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Biol. Cell"},{"issue":"3","key":"10.1016\/j.bbcan.2025.189522_bb0510","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.diff.2013.03.003","article-title":"Extracellular matrix proteins regulate epithelial\u2013mesenchymal transition in mammary epithelial cells","volume":"86","author":"Chen","year":"2013","journal-title":"Differentiation"},{"issue":"1","key":"10.1016\/j.bbcan.2025.189522_bb0515","doi-asserted-by":"crossref","first-page":"17313","DOI":"10.1038\/s41598-017-15170-6","article-title":"Negative regulation of TGF-\u03b21-induced MKK6-p38 and MEK-ERK signalling and epithelial-mesenchymal transition by Rac1b","volume":"7","author":"Witte","year":"2017","journal-title":"Sci. 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Rep."},{"issue":"4","key":"10.1016\/j.bbcan.2025.189522_bb0550","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s10456-011-9229-x","article-title":"Examining the role of Rac1 in tumor angiogenesis and growth: a clinically relevant RNAi-mediated approach","volume":"14","author":"Vader","year":"2011","journal-title":"Angiogenesis"},{"issue":"38","key":"10.1016\/j.bbcan.2025.189522_bb0555","doi-asserted-by":"crossref","first-page":"25602","DOI":"10.1074\/jbc.M109.009894","article-title":"The regulation of vascular endothelial growth factor-induced microvascular permeability requires Rac and reactive oxygen species","volume":"284","author":"Monaghan-Benson","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.bbcan.2025.189522_bb0560","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1161\/01.CIR.0000055324.34758.32","article-title":"Small GTP-binding protein Rac is an essential mediator of vascular endothelial growth factor-induced endothelial fenestrations and vascular permeability","volume":"107","author":"Eriksson","year":"2003","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.bbcan.2025.189522_bb0565","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1161\/01.RES.0000136522.58649.60","article-title":"IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation","volume":"95","author":"Yamaoka-Tojo","year":"2004","journal-title":"Circ. 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