{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:16:41Z","timestamp":1793038601504,"version":"4.5.0"},"reference-count":260,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2023\/006956"],"award-info":[{"award-number":["CRG\/2023\/006956"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015989","name":"Motilal Nehru National Institute of Technology Allahabad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015989","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bbcan.2026.189594","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:25:46Z","timestamp":1776871546000},"page":"189594","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multifaceted role of RSPO2: Epigenetics, immunoregulatory, and therapeutic insights in colorectal cancer"],"prefix":"10.1016","volume":"1881","author":[{"given":"Ankit","family":"Srivastava","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Tyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Mubashra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akansha","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbcan.2026.189594_bb0005","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nrm4048","article-title":"Epigenetic regulation of ageing: linking environmental inputs to genomic stability","volume":"16","author":"Benayoun","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0010","doi-asserted-by":"crossref","first-page":"75","DOI":"10.31557\/apjcb.2023.8.1.75-89","article-title":"Epigenetics and cancer: a comprehensive review","volume":"8","author":"Pathak","year":"2023","journal-title":"Asian Pac. J. Cancer Biol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0015","doi-asserted-by":"crossref","first-page":"10383","DOI":"10.1007\/s11033-023-08879-3","article-title":"Involvement of CCCTC-binding factor in epigenetic regulation of cancer","volume":"50","author":"Bose","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.bbcan.2026.189594_bb0020","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.molcel.2016.05.013","article-title":"The aging epigenome","volume":"62","author":"Booth","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbcan.2026.189594_bb0025","series-title":"Advances in Genomic Profiling of Colorectal cancer Using Nature-Inspired Computing Techniques, Nature-Inspired Intelligent Computing Techniques in Bioinformatics","first-page":"63","author":"Rikhari","year":"2022"},{"key":"10.1016\/j.bbcan.2026.189594_bb0030","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S1470-2045(02)00932-4","article-title":"Epigenetics in cancer: implications for early detection and prevention","volume":"3","author":"Verma","year":"2002","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0035","first-page":"387","article-title":"Computational intelligence-based gene expression analysis in colorectal cancer: a review, computational intelligence in oncology: applications in diagnosis","author":"Srivastava","year":"2022","journal-title":"Prognos. Therap. Cancers"},{"key":"10.1016\/j.bbcan.2026.189594_bb0040","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4161\/cc.5.1.2305","article-title":"R-Spondin proteins: a novel link to \u03b2-catenin activation","volume":"5","author":"Kim","year":"2006","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbcan.2026.189594_bb0045","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1016\/j.biocel.2012.09.006","article-title":"The r-spondin family of proteins: emerging regulators of WNT signaling","volume":"44","author":"Jin","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0050","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bbaexp.2003.10.009","article-title":"R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants","volume":"1676","author":"Kamata","year":"2004","journal-title":"Biochim. Biophys. Acta-Gene Struct. Expres."},{"key":"10.1016\/j.bbcan.2026.189594_bb0055","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nature11019","article-title":"ZNRF3 promotes Wnt receptor turnover in an r-spondin-sensitive manner","volume":"485","author":"Hao","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2026.189594_bb0060","doi-asserted-by":"crossref","first-page":"10796","DOI":"10.1038\/s41598-023-37856-w","article-title":"LGR4 and LGR5 form distinct homodimers that only LGR4 complexes with RNF43\/ZNRF3 to provide high affinity binding of r-spondin ligands","volume":"13","author":"Toh","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2026.189594_bb0065","doi-asserted-by":"crossref","first-page":"E1221","DOI":"10.1073\/pnas.1323106111","article-title":"RSPO\u2013LGR4 functions via IQGAP1 to potentiate Wnt signaling","volume":"111","author":"Carmon","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbcan.2026.189594_bb0070","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.gendis.2023.01.013","article-title":"RSPO2 as Wnt signaling enabler: important roles in cancer development and therapeutic opportunities","volume":"11","author":"Srivastava","year":"2024","journal-title":"Genes Dis."},{"key":"10.1016\/j.bbcan.2026.189594_bb0075","article-title":"Palmdelphin facilitates R-spondin2 secretion to activate Wnt signaling and promote colorectal cancer stemness and tumorigenesis","author":"Yang","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.bbcan.2026.189594_bb0080","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nrc3130","article-title":"A decade of exploring the cancer epigenome \u2014 biological and translational implications","volume":"11","author":"Baylin","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2026.189594_bb0085","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/ijc.31380","article-title":"Colorectal cancer early methylation alterations affect the crosstalk between cell and surrounding environment, tracing a biomarker signature specific for this tumor","volume":"143","author":"Fadda","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbcan.2026.189594_bb0090","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1242\/dev.013359","article-title":"R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis","volume":"135","author":"Bell","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.bbcan.2026.189594_bb0095","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1440-169X.2007.00978.x","article-title":"R-spondin2 expression in the apical ectodermal ridge is essential for outgrowth and patterning in mouse limb development","volume":"50","author":"Aoki","year":"2008","journal-title":"Develop. Growth Differ."},{"key":"10.1016\/j.bbcan.2026.189594_bb0100","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.bbrc.2009.02.066","article-title":"Craniofacial malformation in r-spondin2 knockout mice","volume":"381","author":"Yamada","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbcan.2026.189594_bb0105","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1136\/gut.52.4.502","article-title":"Promoter methylation of e-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer","volume":"52","author":"Chan","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.bbcan.2026.189594_bb0110","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1158\/1078-0432.CCR-05-2096","article-title":"High levels of aberrant DNA methylation in Helicobacter pylori\u2013infected gastric mucosae and its possible association with gastric cancer risk","volume":"12","author":"Maekita","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb0115","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1158\/1055-9965.EPI-15-0388","article-title":"Prevention, DNA methylation predicts progression of human gastric lesions","volume":"24","author":"Schneider","year":"2015","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.bbcan.2026.189594_bb0120","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1158\/1541-7786.MCR-16-0472","article-title":"Novel insights into gastric cancer: methylation of r-spondins and regulation of LGR5 by SP1","volume":"15","author":"Wilhelm","year":"2017","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb0125","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/S0002-9440(10)61128-5","article-title":"CpG island methylation in aberrant crypt foci of the colorectum","volume":"160","author":"Chan","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0130","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1093\/carcin\/bgi373","article-title":"Epigenetic alterations in RASSF1A in human aberrant crypt foci","volume":"27","author":"Greenspan","year":"2006","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbcan.2026.189594_bb0135","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/bjc.2014.545","article-title":"B-RAF mutation and accumulated gene methylation in aberrant crypt foci (ACF), sessile serrated adenoma\/polyp (SSA\/P) and cancer in SSA\/P","volume":"112","author":"Inoue","year":"2015","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbcan.2026.189594_bb0140","doi-asserted-by":"crossref","first-page":"100078","DOI":"10.1016\/j.gmg.2025.100078","article-title":"Hierarchical clustering defines hypermethylated RSPO2 as early-stage potential biomarker in colorectal cancer","volume":"12","author":"Srivastava","year":"2025","journal-title":"Glob. Med. Genet"},{"key":"10.1016\/j.bbcan.2026.189594_bb0145","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/bs.apcsb.2023.11.011","article-title":"Multiomics data identifies RSPO2 as a prognostic biomarker in human tumors associated with pan-cancer","volume":"139","author":"Srivastava","year":"2024","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0150","doi-asserted-by":"crossref","first-page":"5035","DOI":"10.1038\/onc.2017.130","article-title":"Genome-wide DNA methylation profiling reveals cancer-associated changes within early colonic neoplasia","volume":"36","author":"Hanley","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2026.189594_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109722","article-title":"DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity","volume":"36","author":"Du","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbcan.2026.189594_bb0160","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13072-019-0316-3","article-title":"The SMART app: an interactive web application for comprehensive DNA methylation analysis and visualization","volume":"12","author":"Li","year":"2019","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.bbcan.2026.189594_bb0165","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1056\/NEJMra072067","article-title":"Epigenetics in cancer","volume":"358","author":"Esteller","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2026.189594_bb0170","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.tig.2013.06.006","article-title":"Balancing chromatin remodeling and histone modifications in transcription","volume":"29","author":"Petty","year":"2013","journal-title":"Trends Genet."},{"key":"10.1016\/j.bbcan.2026.189594_bb0175","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/cr.2011.22","article-title":"Regulation of chromatin by histone modifications","volume":"21","author":"Bannister","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb0180","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019505","article-title":"Epigenetic determinants of cancer","volume":"8","author":"Baylin","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0185","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S1535-6108(04)00114-X","article-title":"Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis","volume":"5","author":"Zhu","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2026.189594_bb0190","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.gene.2016.01.029","article-title":"Epigenetic drift towards histone modifications regulates CAV1 gene expression in colon cancer","volume":"581","author":"Deb","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.bbcan.2026.189594_bb0195","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13072-025-00611-8","article-title":"H3K4me3 regulates the transcription of RSPO3 in dermal papilla cells to influence hair follicle morphogenesis and development","volume":"18","author":"Zhong","year":"2025","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.bbcan.2026.189594_bb0200","first-page":"1422","article-title":"Altered promoter nucleosome positioning is an early event in gene silencing","volume":"9","author":"Hesson","year":"2014"},{"key":"10.1016\/j.bbcan.2026.189594_bb0205","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1158\/0008-5472.CAN-09-2161","article-title":"FOXQ1 is overexpressed in colorectal cancer and enhances tumorigenicity and tumor growth","volume":"70","author":"Kaneda","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb0210","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1002\/hep.27198","article-title":"Genomic portrait of resectable hepatocellular carcinomas: implications of RB1 and FGF19 aberrations for patient stratification","volume":"60","author":"Ahn","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.bbcan.2026.189594_bb0215","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0092-8674(02)00654-2","article-title":"Cooperation between complexes that regulate chromatin structure and transcription","volume":"108","author":"Narlikar","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2026.189594_bb0220","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.3390\/cells9092125","article-title":"Transcriptional regulation of Wnt\/\u03b2-catenin pathway in colorectal cancer","volume":"9","author":"Bian","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bbcan.2026.189594_bb0225","doi-asserted-by":"crossref","first-page":"10249","DOI":"10.3390\/ijms241210249","article-title":"The roles of zinc finger proteins in colorectal cancer","volume":"24","author":"Iyer","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2026.189594_bb0230","doi-asserted-by":"crossref","first-page":"337","DOI":"10.17533\/udea.vitae.7443","article-title":"Pro-apoptotic effects of apple procyanidins in human colon cancer cells and their derived metastatic cells","volume":"17","author":"Maldonado","year":"2010","journal-title":"Vitae"},{"key":"10.1016\/j.bbcan.2026.189594_bb0235","article-title":"BCL-3 promotes a cancer stem cell phenotype by enhancing \u03b2-catenin signalling in colorectal tumour cells","volume":"12","author":"Legge","year":"2019","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bbcan.2026.189594_bb0240","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.ccell.2015.11.001","article-title":"HOXA5 counteracts stem cell traits by inhibiting Wnt signaling in colorectal cancer","volume":"28","author":"Ord\u00f3\u00f1ez-Mor\u00e1n","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2026.189594_bb0245","doi-asserted-by":"crossref","first-page":"W171","DOI":"10.1093\/nar\/gky458","article-title":"EXpression2Kinases (X2K) web: linking expression signatures to upstream cell signaling networks","volume":"46","author":"Clarke","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb0250","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/bioinformatics\/18.2.333","article-title":"PROMO: detection of known transcription regulatory elements using species-tailored searches","volume":"18","author":"Messeguer","year":"2002","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbcan.2026.189594_bb0255","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.molcel.2010.08.013","article-title":"Loss of miR-200 inhibition of suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells","volume":"39","author":"Iliopoulos","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbcan.2026.189594_bb0260","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1053\/j.gastro.2009.11.004","article-title":"Antimetastatic role of smad4 signaling in colorectal cancer","volume":"138","author":"Zhang","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2026.189594_bb0265","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1002\/cam4.2967","article-title":"HOXD9 promote epithelial-mesenchymal transition and metastasis in colorectal carcinoma","volume":"9","author":"Liu","year":"2020","journal-title":"Cancer Med."},{"key":"10.1016\/j.bbcan.2026.189594_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2021.104714","article-title":"SMAD7 and SMAD4 expression in colorectal cancer progression and therapy response","volume":"123","author":"Rosic","year":"2021","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0275","first-page":"673","article-title":"Cancer, deregulated expression of microRNA-200b\/c and SUZ12, a polycomb repressive complex 2 subunit, in chemoresistant colorectal cancer cells","volume":"8","author":"San","year":"2017","journal-title":"Genes"},{"key":"10.1016\/j.bbcan.2026.189594_bb0280","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12964-018-0316-0","article-title":"Epigenetic inactivation of HOXD10 is associated with human colon cancer via inhibiting the RHOC\/AKT\/MAPK signaling pathway","volume":"17","author":"Yuan","year":"2019","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.bbcan.2026.189594_bb0285","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.771528","article-title":"Restoring HOXD10 exhibits therapeutic potential for ameliorating malignant progression and 5-fluorouracil resistance in colorectal cancer","volume":"11","author":"Pan","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0290","article-title":"Promoting effect of PAX5-activated lncRNA UASR1 on growth of colorectal cancer by regulating the mTOR pathway","volume":"24","author":"Wang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.bbcan.2026.189594_bb0295","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1186\/s12885-022-10039-y","article-title":"Clinical significance of p53 protein expression and TP53 variation status in colorectal cancer","volume":"22","author":"Kim","year":"2022","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bbcan.2026.189594_bb0300","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1136\/gutjnl-2020-321825","article-title":"TP53, a gene for colorectal cancer predisposition in the absence of Li-Fraumeni-associated phenotypes","volume":"70","author":"Terradas","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.bbcan.2026.189594_bb0305","first-page":"528","article-title":"A novel role of miR-326 in colorectal carcinoma by regulating E2F1 expression","volume":"26","author":"Bao","year":"2021","journal-title":"JBUON"},{"key":"10.1016\/j.bbcan.2026.189594_bb0310","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s11658-022-00392-y","article-title":"E2F1 promotes cell cycle progression by stabilizing spindle fiber in colorectal cancer cells","volume":"27","author":"Fang","year":"2022","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.bbcan.2026.189594_bb0315","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/mc.21841","article-title":"JAK\/STAT\/SOCS-signaling pathway and colon and rectal cancer","volume":"52","author":"Slattery","year":"2013","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.bbcan.2026.189594_bb0320","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1111\/cas.14141","article-title":"C-Myb promotes growth and metastasis of colorectal cancer through c-fos-induced epithelial-mesenchymal transition","volume":"110","author":"Qu","year":"2019","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bbcan.2026.189594_bb0325","doi-asserted-by":"crossref","first-page":"5613","DOI":"10.1038\/s41388-021-01961-9","article-title":"B-Myb accelerates colorectal cancer progression through reciprocal feed-forward transactivation of E2F2","volume":"40","author":"Fan","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2026.189594_bb0330","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021726","article-title":"NF\u03baB1 and NF\u03baBIA polymorphisms are associated with increased risk for sporadic colorectal cancer in a southern Chinese population","volume":"6","author":"Song","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2026.189594_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmgh.2024.05.004","article-title":"NF-\u03baB inducing kinase attenuates colorectal cancer by regulating noncanonical NF-\u03baB mediated colonic epithelial cell regeneration","volume":"18","author":"Morrison","year":"2024","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0340","doi-asserted-by":"crossref","DOI":"10.1177\/10732748241272721","article-title":"A new genetic signature of lactate metabolism-associated genes predicting clinically distinctive features and tumor microenvironment in colorectal cancer","volume":"31","author":"Wang","year":"2024","journal-title":"Cancer Control"},{"key":"10.1016\/j.bbcan.2026.189594_bb0345","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s11010-019-03523-w","article-title":"GATA1 promotes colorectal cancer cell proliferation, migration and invasion via activating AKT signaling pathway","volume":"457","author":"Yu","year":"2019","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbcan.2026.189594_bb0350","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.15602","article-title":"Role of ELK1 in regulating colorectal cancer progression: MiR-31-5p\/CDIP1 axis in CRC pathogenesis","volume":"11","author":"Yan","year":"2023","journal-title":"PeerJ"},{"key":"10.1016\/j.bbcan.2026.189594_bb0355","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3892\/ijmm.2021.4971","article-title":"ELK1-mediated upregulation of lncRNA LBX2-AS1 facilitates cell proliferation and invasion via regulating miR-491-5p\/S100A11 axis in colorectal cancer","volume":"48","author":"Ma","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbcan.2026.189594_bb0360","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1479-5876-8-123","article-title":"LEF-1 and TCF4 expression correlate inversely with survival in colorectal cancer","volume":"8","author":"Kriegl","year":"2010","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbcan.2026.189594_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112091","article-title":"LEF1 silencing sensitizes colorectal cancer cells to oxaliplatin, 5-FU, and irinotecan","volume":"143","author":"Fakhr","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbcan.2026.189594_bb0370","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.7314\/APJCP.2012.13.3.1053","article-title":"Activating transcription factor 1 is a prognostic marker of colorectal cancer","volume":"13","author":"Huang","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.bbcan.2026.189594_bb0375","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ajhg.2019.05.004","article-title":"Systematic functional interrogation of genes in GWAS loci identified ATF1 as a key driver in colorectal cancer modulated by a promoter-enhancer interaction","volume":"105","author":"Tian","year":"2019","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbcan.2026.189594_bb0380","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/1471-2407-8-328","article-title":"Clinicopathological significance of expression of pc-Jun, TCF4 and beta-catenin in colorectal tumors","volume":"8","author":"Takeda","year":"2008","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bbcan.2026.189594_bb0385","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1002\/cbin.12069","article-title":"C-JUN-induced upregulation of LINC00174 contributes to colorectal cancer proliferation and invasion through accelerating USP21 expression","volume":"47","author":"Liang","year":"2023","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.bbcan.2026.189594_bb0390","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1159\/000104490","article-title":"Identification of consensus genes and key regulatory elements in 5-fluorouracil resistance in gastric and colon cancer","volume":"30","author":"Sz\u00f6ke","year":"2007","journal-title":"Oncol. Res. Treat."},{"key":"10.1016\/j.bbcan.2026.189594_bb0395","doi-asserted-by":"crossref","first-page":"12902","DOI":"10.1038\/s41598-023-39488-6","article-title":"YWHAZ and TBP are potential reference gene candidates for qPCR analysis of response to radiation therapy in colorectal cancer","volume":"13","author":"Kim","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2026.189594_bb0400","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1158\/1541-7786.MCR-07-0375","article-title":"TATA box-binding protein\u2013associated factor 12 is important for RAS-induced transformation properties of colorectal cancer cells","volume":"6","author":"Voulgari","year":"2008","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb0405","first-page":"4253","article-title":"Genome-wide ChIP-seq analysis of TCF4 binding regions in colorectal cancer cells","volume":"7","author":"Chen","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.bbcan.2026.189594_bb0410","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s11658-020-00217-w","article-title":"TCF 4 tumor suppressor: a molecular target in the prognosis of sporadic colorectal cancer in humans","volume":"25","author":"Anwar","year":"2020","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.bbcan.2026.189594_bb0415","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.4103\/IJPM.IJPM_96_20","article-title":"Loss of YY1 expression predicts unfavorable prognosis in stage III colorectal cancer","volume":"64","author":"Kim","year":"2021","journal-title":"Indian J. Pathol. Microbiol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0420","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41419-024-06740-4","article-title":"The role of USP7-YY1 interaction in promoting colorectal cancer growth and metastasis","volume":"15","author":"Shao","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbcan.2026.189594_bb0425","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/s41392-021-00761-7","article-title":"XBP1 regulates the protumoral function of tumor-associated macrophages in human colorectal cancer","volume":"6","author":"Zhao","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bbcan.2026.189594_bb0430","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1179\/1973947815Y.0000000006","article-title":"X-box binding protein 1 (XBP-1) enhances colorectal cancer cell invasion","volume":"27","author":"Mhaidat","year":"2015","journal-title":"J. Chemother."},{"key":"10.1016\/j.bbcan.2026.189594_bb0435","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2147\/CMAR.S186236","article-title":"IRF1 inhibits the proliferation and metastasis of colorectal cancer by suppressing the RAS-RAC1 pathway","author":"Hong","year":"2018","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb0440","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.136720","article-title":"Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer","volume":"5","author":"Karki","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbcan.2026.189594_bb0445","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.747057","article-title":"MiR-181a targets RSPO2 and regulates bone morphogenetic protein\u2013WNT signaling crosstalk during chondrogenic differentiation of mesenchymal stromal cells","volume":"9","author":"Melnik","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0450","first-page":"3081","article-title":"MicroRNA-196a promotes osteogenic differentiation and inhibit adipogenic differentiation of adipose stem cells via regulating \u03b2-catenin pathway","volume":"11","author":"Ai","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb0455","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.7150\/jca.62652","article-title":"MiR-497-5p-RSPO2 axis inhibits cell growth and metastasis in glioblastoma","volume":"13","author":"Chen","year":"2022","journal-title":"J. Cancer"},{"key":"10.1016\/j.bbcan.2026.189594_bb0460","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.mce.2015.06.003","article-title":"Roles of miR-196a on gene regulation of neuroendocrine tumor cells","volume":"412","author":"Li","year":"2015","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0465","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.biopha.2017.06.047","article-title":"MicroRNA-493 suppresses hepatocellular carcinoma tumorigenesis through down-regulation of anthrax toxin receptor 1 (ANTXR1) and R-Spondin 2 (RSPO2)","volume":"93","author":"Xu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbcan.2026.189594_bb0470","doi-asserted-by":"crossref","first-page":"13393","DOI":"10.2147\/CMAR.S274171","article-title":"MiR-196b-5p promotes proliferation, migration and invasion of lung adenocarcinoma cells via targeting RSPO2","author":"Xu","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb0475","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2014.06.005","article-title":"MicroRNAs in cancer: biomarkers, functions and therapy","volume":"20","author":"Hayes","year":"2014","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbcan.2026.189594_bb0480","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.biopha.2018.07.098","article-title":"MiR-92a promotes tumorigenesis of colorectal cancer, a transcriptomic and functional based study","volume":"106","author":"Chen","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbcan.2026.189594_bb0485","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/cas.13451","article-title":"Micro RNA 26b promotes colorectal cancer metastasis by downregulating phosphatase and tensin homolog and wingless-type MMTV integration site family member 5A","volume":"109","author":"Fan","year":"2018","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bbcan.2026.189594_bb0490","doi-asserted-by":"crossref","first-page":"42513","DOI":"10.18632\/oncotarget.9893","article-title":"Wnt\/\u03b2-catenin pathway transactivates microRNA-150 that promotes EMT of colorectal cancer cells by suppressing CREB signaling","volume":"7","author":"Guo","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbcan.2026.189594_bb0495","doi-asserted-by":"crossref","first-page":"45199","DOI":"10.18632\/oncotarget.9900","article-title":"MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating smad4","volume":"7","author":"Cheng","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbcan.2026.189594_bb0500","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s43141-023-00532-7","article-title":"In silico analysis reveals mir-98-5p as a potential inhibitor of tumor cell proliferation and metastasis in colorectal cancer by targeting the fzd3 receptor of the Wnt signaling pathway","volume":"21","author":"Kenneth","year":"2023","journal-title":"J. Genet. Eng. Biotechnol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0505","doi-asserted-by":"crossref","first-page":"D127","DOI":"10.1093\/nar\/gkz757","article-title":"MiRDB: an online database for prediction of functional microRNA targets","volume":"48","author":"Chen","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb0510","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.omtn.2017.11.011","article-title":"Long non-coding RNA LINC00339 stimulates glioma vasculogenic mimicry formation by regulating the miR-539-5p\/TWIST1\/MMPs axis","volume":"10","author":"Guo","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.bbcan.2026.189594_bb0515","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154365","article-title":"LncRNA TP73-AS1 enhances the malignant properties of colorectal cancer by increasing SPP-1 expression through miRNA-539\u20135p sponging","volume":"243","author":"Ding","year":"2023","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.bbcan.2026.189594_bb0520","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/bjc.2017.105","article-title":"Targeting of CCBE1 by miR-330-3p in human breast cancer promotes metastasis","volume":"116","author":"Mesci","year":"2017","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbcan.2026.189594_bb0525","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/bab.1691","article-title":"MiR-330-3p promotes lung cancer cells invasion, migration, and metastasis by directly targeting hSOD2b","volume":"66","author":"Shen","year":"2019","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.bbcan.2026.189594_bb0530","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.18632\/aging.102201","article-title":"MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer","volume":"11","author":"Wei","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.bbcan.2026.189594_bb0535","doi-asserted-by":"crossref","first-page":"53","DOI":"10.31083\/j.fbl2902053","article-title":"MiR-330-5p suppress cell growth and invasion via disrupting HSF4-mediated MACC1\/STAT3 pathway in colorectal cancer","volume":"29","author":"Liu","year":"2024","journal-title":"Front. Biosci."},{"key":"10.1016\/j.bbcan.2026.189594_bb0540","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.canlet.2014.10.041","article-title":"MicroRNA-362-5p promotes tumor growth and metastasis by targeting CYLD in hepatocellular carcinoma","volume":"356","author":"Ni","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbcan.2026.189594_bb0545","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1016\/j.febslet.2015.05.056","article-title":"MiR-362-5p inhibits proliferation and migration of neuroblastoma cells by targeting phosphatidylinositol 3-kinase-C2\u03b2","volume":"589","author":"Wu","year":"2015","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbcan.2026.189594_bb0550","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1007\/s10528-022-10316-2","article-title":"Circ-IGF1R affects the progression of colorectal cancer by activating the miR-362-5p\/HMGB3-mediated wnt\/\u03b2-catenin signal pathway","volume":"61","author":"Gao","year":"2023","journal-title":"Biochem. Genet."},{"key":"10.1016\/j.bbcan.2026.189594_bb0555","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160961","article-title":"MiR-6734 up-regulates p21 gene expression and induces cell cycle arrest and apoptosis in colon cancer cells","volume":"11","author":"Kang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2026.189594_bb0560","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.biopha.2017.04.029","article-title":"MiR-493-5p suppresses hepatocellular carcinoma cell proliferation through targeting GP73","volume":"90","author":"Zhao","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbcan.2026.189594_bb0565","first-page":"1740","article-title":"MicroRNA-493-5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2","volume":"41","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbcan.2026.189594_bb0570","doi-asserted-by":"crossref","first-page":"82303","DOI":"10.18632\/oncotarget.19398","article-title":"C-met, CREB1 and EGFR are involved in miR-493-5p inhibition of EMT via AKT\/GSK-3\u03b2\/snail signaling in prostate cancer","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbcan.2026.189594_bb0575","article-title":"MicroRNA-493-5p suppresses colorectal cancer progression via the PI3K-Akt-FoxO3a signaling pathway","volume":"24","author":"Cui","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.bbcan.2026.189594_bb0580","first-page":"765","article-title":"Radiopharmaceuticals, LINC01123 promotes the progression of colorectal cancer via miR-625-5p\/LASP1 axis","volume":"36","author":"Shang","year":"2021"},{"key":"10.1016\/j.bbcan.2026.189594_bb0585","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s12079-016-0351-9","article-title":"MicroRNA-1275 suppresses cell growth, and retards G1\/S transition in human nasopharyngeal carcinoma by down-regulation of HOXB5","volume":"10","author":"Sun","year":"2016","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.bbcan.2026.189594_bb0590","article-title":"MiR-1275 promotes non-small cell lung cancer cell proliferation and metastasis by regulating LZTS3 expression","volume":"22","author":"He","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.bbcan.2026.189594_bb0595","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.bbrc.2018.07.125","article-title":"LncRNA HAND2-AS1 sponging miR-1275 suppresses colorectal cancer progression by upregulating KLF14","volume":"503","author":"Zhou","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbcan.2026.189594_bb0600","first-page":"1166","article-title":"Down-regulation of miR-4500 promoted non-small cell lung cancer growth","volume":"34","author":"Zhang","year":"2014","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbcan.2026.189594_bb0605","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1080\/15384047.2016.1235661","article-title":"MiR-4500 is epigenetically downregulated in colorectal cancer and functions as a novel tumor suppressor by regulating HMGA2","volume":"17","author":"Yu","year":"2016","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.bbcan.2026.189594_bb0610","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.abb.2018.09.008","article-title":"MicroRNA-141-3p fosters the growth, invasion, and tumorigenesis of cervical cancer cells by targeting FOXA2","volume":"657","author":"Li","year":"2018","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbcan.2026.189594_bb0615","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11010-016-2816-9","article-title":"Involvement of microRNA-141-3p in 5-fluorouracil and oxaliplatin chemo-resistance in esophageal cancer cells via regulation of PTEN","volume":"422","author":"Jin","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbcan.2026.189594_bb0620","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.yexmp.2018.11.014","article-title":"MiR-141-3p suppresses gastric cancer induced transition of normal fibroblast and BMSC to cancer-associated fibroblasts via targeting STAT4","volume":"107","author":"Zhou","year":"2019","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0625","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.bbrc.2017.05.179","article-title":"MiR-141-3p functions as a tumor suppressor modulating activating transcription factor 5 in glioma","volume":"490","author":"Wang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbcan.2026.189594_bb0630","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1177\/1533034617705056","article-title":"A qRT-PCR and gene functional enrichment study focused on downregulation of miR-141-3p in hepatocellular carcinoma and its clinicopathological significance","volume":"16","author":"Liu","year":"2017","journal-title":"Tech. Cancer Res. Treat"},{"key":"10.1016\/j.bbcan.2026.189594_bb0635","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s13046-017-0645-7","article-title":"Downregulation of miR-141-3p promotes bone metastasis via activating NF-\u03baB signaling in prostate cancer","volume":"36","author":"Huang","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb0640","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3892\/ol.2015.3179","article-title":"Identification and characterization of tumor suppressor and oncogenic miRNAs in gastric cancer","volume":"10","author":"Chen","year":"2015","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.bbcan.2026.189594_bb0645","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12935-018-0602-3","article-title":"33 promotes the proliferation of human HCC by sponging miR-200a-3p and upregulating CDK6","volume":"18","author":"Gong","year":"2018","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.bbcan.2026.189594_bb0650","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.bbrc.2016.01.095","article-title":"MicroRNA-200a-3p suppresses tumor proliferation and induces apoptosis by targeting SPAG9 in renal cell carcinoma","volume":"470","author":"Wang","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbcan.2026.189594_bb0655","doi-asserted-by":"crossref","first-page":"11103","DOI":"10.3389\/bjbs.2023.11103","article-title":"CCAT 1-a pivotal oncogenic long non-coding RNA in colorectal cancer","volume":"80","author":"Liau","year":"2023","journal-title":"Br. J. Biomed. Sci."},{"key":"10.1016\/j.bbcan.2026.189594_bb0660","first-page":"323","article-title":"Function, long noncoding RNA LINC00261 regulates endometrial carcinoma progression by modulating miRNA\/FOXO1 expression","volume":"36","author":"Fang","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbcan.2026.189594_bb0665","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.celrep.2015.04.023","article-title":"Principles of long noncoding RNA evolution derived from direct comparison of transcriptomes in 17 species","volume":"11","author":"Hezroni","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbcan.2026.189594_bb0670","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.cell.2013.01.034","article-title":"Xist RNA is a potent suppressor of hematologic cancer in mice","volume":"152","author":"Yildirim","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2026.189594_bb0675","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s13046-017-0658-2","article-title":"Linc-ROR promotes esophageal squamous cell carcinoma progression through the derepression of SOX9","volume":"36","author":"Wang","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb0680","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.32604\/or.2024.044174","article-title":"LncRNA HOTAIR promotes DNA damage repair and radioresistance by targeting ATR in colorectal cancer","volume":"32","author":"Hu","year":"2024","journal-title":"Oncol. Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb0685","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12890-019-0816-8","article-title":"Clinical significance of long non-coding RNA HOTTIP in early-stage non-small-cell lung cancer","volume":"19","author":"Navarro","year":"2019","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.bbcan.2026.189594_bb0690","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/ncb3295","article-title":"The LINK-A lncRNA activates normoxic HIF1\u03b1 signalling in triple-negative breast cancer","volume":"18","author":"Lin","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0695","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/nbt.1914","article-title":"Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression","volume":"29","author":"Prensner","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0700","doi-asserted-by":"crossref","first-page":"8001","DOI":"10.2147\/OTT.S172379","article-title":"Therapy, long noncoding RNA h19 mediated the chemosensitivity of breast cancer cells via Wnt pathway and EMT process","author":"Gao","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbcan.2026.189594_bb0705","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1080\/15384101.2016.1149660","article-title":"MYC and PVT1 synergize to regulate RSPO1 levels in breast cancer","volume":"15","author":"Sarver","year":"2016","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbcan.2026.189594_bb0710","doi-asserted-by":"crossref","DOI":"10.1002\/jgm.3382","article-title":"Inhibition of the long non-coding RNA UNC5B-AS1\/miR-4455\/RSPO4 axis reduces cervical cancer growth in vitro and in vivo","volume":"23","author":"Fu","year":"2021","journal-title":"J. Gene Med."},{"key":"10.1016\/j.bbcan.2026.189594_bb0715","doi-asserted-by":"crossref","first-page":"7120","DOI":"10.3390\/ijms21197120","article-title":"Transcriptome and gene fusion analysis of synchronous lesions reveals lncMRPS31P5 as a novel transcript involved in colorectal cancer","volume":"21","author":"Panza","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2026.189594_bb0720","doi-asserted-by":"crossref","first-page":"14244","DOI":"10.1038\/s41598-018-32652-3","article-title":"Identification of RSPO2 fusion mutations and target therapy using a porcupine inhibitor","volume":"8","author":"Li","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2026.189594_bb0725","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nature02536","article-title":"Transcriptional disruption by the l1 retrotransposon and implications for mammalian transcriptomes","volume":"429","author":"Han","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2026.189594_bb0730","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1111\/cas.14901","article-title":"Identification of cancer driver genes using sleeping beauty transposon mutagenesis","volume":"112","author":"Takeda","year":"2021","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bbcan.2026.189594_bb0735","series-title":"Mapping Function and Cooperativity in the Cancer Genome: RSPO2 and WAC","author":"Conboy","year":"2014"},{"key":"10.1016\/j.bbcan.2026.189594_bb0740","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1126\/science.1163040","article-title":"A transposon-based genetic screen in mice identifies genes altered in colorectal cancer","volume":"323","author":"Starr","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.bbcan.2026.189594_bb0745","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/ng.3175","article-title":"Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression","volume":"47","author":"Takeda","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbcan.2026.189594_bb0750","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1038\/ncomms4149","article-title":"RSPO2\u2013LGR5 signaling has tumour-suppressive activity in colorectal cancer","volume":"5","author":"Wu","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2026.189594_bb0755","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2217\/epi-2019-0133","article-title":"Genome-wide methylation and expression profiling identify methylation-associated genes in colorectal cancer","volume":"12","author":"Sun","year":"2020","journal-title":"Epigenomics"},{"key":"10.1016\/j.bbcan.2026.189594_bb0760","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s13148-023-01546-1","article-title":"CRISPR\/dCAS9-mediated DNA demethylation screen identifies functional epigenetic determinants of colorectal cancer","volume":"15","author":"Tejedor","year":"2023","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.bbcan.2026.189594_bb0765","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1002\/1878-0261.12767","article-title":"Identification and validation of novel DNA methylation markers for early diagnosis of lung adenocarcinoma","volume":"14","author":"Li","year":"2020","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0770","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12863-022-01100-7","article-title":"Consequences of aberrated DNA methylation in colon adenocarcinoma: a bioinformatic-based multi-approach","volume":"23","author":"Moradi","year":"2022","journal-title":"BMC Genom. Data"},{"key":"10.1016\/j.bbcan.2026.189594_bb0775","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/CCO.0b013e328352ea02","article-title":"Rectal cancer: state of the art in 2012","volume":"24","author":"R\u00f6del","year":"2012","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0780","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174461","article-title":"Abnormal expression of mRNA, microRNA alteration and aberrant DNA methylation patterns in rectal adenocarcinoma","volume":"12","author":"Hua","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2026.189594_bb0785","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cell.2016.02.025","article-title":"Metastatic latency and immune evasion through autocrine inhibition of WNT","volume":"165","author":"Malladi","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2026.189594_bb0790","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nm.4496","article-title":"DKK2 imparts tumor immunity evasion through \u03b2-catenin-independent suppression of cytotoxic immune-cell activation","volume":"24","author":"Xiao","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2026.189594_bb0795","series-title":"Srivastava, Autophagy: A Critical Link between Immune Response and Cancer Progression, Role of Autophagy and Reactive Oxygen Species in Cancer Treatment: Principles and Current Strategies","first-page":"209","author":"Mubashra","year":"2024"},{"key":"10.1016\/j.bbcan.2026.189594_bb0800","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.3389\/fimmu.2019.02293","article-title":"WNT\/\u03b2-catenin signaling pathway regulating t cell-inflammation in the tumor microenvironment","volume":"10","author":"Li","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0805","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.3892\/mmr.2016.5642","article-title":"Rspo2 suppresses CD36-mediated apoptosis in oxidized low density lipoprotein-induced macrophages","volume":"14","author":"Yan","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bbcan.2026.189594_bb0810","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s12094-022-02968-8","article-title":"Cartilage oligomeric matrix protein acts as a molecular biomarker in multiple cancer types","volume":"25","author":"Guo","year":"2023","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0815","series-title":"Wnt Signaling in the Tumor Microenvironment, Tumor Microenvironment: Signaling Pathways\u2013Part B","first-page":"107","author":"Ruan","year":"2020"},{"key":"10.1016\/j.bbcan.2026.189594_bb0820","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1158\/2159-8290.CD-20-0833","article-title":"Tumor microenvironment\u2013derived r-spondins enhance antitumor immunity to suppress tumor growth and sensitize for immune checkpoint blockade therapy","volume":"11","author":"Tang","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bbcan.2026.189594_bb0825","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1189\/jlb.0209062","article-title":"Transmigration across activated endothelium induces transcriptional changes, inhibits apoptosis, and decreases antimicrobial protein expression in human monocytes","volume":"86","author":"Williams","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0830","doi-asserted-by":"crossref","first-page":"293","DOI":"10.15252\/emmm.201606773","article-title":"Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO 3 fusions","volume":"9","author":"Picco","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bbcan.2026.189594_bb0835","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1073\/pnas.1618650114","article-title":"Aberrantly expressed LGR4 empowers wnt signaling in multiple myeloma by hijacking osteoblast-derived r-spondins","volume":"114","author":"Van Andel","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbcan.2026.189594_bb0840","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s10020-018-0048-z","article-title":"RSPO3 impairs barrier function of human vascular endothelial monolayers and synergizes with pro-inflammatory IL-1","volume":"24","author":"Skaria","year":"2018","journal-title":"Mol. Med."},{"key":"10.1016\/j.bbcan.2026.189594_bb0845","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13104-020-4930-8","article-title":"R-spondin 2 mediates neutrophil egress into the alveolar space through increased lung permeability","volume":"13","author":"Jackson","year":"2020","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.bbcan.2026.189594_bb0850","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109559","article-title":"RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia","volume":"36","author":"Sun","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbcan.2026.189594_bb0855","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029455","article-title":"Recombinant r-spondin2 and wnt3a up-and down-regulate novel target genes in C57MG mouse mammary epithelial cells","volume":"7","author":"Baljinnyam","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2026.189594_bb0860","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1089\/dna.2019.5224","article-title":"Expression and prognostic values of the roof plate-specific spondin family in bladder cancer","volume":"39","author":"Gao","year":"2020","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0865","doi-asserted-by":"crossref","first-page":"E124","DOI":"10.1002\/tox.24209","article-title":"RETRACTED: RSPO2-associated mitochondrial metabolism defines molecular subtypes with distinct clinical and immune features in esophageal cancer","volume":"40","author":"Peng","year":"2025","journal-title":"J. Toxicol. Environ."},{"key":"10.1016\/j.bbcan.2026.189594_bb0870","article-title":"Whole genome sequencing of 2,023 colorectal cancers reveals mutational landscapes, new driver genes and immune interactions","author":"Cornish","year":"2022","journal-title":"BioRxiv"},{"key":"10.1016\/j.bbcan.2026.189594_bb0875","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1093\/bioinformatics\/btz210","article-title":"TISIDB: an integrated repository portal for tumor\u2013immune system interactions","volume":"35","author":"Ru","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbcan.2026.189594_bb0880","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1096\/fj.08-109009","article-title":"Crosstalk between AHR and Wnt signaling through R-Spondin1 impairs tissue regeneration in zebrafish","volume":"22","author":"Mathew","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.bbcan.2026.189594_bb0885","doi-asserted-by":"crossref","first-page":"14117","DOI":"10.1074\/jbc.M808337200","article-title":"Wnt11 promotes osteoblast maturation and mineralization through r-spondin 2","volume":"284","author":"Friedman","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2026.189594_bb0890","doi-asserted-by":"crossref","DOI":"10.3390\/cells9030783","article-title":"A wnt-BMP4 signaling axis induces MSX and NOTCH proteins and promotes growth suppression and differentiation in neuroblastoma","volume":"9","author":"Szemes","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bbcan.2026.189594_bb0895","first-page":"3875","article-title":"Regulation of WNT5A and WNT11 during MSC in vitro chondrogenesis: WNT inhibition lowers BMP and hedgehog activity, and reduces hypertrophy","volume":"76","author":"Diederichs","year":"2019"},{"key":"10.1016\/j.bbcan.2026.189594_bb0900","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.devcel.2004.07.019","article-title":"R-Spondin2 is a secreted activator of Wnt\/\u03b2-catenin signaling and is required for xenopus myogenesis","volume":"7","author":"Kazanskaya","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbcan.2026.189594_bb0905","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202400144","article-title":"An\u201c r-spondin code\u201d for multimodal signaling ON-OFF states","volume":"46","author":"Niehrs","year":"2024","journal-title":"BioEssays"},{"key":"10.1016\/j.bbcan.2026.189594_bb0910","doi-asserted-by":"crossref","first-page":"5570","DOI":"10.1038\/s41467-020-19373-w","article-title":"R-spondins are BMP receptor antagonists in xenopus early embryonic development","volume":"11","author":"Lee","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2026.189594_bb0915","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/cr.2008.302","article-title":"Signaling cross-talk between TGF-\u03b2\/BMP and other pathways","volume":"19","author":"Guo","year":"2009","journal-title":"Cell Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb0920","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022137","article-title":"Signaling cross talk between TGF-\u03b2\/Smad and other signaling pathways","volume":"9","author":"Luo","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bbcan.2026.189594_bb0925","doi-asserted-by":"crossref","first-page":"7118","DOI":"10.1038\/onc.2008.293","article-title":"Prostate tumor progression is mediated by a paracrine TGF-\u03b2\/Wnt3a signaling axis","volume":"27","author":"Li","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2026.189594_bb0930","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.3390\/cells12081139","article-title":"TGF\u03b2 and the tumor microenvironment in colorectal cancer","volume":"12","author":"Waldner","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.bbcan.2026.189594_bb0935","first-page":"755","article-title":"Distinguishing right from left colon by the pattern of gene expression, cancer epidemiology biomarkers prevention","volume":"12","author":"Glebov","year":"2003"},{"key":"10.1016\/j.bbcan.2026.189594_bb0940","doi-asserted-by":"crossref","first-page":"35598","DOI":"10.1074\/jbc.C600200200","article-title":"Suppressing Wnt signaling by the hedgehog pathway through sFRP-1","volume":"281","author":"He","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2026.189594_bb0945","doi-asserted-by":"crossref","first-page":"4577","DOI":"10.1038\/sj.onc.1207605","article-title":"Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling","volume":"23","author":"Taylor","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2026.189594_bb0950","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.canlet.2007.12.030","article-title":"Crosstalk of hedgehog and Wnt pathways in gastric cancer","volume":"263","author":"Yanai","year":"2008","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbcan.2026.189594_bb0955","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.3390\/ijerph15071442","article-title":"Cross-talk between Wnt and Hh signaling pathways in the pathology of basal cell carcinoma","volume":"15","author":"Noubissi","year":"2018","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.bbcan.2026.189594_bb0960","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.046573","article-title":"Disruption of a hedgehog-foxf1-rspo2 signaling axis leads to tracheomalacia and a loss of sox9+ tracheal chondrocytes","volume":"14","author":"Nasr","year":"2021","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bbcan.2026.189594_bb0965","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119817","article-title":"RSPO2 silence inhibits tumorigenesis of nasopharyngeal carcinoma by ZNRF3\/hedgehog-Gli1 signal pathway","volume":"282","author":"Wang","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.bbcan.2026.189594_bb0970","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.yexcr.2006.12.020","article-title":"Bone morphogenetic protein-4 is overexpressed in colonic adenocarcinomas and promotes migration and invasion of HCT116 cells","volume":"313","author":"Deng","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb0975","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s41232-020-00141-8","article-title":"Altered FGF expression profile in human scalp-derived fibroblasts upon WNT activation: implication of their role to provide folliculogenetic microenvironment","volume":"40","author":"Kinoshita-Ise","year":"2020","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.bbcan.2026.189594_bb0980","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.devcel.2011.01.006","article-title":"Rspo3 binds syndecan 4 and induces Wnt","volume":"20","author":"Ohkawara","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbcan.2026.189594_bb0985","doi-asserted-by":"crossref","first-page":"5114","DOI":"10.1038\/s41467-020-18643-x","article-title":"Fgf and Wnt signaling interaction in the mesenchymal niche regulates the murine hair cycle clock","volume":"11","author":"Harshuk-Shabso","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2026.189594_bb0990","article-title":"Rspo2 antagonizes FGF signaling during vertebrate mesoderm formation and patterning","volume":"147","author":"Reis","year":"2020","journal-title":"Development"},{"key":"10.1016\/j.bbcan.2026.189594_bb0995","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/s41467-024-44951-7","article-title":"R-Spondin 2 governs xenopus left-right body axis formation by establishing an FGF signaling gradient","volume":"15","author":"Lee","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2026.189594_bb1000","doi-asserted-by":"crossref","first-page":"17365","DOI":"10.1038\/s41598-019-53907-7","article-title":"FGF signalling in the self-renewal of colon cancer organoids","volume":"9","author":"Otte","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2026.189594_bb1005","series-title":"Targeting the Altered Tyrosine Kinases in Colorectal cancer: From Inhibitors to Drugs, Protein Kinase Inhibitors","first-page":"361","author":"Srivastava","year":"2022"},{"key":"10.1016\/j.bbcan.2026.189594_bb1010","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12943-022-01616-7","article-title":"Wnt signaling in colorectal cancer: pathogenic role and therapeutic target","volume":"21","author":"Zhao","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbcan.2026.189594_bb1015","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature11282","article-title":"Recurrent r-spondin fusions in colon cancer","volume":"488","author":"Seshagiri","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2026.189594_bb1020","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1158\/0008-5472.CAN-14-1327","article-title":"RSPO2 enhances canonical Wnt signaling to confer stemness-associated traits to susceptible pancreatic cancer cells","volume":"75","author":"Ilmer","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb1025","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1038\/bjc.2017.131","article-title":"Clinical value of r-spondins in triple-negative and metaplastic breast cancers","volume":"116","author":"Coussy","year":"2017","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbcan.2026.189594_bb1030","doi-asserted-by":"crossref","first-page":"9043","DOI":"10.18632\/aging.102372","article-title":"T5224, RSPO2 and AZD5363 are novel drugs against functional pituitary adenoma","volume":"11","author":"Zhong","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.bbcan.2026.189594_bb1035","doi-asserted-by":"crossref","DOI":"10.1172\/JCI144579","article-title":"RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis","volume":"132","author":"Yue","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2026.189594_bb1040","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3892\/ol.2021.12447","article-title":"Curcumin suppresses colorectal tumorigenesis via the Wnt\/\u03b2-catenin signaling pathway by downregulating axin2","volume":"21","author":"Hao","year":"2021","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.bbcan.2026.189594_bb1045","doi-asserted-by":"crossref","first-page":"8990","DOI":"10.3390\/app12188990","article-title":"An insight into neuropeptides inhibitors in the biology of colorectal cancer: opportunity and translational perspectives","volume":"12","author":"Srivastava","year":"2022","journal-title":"J. Appl. Sci."},{"key":"10.1016\/j.bbcan.2026.189594_bb1050","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1083\/jcb.200102028","article-title":"Vitamin d3 promotes the differentiation of colon carcinoma cells by the induction of e-cadherin and the inhibition of \u03b2-catenin signaling","volume":"154","author":"P\u00e1lmer","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbcan.2026.189594_bb1055","first-page":"2613","article-title":"Vitamin d and Wnt\/\u03b2-catenin pathway in colon cancer: role and regulation of DICKKOPF genes","volume":"28","author":"Pendas-Franco","year":"2008","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb1060","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.biopha.2018.11.082","article-title":"Therapeutic potential of targeting the Wnt\/\u03b2-catenin signaling pathway in colorectal cancer","volume":"110","author":"Cheng","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbcan.2026.189594_bb1065","first-page":"97","article-title":"The inhibition of Wnt\/\u03b2-catenin signaling pathway in human colon cancer cells by sulindac","volume":"100","author":"Tai","year":"2014","journal-title":"Tumori J"},{"key":"10.1016\/j.bbcan.2026.189594_bb1070","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.lfs.2018.08.027","article-title":"Pimozide suppresses colorectal cancer via inhibition of Wnt\/\u03b2-catenin signaling pathway","volume":"209","author":"Ren","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.bbcan.2026.189594_bb1075","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1158\/1940-6207.CAPR-20-0216","article-title":"Effect of low-dose and standard-dose aspirin on PGE2 biosynthesis among individuals with colorectal adenomas: a randomized clinical trial","volume":"13","author":"Drew","year":"2020","journal-title":"Cancer Prev. Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb1080","doi-asserted-by":"crossref","first-page":"40264","DOI":"10.18632\/oncotarget.16828","article-title":"Curcumin enhances the effects of irinotecan on colorectal cancer cells through the generation of reactive oxygen species and activation of the endoplasmic reticulum stress pathway","volume":"8","author":"Huang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbcan.2026.189594_bb1085","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/sj.onc.1204123","article-title":"The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate \u03b2-catenin\/TCF-4 signaling","volume":"20","author":"Dihlmann","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2026.189594_bb1090","doi-asserted-by":"crossref","first-page":"3910","DOI":"10.1158\/1538-7445.AM2018-3910","article-title":"Characterization of BNC101 a human specific monoclonal antibody targeting the GPCR LGR5: first-in-human evidence of target engagement","volume":"78","author":"Inglis","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb1095","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s12276-020-0380-6","article-title":"Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond \u03b2-catenin and the destruction complex","volume":"52","author":"Jung","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbcan.2026.189594_bb1100","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1158\/0008-5472.CAN-10-3978","article-title":"Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations","volume":"71","author":"Osada","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb1105","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1200\/JCO.2019.37.15_suppl.3551","article-title":"Modulation of autophagy: a phase II study of vorinostat (VOR) plus hydroxychloroquine (HCQ) vs regorafenib (RGF) in chemo-refractory metastatic colorectal cancer (mCRC)","volume":"37","author":"Arora","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2026.189594_bb1110","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40659-017-0151-6","article-title":"The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology","volume":"51","author":"Norum","year":"2018","journal-title":"Biol. Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb1115","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2019.37.15_suppl.e15185","article-title":"Effects of SM08502, a novel, oral small-molecule inhibitor of Wnt pathway signaling, on gene expression and antitumor activity in colorectal cancer (CRC) models","volume":"37","author":"Bossard","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2026.189594_bb1120","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1158\/0008-5472.CAN-15-1519","article-title":"A small-molecule antagonist of the \u03b2-catenin\/TCF4 interaction blocks the self-renewal of cancer stem cells and suppresses tumorigenesis","volume":"76","author":"Fang","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb1125","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s12672-025-02154-6","article-title":"NEK2 promotes cancer cell progression and 5-fluorouracil resistance via the Wnt\/\u03b2-catenin signaling pathway in colorectal cancer","volume":"16","author":"Cui","year":"2025","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.bbcan.2026.189594_bb1130","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nchembio.137","article-title":"Small molecule\u2013mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer","volume":"5","author":"Chen","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbcan.2026.189594_bb1135","doi-asserted-by":"crossref","first-page":"5889","DOI":"10.1021\/acs.jmedchem.5b00507","article-title":"Discovery and optimization of a porcupine inhibitor","volume":"58","author":"Duraiswamy","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbcan.2026.189594_bb1140","author":"Kopetz","year":"2022"},{"key":"10.1016\/j.bbcan.2026.189594_bb1145","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.canlet.2017.05.024","article-title":"RSPO2 suppresses colorectal cancer metastasis by counteracting the Wnt5a\/Fzd7-driven noncanonical Wnt pathway","volume":"402","author":"Dong","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbcan.2026.189594_bb1150","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.cpt.2025.02.002","article-title":"Whole transcriptome analysis identifies ALB-EEF1A1 fusion as a novel biomarker in metastatic colorectal cancer","volume":"3","author":"Rikhari","year":"2025","journal-title":"Cancer Pathog. Ther."},{"key":"10.1016\/j.bbcan.2026.189594_bb1155","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1038\/onc.2015.280","article-title":"Wnt addiction of genetically defined cancers reversed by PORCN inhibition","volume":"35","author":"Madan","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2026.189594_bb1160","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nrd4233","article-title":"Can we safely target the WNT pathway?","volume":"13","author":"Kahn","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbcan.2026.189594_bb1165","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/\u03b2-catenin signaling, disease, and emerging therapeutic modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2026.189594_bb1170","series-title":"Phase 1 Study of WNT Pathway Porcupine Inhibitor CGX1321 and Phase 1b Study of CGX1321+ Pembrolizumab (Pembro) in Patients (Pts) with Advanced Gastrointestinal (GI) Tumors","author":"Giannakis","year":"2023"},{"key":"10.1016\/j.bbcan.2026.189594_bb1175","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/oncolo\/oyad007","article-title":"A phase Ib\/II study of WNT974+ encorafenib+ cetuximab in patients with BRAF V600E-mutant KRAS wild-type metastatic colorectal cancer","volume":"28","author":"Tabernero","year":"2023","journal-title":"Oncologist"},{"key":"10.1016\/j.bbcan.2026.189594_bb1180","doi-asserted-by":"crossref","first-page":"15270","DOI":"10.1038\/s41598-017-15704-y","article-title":"RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations","volume":"7","author":"Fischer","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2026.189594_bb1185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0211916","article-title":"Salinomycin: anti-tumor activity in a pre-clinical colorectal cancer model","volume":"14","author":"Klose","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2026.189594_bb1190","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.3390\/cancers12123638","article-title":"Targeting Wnt signaling for gastrointestinal cancer therapy: present and evolving views","volume":"12","author":"Kim","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.bbcan.2026.189594_bb1195","series-title":"Wnt\/\u03b2-catenin Pathway, December 28, Online","author":"Thaman","year":"2021"},{"key":"10.1016\/j.bbcan.2026.189594_bb1200","doi-asserted-by":"crossref","DOI":"10.1593\/neo.101172","article-title":"Intervening in \u03b2-catenin signaling by sulindac inhibits S100A4-dependent colon cancer metastasis","volume":"13","author":"Stein","year":"2011","journal-title":"Neoplasia"},{"key":"10.1016\/j.bbcan.2026.189594_bb1205","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.addr.2020.12.010","article-title":"Therapeutic targeting of the oncogenic Wnt signaling pathway for treating colorectal cancer and other colonic disorders","volume":"169","author":"Caspi","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bbcan.2026.189594_bb1210","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13045-024-01563-4","article-title":"Wnt\/\u03b2-catenin signaling pathway in carcinogenesis and cancer therapy","volume":"17","author":"Song","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bbcan.2026.189594_bb1215","article-title":"Molecular pathways and targeted therapies in colorectal liver metastasis: from bench to bedside","volume":"1-5","author":"Liu","year":"2025","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.bbcan.2026.189594_bb1220","first-page":"C511","article-title":"Targeting Wnt signaling in colorectal cancer. A review in the theme: cell signaling: proteins, pathways and mechanisms","volume":"309","author":"Novellasdemunt","year":"2015","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.bbcan.2026.189594_bb1225","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1158\/0008-5472.CAN-12-4562","article-title":"A novel tankyrase small-molecule inhibitor suppresses APC mutation\u2013driven colorectal tumor growth","volume":"73","author":"Lau","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189594_bb1230","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.celrep.2016.05.071","article-title":"Direct targeting of \u03b2-catenin by a small molecule stimulates proteasomal degradation and suppresses oncogenic Wnt\/\u03b2-catenin signaling","volume":"16","author":"Hwang","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbcan.2026.189594_bb1235","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/nyas.14027","article-title":"The Wnt signaling pathway: a potential therapeutic target against cancer","volume":"1443","author":"Ghosh","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbcan.2026.189594_bb1240","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ebiom.2017.09.029","article-title":"A small molecule inhibitor of the \u03b2-catenin-TCF4 interaction suppresses colorectal cancer growth in vitro and in vivo","volume":"25","author":"Shin","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bbcan.2026.189594_bb1245","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1535-6108(03)00334-9","article-title":"Small-molecule antagonists of the oncogenic Tcf\/\u03b2-catenin protein complex","volume":"5","author":"Lepourcelet","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2026.189594_bb1250","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1021\/bi201428h","article-title":"Structure-based discovery of a novel inhibitor targeting the \u03b2-catenin\/Tcf4 interaction","volume":"51","author":"Tian","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbcan.2026.189594_bb1255","article-title":"LMO2 attenuates tumor growth by targeting the Wnt signaling pathway in breast and colorectal cancer","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2026.189594_bb1260","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinre.2023.102086","article-title":"The research progress of Wnt\/\u03b2-catenin signaling pathway in colorectal cancer","volume":"47","author":"Zhang","year":"2023","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"10.1016\/j.bbcan.2026.189594_bb1265","series-title":"Lee, Randomized Phase 2 Study of DKN-01 plus FOLFIRI\/FOLFOX and Bevacizumab Versus FOLFIRI\/FOLFOX and Bevacizumab as Second-Line Treatment of Advanced Colorectal cancer (DeFianCe)","author":"Wainberg","year":"2023"},{"key":"10.1016\/j.bbcan.2026.189594_bb1270","doi-asserted-by":"crossref","first-page":"iv36","DOI":"10.1093\/annonc\/mdz155.132","article-title":"A randomized, multicenter, open-label controlled phase 2 trial of foxy-5 as neoadjuvant therapy in patients with WNT5A negative colon cancer","volume":"30","author":"Vermorken","year":"2019","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.bbcan.2026.189594_bb1275","series-title":"Epigenetic Modulation in BRAF Mutated Metastatic Colorectal cancer","author":"Morris","year":"2016"},{"key":"10.1016\/j.bbcan.2026.189594_bb1280","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1002\/hep4.1422","article-title":"R-spondin 2 drives liver tumor development in a yes-associated protein-dependent manner","volume":"3","author":"Conboy","year":"2019","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.bbcan.2026.189594_bb1285","article-title":"Colorectal cancer stem cells crosstalk in tumor immune microenvironment and targeted therapeutic strategies","volume":"16","author":"Duan","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2026.189594_bb1290","doi-asserted-by":"crossref","DOI":"10.1093\/annonc\/mdz244.070","article-title":"Inhibition of Rspo-Wnt pathway facilitates checkpoint blockade therapy by anti-RSPO3 antibody (DBPR117)","volume":"30","author":"Hsu","year":"2019","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.bbcan.2026.189594_bb1295","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature16466","article-title":"Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function","volume":"529","author":"Storm","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2026.189594_bb1300","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.1158\/0008-5472.CAN-18-0152","article-title":"Inhibition of Rspo-Lgr4 facilitates checkpoint blockade therapy by switching macrophage polarization","volume":"78","author":"Tan","year":"2018","journal-title":"Cancer Res."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X26000661?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X26000661?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:23:42Z","timestamp":1783085022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304419X26000661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":260,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0304419X26000661"],"URL":"https:\/\/doi.org\/10.1016\/j.bbcan.2026.189594","relation":{},"ISSN":["0304-419X"],"issn-type":[{"value":"0304-419X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multifaceted role of RSPO2: Epigenetics, immunoregulatory, and therapeutic insights in colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbcan.2026.189594","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"189594"}}