"1978","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2025.189376_bb0085","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.cell.2017.08.002","article-title":"Genome regulation by polycomb and trithorax: 70 years and counting","volume":"171","author":"Schuettengruber","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2025.189376_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2019.11.021","article-title":"Histone H2AK119 mono-ubiquitination is essential for polycomb-mediated transcriptional repression","volume":"77","author":"Tamburri","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbcan.2025.189376_bb0095","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1042\/BST20160173","article-title":"Molecular architecture of polycomb repressive complexes","volume":"45","author":"Chittock","year":"2017","journal-title":"Biochem. Soc. Trans."},{"issue":"3","key":"10.1016\/j.bbcan.2025.189376_bb0100","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.molcel.2012.01.002","article-title":"PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes","volume":"45","author":"Gao","year":"2012","journal-title":"Mol. Cell"},{"issue":"5","key":"10.1016\/j.bbcan.2025.189376_bb0105","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/s41580-021-00341-1","article-title":"The roles of Polycomb repressive complexes in mammalian development and cancer","volume":"22","author":"Piunti","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbcan.2025.189376_bb0110","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.18591","article-title":"RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes","volume":"5","author":"Rose","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.bbcan.2025.189376_bb0115","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.00205","article-title":"KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands","volume":"1","author":"Farcas","year":"2012","journal-title":"Elife"},{"issue":"5","key":"10.1016\/j.bbcan.2025.189376_bb0120","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/j.celrep.2014.04.012","article-title":"Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment","volume":"7","author":"Cooper","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbcan.2025.189376_bb0125","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1126\/science.1076997","article-title":"Role of histone H3 lysine 27 methylation in Polycomb-group silencing","volume":"298","author":"Cao","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bbcan.2025.189376_bb0130","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.tcb.2019.05.004","article-title":"The complexity of PRC2 subcomplexes","volume":"29","author":"Van Mierlo","year":"2019","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbcan.2025.189376_bb0135","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/nsmb.2434","article-title":"Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity","volume":"19","author":"Ballar\u00e9","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbcan.2025.189376_bb0140","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1038\/nsmb.2449","article-title":"Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation","volume":"19","author":"Brien","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbcan.2025.189376_bb0145","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.molcel.2012.11.026","article-title":"An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting","volume":"49","author":"Cai","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbcan.2025.189376_bb0150","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/nsmb.3488","article-title":"DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation","volume":"24","author":"Choi","year":"2017","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbcan.2025.189376_bb0155","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nature23881","article-title":"Polycomb-like proteins link the PRC2 complex to CpG islands","volume":"549","author":"Li","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2025.189376_bb0160","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.molcel.2016.10.018","article-title":"EPOP functionally links Elongin and Polycomb in pluripotent stem cells","volume":"64","author":"Beringer","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbcan.2025.189376_bb0165","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.molcel.2016.10.019","article-title":"EPOP interacts with Elongin BC and USP7 to modulate the chromatin landscape","volume":"64","author":"Liefke","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbcan.2025.189376_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2018.03.005","article-title":"A family of vertebrate-specific Polycombs encoded by the LCOR\/LCORL genes balance PRC2 subtype activities","volume":"70","author":"Conway","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbcan.2025.189376_bb0175","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1242\/dev.123935","article-title":"Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs","volume":"143","author":"Grijzenhout","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.bbcan.2025.189376_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2019.12.001","article-title":"PRC1 catalytic activity is central to Polycomb system function","volume":"77","author":"Blackledge","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbcan.2025.189376_bb0185","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13661","article-title":"Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2","volume":"7","author":"Cooper","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2025.189376_bb0190","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nsmb.2833","article-title":"Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression","volume":"21","author":"Kalb","year":"2014","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbcan.2025.189376_bb0195","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nsmb.3487","article-title":"Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA","volume":"24","author":"Wang","year":"2017","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbcan.2025.189376_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2019.08.012","article-title":"PRC2.1 and PRC2.2 synergize to coordinate H3K27 trimethylation","volume":"76","author":"Healy","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbcan.2025.189376_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2019.07.031","article-title":"Non-core subunits of the PRC2 complex are collectively required for its target-site specificity","volume":"76","author":"H\u00f8jfeldt","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbcan.2025.189376_bb0210","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1158\/2159-8290.CD-19-0789","article-title":"EZH2-deficient T-cell acute lymphoblastic leukemia is sensitized to CHK1 inhibition through enhanced replication stress","volume":"10","author":"Le\u00f3n","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bbcan.2025.189376_bb0215","doi-asserted-by":"crossref","first-page":"11316","DOI":"10.1038\/ncomms11316","article-title":"Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2","volume":"7","author":"Justin","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2025.189376_bb0220","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.exphem.2018.10.008","article-title":"Emerging role of noncanonical Polycomb repressive complexes in normal and malignant hematopoiesis","volume":"68","author":"Isshiki","year":"2018","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.bbcan.2025.189376_bb0225","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.molcel.2004.06.020","article-title":"SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex","volume":"15","author":"Cao","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbcan.2025.189376_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2018.01.039","article-title":"Unique structural platforms of suz12 dictate distinct classes of PRC2 for chromatin binding","volume":"69","author":"Chen","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbcan.2025.189376_bb0235","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molcel.2019.03.011","article-title":"Molecular mechanisms directing PRC2 recruitment and H3K27 methylation","volume":"74","author":"Laugesen","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbcan.2025.189376_bb0240","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nature09784","article-title":"The Polycomb complex PRC2 and its mark in life","volume":"469","author":"Margueron","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2025.189376_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/genes12101485","article-title":"Polycomb repressive complex(es) and their role in adult stem cells","volume":"12","author":"Flora","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.bbcan.2025.189376_bb0250","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1101\/gad.173930.111","article-title":"PRC2 directly methylates GATA4 and represses its transcriptional activity","volume":"26","author":"He","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbcan.2025.189376_bb0255","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1182\/blood-2015-03-634428","article-title":"Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner","volume":"126","author":"Mochizuki-Kashio","year":"2015","journal-title":"Blood"},{"issue":"16","key":"10.1016\/j.bbcan.2025.189376_bb0260","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1182\/blood.2019000015","article-title":"Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia","volume":"134","author":"Broux","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.bbcan.2025.189376_bb0265","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.isci.2018.10.008","article-title":"Ezh1 targets bivalent genes to maintain self-renewing stem cells in Ezh2-insufficient myelodysplastic syndrome","volume":"9","author":"Aoyama","year":"2018","journal-title":"IScience"},{"key":"10.1016\/j.bbcan.2025.189376_bb0270","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.stem.2013.10.001","article-title":"Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner","volume":"14","author":"Xie","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbcan.2025.189376_bb0275","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1182\/blood-2014-12-615898","article-title":"Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis","volume":"126","author":"Lee","year":"2015","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.bbcan.2025.189376_bb0280","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1084\/jem.20170084","article-title":"Signaling function of PRC2 is essential for TCR-driven T cell responses","volume":"215","author":"Dobenecker","year":"2018","journal-title":"J. Exp. Med."},{"issue":"12","key":"10.1016\/j.bbcan.2025.189376_bb0285","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1084\/jem.20180570","article-title":"PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia","volume":"215","author":"Ari\u00ebs","year":"2018","journal-title":"J. Exp. Med."},{"issue":"9","key":"10.1016\/j.bbcan.2025.189376_bb0290","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1182\/blood-2016-10-706465","article-title":"The genetics and molecular biology of T-ALL","volume":"129","author":"Girardi","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.bbcan.2025.189376_bb0295","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1182\/blood-2014-03-559542","article-title":"Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia","volume":"124","author":"Kiel","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.bbcan.2025.189376_bb0300","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1101\/gad.186411.111","article-title":"A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia","volume":"26","author":"Simon","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbcan.2025.189376_bb0305","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nm.2651","article-title":"Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia","volume":"18","author":"Ntziachristos","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2025.189376_bb0310","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/j.celrep.2016.01.064","article-title":"Ezh2 controls an early hematopoietic program and growth and survival signaling in early T cell precursor acute lymphoblastic leukemia","volume":"14","author":"Danis","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbcan.2025.189376_bb0315","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1172\/JCI94645","article-title":"Ezh2 loss propagates hypermethylation at T cell differentiation-regulating genes to promote leukemic transformation","volume":"128","author":"Wang","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.bbcan.2025.189376_bb0320","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1600972","article-title":"Maintenance of leukemic cell identity by the activity of the Polycomb complex PRC1 in mice","volume":"2","author":"Rossi","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbcan.2025.189376_bb0325","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1007\/s00432-016-2174-8","article-title":"EZH2 mutations and promoter hypermethylation in childhood acute lymphoblastic leukemia","volume":"142","author":"Sch\u00e4fer","year":"2016","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2025.189376_bb0330","doi-asserted-by":"crossref","unstructured":"J. Zhang, Y. Zhang, M. Zhang, C. Liu, X. Liu, J. Yin, P. Wu, X. Chen, W. Yang, L. Zhang, Y. Guo, Y. Zou, Y. Chen, Y. Cao, T. Cheng, X. Zhu, FLT3 pathway is a potential therapeutic target for PRC2-mutated T-cell acute lymphoblastic leukemia., Blood. 132 (2018) 2520\u20132524. https:\/\/doi.org\/10.1182\/blood-2018-04-845628.","DOI":"10.1182\/blood-2018-04-845628"},{"key":"10.1016\/j.bbcan.2025.189376_bb0335","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1182\/blood.2020010081","article-title":"PRC2 loss of function confers a targetable vulnerability to BET proteins in T-ALL","volume":"138","author":"Andrieu","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.bbcan.2025.189376_bb0340","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13046-015-0191-0","article-title":"EZH2 is increased in paediatric T-cell acute lymphoblastic leukemia and is a suitable molecular target in combination treatment approaches","volume":"34","author":"D\u2019Angelo","year":"2015","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2025.189376_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2025.01.013","article-title":"EZH1\/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models","volume":"43","author":"Porazzi","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2025.189376_bb0350","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1182\/blood.2022016862","article-title":"An open-label, single-arm phase 2 trial of\u00a0valemetostat\u00a0for relapsed or refractory adult T-cell\u00a0leukemia\/lymphoma","volume":"141","author":"Izutsu","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.bbcan.2025.189376_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116154","article-title":"Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2","volume":"267","author":"Velez","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bbcan.2025.189376_bb0360","doi-asserted-by":"crossref","first-page":"6891","DOI":"10.7150\/thno.53170","article-title":"Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2","volume":"11","author":"Huang","year":"2021","journal-title":"Theranostics"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X25001180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X25001180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T21:11:32Z","timestamp":1762290692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304419X25001180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":72,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0304419X25001180"],"URL":"https:\/\/doi.org\/10.1016\/j.bbcan.2025.189376","relation":{},"ISSN":["0304-419X"],"issn-type":[{"type":"print","value":"0304-419X"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Meet PRC2: A new player in T-cell acute lymphoblastic leukemia","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbcan.2025.189376","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"189376"}}