{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:07:43Z","timestamp":1789520863696,"version":"build-2803163510"},"reference-count":80,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010854","name":"Jiangsu Provincial Health Commission","doi-asserted-by":"publisher","award":["X20241377"],"award-info":[{"award-number":["X20241377"]}],"id":[{"id":"10.13039\/501100010854","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbcan.2026.189667","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:36:43Z","timestamp":1784853403000},"page":"189667","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The dual role of retinoic acid signaling in clear cell renal cell carcinoma and wilms tumor: A tale of two entities"],"prefix":"10.1016","volume":"1881","author":[{"given":"S.H.I.","family":"Qiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.I.","family":"Zehua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.U.","family":"Huilin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.H.I.","family":"Haifeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.U.","family":"Jie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbcan.2026.189667_bb0005","article-title":"Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity: a pan-cancer analysis","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbcan.2026.189667_bb0010","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ccell.2022.12.001","article-title":"Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness","volume":"41","author":"Li","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2026.189667_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120773","article-title":"Multi-omics and machine learning framework reveals ABCG2 as a therapeutic target of eleven flavored Shenqi tablets in clear cell renal cell carcinoma","volume":"356","author":"Zhang","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbcan.2026.189667_bb0020","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-021-00308-8","article-title":"Wilms tumour","volume":"7","author":"Spreafico","year":"2021","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.bbcan.2026.189667_bb0025","article-title":"Pediatric renal tumor epidemiology: global perspectives, progress, and challenges","author":"Libes","year":"2022","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.bbcan.2026.189667_bb0030","doi-asserted-by":"crossref","first-page":"T13","DOI":"10.1530\/JME-22-0097","article-title":"Retinoic acid receptors at 35 years","volume":"69","author":"Petkovich","year":"2022","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.bbcan.2026.189667_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116281","article-title":"Retinoic acid tiers mitochondrial metabolism to Sertoli cell-mediated efferocytosis via a non-RAR-dependent mechanism","volume":"225","author":"Wu","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbcan.2026.189667_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110773","article-title":"Retinoic acid signaling in development and differentiation commitment and its regulatory topology","volume":"387","author":"Wu","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bbcan.2026.189667_bb0045","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2426739122","article-title":"Retinoic acid receptor assembly dynamics governs dual functions in cochlear organogenesis","volume":"122","author":"Chakraborty","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbcan.2026.189667_bb0050","article-title":"Dual role of CRABP2 in colorectal cancer: oncogenesis via nuclear RB1 and cytoplasmic AFG3L2\/SLC25A39 axis, while limiting liver metastasis through cytoplasmic AFG3L2\/PINK1\/Parkin-mediated mitophagy","volume":"12","author":"Tian","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.bbcan.2026.189667_bb0055","doi-asserted-by":"crossref","first-page":"54","DOI":"10.2174\/0109298665308502240820115618","article-title":"Exploring the regulatory interaction of differentially expressed proteins in cleft palate induced by retinoic acid","volume":"32","author":"Chen","year":"2025","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.bbcan.2026.189667_bb0060","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-023-02869-w","article-title":"Anti-tumor activity of all-trans retinoic acid in gastric-cancer: gene-networks and molecular mechanisms","volume":"42","author":"Guarrera","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189667_bb0065","article-title":"All-trans retinoic acid promotes a tumor suppressive OTUD6B-\u03b2-TrCP-SNAIL axis in esophageal squamous cell carcinoma and enhances immunotherapy","volume":"10","author":"Li","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.bbcan.2026.189667_bb0070","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000520803","article-title":"Involvement of miR-769-5p\/retinoic acid receptor responder 1 axis in the progression of osteosarcoma: characterization of potential therapeutic targets","volume":"107","author":"Ma","year":"2022","journal-title":"Pharmacology"},{"key":"10.1016\/j.bbcan.2026.189667_bb0075","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12935-023-02928-4","article-title":"Blockage of retinoic acid signaling via RAR\u03b3 suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phase","volume":"23","author":"Yamakawa","year":"2023","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.bbcan.2026.189667_bb0080","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/bs.ctdb.2024.11.001","article-title":"Retinoic acid homeostasis and disease","volume":"161","author":"Kane","year":"2025","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.bbcan.2026.189667_bb0085","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbalip.2011.04.004","article-title":"Alcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout models","volume":"1821","author":"Kumar","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbcan.2026.189667_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.968215","article-title":"The relationship between thyroid disorders and vitamin A.: a narrative minireview","volume":"13","author":"Capriello","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.bbcan.2026.189667_bb0095","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.pharmthera.2017.01.004","article-title":"Cellular retinoid binding-proteins, CRBP, CRABP, FABP5: effects on retinoid metabolism, function and related diseases","volume":"173","author":"Napoli","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbcan.2026.189667_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.126069","article-title":"A \u201cstealth\u201d gene delivery system targeting hepatic stellate cells for the treatment of liver fibrosis","volume":"683","author":"Zhao","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bbcan.2026.189667_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.107400","article-title":"Biochemical and physiological importance of the CYP26 retinoic acid hydroxylases","volume":"204","author":"Isoherranen","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbcan.2026.189667_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108481","article-title":"Vitamin a and retinoid signaling in the kidneys","volume":"248","author":"DiKun","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbcan.2026.189667_bb0115","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1158\/1541-7786.MCR-21-1039","article-title":"Loss of PBRM1 alters promoter histone modifications and activates ALDH1A1 to drive renal cell carcinoma","volume":"20","author":"Schoenfeld","year":"2022","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189667_bb0120","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3892\/ijmm.2017.3051","article-title":"Regulation of retinoic acid synthetic enzymes by WT1 and HDAC inhibitors in 293 cells","volume":"40","author":"Li","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbcan.2026.189667_bb0125","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/path.5518","article-title":"Expansion of the renal capsular stroma, ureteric bud branching defects and cryptorchidism in mice with Wilms tumor 1 gene deletion in the stromal compartment of the developing kidney","volume":"252","author":"Weiss","year":"2020","journal-title":"J. Pathol."},{"key":"10.1016\/j.bbcan.2026.189667_bb0130","doi-asserted-by":"crossref","DOI":"10.1242\/dev.167502","article-title":"Retinoic acid signaling pathways","volume":"146","author":"Ghyselinck","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.bbcan.2026.189667_bb0135","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/bs.mie.2020.02.007","article-title":"Protein-protein interactions in the regulation of RAR-RXR heterodimers transcriptional activity","volume":"637","author":"le Maire","year":"2020","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbcan.2026.189667_bb0140","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.molcel.2005.03.026","article-title":"A ligand-activated nuclear localization signal in cellular retinoic acid binding protein-II","volume":"18","author":"Sessler","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbcan.2026.189667_bb0145","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1128\/MCB.22.8.2632-2641.2002","article-title":"Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest","volume":"22","author":"Budhu","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbcan.2026.189667_bb0150","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1016\/j.str.2024.09.020","article-title":"Structural requirements for the specific binding of CRABP2 to cyclin D3","volume":"32","author":"Pastok","year":"2024","journal-title":"Structure"},{"key":"10.1016\/j.bbcan.2026.189667_bb0155","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1134\/S0006297923120131","article-title":"Opposite effects of CRABP1 and CRABP2 homologs on proliferation of breast cancer cells and their sensitivity to retinoic acid","volume":"88","author":"Enikeev","year":"2023","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1016\/j.bbcan.2026.189667_bb0160","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13000-018-0686-z","article-title":"Tissue expression of retinoic acid receptor alpha and CRABP2 in metastatic nephroblastomas","volume":"13","author":"Percicote","year":"2018","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.bbcan.2026.189667_bb0165","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2217\/bmm.16.12","article-title":"Expression and clinicopathological correlations of retinoid acid receptor responder protein 1 in renal cell carcinomas","volume":"10","author":"Zimpfer","year":"2016","journal-title":"Biomark. Med."},{"key":"10.1016\/j.bbcan.2026.189667_bb0170","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1038\/s41416-020-0798-6","article-title":"Expression of RARRES1 and AGBL2 and progression of conventional renal cell carcinoma","volume":"122","author":"Peterfi","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbcan.2026.189667_bb0175","doi-asserted-by":"crossref","DOI":"10.3389\/ebm.2024.10167","article-title":"Single-cell RNA sequencing data locate ALDH1A2-mediated retinoic acid synthetic pathway to glomerular parietal epithelial cells","volume":"249","author":"Liu","year":"2024","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.bbcan.2026.189667_bb0180","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2311803121","article-title":"Retinoic acid receptor \u03b1 activity in proximal tubules prevents kidney injury and fibrosis","volume":"121","author":"DiKun","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbcan.2026.189667_bb0185","doi-asserted-by":"crossref","first-page":"F683","DOI":"10.1152\/ajprenal.00045.2021","article-title":"Disparate roles of retinoid acid signaling molecules in kidney disease","volume":"320","author":"Chen","year":"2021","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbcan.2026.189667_bb0190","doi-asserted-by":"crossref","first-page":"10045","DOI":"10.1074\/jbc.RA119.011614","article-title":"Agonist binding directs dynamic competition among nuclear receptors for heterodimerization with retinoid X receptor","volume":"295","author":"Fadel","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbcan.2026.189667_bb0195","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1006\/bbrc.2001.5640","article-title":"Expression of peroxisome proliferator-activated receptor gamma in renal cell carcinoma and growth inhibition by its agonists","volume":"287","author":"Inoue","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbcan.2026.189667_bb0200","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bbalip.2011.04.003","article-title":"Modulation of RXR function through ligand design","volume":"1821","author":"P\u00e9rez","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbcan.2026.189667_bb0205","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.urology.2004.10.019","article-title":"Ligands for peroxisome proliferator-activated receptor gamma have potent antitumor effect against human renal cell carcinoma","volume":"65","author":"Yuan","year":"2005","journal-title":"Urology"},{"key":"10.1016\/j.bbcan.2026.189667_bb0210","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/s41586-024-07812-3","article-title":"Mitochondrial complex I promotes kidney cancer metastasis","volume":"633","author":"Bezwada","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2026.189667_bb0215","doi-asserted-by":"crossref","DOI":"10.1172\/JCI162480","article-title":"Von Hippel-Lindau disease: insights into oxygen sensing, protein degradation, and cancer","volume":"132","author":"Kaelin","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2026.189667_bb0220","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1001\/jama.2024.12848","article-title":"Renal Cell Carcinoma","volume":"332","author":"Rose","year":"2024","journal-title":"JAMA"},{"key":"10.1016\/j.bbcan.2026.189667_bb0225","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.bbrc.2019.12.112","article-title":"VHL enhances 9-cis-retinoic acid treatment by down-regulating retinoid X receptor \u03b1 in renal cell carcinomas","volume":"523","author":"Wang","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbcan.2026.189667_bb0230","first-page":"331","article-title":"Predictive impact of retinoid X receptor-alpha-expression in renal-cell carcinoma","volume":"19","author":"Buentig","year":"2004","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.bbcan.2026.189667_bb0235","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241512089","article-title":"Deregulation of all-trans retinoic acid signaling and development in Cancer","volume":"24","author":"Brown","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2026.189667_bb0240","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1158\/1078-0432.CCR-04-1092","article-title":"Epigenetic modulation of retinoic acid receptor \u03b22 by the histone deacetylase inhibitor MS-275 in human renal cell carcinoma","volume":"11","author":"Wang","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189667_bb0245","doi-asserted-by":"crossref","first-page":"7264","DOI":"10.2174\/0929867327666200102115720","article-title":"Recent advances in multi-target drugs targeting protein kinases and histone deacetylases in cancer therapy","volume":"27","author":"Ling","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbcan.2026.189667_bb0250","first-page":"1077","article-title":"Expression of retinoic acid receptor beta in human renal cell carcinomas correlates with sensitivity to the antiproliferative effects of 13-cis-retinoic acid","volume":"2","author":"Hoffman","year":"1996","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189667_bb0255","first-page":"1671","article-title":"Up-regulation of retinoic acid receptor beta expression in renal cancers in vivo correlates with response to 13-cis-retinoic acid and interferon-alpha-2a","volume":"5","author":"Berg","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189667_bb0260","article-title":"Wilms' tumor: a review of clinical characteristics, treatment advances, and research opportunities","volume":"61","author":"Neagu","year":"2025","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.bbcan.2026.189667_bb0265","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/s41581-019-0112-0","article-title":"The genetic changes of Wilms tumour","volume":"15","author":"Treger","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bbcan.2026.189667_bb0270","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/1476-4598-10-136","article-title":"Retinoic acid pathway activity in Wilms tumors and characterization of biological responses in vitro","volume":"10","author":"Wegert","year":"2011","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbcan.2026.189667_bb0275","article-title":"Inhibition of GSK3 represses the expression of retinoic acid synthetic enzyme ALDH1A2 via Wnt\/\u03b2-catenin signaling in WiT49 cells","volume":"8","author":"Li","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbcan.2026.189667_bb0280","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.3390\/biomedicines13071678","article-title":"Epigenetic regulation in wilms tumor","volume":"13","author":"Bolitho","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbcan.2026.189667_bb0285","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.982045","article-title":"Interaction of RARRES1 with ICAM1 modulates macrophages to suppress the progression of kidney renal clear cell carcinoma","volume":"13","author":"Geng","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2026.189667_bb0290","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/j.juro.2007.05.119","article-title":"Prognostic significance of vitamin D receptor and retinoid X receptor expression in renal cell carcinoma","volume":"178","author":"Obara","year":"2007","journal-title":"J. Urol."},{"key":"10.1016\/j.bbcan.2026.189667_bb0295","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.molmet.2018.05.013","article-title":"PPAR\u03b3 is dispensable for clear cell renal cell carcinoma progression","volume":"14","author":"Sanchez","year":"2018","journal-title":"Mol Metab"},{"key":"10.1016\/j.bbcan.2026.189667_bb0300","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.3892\/ijo.2016.3460","article-title":"Hormone signaling pathways as treatment targets in renal cell cancer (review)","volume":"48","author":"Czarnecka","year":"2016","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbcan.2026.189667_bb0305","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/s41585-025-01056-0","article-title":"Molecular and therapeutic landscape of non-clear cell renal carcinoma","volume":"22","author":"Nepali","year":"2025","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.bbcan.2026.189667_bb0310","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.2147\/DDDT.S242557","article-title":"The PPAR\u03b3 agonist rosiglitazone enhances the radiosensitivity of human pancreatic cancer cells","volume":"14","author":"Wang","year":"2020","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.bbcan.2026.189667_bb0315","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12964-024-01492-2","article-title":"Cellular and micro-environmental responses influencing the antitumor activity of all-trans retinoic acid in breast cancer","volume":"22","author":"Caricasulo","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.bbcan.2026.189667_bb0320","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41416-024-02734-3","article-title":"Synthetic retinoid-mediated preconditioning of cancer-associated fibroblasts and macrophages improves cancer response to immune checkpoint blockade","volume":"131","author":"Owaki","year":"2024","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbcan.2026.189667_bb0325","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.ccell.2024.02.004","article-title":"Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells","volume":"42","author":"Colucci","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2026.189667_bb0330","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.4049\/jimmunol.1303245","article-title":"Modulation of T cell and innate immune responses by retinoic acid","volume":"192","author":"Raverdeau","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbcan.2026.189667_bb0335","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s00262-013-1432-8","article-title":"Blocking retinoic acid receptor-\u03b1 enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells","volume":"62","author":"Galvin","year":"2013","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.bbcan.2026.189667_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113933","article-title":"ATRA derived lipid nanoparticles for co-delivery of siCYP26A1 to overcome metabolic limitations of differentiation therapy in solid tumors","volume":"384","author":"Yang","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bbcan.2026.189667_bb0345","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/CJI.0b013e31805449a8","article-title":"Phase 1\/2 clinical trial of interferon alpha2b and weekly liposome-encapsulated all-trans retinoic acid in patients with advanced renal cell carcinoma","volume":"30","author":"Boorjian","year":"2007","journal-title":"J. Immunother."},{"key":"10.1016\/j.bbcan.2026.189667_bb0350","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3390\/biomedicines10030657","article-title":"Renal cell carcinoma in end-stage renal disease: a review and update","volume":"10","author":"El-Zaatari","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbcan.2026.189667_bb0355","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1200\/JCO.2005.07.114","volume":"23","author":"Aass","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2026.189667_bb0360","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1097\/00001813-200410000-00001","article-title":"Application of retinoids in the treatment of renal cell carcinoma--a futile effort?","volume":"15","author":"Schrader","year":"2004","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.bbcan.2026.189667_bb0365","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/pbc.21011","article-title":"A phase 2 trial of all-trans-retinoic acid in combination with interferon-alpha2a in children with recurrent neuroblastoma or wilms tumor: a pediatric oncology branch, NCI and children's oncology group study","volume":"49","author":"Adamson","year":"2007","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.bbcan.2026.189667_bb0370","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa1300874","article-title":"Gruppo italiano malattie ematologiche dell'Adulto, german-austrian acute myeloid leukemia study group, study alliance leukemia, retinoic acid and arsenic trioxide for acute promyelocytic leukemia","volume":"369","author":"Lo-Coco","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2026.189667_bb0375","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1182\/blood-2011-01-329433","article-title":"Missense mutations in PML-RARA are critical for the lack of responsiveness to arsenic trioxide treatment","volume":"118","author":"Goto","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bbcan.2026.189667_bb0380","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1159\/000078804","article-title":"All-trans retinoic acid and interferon-alpha for treatment of human renal cell carcinoma multicellular tumor spheroids","volume":"73","author":"Rohde","year":"2004","journal-title":"Urol. Int."},{"key":"10.1016\/j.bbcan.2026.189667_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.exphem.2025.104822","article-title":"Advances in RAR\u03b1 fusion genes in acute promyelocytic leukemia","volume":"149","author":"Zhang","year":"2025","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.bbcan.2026.189667_bb0390","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1056\/NEJM199910143411601","article-title":"Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group","volume":"341","author":"Matthay","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbcan.2026.189667_bb0395","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s10637-019-00880-7","article-title":"NCI 6896: a phase I trial of vorinostat (SAHA) and isotretinoin (13-cis retinoic acid) in the treatment of patients with advanced renal cell carcinoma","volume":"38","author":"Molina","year":"2020","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.bbcan.2026.189667_bb0400","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3109\/07357900009032812","article-title":"Interferon alpha-2a and 13-cis-retinoic acid in patients with metastatic renal cell cancer: original article","volume":"18","author":"Jacobs","year":"2000","journal-title":"Cancer Invest."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X26001393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X26001393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:22:12Z","timestamp":1789518132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304419X26001393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":80,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0304419X26001393"],"URL":"https:\/\/doi.org\/10.1016\/j.bbcan.2026.189667","relation":{},"ISSN":["0304-419X"],"issn-type":[{"value":"0304-419X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The dual role of retinoic acid signaling in clear cell renal cell carcinoma and wilms tumor: A tale of two entities","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbcan.2026.189667","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"189667"}}