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Res."},{"key":"10.1016\/j.bbcan.2025.189517_bb0580","article-title":"Vessels that encapsulate tumour clusters vascular pattern in hepatocellular carcinoma","volume":"5","author":"Liu","year":"2023","journal-title":"JHEP Rep."},{"key":"10.1016\/j.bbcan.2025.189517_bb0585","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12575-023-00196-0","article-title":"Macrophage-derived MMP-9 and MMP-2 are closely related to the rupture of the fibrous capsule of hepatocellular carcinoma leading to tumor invasion","volume":"25","author":"Cui","year":"2023","journal-title":"Biol. 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