{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:05:11Z","timestamp":1790136311954,"version":"4.0.1"},"reference-count":297,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073096"],"award-info":[{"award-number":["82073096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303362"],"award-info":[{"award-number":["82303362"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016104","name":"Key Project of Research and Development Plan of Hunan Province","doi-asserted-by":"publisher","award":["2024DK2006"],"award-info":[{"award-number":["2024DK2006"]}],"id":[{"id":"10.13039\/100016104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ30039"],"award-info":[{"award-number":["2025JJ30039"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.bbcan.2025.189518","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:10:02Z","timestamp":1766535002000},"page":"189518","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Astrocytes in glioblastoma tumor microenvironment"],"prefix":"10.1016","volume":"1881","author":[{"given":"Shu","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuetong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmiao","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbcan.2025.189518_bb0005","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/S0140-6736(23)01054-1","article-title":"Primary brain tumours in adults","volume":"402","author":"Van Den Bent","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.bbcan.2025.189518_bb0010","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41572-024-00516-y","article-title":"Glioma","volume":"10","author":"Weller","year":"2024","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bbcan.2025.189518_bb0015","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.ccell.2017.08.017","article-title":"Integrated molecular Meta-analysis of 1,000 pediatric high-grade and diffuse intrinsic pontine glioma","volume":"32","author":"Mackay","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2025.189518_bb0020","article-title":"Systematic review of diffuse hemispheric glioma, H3 G34-mutant: Outcomes and associated clinical factors","volume":"4","author":"Crowell","year":"2022","journal-title":"Neurooncol Adv"},{"key":"10.1016\/j.bbcan.2025.189518_bb0025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.trecan.2022.09.005","article-title":"Challenges in glioblastoma research: focus on the tumor microenvironment","volume":"9","author":"Bikfalvi","year":"2023","journal-title":"Trends Cancer"},{"key":"10.1016\/j.bbcan.2025.189518_bb0030","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","article-title":"Astrocytes: biology and pathology","volume":"119","author":"Sofroniew","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0035","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/glia.23520","article-title":"Astrocytes, the rising stars of the glioblastoma microenvironment","volume":"67","author":"Brandao","year":"2019","journal-title":"Glia"},{"key":"10.1016\/j.bbcan.2025.189518_bb0040","doi-asserted-by":"crossref","first-page":"6927","DOI":"10.1007\/s12035-018-0880-8","article-title":"Reactive astrocytes in glioblastoma Multiforme","volume":"55","author":"Guan","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0045","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s13277-015-4242-0","article-title":"The role of astrocytes in the progression of brain cancer: complicating the picture of the tumor microenvironment","volume":"37","author":"Placone","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0050","doi-asserted-by":"crossref","first-page":"7321","DOI":"10.1158\/0008-5472.CAN-13-2978","article-title":"Astrocyte elevated gene-1 (AEG-1) interacts with Akt isoform 2 to control glioma growth, survival and pathogenesis","volume":"74","author":"Hu","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb0055","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1186\/s12967-024-05301-9","article-title":"The tumour microenvironment, treatment resistance and recurrence in glioblastoma","volume":"22","author":"White","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbcan.2025.189518_bb0160","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1038\/s41467-020-17186-5","article-title":"Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy","volume":"11","author":"Couturier","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2025.189518_bb0440","doi-asserted-by":"crossref","first-page":"1217451","DOI":"10.3389\/fnins.2023.1217451","article-title":"Astrocyte metabolism and signaling pathways in the CNS","volume":"17","author":"Zhang","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0445","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.12688\/f1000research.10509.1","article-title":"Inducible targeting of CNS astrocytes in Aldh1l1-CreERT2 BAC transgenic mice","volume":"5","author":"Winchenbach","year":"2016","journal-title":"F1000Research"},{"key":"10.1016\/j.bbcan.2025.189518_bb0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106327","article-title":"Metabolic remodeling in astrocytes: paving the path to brain tumor development","volume":"188","author":"Jara\u00edz-Rodr\u00edguez","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbcan.2025.189518_bb0085","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.1093\/brain\/awac222","article-title":"Astrocyte immunometabolic regulation of the tumour microenvironment drives glioblastoma pathogenicity","volume":"145","author":"Perelroizen","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.bbcan.2025.189518_bb0170","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1038\/s41467-019-10493-6","article-title":"Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma","volume":"10","author":"Henrik Heiland","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2025.189518_bb0455","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/s41467-024-45067-8","article-title":"A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1","volume":"15","author":"Hai","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2025.189518_bb0460","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/s41586-025-08997-x","article-title":"Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity","volume":"643","author":"Faust Akl","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2025.189518_bb0465","doi-asserted-by":"crossref","first-page":"1098482","DOI":"10.3389\/fcell.2023.1098482","article-title":"Roles of STAT3 in the pathogenesis and treatment of glioblastoma","volume":"11","author":"Fu","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0245","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/glia.24506","article-title":"Glioma stem cell-derived exosomes induce the transformation of astrocytes via the miR-3065-5p\/DLG2 signaling axis","volume":"72","author":"Li","year":"2024","journal-title":"Glia"},{"key":"10.1016\/j.bbcan.2025.189518_bb0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0194183","article-title":"Presence of stromal cells in a bioengineered tumor microenvironment alters glioblastoma migration and response to STAT3 inhibition","volume":"13","author":"Herrera-Perez","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2025.189518_bb0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054752","article-title":"Astrocytes enhance the invasion potential of glioblastoma stem-like cells","volume":"8","author":"Rath","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2025.189518_bb0470","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3390\/genes16050573","article-title":"Olig1\/2 drive astrocytic glioblastoma proliferation through transcriptional co-regulation of various cyclins","volume":"16","author":"Tian","year":"2025","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.bbcan.2025.189518_bb0370","doi-asserted-by":"crossref","first-page":"2304609","DOI":"10.1002\/advs.202304609","article-title":"Radiotherapy-induced astrocyte senescence promotes an immunosuppressive microenvironment in glioblastoma to facilitate tumor regrowth","volume":"11","author":"Ji","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.bbcan.2025.189518_bb0475","doi-asserted-by":"crossref","first-page":"5935","DOI":"10.1158\/0008-5472.CAN-21-0752","article-title":"Elimination of radiation-induced senescence in the brain tumor microenvironment attenuates glioblastoma recurrence","volume":"81","author":"Fletcher-Sananikone","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb0655","doi-asserted-by":"crossref","first-page":"15458","DOI":"10.1038\/s41598-019-51865-8","article-title":"LXR\u03b2 controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1","volume":"9","author":"Patel","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2025.189518_bb0660","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1186\/s40001-023-01370-6","article-title":"Drug metabolism-related gene ABCA1 augments temozolomide chemoresistance and immune infiltration abundance of M2 macrophages in glioma","volume":"28","author":"Yan","year":"2023","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb0665","doi-asserted-by":"crossref","first-page":"1513992","DOI":"10.3389\/fonc.2025.1513992","article-title":"A pan-cancer analysis targeting the oncogenic role of ATP-binding cassette transporter A1 in human tumors","volume":"15","author":"Wu","year":"2025","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0670","article-title":"Metabolic-related gene pairs signature analysis identifies ABCA1 expression levels on tumor-associated macrophages as a prognostic biomarker in primary IDHWT glioblastoma","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0675","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e41601","article-title":"Comprehensive analysis reveals cholesterol metabolism-related signature for predicting prognosis and guiding individualized treatment of glioma","volume":"11","author":"Lu","year":"2025","journal-title":"Heliyon"},{"key":"10.1016\/j.bbcan.2025.189518_bb0680","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3390\/ph18010102","article-title":"Revisiting ABC transporters and their clinical significance in glioblastoma","volume":"18","author":"Phon","year":"2025","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bbcan.2025.189518_bb0685","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1136\/jim-2018-000962","article-title":"Targeting cholesterol metabolism in glioblastoma: a new therapeutic approach in cancer therapy","volume":"67","author":"Pirmoradi","year":"2019","journal-title":"J. Investig. Med."},{"key":"10.1016\/j.bbcan.2025.189518_bb0910","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/s41586-025-09191-9","article-title":"Barcoded viral tracing identifies immunosuppressive astrocyte-glioma interactions","volume":"644","author":"Andersen","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2025.189518_bb1385","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/s41586-025-08997-x","article-title":"Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity","volume":"643","author":"Faust Akl","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2025.189518_bb0975","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.1038\/s41467-022-32430-w","article-title":"Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma","volume":"13","author":"Coy","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2025.189518_bb1390","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1101\/gad.350693.123","article-title":"Metabolic partitioning in the brain and its hijacking by glioblastoma","volume":"37","author":"de Ruiter Swain","year":"2023","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbcan.2025.189518_bb0995","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.ccell.2016.09.008","article-title":"An LXR-cholesterol Axis creates a metabolic co-dependency for brain cancers","volume":"30","author":"Villa","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2025.189518_bb1395","doi-asserted-by":"crossref","first-page":"5478","DOI":"10.1158\/0008-5472.CAN-19-3923","article-title":"Brain tumor stem cell dependence on Glutaminase reveals a metabolic vulnerability through the amino acid deprivation response pathway","volume":"80","author":"Restall","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb1005","doi-asserted-by":"crossref","first-page":"8981","DOI":"10.1158\/0008-5472.CAN-10-1666","article-title":"Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1","volume":"70","author":"Seltzer","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb1400","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.2174\/1570159X20999220131163504","article-title":"Transient opening of the blood-brain barrier by vasoactive peptides to increase CNS drug delivery: reality versus wishful thinking?","volume":"20","author":"Smith-Cohn","year":"2022","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.bbcan.2025.189518_bb1405","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1084\/jem.20102099","article-title":"A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas","volume":"208","author":"Agnihotri","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbcan.2025.189518_bb1060","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1172\/JCI59334","article-title":"Alkylpurine\u2013DNA\u2013N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients","volume":"122","author":"Agnihotri","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2025.189518_bb1410","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/neuonc\/nor010","article-title":"Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+ tumor-derived cells","volume":"13","author":"Short","year":"2011","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.bbcan.2025.189518_bb1040","doi-asserted-by":"crossref","first-page":"2307097","DOI":"10.1002\/smll.202307097","article-title":"HDL Nanodiscs loaded with liver X receptor agonist decreases tumor burden and mediates Long-term survival in mouse glioma model","volume":"21","author":"Halseth","year":"2025","journal-title":"Small"},{"key":"10.1016\/j.bbcan.2025.189518_bb1415","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.3892\/or.2011.1213","article-title":"Enhanced anti-glioblastoma activity of microglia by AAV2-mediated IL-12 through TRAIL and phagocytosis in vitro","volume":"25","author":"Chiu","year":"2011","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bbcan.2025.189518_bb1420","doi-asserted-by":"crossref","first-page":"423","DOI":"10.2217\/nnm-2017-0300","article-title":"Magnetoelectric nanoparticles for delivery of antitumor peptides into glioblastoma cells by magnetic fields","volume":"13","author":"Stewart","year":"2018","journal-title":"Nanomedicine (London)"},{"key":"10.1016\/j.bbcan.2025.189518_bb1280","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/s41416-022-01865-9","article-title":"Selective cell cycle arrest in glioblastoma cell lines by quantum molecular resonance alone or in combination with temozolomide","volume":"127","author":"Catanzaro","year":"2022","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbcan.2025.189518_bb1425","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jconrel.2016.01.015","article-title":"Glioma-targeted therapy using Cilengitide nanoparticles combined with UTMD enhanced delivery","volume":"224","author":"Zhao","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bbcan.2025.189518_bb1430","doi-asserted-by":"crossref","first-page":"eabd0772","DOI":"10.1126\/sciadv.abd0772","article-title":"Neuronavigation-guided focused ultrasound for transcranial blood-brain barrier opening and immunostimulation in brain tumors","volume":"7","author":"Chen","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbcan.2025.189518_bb1435","article-title":"Anti-PD-1 and anti-PD-L1 antibodies for glioma","volume":"1","author":"de Melo","year":"2025","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bbcan.2025.189518_bb0950","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1093\/neuonc\/noac116","article-title":"Phase III trial of chemoradiotherapy with temozolomide plus nivolumab or placebo for newly diagnosed glioblastoma with methylated MGMT promoter","volume":"24","author":"Lim","year":"2022","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.bbcan.2025.189518_bb1440","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1093\/neuonc\/noaa170","article-title":"Immuno-synergy? Neoantigen vaccines and checkpoint blockade in glioblastoma","volume":"22","author":"Woroniecka","year":"2020","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.bbcan.2025.189518_bb1170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/jamaoncol.2020.1024","article-title":"Effect of Nivolumab vs bevacizumab in patients with recurrent glioblastoma","volume":"6","author":"Reardon","year":"2020","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.bbcan.2025.189518_bb1445","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1007\/s00262-018-2214-0","article-title":"High-grade glioma associated immunosuppression does not prevent immune responses induced by therapeutic vaccines in combination with Treg depletion","volume":"67","author":"L\u00f6hr","year":"2018","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.bbcan.2025.189518_bb1450","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/neuonc\/noac099","article-title":"Radiotherapy combined with nivolumab or temozolomide for newly diagnosed glioblastoma with unmethylated MGMT promoter: an international randomized phase III trial","volume":"25","author":"Omuro","year":"2023","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.bbcan.2025.189518_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110086","article-title":"Novel insights into astrocyte-mediated signaling of proliferation, invasion and tumor immune microenvironment in glioblastoma","volume":"126","author":"Zhang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbcan.2025.189518_bb0065","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/cac2.12361","article-title":"An update on the molecular biology of glioblastoma, with clinical implications and progress in its treatment","volume":"42","author":"Verdugo","year":"2022","journal-title":"Cancer Commun. (Lond.)"},{"key":"10.1016\/j.bbcan.2025.189518_bb0070","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.622615","article-title":"The Normal and brain tumor vasculature: morphological and functional characteristics and therapeutic targeting","volume":"12","author":"Guyon","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0075","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood-brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0080","article-title":"Unlocking temozolomide resistance in glioblastoma: the pivotal role of MicroRNAs and in-silico insights","volume":"42","author":"S. A, A. A, A. I, A. Z, S. S, R.M. Fr, M. V, B. O, K. Mi, A. F, Y. A","year":"2025","journal-title":"Medical Oncology (Northwood, London, England)"},{"key":"10.1016\/j.bbcan.2025.189518_bb0090","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1038\/s41591-023-02555-6","article-title":"A H3K27M-targeted vaccine in adults with diffuse midline glioma","volume":"29","author":"Grassl","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2025.189518_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semcdb.2024.12.006","article-title":"Spatial omics shed light on the tumour organisation of glioblastoma","volume":"167","author":"Whittle","year":"2025","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0100","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1016\/j.cell.2023.11.016","article-title":"Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain","volume":"186","author":"Li","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2025.189518_bb0105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1126\/science.abm1741","article-title":"Conservation and divergence of cortical cell organization in human and mouse revealed by MERFISH","volume":"377","author":"Fang","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.bbcan.2025.189518_bb0110","doi-asserted-by":"crossref","first-page":"1515981","DOI":"10.3389\/fneur.2024.1515981","article-title":"Unraveling Alzheimer\u2019s disease: insights from single-cell sequencing and spatial transcriptomic","volume":"15","author":"He","year":"2024","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0115","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41586-025-09010-1","article-title":"Spatial transcriptomics reveals human cortical layer and area specification","volume":"644","author":"Qian","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2025.189518_bb0120","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/j.neuron.2025.03.002","article-title":"Molecular pathways and diagnosis in spatially resolved Alzheimer\u2019s hippocampal atlas","volume":"113","author":"Wang","year":"2025","journal-title":"Neuron"},{"key":"10.1016\/j.bbcan.2025.189518_bb0125","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.cell.2022.12.010","article-title":"Molecular and spatial signatures of mouse brain aging at single-cell resolution","volume":"186","author":"Allen","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2025.189518_bb0130","doi-asserted-by":"crossref","first-page":"eadq2084","DOI":"10.1126\/science.adq2084","article-title":"Deep-tissue transcriptomics and subcellular imaging at high spatial resolution","volume":"388","author":"Gandin","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.bbcan.2025.189518_bb0135","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1093\/neuonc\/noac085","article-title":"Glioblastoma scRNA-seq shows treatment-induced, immune-dependent increase in mesenchymal cancer cells and structural variants in distal neural stem cells","volume":"24","author":"Couturier","year":"2022","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.bbcan.2025.189518_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.109663","article-title":"ESTRO-EANO guideline on target delineation and radiotherapy details for glioblastoma","volume":"184","author":"Niyazi","year":"2023","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0145","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.bbcan.2025.189518_bb0150","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1038\/s41467-023-38186-1","article-title":"Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic and targetable tissue states","volume":"14","author":"Al-Dalahmah","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2025.189518_bb0155","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.cell.2019.06.024","article-title":"An integrative model of cellular states, plasticity and genetics for glioblastoma","volume":"178","author":"Neftel","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2025.189518_bb0165","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1038\/s41467-023-39933-0","article-title":"Spatial cellular architecture predicts prognosis in glioblastoma","volume":"14","author":"Zheng","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2025.189518_bb0175","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","article-title":"Reactive astrocytes: production, function, and therapeutic potential","volume":"46","author":"Liddelow","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.bbcan.2025.189518_bb0180","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2025.189518_bb0185","first-page":"157","article-title":"Gradient of developmental and injury response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity","volume":"2","author":"Richards","year":"2021","journal-title":"Nat. Can."},{"key":"10.1016\/j.bbcan.2025.189518_bb0190","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1073\/pnas.1910856117","article-title":"CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas","volume":"117","author":"Flores-Toro","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbcan.2025.189518_bb0195","doi-asserted-by":"crossref","first-page":"7285","DOI":"10.1158\/0008-5472.CAN-14-1240","article-title":"RAGE expression in tumor-associated macrophages promotes angiogenesis in glioma","volume":"74","author":"Chen","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb0200","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13024-020-00416-1","article-title":"Astrocyte-derived clusterin suppresses amyloid formation in vivo","volume":"15","author":"Wojtas","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bbcan.2025.189518_bb0205","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00401-012-0996-2","article-title":"The genetics and neuropathology of Alzheimer\u2019s disease","volume":"124","author":"Schellenberg","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0210","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40478-020-0880-6","article-title":"Single-nucleus RNA-seq identifies Huntington disease astrocyte states","volume":"8","author":"Al-Dalahmah","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.bbcan.2025.189518_bb0215","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.3390\/ijms20102496","article-title":"The expression of the chemokine CXCL14 correlates with several aggressive aspects of glioblastoma and promotes key properties of glioblastoma cells","volume":"20","author":"Fazi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0220","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41586-022-05680-3","article-title":"Single-cell spatial immune landscapes of primary and metastatic brain tumours","volume":"614","author":"Karimi","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2025.189518_bb0225","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/bpa.12348","article-title":"Intrinsic astrocyte heterogeneity influences tumor growth in glioma mouse models","volume":"27","author":"Irvin","year":"2016","journal-title":"Brain Pathol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0230","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.canlet.2014.07.034","article-title":"Tumoral RANKL activates astrocytes that promote glioma cell invasion through cytokine signaling","volume":"353","author":"Kim","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbcan.2025.189518_bb0235","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1002\/glia.20845","article-title":"Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)-regulated glial proliferation","volume":"57","author":"Yeh","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.bbcan.2025.189518_bb0240","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41419-024-06971-5","article-title":"Astrocytes and the tumor microenvironment inflammatory state dictate the killing of glioblastoma cells by Smac mimetic compounds","volume":"15","author":"Malone","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbcan.2025.189518_bb0250","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrc1121","article-title":"Molecular mechanisms of glioma invasiveness: the role of proteases","volume":"3","author":"Rao","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2025.189518_bb0255","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1093\/brain\/awt025","article-title":"Side population in human glioblastoma is non-tumorigenic and characterizes brain endothelial cells","volume":"136","author":"Golebiewska","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.bbcan.2025.189518_bb0260","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1593\/neo.07909","article-title":"The role of Fascin in the migration and invasiveness of malignant glioma cells","volume":"10","author":"Hyun Hwang","year":"2008","journal-title":"Neoplasia"},{"key":"10.1016\/j.bbcan.2025.189518_bb0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032453","article-title":"Astrocyte-specific expression patterns associated with the PDGF-induced glioma microenvironment","volume":"7","author":"Katz","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2025.189518_bb0280","doi-asserted-by":"crossref","first-page":"8498","DOI":"10.3390\/ijms24108498","article-title":"Role of senescent astrocytes in health and disease","volume":"24","author":"Meldolesi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0285","first-page":"337","article-title":"Astrocytes and aging, Frontiers in aging","volume":"10","author":"Palmer","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbcan.2025.189518_bb0290","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3389\/fnagi.2016.00208","article-title":"Changes in the transcriptome of human astrocytes accompanying oxidative stress-induced senescence","volume":"8","author":"Crowe","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0295","doi-asserted-by":"crossref","first-page":"644","DOI":"10.3389\/fphar.2019.00644","article-title":"Astrocyte function is affected by aging and not Alzheimer\u2019s disease: a preliminary investigation in hippocampi of 3xTg-AD mice","volume":"10","author":"Bronzuoli","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0300","article-title":"Astrocyte senescence may drive alterations in GFAP\u03b1, CDKN2A p14ARF, and TAU3 transcript expression and contribute to cognitive decline","volume":"41","author":"Jj","year":"2019","journal-title":"GeroScience"},{"key":"10.1016\/j.bbcan.2025.189518_bb0305","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.celrep.2017.12.039","article-title":"The aging astrocyte transcriptome from multiple regions of the mouse brain","volume":"22","author":"Boisvert","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbcan.2025.189518_bb0310","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cbi.2018.02.002","article-title":"Ginsenoside F1 suppresses astrocytic senescence-associated secretory phenotype","volume":"283","author":"Hou","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bbcan.2025.189518_bb0315","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40478-023-01526-9","article-title":"Roles of neuropathology-associated reactive astrocytes: a systematic review","volume":"11","author":"Lawrence","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.bbcan.2025.189518_bb0320","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3389\/fnagi.2020.00096","article-title":"Astroglia and tau: new perspectives","volume":"12","author":"Kovacs","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0325","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fnagi.2019.00059","article-title":"Astrocyte heterogeneity: impact to brain aging and disease","volume":"11","author":"Matias","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0330","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/bpa.12593","article-title":"Aging-related tau astrogliopathy (ARTAG): not only tau phosphorylation in astrocytes","volume":"28","author":"Ferrer","year":"2018","journal-title":"Brain Pathol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0335","first-page":"432","article-title":"Epigenetic regulation of astrocyte function in Neuroinflammation and neurodegeneration","volume":"2018","author":"Neal","year":"1864","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbcan.2025.189518_bb0340","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s42003-020-01418-x","article-title":"Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia","volume":"3","author":"Chucair-Elliott","year":"2020","journal-title":"Commun Biol"},{"key":"10.1016\/j.bbcan.2025.189518_bb0345","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.tcb.2023.02.004","article-title":"The autophagy-NAD axis in longevity and disease","volume":"33","author":"Wilson","year":"2023","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0350","doi-asserted-by":"crossref","unstructured":"J. Boot, G. Rosser, D. Kancheva, C. Vinel, Y.M. Lim, N. Pomella, X. Zhang, L. Guglielmi, D. Sheer, M. Barnes, S. Brandner, S. Nelander, K. Movahedi, S. Marino, Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape, eLife, 11 (n.d.) e77335.","DOI":"10.7554\/eLife.77335"},{"key":"10.1016\/j.bbcan.2025.189518_bb0355","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1158\/1535-7163.MCT-21-0903","article-title":"Transcription Factor\u2013Forced Astrocytic Differentiation Impairs Human Glioblastoma Growth In Vitro and In Vivo","volume":"22","author":"Trovato","year":"2023","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bbcan.2025.189518_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104484","article-title":"Metformin and simvastatin exert additive antitumour effects in glioblastoma via senescence-state: clinical and translational evidence","volume":"90","author":"Fuentes-Fayos","year":"2023","journal-title":"eBioMedicine"},{"key":"10.1016\/j.bbcan.2025.189518_bb0365","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/s41568-019-0156-2","article-title":"Unmasking senescence: context-dependent effects of SASP in cancer","volume":"19","author":"Faget","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2025.189518_bb0375","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nrm3823","article-title":"Cellular senescence: from physiology to pathology","volume":"15","author":"Mu\u00f1oz-Esp\u00edn","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0380","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.trecan.2020.05.004","article-title":"Senescent cells in Cancer therapy: friends or foes?","volume":"6","author":"Wang","year":"2020","journal-title":"Trends Cancer"},{"key":"10.1016\/j.bbcan.2025.189518_bb0385","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ccell.2019.10.001","article-title":"Small molecule MYC inhibitors suppress tumor growth and enhance immunotherapy","volume":"36","author":"Han","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2025.189518_bb0390","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s11060-025-05110-0","article-title":"Clinical utility of GAL-8, ITG\u0392-1, and HIF-1\u03b1 as non-invasive diagnostic and prognostic biomarkers for assessing glioma","volume":"174","author":"Turan","year":"2025","journal-title":"J. Neuro-Oncol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0395","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.tins.2020.10.014","article-title":"Extracellular vesicle-mediated bilateral communication between glioblastoma and astrocytes","volume":"44","author":"Nieland","year":"2021","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0400","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/s41591-018-0044-4","article-title":"STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis","volume":"24","author":"Priego","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2025.189518_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101420","article-title":"Glioblastoma-Derived Extracellular Vesicles Facilitate Transformation of Astrocytes via Reprogramming Oncogenic Metabolism","volume":"23","author":"Zeng","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.bbcan.2025.189518_bb0410","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.ccell.2022.05.009","article-title":"Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma","volume":"40","author":"Ravi","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2025.189518_bb0415","first-page":"20160477","article-title":"Glioblastoma multiforme-derived extracellular vesicles drive normal astrocytes towards a tumour-enhancing phenotype","volume":"373","author":"Oushy","year":"2018","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0420","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1016\/j.celrep.2020.01.089","article-title":"Gliomas interact with non-glioma brain cells via extracellular vesicles","volume":"30","author":"Gao","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbcan.2025.189518_bb0425","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002893","article-title":"Identification and characterization of tumor-associated astrocyte subpopulations and their interactions with the tumor microenvironment in experimental glioblastomas","volume":"23","author":"Ghosh","year":"2025","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0430","doi-asserted-by":"crossref","first-page":"6329","DOI":"10.2147\/JIR.S473932","article-title":"Alterations in astrocyte subpopulations in glioma and identification of Cuproptosis-related genes using single-cell RNA sequencing","volume":"17","author":"Huang","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb0435","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.ajpath.2025.04.013","article-title":"Deciphering the dialogue between brain tumors, neurons, and astrocytes","volume":"195","author":"Westerlund","year":"2025","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0480","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nn.4185","article-title":"The role of microglia and macrophages in glioma maintenance and progression","volume":"19","author":"Hambardzumyan","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0485","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.critrevonc.2013.08.004","article-title":"Interleukin-6: an angiogenic target in solid tumours","volume":"89","author":"Middleton","year":"2014","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0490","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cmet.2019.04.002","article-title":"Cholesterol induces CD8+ T-cell exhaustion in the tumor microenvironment","volume":"30","author":"Ma","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbcan.2025.189518_bb0495","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.cell.2017.12.026","article-title":"LXR\/ApoE activation restricts innate immune suppression in cancer","volume":"172","author":"Tavazoie","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2025.189518_bb0500","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1038\/onc.2009.104","article-title":"Aryl hydrocarbon receptor inhibition downregulates the TGF-beta\/Smad pathway in human glioblastoma cells","volume":"28","author":"Gramatzki","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2025.189518_bb0505","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1186\/s12967-025-06743-5","article-title":"Spatial transcriptomics and multi-omics reveal relapse and resistance mechanisms of EndMT-derived CAFs mediated by TNC and FLNC in glioblastoma","volume":"23","author":"Ji","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbcan.2025.189518_bb0510","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s12264-014-1522-4","article-title":"Tunneling nanotubes between rat primary astrocytes and C6 glioma cells alter proliferation potential of glioma cells","volume":"31","author":"Zhang","year":"2015","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.bbcan.2025.189518_bb0515","doi-asserted-by":"crossref","first-page":"6017","DOI":"10.3390\/ijms20236017","article-title":"Pre-clinical drug testing in 2D and 3D human in vitro models of glioblastoma incorporating non-neoplastic astrocytes: tunneling Nano tubules and mitochondrial transfer modulates cell behavior and therapeutic Respons","volume":"20","author":"Civita","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0520","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.pneurobio.2015.10.005","article-title":"Alternative mitochondrial Electron transfer for the treatment of neurodegenerative diseases and cancers: methylene blue connects the dots","volume":"157","author":"Yang","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0525","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.mod.2012.11.006","article-title":"Tunneling nanotubes, an emerging intercellular communication route in development","volume":"130","author":"Gerdes","year":"2013","journal-title":"Mech. Dev."},{"key":"10.1016\/j.bbcan.2025.189518_bb0530","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3389\/fbioe.2019.00403","article-title":"Differential exchange of multifunctional liposomes between glioblastoma cells and healthy astrocytes via tunneling nanotubes","volume":"7","author":"Formicola","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0535","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature16071","article-title":"Brain tumour cells interconnect to a functional and resistant network","volume":"528","author":"Osswald","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2025.189518_bb0540","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/s41467-021-21117-3","article-title":"Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma","volume":"12","author":"Jung","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2025.189518_bb0545","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1242\/jcs.083279","article-title":"Wiring through tunneling nanotubes--from electrical signals to organelle transfer","volume":"125","author":"Abounit","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0550","doi-asserted-by":"crossref","first-page":"14556","DOI":"10.1038\/s41598-021-93775-8","article-title":"Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions","volume":"11","author":"Valdebenito","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2025.189518_bb0555","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1221671","article-title":"GFAP serves as a structural element of tunneling nanotubes between glioblastoma cells and could play a role in the intercellular transfer of mitochondria","volume":"11","author":"Simone","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0560","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1042\/BCJ20200710","article-title":"Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids","volume":"478","author":"Pinto","year":"2021","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbcan.2025.189518_bb0565","doi-asserted-by":"crossref","first-page":"6017","DOI":"10.3390\/ijms20236017","article-title":"Pre-clinical drug testing in 2D and 3D human in vitro models of glioblastoma incorporating non-neoplastic astrocytes: tunneling Nano tubules and mitochondrial transfer modulates cell behavior and therapeutic Respons","volume":"20","author":"Civita","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0570","first-page":"648","article-title":"GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity","volume":"4","author":"Watson","year":"2023","journal-title":"Nat. Can."},{"key":"10.1016\/j.bbcan.2025.189518_bb0575","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1023\/A:1006859115450","article-title":"Dihydroorotat-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides","volume":"174","author":"L\u00f6ffler","year":"1997","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbcan.2025.189518_bb0580","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1038\/s41388-025-03429-6","article-title":"Functional mitochondrial respiration is essential for glioblastoma tumour growth","volume":"44","author":"Brisudova","year":"2025","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2025.189518_bb0585","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s41419-023-06045-y","article-title":"The diversified role of mitochondria in ferroptosis in cancer","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbcan.2025.189518_bb0590","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.bbrc.2020.08.101","article-title":"Mitochondria transfer from tumor-activated stromal cells (TASC) to primary glioblastoma cells","volume":"533","author":"Salaud","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbcan.2025.189518_bb0595","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.4103\/NRR.NRR-D-24-01129","article-title":"Role of tunneling nanotubes in neuroglia","volume":"21","author":"Xu","year":"2026","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb0600","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.7150\/thno.33100","article-title":"Endocytosis-mediated mitochondrial transplantation: transferring normal human astrocytic mitochondria into glioma cells rescues aerobic respiration and enhances radiosensitivity","volume":"9","author":"Sun","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.bbcan.2025.189518_bb0605","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00041433-200104000-00003","article-title":"Cholesterol metabolism in the brain","volume":"12","author":"Dietschy","year":"2001","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0610","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3390\/ijms26020669","article-title":"The impact of metabolic rewiring in glioblastoma: the immune landscape and therapeutic strategies","volume":"26","author":"Vijayanathan","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0615","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2217\/cns.13.20","article-title":"Lipid metabolism emerges as a promising target for malignant glioma therapy","volume":"2","author":"Guo","year":"2013","journal-title":"CNS Oncol"},{"key":"10.1016\/j.bbcan.2025.189518_bb0620","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.7150\/jca.63609","article-title":"Cholesterol metabolism and its implication in glioblastoma therapy","volume":"13","author":"Guo","year":"2022","journal-title":"J. Cancer"},{"key":"10.1016\/j.bbcan.2025.189518_bb0625","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s11095-020-02904-x","article-title":"Lauroylated histidine-enriched S413-PV peptide as an efficient gene silencing mediator in Cancer cells","volume":"37","author":"Morais","year":"2020","journal-title":"Pharm. Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb0630","doi-asserted-by":"crossref","first-page":"15458","DOI":"10.1038\/s41598-019-51865-8","article-title":"LXR\u03b2 controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1","volume":"9","author":"Patel","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2025.189518_bb0635","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13073-024-01321-8","article-title":"Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts","volume":"16","author":"Yabo","year":"2024","journal-title":"Genome Med."},{"key":"10.1016\/j.bbcan.2025.189518_bb0640","doi-asserted-by":"crossref","first-page":"1561388","DOI":"10.3389\/fimmu.2025.1561388","article-title":"Single-cell and spatial transcriptomic insights into glioma cellular heterogeneity and metabolic adaptations","volume":"16","author":"Fu","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0645","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ccell.2017.06.003","article-title":"Tumor evolution of glioma intrinsic gene expression subtype associates with immunological changes in the microenvironment","volume":"32","author":"Wang","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2025.189518_bb0650","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3389\/fnins.2019.00164","article-title":"Clusterin in Alzheimer\u2019s Disease: Mechanisms, genetics, and lessons from other pathologies","volume":"13","author":"Foster","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0690","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12987-018-0114-5","article-title":"Tunneling nanotubes evoke pericyte\/endothelial communication during normal and tumoral angiogenesis","volume":"15","author":"Errede","year":"2018","journal-title":"Fluids and Barriers of the CNS"},{"key":"10.1016\/j.bbcan.2025.189518_bb0695","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110565","article-title":"Astroglia proliferate upon the biogenesis of tunneling nanotubes via \u03b1-synuclein dependent transient nuclear translocation of focal adhesion kinase","volume":"27","author":"Raghavan","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.bbcan.2025.189518_bb0700","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/cdd.2010.147","article-title":"Tunneling-nanotube development in astrocytes depends on p53 activation","volume":"18","author":"Wang","year":"2011","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbcan.2025.189518_bb0705","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12989-024-00562-0","article-title":"ROS\/mtROS promotes TNTs formation via the PI3K\/AKT\/mTOR pathway to protect against mitochondrial damages in glial cells induced by engineered nanomaterials","volume":"21","author":"Lin","year":"2024","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0710","doi-asserted-by":"crossref","first-page":"7371","DOI":"10.3390\/ijms21197371","article-title":"Endothelial-tumor cell interaction in brain and CNS malignancies","volume":"21","author":"Peleli","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0715","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/neuonc\/now014","article-title":"A malignant cellular network in gliomas: potential clinical implications","volume":"18","author":"Osswald","year":"2016","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.bbcan.2025.189518_bb0720","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1523\/JNEUROSCI.22-01-00239.2002","article-title":"Growth-associated Protein-43 is required for commissural axon guidance in the developing vertebrate nervous system","volume":"22","author":"Shen","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0725","article-title":"Brain tumour cells interconnect to a functional and resistant network","volume":"528","author":"O. M, J. E, S. F, S. G, V. V, B. J, W. S, H. H, W. B, S. M, H. L, R. M, K.J. K, K. Ft, S. T, L. D, G. M, P. M, L. Y, H. P","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2025.189518_bb0730","article-title":"Gap junctions in human glioblastomas: implications for suicide gene therapy","volume":"18","author":"C. S, G. Pv, C. L, C. M","year":"2011","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.bbcan.2025.189518_bb0735","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.preteyeres.2015.09.004","article-title":"Connexin43 in retinal injury and disease","volume":"51","author":"Danesh-Meyer","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb0740","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1021\/acs.bioconjchem.4c00300","article-title":"Gastrodin liposomes block crosstalk between astrocytes and glioma cells via downregulating Cx43 to improve Antiglioblastoma efficacy of Temozolomide","volume":"35","author":"Song","year":"2024","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.bbcan.2025.189518_bb0745","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/neuonc\/noae237","article-title":"Glioma\u2013astrocyte connexin43 confers temozolomide resistance through activation of the E2F1\/ERCC1 axis","volume":"27","author":"Gui","year":"2025","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.bbcan.2025.189518_bb0750","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1158\/1541-7786.MCR-21-0199","article-title":"Glioblastoma-astrocyte Connexin 43 gap junctions promote tumor invasion","volume":"20","author":"McCutcheon","year":"2022","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb0755","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.111","article-title":"Temozolomide resistance in glioblastoma cells occurs partly through epidermal growth factor receptor-mediated induction of connexin 43","volume":"5","author":"Munoz","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbcan.2025.189518_bb0760","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.canlet.2018.06.041","article-title":"Delivery of MGMT mRNA to glioma cells by reactive astrocyte-derived exosomes confers a temozolomide resistance phenotype","volume":"433","author":"Yu","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbcan.2025.189518_bb0765","article-title":"Transformed astrocytes confer temozolomide resistance on glioblastoma via delivering ALKBH7 to enhance APNG expression after educating by glioblastoma stem cells-derived exosomes","volume":"30","author":"Liu","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.bbcan.2025.189518_bb0770","article-title":"Reduced expression of connexin-43 and functional gap junction coupling in human gliomas","volume":"33","author":"S. L, M. Tj, S. H","year":"2001","journal-title":"Glia"},{"key":"10.1016\/j.bbcan.2025.189518_bb0775","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrc.2016.105","article-title":"Gap junctions and Cancer: communicating for 50 years","volume":"16","author":"Aasen","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2025.189518_bb0780","doi-asserted-by":"crossref","first-page":"4855","DOI":"10.1038\/s41467-020-18634-y","article-title":"The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication","volume":"11","author":"Fumagalli","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2025.189518_bb0785","article-title":"Fluoxetine enhances the antitumor effect of olfactory ensheathing cell-thymidine kinase\/ganciclovir gene therapy in human glioblastoma multiforme cells through upregulation of Connexin43 levels","volume":"84","author":"H. S, D. Ar, D. S, J. Sah, A. B, F. A, H. M","year":"2023","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb0790","doi-asserted-by":"crossref","first-page":"12231","DOI":"10.3390\/ijms252212231","article-title":"Integrated transcriptome profiling and Pan-Cancer analyses reveal oncogenic networks and tumor-immune modulatory roles for FABP7 in brain cancers","volume":"25","author":"Lee","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0795","first-page":"20160477","article-title":"Glioblastoma multiforme-derived extracellular vesicles drive normal astrocytes towards a tumour-enhancing phenotype","volume":"373","author":"Oushy","year":"2018","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0800","doi-asserted-by":"crossref","first-page":"4566","DOI":"10.1007\/s12035-018-1385-1","article-title":"Extracellular vesicles released by glioblastoma cells stimulate Normal astrocytes to acquire a tumor-supportive phenotype via p53 and MYC signaling pathways","volume":"56","author":"Hallal","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0805","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.1038\/ncomms5196","article-title":"Disruption of astrocyte-vascular coupling and the blood-brain barrier by invading glioma cells","volume":"5","author":"Watkins","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2025.189518_bb0810","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nature15376","article-title":"Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth","volume":"527","author":"Zhang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2025.189518_bb0815","doi-asserted-by":"crossref","first-page":"7312","DOI":"10.1073\/pnas.1220998110","article-title":"Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development","volume":"110","author":"Kucharzewska","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbcan.2025.189518_bb0820","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.cell.2024.11.002","article-title":"Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing","volume":"188","author":"Tetzlaff","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2025.189518_bb0825","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/s41586-019-1563-y","article-title":"Electrical and synaptic integration of glioma into neural circuits","volume":"573","author":"Venkatesh","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2025.189518_bb0830","doi-asserted-by":"crossref","unstructured":"A.L. Hsieh, S. Ganesh, T. Kula, M. Irshad, E.A. Ferenczi, W. Wang, Y.-C. Chen, S.-H. Hu, Z. Li, S. Joshi, M.C. Haigis, B.L. Sabatini, Widespread neuroanatomical integration and distinct electrophysiological properties of glioma-innervating neurons, Proc. Natl. Acad. Sci. USA, 121 (n.d.) e2417420121.","DOI":"10.1073\/pnas.2417420121"},{"key":"10.1016\/j.bbcan.2025.189518_bb0835","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1016\/j.cell.2022.06.054","article-title":"Glioblastoma hijacks neuronal mechanisms for brain invasion","volume":"185","author":"Venkataramani","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2025.189518_bb0840","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nature24014","article-title":"Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma","volume":"549","author":"Venkatesh","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2025.189518_bb0845","doi-asserted-by":"crossref","first-page":"8738","DOI":"10.18632\/oncotarget.14434","article-title":"Prognostic impact of CD73 and A2A adenosine receptor expression in non-small-cell lung cancer","volume":"8","author":"Inoue","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbcan.2025.189518_bb0850","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nn.3990","article-title":"GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury","volume":"18","author":"Zonouzi","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0855","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.ccell.2024.08.009","article-title":"Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma","volume":"42","author":"Curry","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2025.189518_bb0860","doi-asserted-by":"crossref","DOI":"10.1126\/science.aai8478","article-title":"Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq","volume":"355","author":"Venteicher","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.bbcan.2025.189518_bb0865","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1016\/j.cell.2025.05.031","article-title":"Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling","volume":"188","author":"Drexler","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2025.189518_bb0870","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/s41586-023-06267-2","article-title":"Remote neuronal activity drives glioma infiltration via Sema4f","volume":"619","author":"Huang-Hobbs","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2025.189518_bb0875","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1093\/neuonc\/noad252","article-title":"Abrogation of the G2\/M checkpoint as a chemosensitization approach for alkylating agents","volume":"26","author":"Lang","year":"2023","journal-title":"Neuro-Oncology"},{"key":"10.1016\/j.bbcan.2025.189518_bb0880","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1158\/0008-5472.CAN-19-1577","article-title":"Dysregulation of glutamate transport enhances Treg function that promotes VEGF blockade resistance in glioblastoma","volume":"80","author":"Long","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb0885","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1158\/1078-0432.CCR-23-0430","article-title":"Hypoxia-induced neuronal activity in glioma patients polarizes microglia by potentiating RNA m6A demethylation","volume":"30","author":"Guo","year":"2024","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb0890","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.ccell.2022.08.014","article-title":"Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity","volume":"40","author":"Chryplewicz","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2025.189518_bb0895","series-title":"A Paracrine Circuit of IL-1\u03b2\/IL-1R1 between Myeloid and Tumor Cells Drives Genotype-Dependent Glioblastoma Progression","author":"Chen","year":"2025"},{"key":"10.1016\/j.bbcan.2025.189518_bb0900","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/s41591-019-0349-y","article-title":"Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma","volume":"25","author":"Zhao","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2025.189518_bb0905","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1126\/science.1254257","article-title":"Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma","volume":"344","author":"Patel","year":"2014","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.bbcan.2025.189518_bb0915","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nrm.2016.149","article-title":"Necroptosis in development, inflammation and disease","volume":"18","author":"Weinlich","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbcan.2025.189518_bb0920","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1126\/science.aad0395","article-title":"RIPK1 and NF-\u03baB signaling in dying cells determines cross-priming of CD8+ T cells","volume":"350","author":"Yatim","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.bbcan.2025.189518_bb0925","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.freeradbiomed.2017.04.010","article-title":"Cytosolic calcium mediates RIP1\/RIP3 complex-dependent necroptosis through JNK activation and mitochondrial ROS production in human colon cancer cells","volume":"108","author":"Sun","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbcan.2025.189518_bb0930","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1158\/0008-5472.CAN-13-1283","article-title":"Accumulation of cytosolic calcium induces necroptotic cell death in human neuroblastoma","volume":"74","author":"Nomura","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb0935","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/s41593-019-0370-y","article-title":"Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39","volume":"22","author":"Takenaka","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbcan.2025.189518_bb0940","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.cell.2020.04.055","article-title":"Single-cell mapping of human brain Cancer reveals tumor-specific instruction of tissue-invading leukocytes","volume":"181","author":"Friebel","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2025.189518_bb0945","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1016\/j.cell.2023.08.043","article-title":"The local microenvironment drives activation of neutrophils in human brain tumors","volume":"186","author":"Maas","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2025.189518_bb0955","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1158\/1078-0432.CCR-17-3573","article-title":"IDO1 inhibition synergizes with radiation and PD-1 blockade to durably increase survival against advanced glioblastoma","volume":"24","author":"Ladomersky","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb0960","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41591-019-0694-x","article-title":"Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma","volume":"26","author":"Goswami","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2025.189518_bb0965","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1038\/s41591-024-02893-z","article-title":"Intrathecal bivalent CAR T cells targeting EGFR and IL13R\u03b12 in recurrent glioblastoma: phase 1 trial interim results","volume":"30","author":"Bagley","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2025.189518_bb0970","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114577","article-title":"Formyl peptide receptor 1 is involved in surgery-induced neuroinflammation and dysfunction of learning and memory in mice","volume":"452","author":"Ma","year":"2023","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb0980","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1101\/gad.350693.123","article-title":"Metabolic partitioning in the brain and its hijacking by glioblastoma","volume":"37","author":"de Ruiter Swain","year":"2023","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbcan.2025.189518_bb0985","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1016\/j.cell.2025.02.035","article-title":"Engineering sonogenetic EchoBack-CAR T cells","volume":"188","author":"Liu","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2025.189518_bb0990","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1158\/0008-5472.CAN-24-2286","article-title":"Targeting ARPC1B overcomes immune checkpoint inhibitor resistance in glioblastoma by reversing Protumorigenic macrophage polarization","volume":"85","author":"Liu","year":"2025","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb1000","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/s41419-022-05526-w","article-title":"SLC1A5 enhances malignant phenotypes through modulating ferroptosis status and immune microenvironment in glioma","volume":"13","author":"Han","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbcan.2025.189518_bb1010","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1158\/2159-8290.CD-20-1437","article-title":"Medium-chain acyl-CoA dehydrogenase protects mitochondria from lipid peroxidation in glioblastoma","volume":"11","author":"Puca","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bbcan.2025.189518_bb1015","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1042\/BJ20091024","article-title":"Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia","volume":"425","author":"Wiame","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbcan.2025.189518_bb1020","first-page":"723","article-title":"Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas","volume":"2","author":"Friedrich","year":"2021","journal-title":"Nat. Can."},{"key":"10.1016\/j.bbcan.2025.189518_bb1025","first-page":"201","article-title":"LXR\u03b1 activation and Raf inhibition trigger lethal lipotoxicity in liver cancer","volume":"2","author":"Rudalska","year":"2021","journal-title":"Nat. Can."},{"key":"10.1016\/j.bbcan.2025.189518_bb1030","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nrd4280","article-title":"Liver X receptors in lipid metabolism: opportunities for drug discovery","volume":"13","author":"Hong","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbcan.2025.189518_bb1035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2017.07.010","article-title":"The challenges and promise of targeting the liver X receptors for treatment of inflammatory disease","volume":"181","author":"Fessler","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbcan.2025.189518_bb1045","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1172\/JCI27883","article-title":"Liver X receptors as integrators of metabolic and inflammatory signaling","volume":"116","author":"Zelcer","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2025.189518_bb1050","doi-asserted-by":"crossref","first-page":"5251","DOI":"10.2147\/JIR.S330147","article-title":"New horizons for the roles and association of APE1\/Ref-1 and ABCA1 in atherosclerosis","volume":"14","author":"Chen","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb1055","doi-asserted-by":"crossref","first-page":"788","DOI":"10.3390\/cancers11060788","article-title":"Activation of LXR receptors and inhibition of TRAP1 causes synthetic lethality in solid tumors","volume":"11","author":"Nguyen","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbcan.2025.189518_bb1065","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1007\/s12035-018-1221-7","article-title":"Dehydroepiandrosterone induces Temozolomide resistance through modulating phosphorylation and acetylation of Sp1 in glioblastoma","volume":"56","author":"Yang","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbcan.2025.189518_bb1070","doi-asserted-by":"crossref","first-page":"4836","DOI":"10.1158\/0008-5472.CAN-14-0924","article-title":"Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance","volume":"74","author":"Ohba","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb1075","article-title":"Caspase-8 is a novel modulator of homologous recombination repair in response to ionizing radiations in glioblastoma","volume":"637","author":"Ferri","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbcan.2025.189518_bb1080","doi-asserted-by":"crossref","first-page":"eadj5962","DOI":"10.1126\/scitranslmed.adj5962","article-title":"Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization","volume":"16","author":"Chen","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbcan.2025.189518_bb1085","doi-asserted-by":"crossref","first-page":"6740","DOI":"10.1038\/s41467-024-51214-y","article-title":"Multi-omics and pharmacological characterization of patient-derived glioma cell lines","volume":"15","author":"Wu","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2025.189518_bb1090","doi-asserted-by":"crossref","first-page":"8001","DOI":"10.7150\/thno.37097","article-title":"Extracellular vesicle-based drug delivery systems for cancer treatment","volume":"9","author":"Walker","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.bbcan.2025.189518_bb1095","doi-asserted-by":"crossref","first-page":"462","DOI":"10.3389\/fonc.2018.00462","article-title":"Developments in blood-brain barrier penetrance and drug repurposing for improved treatment of glioblastoma","volume":"8","author":"Harder","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbcan.2025.189518_bb1100","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3390\/pharmaceutics11050245","article-title":"Established and emerging strategies for drug delivery across the blood-brain barrier in brain Cancer","volume":"11","author":"Parodi","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bbcan.2025.189518_bb1105","first-page":"87","article-title":"Extracellular vesicles as carriers of suicide mRNA and\/or protein in Cancer therapy","volume":"2019","author":"Erkan","year":"1895","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbcan.2025.189518_bb1110","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41419-025-07548-6","article-title":"TRMT10A regulates tRNA-ArgCCT m1G9 modification to generate tRNA-derived fragments influencing vasculogenic mimicry formation in glioblastoma","volume":"16","author":"Wei","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbcan.2025.189518_bb1115","doi-asserted-by":"crossref","first-page":"2302831","DOI":"10.1002\/adhm.202302831","article-title":"A 3D bioprinted human neurovascular unit model of glioblastoma tumor growth","volume":"13","author":"Tung","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bbcan.2025.189518_bb1120","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.pharmthera.2015.05.005","article-title":"Glioblastoma multiforme: pathogenesis and treatment","volume":"152","author":"Alifieris","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbcan.2025.189518_bb1125","doi-asserted-by":"crossref","first-page":"795","DOI":"10.3390\/ph18060795","article-title":"The adverse effects and use of bevacizumab in patients with glioblastoma: a systematic review and Meta-analysis","volume":"18","author":"Bruna-Mej\u00edas","year":"2025","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.bbcan.2025.189518_bb1130","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1148\/radiol.2020200978","article-title":"Noninvasive characterization of tumor angiogenesis and oxygenation in bevacizumab-treated recurrent glioblastoma by using dynamic susceptibility MRI: secondary analysis of the European Organization for Research and Treatment of Cancer 26101 trial","volume":"297","author":"Kickingereder","year":"2020","journal-title":"Radiology"},{"key":"10.1016\/j.bbcan.2025.189518_bb1135","doi-asserted-by":"crossref","first-page":"4945","DOI":"10.1200\/JCO.22.02772","article-title":"Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma","volume":"41","author":"Friedman","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2025.189518_bb1140","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1158\/1078-0432.CCR-20-2096","article-title":"MRI and 18FET-PET predict survival benefit from bevacizumab plus radiotherapy in patients with Isocitrate dehydrogenase wild-type glioblastoma: results from the randomized ARTE trial","volume":"27","author":"Wirsching","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb1145","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJMoa1308345","article-title":"Bevacizumab plus Radiotherapy\u2013Temozolomide for Newly Diagnosed Glioblastoma","volume":"370","author":"Chinot","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2025.189518_bb1150","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJMoa1308573","article-title":"A randomized trial of bevacizumab for newly diagnosed glioblastoma","volume":"370","author":"Gilbert","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2025.189518_bb1155","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1200\/JCO.21.02036","article-title":"Therapy for diffuse astrocytic and Oligodendroglial tumors in adults: ASCO-SNO guideline","volume":"40","author":"Mohile","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2025.189518_bb1160","article-title":"Lomustine and Bevacizumab in Progressive Glioblastoma","volume":"377","author":"W. W, G. T, B. M, T. M, S. F, H. I, B. Aa, T. W, D. J, I. A, C. M, C. Pm, S. R, F. M, L.R. E, D. F, W. M, von D. A, G. V, B. Jc","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2025.189518_bb1165","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S1470-2045(14)70314-6","article-title":"Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial","volume":"15","author":"Taal","year":"2014","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.bbcan.2025.189518_bb1175","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1748-717X-9-51","article-title":"The roles of platelet-derived growth factors and their receptors in brain radiation necrosis","volume":"9","author":"Miyata","year":"2014","journal-title":"Radiat. Oncol."},{"key":"10.1016\/j.bbcan.2025.189518_bb1180","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1093\/gerona\/glt057","volume":"68","author":"Ungvari","year":"2013","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.bbcan.2025.189518_bb1185","doi-asserted-by":"crossref","first-page":"6432","DOI":"10.1073\/pnas.1016072108","article-title":"The RecA\/RAD51 protein drives migration of Holliday junctions via polymerization on DNA","volume":"108","author":"Rossi","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbcan.2025.189518_bb1190","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1038\/onc.2015.317","article-title":"Extracellular vesicle-transported Semaphorin3A promotes vascular permeability in glioblastoma","volume":"35","author":"Treps","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2025.189518_bb1195","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.jconrel.2024.07.068","article-title":"An injectable biomimetic hydrogel adapting brain tissue mechanical strength for postoperative treatment of glioblastoma without anti-tumor drugs participation","volume":"373","author":"Jia","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bbcan.2025.189518_bb1200","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.actbio.2024.09.048","article-title":"Tuning a bioengineered hydrogel for studying astrocyte reactivity in glioblastoma","volume":"189","author":"DePalma","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bbcan.2025.189518_bb1205","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.3892\/or_00000795","article-title":"IL-6 augments the invasiveness of U87MG human glioblastoma multiforme cells via up-regulation of MMP-2 and fascin-1","volume":"23","author":"Li","year":"2010","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bbcan.2025.189518_bb1210","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202208227","article-title":"Functional graphene for Peritumoral brain microenvironment modulation therapy in glioblastoma","volume":"19","author":"Chin","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.bbcan.2025.189518_bb1215","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1038\/s41588-024-01880-x","article-title":"Epigenetic therapy potentiates transposable element transcription to create tumor-enriched antigens in glioblastoma cells","volume":"56","author":"Jang","year":"2024","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbcan.2025.189518_bb1220","article-title":"Reprogramming of astrocytes and glioma cells into neurons for central nervous system repair and glioblastoma therapy","volume":"176","author":"W. J, W. M, L. S, H. R, X. W, Z. A, Y. Q, L. H, L. M, C. G","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbcan.2025.189518_bb1225","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fneng.2013.00007","article-title":"The blood-brain barrier: an engineering perspective","volume":"6","author":"Wong","year":"2013","journal-title":"Front Neuroeng"},{"key":"10.1016\/j.bbcan.2025.189518_bb1230","article-title":"Ultrasound-mediated immune regulation in tumor immunotherapy","volume":"14","author":"Sun","year":"2022","journal-title":"Mater. Today Adv."},{"key":"10.1016\/j.bbcan.2025.189518_bb1235","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jconrel.2024.01.034","article-title":"Focused ultrasound-assisted delivery of immunomodulating agents in brain cancer","volume":"367","author":"Memari","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bbcan.2025.189518_bb1240","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11060-024-04795-z","article-title":"Focused ultrasound-mediated enhancement of blood\u2013brain barrier permeability for brain tumor treatment: a systematic review of clinical trials","volume":"170","author":"Zhu","year":"2024","journal-title":"J. Neuro-Oncol."},{"key":"10.1016\/j.bbcan.2025.189518_bb1245","doi-asserted-by":"crossref","first-page":"9050","DOI":"10.1038\/s41598-019-45542-z","article-title":"Boiling histotripsy-induced partial mechanical ablation modulates tumour microenvironment by promoting immunogenic cell death of cancers","volume":"9","author":"Pahk","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2025.189518_bb1250","doi-asserted-by":"crossref","first-page":"14051","DOI":"10.1002\/anie.202102703","article-title":"Transformable Nanosensitizer with tumor microenvironment-activated Sonodynamic process and calcium release for enhanced Cancer immunotherapy","volume":"60","author":"Tan","year":"2021","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.bbcan.2025.189518_bb1255","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1158\/1078-0432.CCR-19-1604","article-title":"High intensity focused ultrasound (HIFU) triggers immune sensitization of refractory murine neuroblastoma to checkpoint inhibitor therapy","volume":"26","author":"Eranki","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb1260","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12967-015-0451-y","article-title":"Focused ultrasound-induced blood\u2013brain barrier opening to enhance interleukin-12 delivery for brain tumor immunotherapy: a preclinical feasibility study","volume":"13","author":"Chen","year":"2015","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbcan.2025.189518_bb1265","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1038\/srep02953","article-title":"Magneto-electric nanoparticles to enable field-controlled high-specificity drug delivery to eradicate ovarian Cancer cells","volume":"3","author":"Guduru","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2025.189518_bb1270","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1038\/ncomms2717","article-title":"Externally controlled on-demand release of anti-HIV drug using magneto-electric nanoparticles as carriers","volume":"4","author":"Nair","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2025.189518_bb1275","doi-asserted-by":"crossref","first-page":"33008","DOI":"10.1021\/acsnano.5c11629","article-title":"Piezodynamic therapy: unleashing mechanical energy and Featuristic next generation therapeutic paradigms for glioblastoma","volume":"19","author":"Muhammad","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.bbcan.2025.189518_bb1285","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3390\/pharmaceutics7030175","article-title":"Neurosurgical Techniques for Disruption of the Blood\u2013Brain Barrier for Glioblastoma Treatment","volume":"7","author":"Rodriguez","year":"2015","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bbcan.2025.189518_bb1290","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1177\/0194599812436648","article-title":"Microbubble therapy enhances anti-tumor properties of cisplatin and Cetuximab in vitro and in vivo","volume":"146","author":"Heath","year":"2012","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.bbcan.2025.189518_bb1295","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1080\/15548627.2019.1687210","article-title":"Manipulation of Mitophagy by \u201call-in-one\u201d nanosensitizer augments sonodynamic glioma therapy","volume":"16","author":"Qu","year":"2025","journal-title":"Autophagy"},{"key":"10.1016\/j.bbcan.2025.189518_bb1300","first-page":"555","article-title":"Non-invasive opening of BBB by focused ultrasound","volume":"86","author":"Hynynen","year":"2003","journal-title":"Acta Neurochir. Suppl."},{"key":"10.1016\/j.bbcan.2025.189518_bb1305","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.7150\/thno.23734","article-title":"Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson\u2019s disease therapy","volume":"8","author":"Zhang","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.bbcan.2025.189518_bb1310","doi-asserted-by":"crossref","first-page":"343re2","DOI":"10.1126\/scitranslmed.aaf6086","article-title":"Clinical trial of blood-brain barrier disruption by pulsed ultrasound","volume":"8","author":"Carpentier","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbcan.2025.189518_bb1315","doi-asserted-by":"crossref","first-page":"E10","DOI":"10.3171\/2017.11.FOCUS17620","article-title":"A review of potential applications of MR-guided focused ultrasound for targeting brain tumor therapy","volume":"44","author":"Lamsam","year":"2018","journal-title":"Neurosurg. Focus"},{"key":"10.1016\/j.bbcan.2025.189518_bb1320","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jconrel.2022.03.035","article-title":"Translation of focused ultrasound for blood-brain barrier opening in glioma","volume":"345","author":"Brighi","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bbcan.2025.189518_bb1325","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.7150\/thno.5576","article-title":"Optimization of the ultrasound-induced blood-brain barrier opening","volume":"2","author":"Konofagou","year":"2012","journal-title":"Theranostics"},{"key":"10.1016\/j.bbcan.2025.189518_bb1330","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/jcbfm.2014.71","article-title":"The size of blood-brain barrier opening induced by focused ultrasound is dictated by the acoustic pressure","volume":"34","author":"Chen","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbcan.2025.189518_bb1335","article-title":"Ultrasound-responsive nanoparticles for imaging and therapy of brain tumors","volume":"32","author":"Chen","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.bbcan.2025.189518_bb1340","doi-asserted-by":"crossref","first-page":"21534","DOI":"10.1038\/s41598-020-78657-9","article-title":"Microbubble formulation influences inflammatory response to focused ultrasound exposure in the brain","volume":"10","author":"McMahon","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2025.189518_bb1345","doi-asserted-by":"crossref","first-page":"6284","DOI":"10.7150\/thno.35892","article-title":"Acoustic feedback enables safe and reliable carboplatin delivery across the blood-brain barrier with a clinical focused ultrasound system and improves survival in a rat glioma model","volume":"9","author":"McDannold","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.bbcan.2025.189518_bb1350","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jconrel.2021.07.042","article-title":"Cavitation modulated inflammatory response following focused ultrasound blood-brain barrier opening","volume":"337","author":"Ji","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bbcan.2025.189518_bb1355","doi-asserted-by":"crossref","first-page":"17036","DOI":"10.1038\/s41598-024-67916-8","article-title":"Comprehensive assessment of blood\u2013brain barrier opening and sterile inflammatory response: unraveling the therapeutic window","volume":"14","author":"Martinez","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2025.189518_bb1360","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.7150\/thno.40908","article-title":"Investigating the effects of dexamethasone on blood-brain barrier permeability and inflammatory response following focused ultrasound and microbubble exposure","volume":"10","author":"McMahon","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.bbcan.2025.189518_bb1365","doi-asserted-by":"crossref","first-page":"45657","DOI":"10.1038\/srep45657","article-title":"Acute effects of focused ultrasound-induced increases in blood-brain barrier permeability on rat microvascular transcriptome","volume":"7","author":"McMahon","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2025.189518_bb1370","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.7150\/thno.21630","article-title":"Acute inflammatory response following increased blood-brain barrier permeability induced by focused ultrasound is dependent on microbubble dose","volume":"7","author":"McMahon","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.bbcan.2025.189518_bb1375","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s11095-022-03185-2","article-title":"Focused ultrasound-mediated drug delivery in humans \u2013 a path towards translation in neurodegenerative diseases","volume":"39","author":"Wasielewska","year":"2022","journal-title":"Pharm. Res."},{"key":"10.1016\/j.bbcan.2025.189518_bb1455","doi-asserted-by":"crossref","first-page":"2404821","DOI":"10.1002\/adhm.202404821","article-title":"A Neuroimmune-oncology microphysiological analysis platform (NEO-MAP) for evaluating astrocytic scar formation and microgliosis in glioblastoma microenvironment","volume":"14","author":"Diep","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bbcan.2025.189518_bb1460","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114777","article-title":"From cells to organoids: the evolution of blood-brain barrier technology for modelling drug delivery in brain cancer","volume":"196","author":"Gonzales-Aloy","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bbcan.2025.189518_bb1465","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120022","article-title":"Assessment of cytotoxic effects of new derivatives of pyrazino[1,2-a] benzimidazole on isolated human glioblastoma cells and mitochondria","volume":"286","author":"Rahimifard","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.bbcan.2025.189518_bb1470","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120505","article-title":"Investigation of anti-cancer effects of new pyrazino[1,2-a]benzimidazole derivatives on human glioblastoma cells through 2D in vitro model and 3D-printed microfluidic device","volume":"302","author":"Rahimifard","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.bbcan.2025.189518_bb1475","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/nm.4181","article-title":"Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small cell lung cancer in preclinical models","volume":"22","author":"Svensson","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2025.189518_bb1480","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fncel.2017.00104","article-title":"Correlative STED And Atomic Force Microscopy on Live Astrocytes Reveals Plasticity of Cytoskeletal Structure and Membrane Physical Properties during Polarized Migration","volume":"vol. 11","author":"Curry","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbcan.2025.189518_bb1485","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.142289","article-title":"In vitro activation of anti-cancer gene expression by delivery of CRISPR\/dCas9 ribonucleoproteins to suppress glioblastoma","volume":"308","author":"Lee","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bbcan.2025.189518_bb1490","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1038\/nn.4593","article-title":"Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems","volume":"20","author":"Chan","year":"2017","journal-title":"Nat. Neurosci."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X25002604?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X25002604?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T18:25:24Z","timestamp":1773944724000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304419X25002604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":297,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0304419X25002604"],"URL":"https:\/\/doi.org\/10.1016\/j.bbcan.2025.189518","relation":{},"ISSN":["0304-419X"],"issn-type":[{"value":"0304-419X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Astrocytes in glioblastoma tumor microenvironment","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbcan.2025.189518","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"189518"}}