{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:43:03Z","timestamp":1787312583944,"version":"build-2736575974"},"reference-count":110,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["L248053"],"award-info":[{"award-number":["L248053"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2025-I2MXHXX-016"],"award-info":[{"award-number":["2025-I2MXHXX-016"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2023-I2M-2-002"],"award-info":[{"award-number":["2023-I2M-2-002"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008235","name":"Peking Union Medical College Hospital","doi-asserted-by":"publisher","award":["UHB1242"],"award-info":[{"award-number":["UHB1242"]}],"id":[{"id":"10.13039\/501100008235","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011176","name":"Peking Union Medical College","doi-asserted-by":"publisher","award":["3332025182"],"award-info":[{"award-number":["3332025182"]}],"id":[{"id":"10.13039\/501100011176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62133006"],"award-info":[{"award-number":["62133006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bbcan.2026.189604","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:21:53Z","timestamp":1778577713000},"page":"189604","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Remodeling the pancreatic tumor microenvironment by chemotherapy: New opportunities for combination therapy"],"prefix":"10.1016","volume":"1881","author":[{"given":"Yuemeng","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feihan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbcan.2026.189604_bb0005","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.4708","article-title":"Estimated projection of US cancer incidence and death to 2040","volume":"4","author":"Rahib","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.bbcan.2026.189604_bb0010","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.22","article-title":"Pancreatic cancer","volume":"2","author":"Kleeff","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bbcan.2026.189604_bb0015","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1097\/SLA.0000000000002234","article-title":"Patterns, timing, and predictors of recurrence following pancreatectomy for pancreatic ductal adenocarcinoma","volume":"267","author":"Groot","year":"2018","journal-title":"Ann. Surg."},{"key":"10.1016\/j.bbcan.2026.189604_bb0020","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/SLA.0000000000005925","article-title":"Neoadjuvant chemotherapy versus upfront surgery for resectable pancreatic adenocarcinoma: an updated nationwide study","volume":"279","author":"Sugawara","year":"2024","journal-title":"Ann. Surg."},{"key":"10.1016\/j.bbcan.2026.189604_bb0025","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1200\/JCO.21.02233","article-title":"Neoadjuvant chemoradiotherapy versus upfront surgery for resectable and borderline resectable pancreatic cancer: long-term results of the Dutch randomized PREOPANC trial","volume":"40","author":"Versteijne","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2026.189604_bb0030","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1056\/NEJMoa1011923","article-title":"FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer","volume":"364","author":"Conroy","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2026.189604_bb0035","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJMoa1304369","article-title":"Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine","volume":"369","author":"Von Hoff","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2026.189604_bb0040","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1056\/NEJMoa1003466","article-title":"Improved survival with ipilimumab in patients with metastatic melanoma","volume":"363","author":"Hodi","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2026.189604_bb0045","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1056\/NEJMoa1510665","article-title":"Nivolumab versus everolimus in advanced renal-cell carcinoma","volume":"373","author":"Motzer","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2026.189604_bb0050","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1056\/NEJMoa2017699","article-title":"Pembrolizumab in microsatellite-instability-high advanced colorectal cancer","volume":"383","author":"Andr\u00e9","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2026.189604_bb0055","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1056\/NEJMoa1801005","article-title":"Pembrolizumab plus chemotherapy in metastatic non-small-cell lung cancer","volume":"378","author":"Gandhi","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2026.189604_bb0060","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1056\/NEJMoa1411087","article-title":"PD-1 blockade with nivolumab in relapsed or refractory Hodgkin\u2019s lymphoma","volume":"372","author":"Ansell","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2026.189604_bb0065","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1056\/NEJMoa1809615","article-title":"Atezolizumab and nab-paclitaxel in advanced triple-negative breast cancer","volume":"379","author":"Schmid","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2026.189604_bb0070","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-007883","article-title":"Nivolumab monotherapy or combination with ipilimumab with or without cobimetinib in previously treated patients with pancreatic adenocarcinoma (CheckMate 032)","volume":"12","author":"Callahan","year":"2024","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.bbcan.2026.189604_bb0075","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1001\/jamaoncol.2019.1588","article-title":"Durvalumab with or without tremelimumab for patients with metastatic pancreatic ductal adenocarcinoma: a phase 2 randomized clinical trial","volume":"5","author":"O\u2019Reilly","year":"2019","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.bbcan.2026.189604_bb0080","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/s41591-022-01829-9","article-title":"Sotigalimab and\/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial","volume":"28","author":"Padr\u00f3n","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2026.189604_bb0085","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/S0140-6736(25)00261-2","article-title":"Pancreatic cancer","volume":"405","author":"Stoop","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.bbcan.2026.189604_bb0095","doi-asserted-by":"crossref","DOI":"10.1126\/science.adk0775","article-title":"Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers","volume":"384","author":"Klomp","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.bbcan.2026.189604_bb0100","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1038\/s41467-021-21736-w","article-title":"KRAS drives immune evasion in a genetic model of pancreatic cancer","volume":"12","author":"Ischenko","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2026.189604_bb0105","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.ccell.2023.07.002","article-title":"KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells","volume":"41","author":"Mahadevan","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2026.189604_bb0110","article-title":"Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia","volume":"21","author":"Y","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2026.189604_bb0115","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1158\/2159-8290.CD-22-1046","article-title":"Cell-autonomous Cxcl1 sustains tolerogenic circuitries and stromal inflammation via neutrophil-derived TNF in pancreatic cancer","volume":"13","author":"Bianchi","year":"2023","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bbcan.2026.189604_bb0120","article-title":"Targeting ESE3\/EHF with Nifurtimox inhibits CXCR2+ neutrophil infiltration and overcomes pancreatic cancer resistance to chemotherapy and immunotherapy","author":"Xie","year":"2024","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2026.189604_bb0125","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1158\/2326-6066.CIR-16-0188","article-title":"CXCR2-dependent accumulation of tumor-associated neutrophils regulates T-cell immunity in pancreatic ductal adenocarcinoma","volume":"4","author":"Chao","year":"2016","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.bbcan.2026.189604_bb0130","doi-asserted-by":"crossref","DOI":"10.1158\/2159-8290.CD-24-0100","article-title":"Oncogenic KRAS-dependent stromal interleukin-33 directs the pancreatic microenvironment to promote tumor growth","author":"Donahue","year":"2024","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bbcan.2026.189604_bb0135","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41586-022-04735-9","article-title":"Neoantigen quality predicts immunoediting in survivors of pancreatic cancer","volume":"606","author":"\u0141uksza","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2026.189604_bb0140","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41586-020-2229-5","article-title":"Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I","volume":"581","author":"Yamamoto","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2026.189604_bb0145","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ccell.2020.02.008","article-title":"Dendritic cell paucity leads to dysfunctional immune surveillance in pancreatic cancer","volume":"37","author":"Hegde","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2026.189604_bb0150","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.cell.2023.02.014","article-title":"Pancreatic cancer: advances and challenges","volume":"186","author":"Halbrook","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2026.189604_bb0155","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201910515","article-title":"Targeting TGF\u03b2R2-mutant tumors exposes vulnerabilities to stromal TGF\u03b2 blockade in pancreatic cancer","volume":"11","author":"Huang","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bbcan.2026.189604_bb0160","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.immuni.2017.07.014","article-title":"Tissue-resident macrophages in pancreatic ductal adenocarcinoma originate from embryonic hematopoiesis and promote tumor progression","volume":"47","author":"Zhu","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.bbcan.2026.189604_bb0165","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1158\/2159-8290.CD-20-0841","article-title":"Leukocyte heterogeneity in pancreatic ductal adenocarcinoma: phenotypic and spatial features associated with clinical outcome","volume":"11","author":"Liudahl","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bbcan.2026.189604_bb0170","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1136\/gutjnl-2015-309193","article-title":"Dual prognostic significance of tumour-associated macrophages in human pancreatic adenocarcinoma treated or untreated with chemotherapy","volume":"65","author":"Di Caro","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.bbcan.2026.189604_bb0175","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.immuni.2014.06.010","article-title":"Tumor-associated macrophages: from mechanisms to therapy","volume":"41","author":"Noy","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.bbcan.2026.189604_bb0180","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/s41573-022-00520-5","article-title":"Macrophages as tools and targets in cancer therapy","volume":"21","author":"Mantovani","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbcan.2026.189604_bb0185","first-page":"1","article-title":"Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bbcan.2026.189604_bb0190","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1136\/gutjnl-2021-326070","article-title":"Single-cell RNA-seq analysis reveals BHLHE40-driven pro-tumour neutrophils with hyperactivated glycolysis in pancreatic tumour microenvironment","volume":"72","author":"Wang","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.bbcan.2026.189604_bb0195","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s13046-024-03178-6","article-title":"Tumor-associated neutrophils upregulate Nectin2 expression, creating the immunosuppressive microenvironment in pancreatic ductal adenocarcinoma","volume":"43","author":"Luo","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189604_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2020.10.015","article-title":"Targeting neutrophil extracellular traps with thrombomodulin prevents pancreatic cancer metastasis","volume":"497","author":"Kajioka","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbcan.2026.189604_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101799","article-title":"Neutrophil elastase facilitates tumor cell intravasation and early metastatic events","volume":"23","author":"Deryugina","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.bbcan.2026.189604_bb0210","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1002\/eji.201242628","article-title":"Polymorphonuclear neutrophils promote dyshesion of tumor cells and elastase-mediated degradation of E-cadherin in pancreatic tumors","volume":"42","author":"Gaida","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bbcan.2026.189604_bb0215","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.785222","article-title":"Neutrophil extracellular traps promote T cell exhaustion in the tumor microenvironment","volume":"12","author":"Kaltenmeier","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2026.189604_bb0220","doi-asserted-by":"crossref","first-page":"6119","DOI":"10.1016\/j.cell.2021.11.017","article-title":"Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer","volume":"184","author":"Raghavan","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2026.189604_bb0225","article-title":"Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer","volume":"214","author":"D","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbcan.2026.189604_bb0230","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1158\/1078-0432.CCR-18-1955","article-title":"Single-cell transcriptomics of pancreatic cancer precursors demonstrates epithelial and microenvironmental heterogeneity as an early event in neoplastic progression","volume":"25","author":"Bernard","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189604_bb0235","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1158\/2159-8290.CD-19-0094","article-title":"Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts","volume":"9","author":"Elyada","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bbcan.2026.189604_bb0240","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.ccell.2022.04.011","article-title":"Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer","volume":"40","author":"Huang","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2026.189604_bb0245","doi-asserted-by":"crossref","first-page":"20212","DOI":"10.1073\/pnas.1320318110","article-title":"Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer","volume":"110","author":"Feig","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbcan.2026.189604_bb0250","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1158\/0008-5472.CAN-12-4601","article-title":"Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner","volume":"73","author":"Mace","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189604_bb0260","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1158\/0008-5472.CAN-22-2316","article-title":"Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer cell-derived cytokines","volume":"83","author":"Schw\u00f6rer","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189604_bb0270","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1053\/j.gastro.2022.02.024","article-title":"Stromal HIF2 regulates immune suppression in the pancreatic cancer microenvironment","volume":"162","author":"Garcia Garcia","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2026.189604_bb0275","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1158\/1078-0432.CCR-19-1864","article-title":"Neoadjuvant therapy remodels the pancreatic cancer microenvironment via depletion of protumorigenic immune cells","volume":"26","author":"Mota Reyes","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189604_bb0280","article-title":"Neoadjuvant chemotherapy drives intratumoral T cells toward a proinflammatory profile in pancreatic cancer","volume":"7","author":"Heiduk","year":"2026","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbcan.2026.189604_bb0285","doi-asserted-by":"crossref","first-page":"6761","DOI":"10.1158\/1078-0432.CCR-21-0998","article-title":"Neoadjuvant FOLFIRINOX therapy is associated with increased effector T cells and reduced suppressor cells in patients with pancreatic cancer","volume":"27","author":"Peng","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189604_bb0290","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.130362","article-title":"Immunologic alterations in the pancreatic cancer microenvironment of patients treated with neoadjuvant chemotherapy and radiotherapy","volume":"5","author":"Farren","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbcan.2026.189604_bb0295","article-title":"Targeting neoadjuvant chemotherapy-induced metabolic reprogramming in pancreatic cancer promotes anti-tumor immunity and chemo-response","volume":"4","author":"Tang","year":"2023","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.bbcan.2026.189604_bb0300","doi-asserted-by":"crossref","first-page":"5167","DOI":"10.1158\/1078-0432.CCR-22-1125","article-title":"Neoadjuvant chemotherapy is associated with altered immune cell infiltration and an anti-tumorigenic microenvironment in resected pancreatic cancer","volume":"28","author":"Dias Costa","year":"2022","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189604_bb0305","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1158\/0008-5472.CAN-19-2959","article-title":"Long-term gemcitabine treatment reshapes the pancreatic tumor microenvironment and sensitizes murine carcinoma to combination immunotherapy","volume":"80","author":"Principe","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189604_bb0310","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/s41467-023-36296-4","article-title":"Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment","volume":"14","author":"Werba","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2026.189604_bb0315","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-000957","article-title":"TIGIT in cancer immunotherapy","volume":"8","author":"Chauvin","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.bbcan.2026.189604_bb0320","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.7150\/thno.86547","article-title":"The spatial coexistence of TIGIT\/CD155 defines poorer survival and resistance to adjuvant chemotherapy in pancreatic ductal adenocarcinoma","volume":"13","author":"Ma","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.bbcan.2026.189604_bb0325","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.ccell.2021.07.007","article-title":"The CD155\/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer","volume":"39","author":"Freed-Pastor","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2026.189604_bb0330","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/s41588-022-01157-1","article-title":"Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer","volume":"54","author":"Cui Zhou","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbcan.2026.189604_bb0335","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001071","article-title":"In pancreatic cancer, chemotherapy increases antitumor responses to tumor-associated antigens and potentiates DNA vaccination","volume":"8","author":"Mandili","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.bbcan.2026.189604_bb0340","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/jnci\/djaa073","article-title":"Tumor microenvironment immune response in pancreatic ductal adenocarcinoma patients treated with neoadjuvant therapy","volume":"113","author":"Michelakos","year":"2021","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bbcan.2026.189604_bb0345","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/s41573-024-00920-9","article-title":"Targeting immunogenic cell stress and death for cancer therapy","volume":"23","author":"Galluzzi","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbcan.2026.189604_bb0350","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nri.2016.107","article-title":"Immunogenic cell death in cancer and infectious disease","volume":"17","author":"Galluzzi","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbcan.2026.189604_bb0355","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.biomaterials.2016.06.032","article-title":"Inducing enhanced immunogenic cell death with nanocarrier-based drug delivery systems for pancreatic cancer therapy","volume":"102","author":"Zhao","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbcan.2026.189604_bb0360","article-title":"Combination chemo-immunotherapy for pancreatic cancer using the immunogenic effects of an irinotecan silicasome nanocarrier plus anti-PD-1","volume":"8","author":"Liu","year":"2021","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.bbcan.2026.189604_bb0365","doi-asserted-by":"crossref","first-page":"6299","DOI":"10.1038\/s41467-020-19970-9","article-title":"Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death","volume":"11","author":"Hayashi","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2026.189604_bb0370","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1378190","article-title":"Neoadjuvant chemotherapy is associated with suppression of the B cell-centered immune landscape in pancreatic ductal adenocarcinoma","volume":"15","author":"Rupp","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2026.189604_bb0375","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-006698","article-title":"Characterization of intratumoral tertiary lymphoid structures in pancreatic ductal adenocarcinoma: cellular properties and prognostic significance","volume":"11","author":"Zou","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.bbcan.2026.189604_bb0380","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1158\/1078-0432.CCR-15-2762","article-title":"Tumor-infiltrating plasma cells are associated with tertiary lymphoid structures, cytolytic T-cell responses, and superior prognosis in ovarian cancer","volume":"22","author":"Kroeger","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189604_bb0385","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s41588-022-01134-8","article-title":"Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment","volume":"54","author":"Hwang","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbcan.2026.189604_bb0390","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s12951-024-02467-8","article-title":"Intelligent nanovesicle for remodeling tumor microenvironment and circulating tumor chemoimmunotherapy amplification","volume":"22","author":"Huai","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bbcan.2026.189604_bb0395","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/gutjnl-2023-330480","article-title":"Enhanced antitumour immunity following neoadjuvant chemoradiotherapy mediates a favourable prognosis in women with resected pancreatic cancer","volume":"73","author":"van Eijck","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.bbcan.2026.189604_bb0400","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/jhbp.883","article-title":"Reduction of gender-associated M2-like tumor-associated macrophages in the tumor microenvironment of patients with pancreatic cancer after neoadjuvant chemoradiotherapy","volume":"28","author":"Matsuki","year":"2021","journal-title":"J. Hepatobiliary Pancreat. Sci."},{"key":"10.1016\/j.bbcan.2026.189604_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2020.01.004","article-title":"Gemcitabine recruits M2-type tumor-associated macrophages into the stroma of pancreatic cancer","volume":"13","author":"Bulle","year":"2020","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.bbcan.2026.189604_bb0410","doi-asserted-by":"crossref","first-page":"12000","DOI":"10.1038\/s41598-018-30437-2","article-title":"Gemcitabine treatment promotes immunosuppressive microenvironment in pancreatic tumors by supporting the infiltration, growth, and polarization of macrophages","volume":"8","author":"Deshmukh","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2026.189604_bb0415","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20212062","article-title":"Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy","volume":"220","author":"Zuo","year":"2023","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbcan.2026.189604_bb0420","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41565-022-01266-2","article-title":"Targeting Xkr8 via nanoparticle-mediated in situ co-delivery of siRNA and chemotherapy drugs for cancer immunochemotherapy","volume":"18","author":"Chen","year":"2023","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.bbcan.2026.189604_bb0425","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12943-019-1022-2","article-title":"Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment","volume":"18","author":"Myers","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbcan.2026.189604_bb0430","first-page":"337","article-title":"Neoadjuvant chemotherapy with gemcitabine plus nab-paclitaxel reduces the number of cancer-associated fibroblasts through depletion of pancreatic stroma","volume":"38","author":"Miyashita","year":"2018","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbcan.2026.189604_bb0435","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1158\/1541-7786.MCR-15-0348","article-title":"Chemotherapy-induced inflammatory gene signature and protumorigenic phenotype in pancreatic CAFs via stress-associated MAPK","volume":"14","author":"Toste","year":"2016","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189604_bb0440","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1158\/0008-5472.CAN-09-3690","article-title":"5-fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity","volume":"70","author":"Vincent","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189604_bb0445","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.mattod.2022.11.008","article-title":"Overcoming pancreatic cancer immune resistance by codelivery of CCR2 antagonist using a STING-activating gemcitabine-based nanocarrier","volume":"62","author":"Wan","year":"2023","journal-title":"Mater. Today (Kidlington)"},{"key":"10.1016\/j.bbcan.2026.189604_bb0450","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nature17403","article-title":"The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression","volume":"532","author":"Seifert","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2026.189604_bb0455","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1158\/0008-5472.CAN-14-2921","article-title":"Chemotherapy-derived inflammatory responses accelerate the formation of immunosuppressive myeloid cells in the tissue microenvironment of human pancreatic cancer","volume":"75","author":"Takeuchi","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189604_bb0460","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1038\/s41416-025-03192-1","article-title":"Gemcitabine-induced neutrophil extracellular traps via interleukin-8-CXCR1\/2 pathway promote chemoresistance in pancreatic cancer","volume":"133","author":"Nogi","year":"2025","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbcan.2026.189604_bb0465","doi-asserted-by":"crossref","DOI":"10.1038\/s41588-024-01890-9","article-title":"Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment","author":"Shiau","year":"2024","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbcan.2026.189604_bb0470","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41421-024-00720-w","article-title":"Targeting a chemo-induced adaptive signaling circuit confers therapeutic vulnerabilities in pancreatic cancer","volume":"10","author":"Saito","year":"2024","journal-title":"Cell Discov."},{"key":"10.1016\/j.bbcan.2026.189604_bb0475","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1158\/0008-5472.CAN-15-1293","article-title":"TGF\u03b2 signaling in the pancreatic tumor microenvironment promotes fibrosis and immune evasion to facilitate tumorigenesis","volume":"76","author":"Principe","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189604_bb0480","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1136\/gutjnl-2021-325272","article-title":"Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6\/AXL signalling axis","volume":"71","author":"Bellomo","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.bbcan.2026.189604_bb0485","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/s41416-021-01639-9","article-title":"Neoadjuvant therapy alters the collagen architecture of pancreatic cancer tissue via Ephrin-A5","volume":"126","author":"Nakajima","year":"2022","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbcan.2026.189604_bb0490","doi-asserted-by":"crossref","first-page":"6292","DOI":"10.1038\/s41467-022-33991-6","article-title":"PD-L1-directed PlGF\/VEGF blockade synergizes with chemotherapy by targeting CD141+ cancer-associated fibroblasts in pancreatic cancer","volume":"13","author":"Kim","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2026.189604_bb0495","doi-asserted-by":"crossref","first-page":"E1147","DOI":"10.1073\/pnas.1717802115","article-title":"Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors","volume":"115","author":"Djurec","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbcan.2026.189604_bb0500","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41575-020-0300-1","article-title":"Pancreatic cancer stroma: an update on therapeutic targeting strategies","volume":"17","author":"Hosein","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbcan.2026.189604_bb0505","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1158\/0008-5472.CAN-22-3645","article-title":"Syk inhibition reprograms tumor-associated macrophages and overcomes gemcitabine-induced immunosuppression in pancreatic ductal adenocarcinoma","volume":"83","author":"Rohila","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189604_bb0510","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/s41591-020-0880-x","article-title":"BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial","volume":"26","author":"Bockorny","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2026.189604_bb0515","article-title":"In situ formed ROS-responsive hydrogel with STING agonist and gemcitabine to intensify immunotherapy against pancreatic ductal adenocarcinoma","volume":"12","author":"Wang","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bbcan.2026.189604_bb0520","doi-asserted-by":"crossref","first-page":"13168","DOI":"10.1021\/acsnano.2c06300","article-title":"Nanocarrier co-formulation for delivery of a TLR7 agonist plus an immunogenic cell death stimulus triggers effective pancreatic cancer chemo-immunotherapy","volume":"16","author":"Luo","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.bbcan.2026.189604_bb0525","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41586-023-06063-y","article-title":"Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer","volume":"618","author":"Rojas","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2026.189604_bb0530","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1158\/1078-0432.CCR-20-1025","article-title":"A phase II study of allogeneic GM-CSF-transfected pancreatic tumor vaccine (GVAX) with ipilimumab as maintenance treatment for metastatic pancreatic cancer","volume":"26","author":"Wu","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189604_bb0535","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-007586","article-title":"Multicenter randomized controlled trial of neoadjuvant chemoradiotherapy alone or in combination with pembrolizumab in patients with resectable or borderline resectable pancreatic adenocarcinoma","volume":"11","author":"Katz","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.bbcan.2026.189604_bb0540","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.1038\/s41467-022-32591-8","article-title":"The CCTG PA.7 phase II trial of gemcitabine and nab-paclitaxel with or without durvalumab and tremelimumab as initial therapy in metastatic pancreatic ductal adenocarcinoma","volume":"13","author":"Renouf","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2026.189604_bb0545","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s41392-024-02031-8","article-title":"Spatial interactions of immune cells as potential predictors to efficacy of toripalimab plus chemotherapy in locally advanced or metastatic pancreatic ductal adenocarcinoma: a phase Ib\/II trial","volume":"9","author":"Cheng","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bbcan.2026.189604_bb0550","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1097\/JS9.0000000000001226","article-title":"Single dual-specific anti-PD-L1\/TGF-\u03b2 antibody synergizes with chemotherapy as neoadjuvant treatment for pancreatic ductal adenocarcinoma: a preclinical experimental study","volume":"110","author":"Zhang","year":"2024","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.bbcan.2026.189604_bb0555","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41392-025-02530-2","article-title":"A phase 1b\/2 study of first-line anti-PD-L1\/ TGF-\u03b2RII fusion protein SHR-1701 combined with nab-paclitaxel and gemcitabine for advanced pancreatic ductal adenocarcinoma","volume":"10","author":"Xue","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bbcan.2026.189604_bb0560","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S1470-2045(16)00078-4","article-title":"Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial","volume":"17","author":"Nywening","year":"2016","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.bbcan.2026.189604_bb0565","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1136\/gutjnl-2017-313738","article-title":"Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma","volume":"67","author":"Nywening","year":"2018","journal-title":"Gut"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X26000764?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X26000764?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T13:24:51Z","timestamp":1785072291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304419X26000764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":110,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0304419X26000764"],"URL":"https:\/\/doi.org\/10.1016\/j.bbcan.2026.189604","relation":{},"ISSN":["0304-419X"],"issn-type":[{"value":"0304-419X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Remodeling the pancreatic tumor microenvironment by chemotherapy: New opportunities for combination therapy","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbcan.2026.189604","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"189604"}}