{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T08:49:01Z","timestamp":1782031741721,"version":"3.54.5"},"reference-count":103,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573365"],"award-info":[{"award-number":["82573365"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["RCYX20231211090114010"],"award-info":[{"award-number":["RCYX20231211090114010"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20240813114900001"],"award-info":[{"award-number":["JCYJ20240813114900001"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009330","name":"Medical Science and Technology Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["A2024611"],"award-info":[{"award-number":["A2024611"]}],"id":[{"id":"10.13039\/501100009330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SZSM202301035"],"award-info":[{"award-number":["SZSM202301035"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SRFS2223-7S05"],"award-info":[{"award-number":["SRFS2223-7S05"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["17105919"],"award-info":[{"award-number":["17105919"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003452","name":"Innovation and Technology Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.bbcan.2026.189554","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T16:36:41Z","timestamp":1770655001000},"page":"189554","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emerging perspectives on metabolic reprogramming in the microenvironment of ovarian cancer metastasis"],"prefix":"10.1016","volume":"1881","author":[{"given":"Jing","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally K.Y.","family":"To","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice S.T.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.bbcan.2026.189554_bb0005","doi-asserted-by":"crossref","first-page":"7018","DOI":"10.1002\/cam4.2560","article-title":"Ovarian cancer: current status and strategies for improving therapeutic outcomes","volume":"8","author":"Chandra","year":"2019","journal-title":"Cancer Med."},{"issue":"6","key":"10.1016\/j.bbcan.2026.189554_bb0010","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1085\/jgp.8.6.519","article-title":"The metabolism of tumors in the body","volume":"8","author":"Warburg","year":"1927","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.bbcan.2026.189554_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drup.2018.03.001","article-title":"How the Warburg effect supports aggressiveness and drug resistance of cancer cells?","volume":"38","author":"Icard","year":"2018","journal-title":"Drug Resist. Updat."},{"issue":"11","key":"10.1016\/j.bbcan.2026.189554_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e11487","article-title":"Recent advances in understanding the metabolic plasticity of ovarian cancer: a systematic review","volume":"8","author":"Kobayashi","year":"2022","journal-title":"Heliyon"},{"issue":"3","key":"10.1016\/j.bbcan.2026.189554_bb0025","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41568-020-00320-2","article-title":"The metabolism of cancer cells during metastasis","volume":"21","author":"Bergers","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2026.189554_bb0030","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1284853","article-title":"Research progress on the mechanism of glycolysis in ovarian cancer","volume":"14","author":"Li","year":"2023","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.bbcan.2026.189554_bb0035","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ygyno.2018.06.013","article-title":"The lncRNA SNHG3 regulates energy metabolism of ovarian cancer by an analysis of mitochondrial proteomes","volume":"150","author":"Li","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.bbcan.2026.189554_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115956","article-title":"Cryptotanshinone suppresses ovarian cancer via simultaneous inhibition of glycolysis and oxidative phosphorylation","volume":"170","author":"Wang","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.bbcan.2026.189554_bb0045","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s42255-020-00329-9","article-title":"The ins and outs of serine and glycine metabolism in cancer","volume":"3","author":"Geeraerts","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.bbcan.2026.189554_bb0050","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1370012","article-title":"Activating transcription factor 4: a regulator of stress response in human cancers","volume":"12","author":"Wu","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0055","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41392-020-00235-2","article-title":"Regulation of cancer cell metabolism: oncogenic MYC in the driver\u2019s seat","volume":"5","author":"Dong","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"issue":"10","key":"10.1016\/j.bbcan.2026.189554_bb0060","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41568-021-00378-6","article-title":"Cancer metabolism: looking forward","volume":"21","author":"Mart\u00ednez-Reyes","year":"2021","journal-title":"Nat. Rev. Cancer"},{"issue":"28","key":"10.1016\/j.bbcan.2026.189554_bb0065","doi-asserted-by":"crossref","first-page":"10004","DOI":"10.12998\/wjcc.v10.i28.10004","article-title":"Review of the pharmacological effects of astragaloside IV and its autophagic mechanism in association with inflammation","volume":"10","author":"Yang","year":"2022","journal-title":"World J. Clin. Cases"},{"key":"10.1016\/j.bbcan.2026.189554_bb0070","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.semcancer.2019.05.012","article-title":"Role of the PI3K\/Akt\/mTOR signaling pathway in ovarian cancer: biological and therapeutic significance","volume":"59","author":"Ediriweera","year":"2019","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bbcan.2026.189554_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155360","article-title":"Nobiletin targets SREBP1\/ACLY to induce autophagy-dependent cell death of gastric cancer cells through PI3K\/Akt\/mTOR signaling pathway","volume":"128","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"issue":"18","key":"10.1016\/j.bbcan.2026.189554_bb0080","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1158\/0008-5472.CAN-22-0042","article-title":"GOT2 silencing promotes reprogramming of glutamine metabolism and sensitizes hepatocellular carcinoma to glutaminase inhibitors","volume":"82","author":"Li","year":"2022","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0085","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41571-021-00549-2","article-title":"The MYC oncogene - the grand orchestrator of cancer growth and immune evasion","volume":"19","author":"Dhanasekaran","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2026.189554_bb0090","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3389\/fendo.2018.00129","article-title":"The role for Myc in coordinating glycolysis, oxidative phosphorylation, glutaminolysis, and fatty acid metabolism in normal and neoplastic tissues","volume":"9","author":"Goetzman","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"9","key":"10.1016\/j.bbcan.2026.189554_bb0095","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/s12276-020-00504-8","article-title":"Glutamine reliance in cell metabolism","volume":"52","author":"Yoo","year":"2020","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0100","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12964-023-01449-x","article-title":"Glutamine addiction in tumor cell: oncogene regulation and clinical treatment","volume":"22","author":"Li","year":"2024","journal-title":"Cell Commun. Signal."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2021.188556","article-title":"Tumor suppressor p53: biology, signaling pathways, and therapeutic targeting","volume":"1876","author":"Hern\u00e1ndez Borrero","year":"2021","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"issue":"10","key":"10.1016\/j.bbcan.2026.189554_bb0110","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1042\/BCJ20190888","article-title":"Glut1 expression is increased by p53 reduction to switch metabolism to glycolysis during osteoblast differentiation","volume":"477","author":"Ohnishi","year":"2020","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.bbcan.2026.189554_bb0115","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41419-023-05625-2","article-title":"p53 promotes peroxisomal fatty acid \u03b2-oxidation to repress purine biosynthesis and mediate tumor suppression","volume":"14","author":"Zhao","year":"2023","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.bbcan.2026.189554_bb0120","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.jhep.2012.11.042","article-title":"Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease","volume":"58","author":"Derdak","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbcan.2026.189554_bb0125","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.772349","article-title":"Characterizing endocrine status, tumor hypoxia and immunogenicity for therapy success in epithelial ovarian cancer","volume":"12","author":"Pereira","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"2","key":"10.1016\/j.bbcan.2026.189554_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2020.188361","article-title":"Targeting tumor microenvironment in ovarian cancer: premise and promise","volume":"1873","author":"Jiang","year":"2020","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"issue":"3","key":"10.1016\/j.bbcan.2026.189554_bb0135","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1002\/humu.23965","article-title":"Comprehensive profiling of BRCA1 and BRCA2 variants in breast and ovarian cancer in Chinese patients","volume":"41","author":"Gao","year":"2020","journal-title":"Hum. Mutat."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0140","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12929-022-00888-x","article-title":"Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-\u03baB and TGF-\u03b22 signaling","volume":"29","author":"Lin","year":"2022","journal-title":"J. Biomed. Sci."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2020.188395","article-title":"Extracellular vesicle-based liquid biopsy holds great promise for the management of ovarian cancer","volume":"1874","author":"Zheng","year":"2020","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"issue":"24","key":"10.1016\/j.bbcan.2026.189554_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21249492","article-title":"Hypoxia-mediated decrease of ovarian cancer cells reaction to treatment: significance for chemo- and immunotherapies","volume":"21","author":"Klemba","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0155","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.1038\/s41467-019-13116-2","article-title":"Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma","volume":"10","author":"Zhang","year":"2019","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.bbcan.2026.189554_bb0160","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1001\/jamaoncol.2021.6987","article-title":"Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019: a systematic analysis for the global burden of disease study 2019","volume":"8","author":"Kocarnik","year":"2022","journal-title":"JAMA Oncol."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0165","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13046-022-02252-1","article-title":"TRPM7 silencing modulates glucose metabolic reprogramming to inhibit the growth of ovarian cancer by enhancing AMPK activation to promote HIF-1\u03b1 degradation","volume":"41","author":"Chen","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0170","doi-asserted-by":"crossref","DOI":"10.1186\/s12860-019-0227-y","article-title":"Proton pump inhibitors can reverse the YAP mediated paclitaxel resistance in epithelial ovarian cancer","volume":"20","author":"He","year":"2019","journal-title":"BMC Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/biom13010103","article-title":"In vitro models of ovarian cancer: bridging the gap between pathophysiology and mechanistic models","volume":"13","author":"Lopez","year":"2023","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2023.189052","article-title":"The high-grade serous ovarian cancer metastasis and chemoresistance in 3D models","volume":"1879","author":"Tadi\u0107","year":"2024","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.bbcan.2026.189554_bb0185","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.738177","article-title":"Aberrant cholesterol metabolism in ovarian cancer: identification of novel therapeutic targets","volume":"11","author":"He","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbcan.2026.189554_bb0190","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3389\/fonc.2020.00239","article-title":"Cross-talk between the tumor microenvironment, extracellular matrix, and cell metabolism in cancer","volume":"10","author":"Nazemi","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbcan.2026.189554_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.109949","article-title":"Sphingolipids as multifaceted mediators in ovarian cancer","volume":"81","author":"Pitman","year":"2021","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbcan.2026.189554_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1101503","article-title":"Partners in crime: the feedback loop between metabolic reprogramming and immune checkpoints in the tumor microenvironment","volume":"12","author":"Benito-Lopez","year":"2023","journal-title":"Front. Oncol."},{"issue":"21","key":"10.1016\/j.bbcan.2026.189554_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14215224","article-title":"Metabolic reprogramming in tumor-associated macrophages in the ovarian tumor microenvironment","volume":"14","author":"Kumar","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"18","key":"10.1016\/j.bbcan.2026.189554_bb0210","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.141115","article-title":"Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis","volume":"5","author":"Xia","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbcan.2026.189554_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108413","article-title":"Metabolic dependencies and targets in ovarian cancer","volume":"245","author":"Zhang","year":"2023","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0220","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s11658-021-00296-3","article-title":"Amelioration of human peritoneal mesothelial cell co-culture-evoked malignant potential of ovarian cancer cells by acacetin involves LPA release-activated RAGE-PI3K\/Akt signaling","volume":"26","author":"Tian","year":"2021","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0225","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s12033-024-01055-3","article-title":"Lipopolysaccharide-educated cancer-associated fibroblasts facilitate malignant progression of ovarian cancer cells via the NF-kB\/IL-6\/JAK2 signal transduction","volume":"67","author":"Wang","year":"2025","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.bbcan.2026.189554_bb0230","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-3-030-59038-3_12","article-title":"The many microenvironments of ovarian cancer","volume":"1296","author":"Micek","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0235","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.cmet.2018.08.007","article-title":"Fibroblasts mobilize tumor cell glycogen to promote proliferation and metastasis","volume":"29","author":"Curtis","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbcan.2026.189554_bb0240","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.956224","article-title":"Pan-cancer analyses and molecular subtypes based on the cancer-associated fibroblast landscape and tumor microenvironment infiltration characterization reveal clinical outcome and immunotherapy response in epithelial ovarian cancer","volume":"13","author":"Zou","year":"2022","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.bbcan.2026.189554_bb0245","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1158\/0008-5472.CAN-16-1615","article-title":"Long noncoding RNA LINC00092 acts in cancer-associated fibroblasts to drive glycolysis and progression of ovarian cancer","volume":"77","author":"Zhao","year":"2017","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.bbcan.2026.189554_bb0250","article-title":"Targeting PDGF signaling of cancer-associated fibroblasts blocks feedback activation of HIF-1\u03b1 and tumor progression of clear cell ovarian cancer","volume":"5","author":"Mori","year":"2024","journal-title":"Cell Rep. Med."},{"issue":"9","key":"10.1016\/j.bbcan.2026.189554_bb0255","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1158\/0008-5472.CAN-22-1821","article-title":"Spatial transcriptomics depict ligand-receptor cross-talk heterogeneity at the tumor-stroma interface in long-term ovarian cancer survivors","volume":"83","author":"Ferri-Borgogno","year":"2023","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0260","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1038\/s41467-024-45595-3","article-title":"Residual ANTXR1+ myofibroblasts after chemotherapy inhibit anti-tumor immunity via YAP1 signaling pathway","volume":"15","author":"Licaj","year":"2024","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.bbcan.2026.189554_bb0265","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/nm.2492","article-title":"Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth","volume":"17","author":"Nieman","year":"2011","journal-title":"Nat. Med."},{"issue":"8","key":"10.1016\/j.bbcan.2026.189554_bb0270","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1158\/0008-5472.CAN-19-1999","article-title":"Adipocyte-induced FABP4 expression in ovarian cancer cells promotes metastasis and mediates carboplatin resistance","volume":"80","author":"Mukherjee","year":"2020","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.bbcan.2026.189554_bb0275","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.3390\/cells12121605","article-title":"The role of CD36 in cancer progression and its value as a therapeutic target","volume":"12","author":"Feng","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.bbcan.2026.189554_bb0280","article-title":"Intestinal lymphangitis carcinomatosa related to ovarian cancer: case report and review of the literature","volume":"33","author":"Cruz","year":"2020","journal-title":"Gynecol. Oncol. Rep."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0285","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/10520295.2019.1627419","article-title":"Tumor apelin immunoreactivity is correlated with body mass index in ovarian high grade serous carcinoma","volume":"95","author":"Unal","year":"2020","journal-title":"Biotech. Histochem."},{"issue":"9","key":"10.1016\/j.bbcan.2026.189554_bb0290","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1158\/1541-7786.MCR-20-0991","article-title":"Adipokine apelin\/APJ pathway promotes peritoneal dissemination of ovarian cancer cells by regulating lipid metabolism","volume":"19","author":"Dogra","year":"2021","journal-title":"Mol. Cancer Res."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0295","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00262-019-02445-2","article-title":"IL-17A promotes fatty acid uptake through the IL-17A\/IL-17RA\/p-STAT3\/FABP4 axis to fuel ovarian cancer growth in an adipocyte-rich microenvironment","volume":"69","author":"Yu","year":"2020","journal-title":"Cancer Immunol. Immunother."},{"issue":"6","key":"10.1016\/j.bbcan.2026.189554_bb0300","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41576-022-00562-w","article-title":"Autophagy genes in biology and disease","volume":"24","author":"Yamamoto","year":"2023","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0305","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1186\/s12964-024-01987-y","article-title":"Exosomal ANXA2 facilitates ovarian cancer peritoneal metastasis by activating peritoneal mesothelial cells through binding with TLR2","volume":"22","author":"Zhang","year":"2024","journal-title":"Cell Commun. Signal"},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.115096","article-title":"P-cadherin mechanoactivates tumor-mesothelium metabolic coupling to promote ovarian cancer metastasis","volume":"44","author":"Ma","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbcan.2026.189554_bb0315","article-title":"Adipocytes are dispensable in shaping the ovarian cancer tumor microenvironment in the omentum","author":"Mintz","year":"2025","journal-title":"bioRxiv"},{"issue":"2","key":"10.1016\/j.bbcan.2026.189554_bb0320","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41389-020-0209-0","article-title":"PDK1 promotes ovarian cancer metastasis by modulating tumor-mesothelial adhesion, invasion, and angiogenesis via \u03b15\u03b21 integrin and JNK\/IL-8 signaling","volume":"9","author":"Siu","year":"2020","journal-title":"Oncogenesis"},{"issue":"4","key":"10.1016\/j.bbcan.2026.189554_bb0325","article-title":"PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1\u03b1","volume":"11","author":"Wei","year":"2023","journal-title":"Genes Dis."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0330","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cmet.2019.06.001","article-title":"Macrophages and metabolism in the tumor microenvironment","volume":"30","author":"Vitale","year":"2019","journal-title":"Cell Metab."},{"issue":"12","key":"10.1016\/j.bbcan.2026.189554_bb0335","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1038\/s41590-023-01675-y","article-title":"The immunometabolic ecosystem in cancer","volume":"24","author":"Bantug","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbcan.2026.189554_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101198","article-title":"Metabolic programming of macrophage functions and pathogens control","volume":"24","author":"Koo","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbcan.2026.189554_bb0345","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.3389\/fimmu.2019.02993","article-title":"New insights on the role of lipid metabolism in the metabolic reprogramming of macrophages","volume":"10","author":"Batista-Gonzalez","year":"2020","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.bbcan.2026.189554_bb0350","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.cmet.2019.02.016","article-title":"Membrane cholesterol efflux drives tumor-associated macrophage reprogramming and tumor progression","volume":"29","author":"Goossens","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbcan.2026.189554_bb0355","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jare.2024.02.009","article-title":"Targeting lipid metabolism of macrophages: a new strategy for tumor therapy","volume":"68","author":"Shao","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.bbcan.2026.189554_bb0360","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.3389\/fphar.2020.01233","article-title":"The role of eicosanoids in gynecological malignancies","volume":"11","author":"Smith","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.bbcan.2026.189554_bb0365","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1002\/jcp.26056","article-title":"Adenosine: an endogenous mediator in the pathogenesis of gynecological cancer","volume":"233","author":"Bahreyni","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0370","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2019-000186","article-title":"On the mechanism of anti-CD39 immune checkpoint therapy","volume":"8","author":"Allard","year":"2020","journal-title":"J. Immunother. Cancer"},{"issue":"3","key":"10.1016\/j.bbcan.2026.189554_bb0375","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001965","article-title":"High-dimensional analysis of the adenosine pathway in high-grade serous ovarian cancer","volume":"9","author":"Bareche","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"4","key":"10.1016\/j.bbcan.2026.189554_bb0380","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1172\/JCI133264","article-title":"Gut epithelial TSC1\/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer","volume":"130","author":"Xie","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.bbcan.2026.189554_bb0385","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/s41571-024-00870-6","article-title":"Regulatory T cell-mediated immunosuppression orchestrated by cancer: towards an immuno-genomic paradigm for precision medicine","volume":"21","author":"Kumagai","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"6","key":"10.1016\/j.bbcan.2026.189554_bb0390","doi-asserted-by":"crossref","DOI":"10.1093\/molehr\/gaab032","article-title":"Lysophosphatidic acid improves oocyte quality during IVM by activating the ERK1\/2 pathway in cumulus cells and oocytes","volume":"27","author":"Ma","year":"2021","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.bbcan.2026.189554_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101272","article-title":"Ovarian cancer modulates the immunosuppressive function of CD11b+Gr1+ myeloid cells via glutamine metabolism","volume":"53","author":"Udumula","year":"2021","journal-title":"Mol. Metab."},{"key":"10.1016\/j.bbcan.2026.189554_bb0400","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.769196","article-title":"The role of succinic acid metabolism in ovarian cancer","volume":"11","author":"Xia","year":"2021","journal-title":"Front. Oncol."},{"issue":"Pt B","key":"10.1016\/j.bbcan.2026.189554_bb0405","article-title":"Crosstalk between macrophages and natural killer cells in the tumor microenvironment","volume":"101","author":"Zhou","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.bbcan.2026.189554_bb0410","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41423-021-00753-1","article-title":"Metabolic programming in dendritic cells tailors immune responses and homeostasis","volume":"19","author":"M\u00f8ller","year":"2022","journal-title":"Cell. Mol. Immunol."},{"issue":"3","key":"10.1016\/j.bbcan.2026.189554_bb0415","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41591-019-0377-7","article-title":"The microbiome, cancer, and cancer therapy","volume":"25","author":"Helmink","year":"2019","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0420","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s10020-021-00295-2","article-title":"The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling","volume":"27","author":"Sipos","year":"2021","journal-title":"Mol. Med."},{"issue":"6","key":"10.1016\/j.bbcan.2026.189554_bb0425","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1002\/jcsm.12804","article-title":"Gut microbiota and short-chain fatty acid alterations in cachectic cancer patients","volume":"12","author":"Ubachs","year":"2021","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"issue":"8","key":"10.1016\/j.bbcan.2026.189554_bb0430","doi-asserted-by":"crossref","first-page":"e374","DOI":"10.1016\/S1470-2045(22)00139-5","article-title":"Clinical research in ovarian cancer: consensus recommendations from the Gynecologic Cancer InterGroup","volume":"23","author":"Vergote","year":"2022","journal-title":"Lancet Oncol."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0435","article-title":"Current understanding of the intratumoral microbiome in various tumors","volume":"4","author":"Xue","year":"2023","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.bbcan.2026.189554_bb0440","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ygyno.2024.06.017","article-title":"NSGO-OV-UMB1\/ENGOT-OV30: a phase II study of durvalumab in combination with the anti-CD73 monoclonal antibody Oleclumab in patients with relapsed ovarian cancer","volume":"188","author":"Mirza","year":"2024","journal-title":"Gynecol. Oncol."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0445","doi-asserted-by":"crossref","DOI":"10.1080\/19336950.2023.2273008","article-title":"A systemic analysis of monocarboxylate transporters in ovarian cancer and possible therapeutic interventions","volume":"17","author":"Chatterjee","year":"2023","journal-title":"Channels (Austin)"},{"issue":"19","key":"10.1016\/j.bbcan.2026.189554_bb0450","doi-asserted-by":"crossref","first-page":"12002","DOI":"10.3390\/ijms231912002","article-title":"IDO1 modulates the sensitivity of epithelial ovarian cancer cells to cisplatin through ROS\/p53-dependent apoptosis","volume":"23","author":"Wang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.bbcan.2026.189554_bb0455","doi-asserted-by":"crossref","first-page":"4086","DOI":"10.1016\/j.celrep.2019.11.079","article-title":"Mesothelial cell HIF1\u03b1 expression is metabolically downregulated by metformin to prevent oncogenic tumor-stromal crosstalk","volume":"29","author":"Hart","year":"2019","journal-title":"Cell Rep."},{"issue":"8","key":"10.1016\/j.bbcan.2026.189554_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114551","article-title":"Carcinoma-associated mesenchymal stem cells promote ovarian cancer heterogeneity and metastasis through mitochondrial transfer","volume":"43","author":"Frisbie","year":"2024","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0465","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s10637-019-00756-w","article-title":"Cytotoxicity of (HuArgI (co)-PEG5000)-induced arginine deprivation to ovarian cancer cells is autophagy dependent","volume":"38","author":"Nasreddine","year":"2020","journal-title":"Invest. New Drugs"},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0470","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-022-03447-y","article-title":"Platinum-induced mitochondrial OXPHOS contributes to cancer stem cell enrichment in ovarian cancer","volume":"20","author":"Sriramkumar","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbcan.2026.189554_bb0475","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1265525","article-title":"Metabolic and senescence characteristics associated with the immune microenvironment in ovarian cancer","volume":"14","author":"Xiong","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bbcan.2026.189554_bb0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2019.110752","article-title":"Regulation of senescence and the SASP by the transcription factor C\/EBP\u03b2","volume":"128","author":"Salotti","year":"2019","journal-title":"Exp. Gerontol."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0485","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-024-01967-3","article-title":"Drug resistance in ovarian cancer: from mechanism to clinical trial","volume":"23","author":"Wang","year":"2024","journal-title":"Mol. Cancer"},{"issue":"35","key":"10.1016\/j.bbcan.2026.189554_bb0490","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abq1475","article-title":"Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice","volume":"8","author":"Landry","year":"2022","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189554_bb0495","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13048-021-00767-3","article-title":"Human recombinant arginase I (HuArgI (Co)-PEG5000)-induced arginine depletion inhibits ovarian cancer cell adhesion and migration through autophagy-mediated inhibition of RhoA","volume":"14","author":"El-Mais","year":"2021","journal-title":"J. Ovarian Res."},{"issue":"11","key":"10.1016\/j.bbcan.2026.189554_bb0500","doi-asserted-by":"crossref","DOI":"10.3390\/cells10113213","article-title":"Resveratrol contrasts LPA-induced ovarian cancer cell migration and platinum resistance by rescuing hedgehog-mediated autophagy","volume":"10","author":"Ferraresi","year":"2021","journal-title":"Cells"},{"issue":"22","key":"10.1016\/j.bbcan.2026.189554_bb0505","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1038\/s41388-019-0728-3","article-title":"Regulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARC","volume":"38","author":"John","year":"2019","journal-title":"Oncogene"},{"issue":"41","key":"10.1016\/j.bbcan.2026.189554_bb0510","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2203480119","article-title":"Ovarian cancer cell fate regulation by the dynamics between saturated and unsaturated fatty acids","volume":"119","author":"Zhao","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbcan.2026.189554_bb0515","article-title":"PFKFB3 regulates chemoresistance, metastasis and stemness via IAP proteins and the NF-\u03baB signaling pathway in ovarian cancer","volume":"12","author":"Jiang","year":"2022","journal-title":"Front. Oncol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X26000260?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X26000260?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T08:38:01Z","timestamp":1782031081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304419X26000260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":103,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0304419X26000260"],"URL":"https:\/\/doi.org\/10.1016\/j.bbcan.2026.189554","relation":{},"ISSN":["0304-419X"],"issn-type":[{"value":"0304-419X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emerging perspectives on metabolic reprogramming in the microenvironment of ovarian cancer metastasis","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbcan.2026.189554","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"189554"}}