{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T14:01:47Z","timestamp":1785074507140,"version":"3.55.0"},"reference-count":188,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Foundation for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bbcan.2026.189607","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T15:30:49Z","timestamp":1778340649000},"page":"189607","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of low and moderate doses of ionizing radiation on colon carcinogenesis: Experimental models and current evidence"],"prefix":"10.1016","volume":"1881","author":[{"given":"M\u00e9lissandre","family":"Gomot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Klokov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Var\u00e8s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bbcan.2026.189607_bb0005","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41571-023-00747-0","article-title":"Global burden of gastric cancer: epidemiological trends, risk factors, screening and prevention","volume":"20","author":"Thrift","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0010","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1136\/gutjnl-2022-327736","article-title":"Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN","volume":"72","author":"Morgan","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.bbcan.2026.189607_bb0015","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3390\/diseases11040148","article-title":"Progress and perspectives in colon cancer pathology, diagnosis, and treatments","volume":"11","author":"Alrushaid","year":"2023","journal-title":"Diseases"},{"key":"10.1016\/j.bbcan.2026.189607_bb0020","article-title":"Molecular network of colorectal cancer and current therapeutic options","volume":"12","author":"Huang","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0025","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pbiomolbio.2023.04.002","article-title":"Colon cancer transcriptome","volume":"180\u2013181","author":"Mokhtari","year":"2023","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0030","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2020.00122","article-title":"Mismatch repair pathway, genome stability and cancer","volume":"7","author":"Pe\u0107ina-\u0160laus","year":"2020","journal-title":"Front. Mol. Biosci."},{"issue":"10","key":"10.1016\/j.bbcan.2026.189607_bb0035","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/s41577-021-00534-x","article-title":"The inflammatory pathogenesis of colorectal cancer","volume":"21","author":"Schmitt","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0040","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.21037\/jgo-21-230","article-title":"Effects of molecular markers on the treatment decision and prognosis of colorectal cancer: a narrative review","volume":"12","author":"Cao","year":"2021","journal-title":"J. Gastrointest Oncol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0045","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5009\/gnl19402","article-title":"Molecular features of the serrated pathway to colorectal cancer: current knowledge and future directions","volume":"15","author":"Satorres","year":"2020","journal-title":"Gut. Liver."},{"key":"10.1016\/j.bbcan.2026.189607_bb0050","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3390\/ijms22010130","article-title":"Molecular mechanisms of colon cancer progression and metastasis: recent insights and advancements","volume":"22","author":"Malki","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2026.189607_bb0055","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.3390\/genes14122225","article-title":"Sex differences in Colon Cancer: genomic and nongenomic signalling of oestrogen","volume":"14","author":"Harvey","year":"2023","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.bbcan.2026.189607_bb0060","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/joim.13036","article-title":"Family history of colorectal cancer and survival: a Swedish population-based study","volume":"287","author":"Pesola","year":"2020","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.bbcan.2026.189607_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-020-01287-2","article-title":"Long noncoding RNAs: functions and mechanisms in colon cancer","volume":"19","author":"Chen","year":"2020","journal-title":"Mol. Cancer."},{"key":"10.1016\/j.bbcan.2026.189607_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14740\/gr1239","article-title":"Colon cancer: a clinician's perspective in 2019","volume":"13","author":"Ahmed","year":"2020","journal-title":"Gastroenterol Res."},{"key":"10.1016\/j.bbcan.2026.189607_bb0075","first-page":"110","article-title":"Developing concerns: Colorectal cancer trends and human development index in South-East Asia","volume":"11","author":"Low","year":"2023","journal-title":"Iran J. Color Res."},{"key":"10.1016\/j.bbcan.2026.189607_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-022-10310-2","article-title":"CT scans and cancer risks: A systematic review and dose-response meta-analysis","volume":"22","author":"Cao","year":"2022","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bbcan.2026.189607_bb0085","article-title":"Exposure to tomographic scans and cancer risks","volume":"4","author":"Shao","year":"2020","journal-title":"JNCI Cancer Spectr."},{"key":"10.1016\/j.bbcan.2026.189607_bb0090","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1001\/jamainternmed.2025.0505","article-title":"Projected lifetime Cancer risks from current computed tomography imaging","volume":"185","author":"Smith-Bindman","year":"2025","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.bbcan.2026.189607_bb0095","first-page":"1","article-title":"The 2007 recommendations of the International Commission on Radiological Protection. ICRP publication 103","volume":"37","author":"Clarke Gonz\u00e1lez","year":"2007","journal-title":"Ann. ICRP"},{"key":"10.1016\/j.bbcan.2026.189607_bb0100","series-title":"Heal Risks from Expo to Low Levels Ioniz Radiat BEIR VII Phase 2","first-page":"1","author":"Health risks from exposure to low levels of ionizing radiation: BEIR VII Phase 2","year":"2006"},{"key":"10.1016\/j.bbcan.2026.189607_bb0105","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/ije\/dyad075","article-title":"Ionizing radiation and solid cancer mortality among US nuclear facility workers","volume":"52","author":"Kelly-Reif","year":"2023","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0110","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1210\/jc.2016-3529","article-title":"Thyroid Cancer following childhood Low-dose Radiation exposure: a pooled analysis of nine cohorts","volume":"102","author":"Lubin","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbcan.2026.189607_bb0115","doi-asserted-by":"crossref","first-page":"e346","DOI":"10.1016\/S2352-3026(18)30092-9","article-title":"Leukaemia and myeloid malignancy among people exposed to low doses (<100 mSv) of ionising radiation during childhood: a pooled analysis of nine historical cohort studies","volume":"5","author":"Little","year":"2018","journal-title":"Lancet Haematol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0120","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2022-074520","article-title":"Cancer mortality after low dose exposure to ionising radiation in workers in France, the United Kingdom, and the United States (INWORKS): cohort study","volume":"382","author":"Richardson","year":"2023","journal-title":"BMJ"},{"key":"10.1016\/j.bbcan.2026.189607_bb0125","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s11894-011-0214-8","article-title":"Cancer risk related to gastrointestinal diagnostic radiation exposure","volume":"13","author":"Chang","year":"2011","journal-title":"Curr. Gastroenterol. Rep."},{"key":"10.1016\/j.bbcan.2026.189607_bb0130","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/ijc.32275","article-title":"Radiation risk of incident colorectal cancer by anatomical site among atomic bomb survivors: 1958\u20132009","volume":"146","author":"Sugiyama","year":"2020","journal-title":"Int. J. Cancer"},{"issue":"5","key":"10.1016\/j.bbcan.2026.189607_bb0135","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/s41416-018-0184-9","article-title":"Cancer mortality and incidence following external occupational radiation exposure: an update of the 3rd analysis of the UK national registry for radiation workers","volume":"119","author":"Haylock","year":"2018","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbcan.2026.189607_bb0140","doi-asserted-by":"crossref","DOI":"10.3389\/fphy.2020.00234","article-title":"Cancer risk of low dose ionizing radiation","volume":"8","author":"Ali","year":"2020","journal-title":"Front. Phys."},{"key":"10.1016\/j.bbcan.2026.189607_bb0145","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1080\/09553002.2018.1484194","article-title":"Low dose radiation, inflammation, cancer and chemoprevention","volume":"95","author":"Maqsudur Rashid","year":"2019","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0150","doi-asserted-by":"crossref","first-page":"6612","DOI":"10.1007\/s00330-021-07734-y","article-title":"Multicentric study of patients receiving 50 or 100 mSv in a single day through CT imaging-frequency determination and imaging protocols involved","volume":"31","author":"Rehani","year":"2021","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0155","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6498\/ac31c1","article-title":"How much should we be concerned about cumulative effective doses in medical imaging?","volume":"42","author":"Martin","year":"2022","journal-title":"J. Radiol. Prot."},{"issue":"12","key":"10.1016\/j.bbcan.2026.189607_bb0160","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1134\/S1063778822100301","article-title":"Radiation dose of population in 2020","volume":"85","author":"Kosterev","year":"2022","journal-title":"Phys. At. Nucl."},{"key":"10.1016\/j.bbcan.2026.189607_bb0165","doi-asserted-by":"crossref","unstructured":"Rehani MM, Yang K, Melick ER, et al. Patients undergoing recurrent CT scans: assessing the magnitude. Eur. Radiol. 2019 304. 2019;30:1828\u201336. doi:https:\/\/doi.org\/10.1007\/S00330-019-06523-Y.","DOI":"10.1007\/s00330-019-06523-y"},{"key":"10.1016\/j.bbcan.2026.189607_bb0170","series-title":"Report to the General Assembly Scientific Annex A\u00a0: Evaluation of Medical Exposure to Ionizing Radiation","author":"UNSCEAR","year":"2022"},{"key":"10.1016\/j.bbcan.2026.189607_bb0175","series-title":"Medical Radiation Exposure of Patients in the United States","author":"NCRP Report No. 184","year":"2019"},{"key":"10.1016\/j.bbcan.2026.189607_bb0180","series-title":"New Public Heal","first-page":"681","article-title":"Environmental and occupational health","author":"Tulchinsky","year":"2023"},{"key":"10.1016\/j.bbcan.2026.189607_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222011047","article-title":"Role of mitochondria in IR responses: epigenetic, metabolic, and Signaling impacts","volume":"22","author":"Averbeck","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2026.189607_bb0190","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1148\/radiol.2511080671","article-title":"The linear no-threshold relationship is inconsistent with Radiation biologic and experimental data","volume":"251","author":"Tubiana","year":"2009","journal-title":"Radiology"},{"key":"10.1016\/j.bbcan.2026.189607_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21020446","article-title":"Cell cycle and DNA repair regulation in the damage response: protein phosphatases take over the reins","volume":"21","author":"Campos","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2026.189607_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241411460","article-title":"Low-dose non-targeted effects and mitochondrial control","volume":"24","author":"Averbeck","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189607_bb0205","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10585-025-10381-y","article-title":"Effects of incidental low-dose radiation on abscopal responses after stereotactic body radiotherapy in patients with metastatic cancer: a retrospective real-world analysis","volume":"43","author":"Kim","year":"2025","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.bbcan.2026.189607_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ame2.12102","article-title":"The role of mouse models in colorectal cancer research\u2014the need and the importance of the orthotopic models","volume":"3","author":"Oliveira","year":"2020","journal-title":"Anim. Models Exp. Med."},{"key":"10.1016\/j.bbcan.2026.189607_bb0215","series-title":"Nonhum Primates Biomed. Res.","first-page":"325","article-title":"Neoplasia and proliferative disorders of nonhuman Primates","author":"Miller","year":"2012"},{"key":"10.1016\/j.bbcan.2026.189607_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15092570","article-title":"Experimental murine models for colorectal cancer research","volume":"15","author":"Neto","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbcan.2026.189607_bb0225","doi-asserted-by":"crossref","DOI":"10.3390\/genes10100788","article-title":"Human colorectal cancer from the perspective of mouse models","author":"Stastna","year":"2019","journal-title":"Genes"},{"key":"10.1016\/j.bbcan.2026.189607_bb0230","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1007\/s10620-024-08384-y","article-title":"Review of animal models of colorectal Cancer in different carcinogenesis pathways","volume":"69","author":"Chen","year":"2024","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.bbcan.2026.189607_bb0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-72179-0","article-title":"Optimization of tamoxifen-induced Cre activity and its effect on immune cell populations","volume":"10","author":"Donocoff","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2026.189607_bb0240","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.3748\/wjg.v26.i13.1394","article-title":"Mouse models of colorectal cancer: past, present and future perspectives","volume":"26","author":"B\u00fcrtin","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106958","article-title":"Mouse models in colon cancer, inferences, and implications","volume":"26","author":"Kucherlapati","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.bbcan.2026.189607_bb0250","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1590\/S0100-879X2002000300010","article-title":"Aberrant crypt foci and colon cancer: comparison between a short-and medium-term bioassay for colon carcinogenesis using dimethylhydrazine in Wistar rats","volume":"35","author":"Rodrigues","year":"2002","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.bbcan.2026.189607_bb0255","doi-asserted-by":"crossref","first-page":"5322","DOI":"10.1158\/1078-0432.CCR-14-0332","article-title":"Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: a pooled analysis of the CAIRO, CAIRO2, COIN, and FOCUS studies","volume":"20","author":"Venderbosch","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189607_bb0260","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1126\/science.2296722","article-title":"A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse","volume":"247","author":"Moser","year":"1990","journal-title":"Science (80- )"},{"key":"10.1016\/j.bbcan.2026.189607_bb0265","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00535-024-02177-w","article-title":"Cancer pathways in serrated polyposis syndrome: is conventional more crucial than serrated?","volume":"60","author":"Ikeda","year":"2025","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0270","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1309\/87BD0C6UCGUG236J","article-title":"Serrated pathway and APC (conventional)-type colorectal polyps molecular-morphologic correlations, genetic pathways, and implications for classification","volume":"125","author":"Goldstein","year":"2006","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0275","first-page":"1","article-title":"Mechanism of APC truncation involved in colorectal cancer tumorigenesis (review)","volume":"29","author":"Wang","year":"2025","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.bbcan.2026.189607_bb0280","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djw332","article-title":"Multiple roles of APC and its therapeutic implications in colorectal cancer","volume":"109","author":"Zhang","year":"2017","journal-title":"JNCI"},{"key":"10.1016\/j.bbcan.2026.189607_bb0285","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.biochi.2018.11.003","article-title":"Role of adenomatous polyposis coli (APC) gene mutations in the pathogenesis of colorectal cancer; current status and perspectives","volume":"157","author":"Aghabozorgi","year":"2019","journal-title":"Biochimie"},{"key":"10.1016\/j.bbcan.2026.189607_bb0290","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.prp.2008.03.004","article-title":"Apc mice: models, modifiers and mutants","volume":"204","author":"McCart","year":"2008","journal-title":"Pathol \u2013 Res. Pract."},{"key":"10.1016\/j.bbcan.2026.189607_bb0295","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s00432-019-02883-6","article-title":"The application of ApcMin\/+ mouse model in colorectal tumor researches","volume":"145","author":"Ren","year":"2019","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0300","doi-asserted-by":"crossref","first-page":"8969","DOI":"10.1073\/pnas.91.19.8969","article-title":"A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors","volume":"91","author":"Fodde","year":"1994","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbcan.2026.189607_bb0305","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1073\/pnas.92.10.4482","article-title":"Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene","volume":"92","author":"Oshima","year":"1995","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbcan.2026.189607_bb0310","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1349-7006.1998.tb00576.x","article-title":"Piroxicam and acarbose as chemopreventive agents for spontaneous intestinal adenomas in APC gene 1309 knockout mice","volume":"89","author":"Quesada","year":"1998","journal-title":"Jpn. J. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189607_bb0315","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1101\/gad.13.10.1309","article-title":"Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development","volume":"13","author":"Smits","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbcan.2026.189607_bb0320","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/carcin\/21.5.953","article-title":"Suppression of polypogenesis in a new mouse strain with a truncated ApC(\u0394474) by a novel COX-2 inhibitor, JTE-522","volume":"21","author":"Sasai","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbcan.2026.189607_bb0325","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1038\/labinvest.3700180","article-title":"Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers","volume":"84","author":"Colnot","year":"2004","journal-title":"Lab. Invest."},{"key":"10.1016\/j.bbcan.2026.189607_bb0330","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.0020146","article-title":"Adenomatous polyposis coli (APC) is required for Normal development of skin and Thymus","volume":"2","author":"Kuraguchi","year":"2006","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbcan.2026.189607_bb0335","doi-asserted-by":"crossref","first-page":"32592","DOI":"10.18632\/oncotarget.8693","article-title":"The levels of serine proteases in colon tissue interstitial fluid and serum serve as an indicator of colorectal cancer progression","volume":"7","author":"Xie","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbcan.2026.189607_bb0340","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1073\/pnas.0908682107","article-title":"Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment","volume":"107","author":"Hung","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbcan.2026.189607_bb0345","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.canlet.2014.03.004","article-title":"Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras","volume":"347","author":"Byun","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbcan.2026.189607_bb0350","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1163466","article-title":"T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations","volume":"14","author":"Cuche","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0355","first-page":"1215","article-title":"The utility of Apc-mutant rats in modeling human colon cancer","volume":"7","author":"Irving","year":"2014","journal-title":"Dis. Model. Mech."},{"issue":"3","key":"10.1016\/j.bbcan.2026.189607_bb0360","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/ng0398-276","article-title":"Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DMA mismatch repair","volume":"18","author":"Prolla","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbcan.2026.189607_bb0365","doi-asserted-by":"crossref","first-page":"6850","DOI":"10.1073\/pnas.96.12.6850","article-title":"Different mutator phenotypes in Mlh1- versus Pms2-deficient mice","volume":"96","author":"Yao","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbcan.2026.189607_bb0370","first-page":"159","article-title":"Microsatellite instability in colorectal cancer","volume":"17","author":"Nojadeh","year":"2018","journal-title":"EXCLI J."},{"key":"10.1016\/j.bbcan.2026.189607_bb0375","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.dnarep.2015.11.015","article-title":"Mouse models of DNA mismatch repair in cancer research","volume":"38","author":"Lee","year":"2015","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.bbcan.2026.189607_bb0380","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/risa.12137","article-title":"Modeling the adenoma and serrated pathway to colorectal CAncer (ASCCA)","volume":"34","author":"Greuter","year":"2014","journal-title":"Risk Anal."},{"key":"10.1016\/j.bbcan.2026.189607_bb0385","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.trecan.2023.09.011","article-title":"Serrated colorectal cancer: preclinical models and molecular pathways","volume":"10","author":"Aiderus","year":"2024","journal-title":"Trends Cancer."},{"key":"10.1016\/j.bbcan.2026.189607_bb0390","article-title":"Overview of research progress and application of experimental models of colorectal cancer","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0395","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25179463","article-title":"From crypts to cancer: a holistic perspective on colorectal carcinogenesis and therapeutic strategies","volume":"25","author":"Gharib","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2026.189607_bb0400","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/ame2.12165","article-title":"Cancer models in preclinical research: a chronicle review of advancement in effective cancer research","volume":"4","author":"Sajjad","year":"2021","journal-title":"Anim. Model. Exp. Med."},{"key":"10.1016\/j.bbcan.2026.189607_bb0405","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1158\/0008-5472.CAN-14-0013","article-title":"Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer","volume":"74","author":"Mouradov","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189607_bb0410","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jcmgh.2017.12.004","article-title":"Pancreas 3D organoids: current and future aspects as a research platform for personalized medicine in pancreatic Cancer","volume":"5","author":"Moreira","year":"2018","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0415","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-019-0829-z","article-title":"Applications of patient-derived tumor xenograft models and tumor organoids","volume":"13","author":"Yoshida","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0420","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.935601","article-title":"SETD2 regulates gene transcription patterns and is associated with radiosensitivity in lung adenocarcinoma","volume":"13","author":"Zeng","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.bbcan.2026.189607_bb0425","first-page":"1","article-title":"Breakthroughs and challenges of organoid models for assessing cancer immunotherapy: a cutting-edge tool for advancing personalised treatments","volume":"11","author":"Wang","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.bbcan.2026.189607_bb0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/ol.2023.13914","article-title":"Tumor organoid model of colorectal cancer (review)","volume":"26","author":"Yang","year":"2023","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.bbcan.2026.189607_bb0435","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3390\/organoids2010003","article-title":"Applications for colon organoid models in cancer research","volume":"2","author":"Burgess","year":"2023","journal-title":"Organoids"},{"key":"10.1016\/j.bbcan.2026.189607_bb0440","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1039\/C9LC00653B","article-title":"Long-term flow through human intestinal organoids with the gut organoid flow chip (GOFlowChip)","volume":"19","author":"Sidar","year":"2019","journal-title":"Lab Chip"},{"key":"10.1016\/j.bbcan.2026.189607_bb0445","first-page":"827","volume":"18","author":"Fujii","year":"2016","journal-title":"Stem Cell."},{"key":"10.1016\/j.bbcan.2026.189607_bb0450","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/hgv.2015.35","article-title":"CD14 and IL18 gene polymorphisms associated with colorectal cancer subsite risks among atomic bomb survivors","volume":"2","author":"Hu","year":"2015","journal-title":"Hum. Genome Var."},{"key":"10.1016\/j.bbcan.2026.189607_bb0455","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/cac2.12096","article-title":"The ongoing trends of patient-derived xenograft models in oncology","volume":"40","author":"Zhuo","year":"2020","journal-title":"Cancer Commun."},{"key":"10.1016\/j.bbcan.2026.189607_bb0460","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1667\/RR13502.1","article-title":"High-energy particle-induced tumorigenesis throughout the gastrointestinal tract","volume":"181","author":"Trani","year":"2014","journal-title":"Radiat. Res."},{"key":"10.1016\/j.bbcan.2026.189607_bb0465","first-page":"45","article-title":"Low and high dose rate heavy ion radiation-induced intestinal and colonic tumorigenesis in APC1638N\/+ mice","volume":"13","author":"Suman","year":"2017","journal-title":"Life Sci. Space Res."},{"key":"10.1016\/j.bbcan.2026.189607_bb0470","doi-asserted-by":"crossref","first-page":"E9832","DOI":"10.1073\/pnas.1807522115","article-title":"Space radiation triggers persistent stress response, increases senescent signaling, and decreases cell migration in mouse intestine","volume":"115","author":"Kumar","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbcan.2026.189607_bb0475","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3109\/09553002.2011.542542","article-title":"Intestinal tumours induced in ApcMin\/+ mice by X-rays and neutrons","volume":"87","author":"Ellender","year":"2011","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0480","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.7150\/jca.17803","article-title":"Increased transgenerational intestinal tumorigenesis in offspring of ionizing radiation exposed parent APC1638N\/+ mice","volume":"8","author":"Suman","year":"2017","journal-title":"J. Cancer"},{"key":"10.1016\/j.bbcan.2026.189607_bb0485","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ijrobp.2012.02.053","article-title":"Sex-dependent differences in intestinal tumorigenesis induced in Apc1638N\/+ mice by exposure to \u03b3 rays","volume":"85","author":"Trani","year":"2013","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.bbcan.2026.189607_bb0490","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1038\/onc.2015.395","article-title":"Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses","volume":"35","author":"Kim","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2026.189607_bb0495","article-title":"New thiophene derivative augments the antitumor activity of \u03b3-irradiation against colorectal cancer in mice via anti-inflammatory and pro-apoptotic pathways","volume":"13","author":"ElBakary","year":"2022","journal-title":"Discov. Oncol."},{"issue":"3","key":"10.1016\/j.bbcan.2026.189607_bb0500","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1007\/s11033-022-08186-3","article-title":"Low dose radiation upregulates Ras\/p38 and NADPH oxidase in mouse colon two months after exposure","volume":"50","author":"Kumar","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.bbcan.2026.189607_bb0505","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1269\/jrr.10121","article-title":"The low-dose ionizing radiation stimulates cell proliferation via activation of the MAPK\/ERK pathway in rat culturedmesenchymal stem cells","volume":"52","author":"Liang","year":"2011","journal-title":"J. Radiat. Res."},{"key":"10.1016\/j.bbcan.2026.189607_bb0510","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.3390\/cancers15184570","article-title":"Prognostic biomarkers of cell proliferation in colorectal cancer (CRC): From immunohistochemistry to molecular biology techniques","volume":"15","author":"Kasprzak","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.bbcan.2026.189607_bb0515","article-title":"Ret kinase-mediated mechanical induction of colon stem cells by tumor growth pressure stimulates cancer progression in vivo","author":"Huong Nguyen Ho-Bouldoires","year":"2003","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0520","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1667\/RR1132.1","article-title":"Low-dose radiation does not induce proliferation in tumor cells in vitro and in vivo","volume":"170","author":"Jiang","year":"2008","journal-title":"Radiat. Res."},{"key":"10.1016\/j.bbcan.2026.189607_bb0525","doi-asserted-by":"crossref","DOI":"10.3390\/cells11030356","article-title":"Advances in the current understanding of how low-dose radiation affects the cell cycle","volume":"11","author":"Khan","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bbcan.2026.189607_bb0530","doi-asserted-by":"crossref","first-page":"456","DOI":"10.4161\/cc.4.3.1249","article-title":"Radiation-stimulated ERK1\/2 and JNK1\/2 signaling can promote cell cycle progression in human colon cancer cells","volume":"4","author":"Car\u00f3n","year":"2005","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbcan.2026.189607_bb0535","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1368-8375(99)00049-4","article-title":"An overview of the cell cycle arrest protein, p21WAF1","volume":"36","author":"Harada","year":"2000","journal-title":"Oral Oncol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0540","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.3390\/ijms23084120","article-title":"KRAS: A druggable target in colon cancer patients","volume":"23","author":"Negri","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2026.189607_bb0545","doi-asserted-by":"crossref","first-page":"7866","DOI":"10.1074\/jbc.M116.768283","article-title":"NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction","volume":"292","author":"Juhasz","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"36","key":"10.1016\/j.bbcan.2026.189607_bb0550","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1038\/onc.2008.133","article-title":"Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6","volume":"27","author":"Adachi","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2026.189607_bb0555","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1365-2036.2006.00039.x","article-title":"Differential expression of cyclo-oxygenase-2 and nuclear \u03b2-catenin in colorectal cancer tissue","volume":"24","author":"Tatsuguchi","year":"2006","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.bbcan.2026.189607_bb0560","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.amjsurg.2005.11.009","article-title":"Colon cancer and apoptosis","volume":"191","author":"Huerta","year":"2006","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.bbcan.2026.189607_bb0565","article-title":"Low-dose total body irradiation can enhance systemic immune related response induced by hypofractionated radiation","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0570","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s12094-017-1624-3","article-title":"Effects of low-dose radiation on adaptive response in colon cancer stem cells","volume":"19","author":"Zhao","year":"2017","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0575","series-title":"Nitric Oxide Biol Pathobiol","first-page":"385","article-title":"NO in Cancer\u2014carcinogenesis, metastasis, and therapy","author":"Somasundaram","year":"2017"},{"key":"10.1016\/j.bbcan.2026.189607_bb0580","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9653244","article-title":"Cancer stem cells: from an insight into the basics to recent advances and therapeutic targeting","volume":"2022","author":"Bisht","year":"2022","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.bbcan.2026.189607_bb0585","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1080\/09553002.2019.1580401","article-title":"Radiation-induced DNA damage response and resistance in colorectal cancer stem-like cells","volume":"95","author":"Anuja","year":"2019","journal-title":"Int. J. Radiat. Biol."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189607_bb0590","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12943-016-0577-4","article-title":"Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation","volume":"16","author":"Lee","year":"2017","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.bbcan.2026.189607_bb0595","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12929-018-0426-4","article-title":"Cancer stem cells as key drivers of tumour progression","volume":"25","author":"Ayob","year":"2018","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.bbcan.2026.189607_bb0600","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1634\/theoncologist.2019-0517","article-title":"The clinical impact of Cancer stem cells","volume":"25","author":"Lathia","year":"2019","journal-title":"Oncologist"},{"key":"10.1016\/j.bbcan.2026.189607_bb0605","doi-asserted-by":"crossref","first-page":"645","DOI":"10.52547\/ijrr.19.3.645","article-title":"Effects of radiation dose on the stemness-related genes expression in colorectal cancer cell line","volume":"19","author":"Soleymanifard","year":"2021","journal-title":"Int. J. Radiat. Res."},{"issue":"1","key":"10.1016\/j.bbcan.2026.189607_bb0610","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13045-018-0605-5","article-title":"The biology and role of CD44 in cancer progression: therapeutic implications","volume":"11","author":"Chen","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0615","first-page":"EC17","article-title":"Evaluation of the role of ALDH1 as Cancer stem cell marker in colorectal carcinoma: an immunohistochemical study","volume":"11","author":"Holah","year":"2017","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.bbcan.2026.189607_bb0620","article-title":"Oct4 promoted proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in colon cancer cells by activating the SCF\/c-kit signaling pathway","volume":"22","author":"Bu","year":"2022","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbcan.2026.189607_bb0625","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.freeradbiomed.2019.11.037","article-title":"In vivo assessment of reactive oxygen species production and oxidative stress effects induced by chronic exposure to gamma radiation in Caenorhabditis elegans","volume":"152","author":"Maremonti","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbcan.2026.189607_bb0630","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1089\/ars.2013.5489","article-title":"Effects of ionizing Radiation on biological molecules\u2014mechanisms of damage and emerging methods of detection","volume":"21","author":"Reisz","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbcan.2026.189607_bb0635","article-title":"The roles of ROS in cancer heterogeneity and therapy","volume":"2017","author":"De S\u00e1","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbcan.2026.189607_bb0640","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.semcdb.2017.05.023","article-title":"ROS signalling in the biology of cancer","volume":"80","author":"Moloney","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0645","article-title":"KRAS-driven ROS promote malignant transformation","volume":"2","author":"Suh","year":"2015","journal-title":"Mol. Cell. Oncol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0650","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/cdd.2014.34","article-title":"Novel signaling axis for ROS generation during K-Ras-induced cellular transformation","volume":"21","author":"Park","year":"2014","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbcan.2026.189607_bb0655","article-title":"Beneficial effects of low dose radiation in response to the oncogenic KRAS induced cellular transformation","volume":"5","author":"Kim","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2026.189607_bb0660","first-page":"1036","article-title":"Effects of low-dose radiation on tumor growth, erythrocyte immune function and SOD activity in tumor-bearing mice","volume":"117","author":"Yu","year":"2004","journal-title":"Chin. Med. J. (Engl)"},{"key":"10.1016\/j.bbcan.2026.189607_bb0665","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1002\/ijc.30235","article-title":"Low-dose radiation may be a novel approach to enhance the effectiveness of cancer therapeutics","volume":"139","author":"Yang","year":"2016","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbcan.2026.189607_bb0670","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1667\/RR2349.1","article-title":"SOD2-mediated effects Induced by WR1065 and Low-dose ionizing Radiation on micronucleus formation in RKO human Colon carcinoma cells","volume":"175","author":"Murley","year":"2011","journal-title":"Radiat. Res."},{"key":"10.1016\/j.bbcan.2026.189607_bb0675","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1080\/09553002.2023.2158246","article-title":"Radiation-induced increases in cancer mortality result from an earlier onset of the disease in mice and atomic bomb survivors","volume":"99","author":"Nakamura","year":"2023","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0680","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6498\/acdfd7","article-title":"The scientific basis for the use of the linear no-threshold (LNT) model at low doses and dose rates in radiological protection","volume":"43","author":"Laurier","year":"2023","journal-title":"J. Radiol. Prot."},{"key":"10.1016\/j.bbcan.2026.189607_bb0685","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.3748\/wjg.v13.i22.3043","article-title":"Radiation-induced intestinal inflammation","volume":"13","author":"Moll\u00e0","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0690","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106212","article-title":"Low dose ionizing radiation effects on the immune system","volume":"149","author":"Lumniczky","year":"2021","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.bbcan.2026.189607_bb0695","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41575-019-0230-y","article-title":"Epigenetics of colorectal cancer: biomarker and therapeutic potential","volume":"17","author":"Jung","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0700","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12864-015-1229-6","article-title":"Identification of radiation-induced aberrant hypomethylation in colon cancer","volume":"16","author":"Bae","year":"2015","journal-title":"BMC Genomics"},{"key":"10.1016\/j.bbcan.2026.189607_bb0705","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.bbrc.2004.06.081","article-title":"Dose-dependence, sex- and tissue-specificity, and persistence of radiation-induced genomic DNA methylation changes","volume":"320","author":"Pogribny","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbcan.2026.189607_bb0710","doi-asserted-by":"crossref","first-page":"5993","DOI":"10.3390\/ijms21175993","article-title":"Ionizing radiation-induced epigenetic modifications and their relevance to radiation protection","volume":"21","author":"Belli","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2026.189607_bb0715","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1101\/gad.351051.123","article-title":"LINE-1 retrotransposition and its deregulation in cancers: implications for therapeutic opportunities","volume":"37","author":"Mendez-Dorantes","year":"2023","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbcan.2026.189607_bb0720","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1158\/1541-7786.MCR-05-0074","article-title":"Fractionated Low-dose Radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine Thymus","volume":"3","author":"Pogribny","year":"2005","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189607_bb0725","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.3390\/ijms16022472","article-title":"Promoter hypermethylation of tumour suppressor genes as potential biomarkers in colorectal cancer","volume":"16","author":"Ng","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.bbcan.2026.189607_bb0730","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1134\/S1062359021110066","article-title":"Radiation-induced DNA methylation disorders: in vitro and in vivo studies","volume":"48","author":"Kuzmina","year":"2022","journal-title":"Biol. Bull."},{"issue":"2","key":"10.1016\/j.bbcan.2026.189607_bb0735","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/72785","article-title":"Aberrant CpG-island methylation has non-random and tumour-type\u2013specific patterns","volume":"24","author":"Costello","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbcan.2026.189607_bb0740","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2022.188722","article-title":"DNA methylation-based diagnostic, prognostic, and predictive biomarkers in colorectal cancer","volume":"1877","author":"M\u00fcller","year":"2022","journal-title":"Biochim. Biophys. Acta \u2013 Rev. Cancer."},{"issue":"11","key":"10.1016\/j.bbcan.2026.189607_bb0745","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/nm.3981","article-title":"The emerging role of lncRNAs in cancer","volume":"21","author":"Huarte","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2026.189607_bb0750","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.109995","article-title":"Micro-RNA: the darkhorse of cancer","volume":"83","author":"Budakoti","year":"2021","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbcan.2026.189607_bb0755","author":"Trani"},{"key":"10.1016\/j.bbcan.2026.189607_bb0760","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1667\/RR2390.1","article-title":"The effect of radiation quality on genomic DNA methylation profiles in irradiated human cell lines","volume":"175","author":"Goetz","year":"2011","journal-title":"Radiat. Res."},{"key":"10.1016\/j.bbcan.2026.189607_bb0765","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3109\/09553000903419957","article-title":"Lack of evidence for low-LET radiation induced bystander response in normal human fibroblasts and colon carcinoma cells lack of evidence for low-LET radiation induced bystander response in normal human fibroblast","volume":"86","author":"Sowa","year":"2010","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0770","doi-asserted-by":"crossref","first-page":"3614","DOI":"10.53730\/ijhs.v7nS1.15270","article-title":"The importance of histopathological evaluation in cancer diagnosis and treatment","volume":"7","author":"Aljehani","year":"2023","journal-title":"Int. J. Health Sci."},{"key":"10.1016\/j.bbcan.2026.189607_bb0775","article-title":"The AOM\/DSS murine model for the study of colon carcinogenesis: from pathways to diagnosis and therapy studies","volume":"10","author":"De Robertis","year":"2011","journal-title":"J. Carcinog."},{"key":"10.1016\/j.bbcan.2026.189607_bb0780","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1349-7006.2005.00020.x","article-title":"\u0392-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate","volume":"96","author":"Kohno","year":"2005","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bbcan.2026.189607_bb0785","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4132\/KoreanJPathol.2013.47.1.1","article-title":"Radiotherapy response in microsatellite instability related rectal Cancer","volume":"47","author":"Shin","year":"2013","journal-title":"Korean J. Pathol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0790","article-title":"In vitro study of radiosensitivity in colorectal cancer cell lines associated with Lynch syndrome","volume":"12","author":"Sun","year":"2024","journal-title":"Front. Public Heal."},{"key":"10.1016\/j.bbcan.2026.189607_bb0795","doi-asserted-by":"crossref","DOI":"10.1016\/j.cancergen.2025.10.003","article-title":"The prevalence of TP53, APC, and PIK3CA gene mutations in colorectal cancer patients: a systematic review and meta-analysis","author":"Gheibi","year":"2025","journal-title":"Cancer Genet."},{"key":"10.1016\/j.bbcan.2026.189607_bb0800","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3390\/radiation4040023","article-title":"Exploring the role of p53 in radiosensitivity: a key player in cancer therapy","volume":"4","author":"Al-Arafat","year":"2024","journal-title":"Radiation"},{"key":"10.1016\/j.bbcan.2026.189607_bb0805","article-title":"CircRNA ITGA7 restrains growth and enhances radiosensitivity by up-regulating SMAD4 in colorectal carcinoma","author":"Li","year":"2023","journal-title":"Open Med."},{"key":"10.1016\/j.bbcan.2026.189607_bb0810","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1038\/sj.bjc.6604691","article-title":"Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines","volume":"99","author":"Vilar","year":"2008","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbcan.2026.189607_bb0815","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.1158\/0008-5472.CAN-04-0975","article-title":"Hypersensitivity of tumor cell lines with microsatellite instability to DNA double Strand break producing chemotherapeutic agent bleomycin","volume":"64","author":"Li","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189607_bb0820","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/386623a0","article-title":"Genetic instability in colorectal cancers","volume":"386","author":"Lengauer","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2026.189607_bb0825","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.12130","article-title":"RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis","volume":"7","author":"Bond","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbcan.2026.189607_bb0830","doi-asserted-by":"crossref","first-page":"6912","DOI":"10.1158\/1078-0432.CCR-09-1698","article-title":"Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells","volume":"15","author":"Yan","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189607_bb0835","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3390\/cancers13020227","article-title":"A 3D view of colorectal cancer models in predicting therapeutic responses and resistance","volume":"13","author":"Reidy","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.bbcan.2026.189607_bb0840","doi-asserted-by":"crossref","unstructured":"Kolenda T, Kapa\u0142czy\u0144ska M, Przyby\u0142a W, et al. State of the art paper 2D and 3D cell cultures-a comparison of different types of cancer cell cultures. 2016. doi:https:\/\/doi.org\/10.5114\/aoms.2016.63743.","DOI":"10.5114\/aoms.2016.63743"},{"key":"10.1016\/j.bbcan.2026.189607_bb0845","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25116188","article-title":"The crucial role of inflammation and the immune system in colorectal cancer carcinogenesis: a comprehensive perspective","volume":"25","author":"Burgos-Molina","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2026.189607_bb0850","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1667\/RR2160.1","article-title":"Effects of low-dose radiation on the immune system of mice after total-body irradiation","volume":"174","author":"Bogd\u00e1ndi","year":"2010","journal-title":"Radiat. Res."},{"key":"10.1016\/j.bbcan.2026.189607_bb0855","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/toxres\/tfaa017","article-title":"Effects of low dose radiation on immune cells subsets and cytokines in mice","volume":"9","author":"Liu","year":"2020","journal-title":"Toxicol. Res. (Camb)."},{"key":"10.1016\/j.bbcan.2026.189607_bb0860","doi-asserted-by":"crossref","DOI":"10.1177\/1179064418761639","article-title":"The impact of radiation on the tumor microenvironment: effect of dose and fractionation schedules","volume":"11","author":"Arnold","year":"2018","journal-title":"Cancer Growth Metastasis."},{"key":"10.1016\/j.bbcan.2026.189607_bb0865","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1667\/RR1764.1","article-title":"Low-dose Radiation-Induced senescent stromal fibroblasts render nearby breast Cancer cells radioresistant","volume":"172","author":"Tsai","year":"2009","journal-title":"Radiat. Res."},{"key":"10.1016\/j.bbcan.2026.189607_bb0870","doi-asserted-by":"crossref","first-page":"E586","DOI":"10.1016\/j.ijrobp.2017.06.2010","article-title":"Cancer-associated fibroblasts: development and responses to ionizing Radiation","volume":"99","author":"Domogauer","year":"2017","journal-title":"Int. J. Radiat. Oncol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0875","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/s41416-019-0672-6","article-title":"Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery","volume":"122","author":"Powley","year":"2020","journal-title":"Br. J. Cancer"},{"issue":"5","key":"10.1016\/j.bbcan.2026.189607_bb0880","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41587-024-02301-4","article-title":"Patient-derived mini-colons enable long-term modeling of tumor\u2013microenvironment complexity","volume":"43","author":"Lorenzo-Mart\u00edn","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0885","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1007\/s12010-021-03498-9","article-title":"Exploring the role of gut microbiome in colon cancer","volume":"193","author":"Chattopadhyay","year":"2021","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0890","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-017-0325-z","article-title":"Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome","volume":"5","author":"Casero","year":"2017","journal-title":"Microbiome"},{"key":"10.1016\/j.bbcan.2026.189607_bb0895","article-title":"Effect of low-dose radiation on thyroid function and the gut microbiota","volume":"28","author":"Jun-Yu","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0900","first-page":"1","article-title":"Impact of chronic low-dose external gamma- and internal tritium beta-irradiation on the gut microbiome in the context of intestinal tumorigenesis in ApcMin\/+ mice","volume":"0","author":"Laakso","year":"2026","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0905","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011222","article-title":"Low doses of ionizing Radiation promote tumor growth and metastasis by enhancing angiogenesis","volume":"5","author":"Sofia Vala","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.bbcan.2026.189607_bb0910","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0167-8140(93)90101-D","article-title":"Suppressive effect of low dose total body irradiation on lung metastasis: dose dependency and effective period","volume":"26","author":"Hosoi","year":"1993","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0915","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1038\/s41388-018-0155-x","article-title":"The path to metastatic mouse models of colorectal cancer","volume":"37","author":"Romano","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2026.189607_bb0920","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1080\/09553002.2021.1876955","article-title":"Low- and moderate-dose non-cancer effects of ionizing radiation in directly exposed individuals, especially circulatory and ocular diseases: a review of the epidemiology","volume":"97","author":"Little","year":"2021","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.bbcan.2026.189607_bb0925","series-title":"Sources and Effects of Ionizing Radiation, United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) 2000 Report, Volume I: Report to the General Assembly, with Scientific Annexes - Sources","author":"UNSCEAR","year":"2000"},{"key":"10.1016\/j.bbcan.2026.189607_bb0930","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/EDE.0000000000001148","article-title":"The increasing exposure of the global population to ionizing Radiation","volume":"31","author":"Ruano-Ravina","year":"2020","journal-title":"Epidemiology"},{"key":"10.1016\/j.bbcan.2026.189607_bb0935","doi-asserted-by":"crossref","first-page":"222","DOI":"10.14407\/jrpr.2017.42.4.222","article-title":"Radiation exposure from nuclear power plants in Korea: 2011-2015","volume":"42","author":"Lim","year":"2017","journal-title":"J. Radiat. Prot. Res."},{"key":"10.1016\/j.bbcan.2026.189607_bb0940","doi-asserted-by":"crossref","first-page":"5675","DOI":"10.1007\/s00330-023-09541-z","article-title":"Occupational exposure to ionizing radiation in medical staff: trends during the 2009\u20132019 period in a multicentric study","volume":"33","author":"Baudin","year":"2023","journal-title":"Eur. Radiol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X2600079X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X2600079X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T13:27:20Z","timestamp":1785072440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304419X2600079X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":188,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0304419X2600079X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbcan.2026.189607","relation":{},"ISSN":["0304-419X"],"issn-type":[{"value":"0304-419X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of low and moderate doses of ionizing radiation on colon carcinogenesis: Experimental models and current evidence","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbcan.2026.189607","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"189607"}}