{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:06:23Z","timestamp":1789520783886,"version":"build-2803163510"},"reference-count":151,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre Poland","doi-asserted-by":"publisher","award":["2024\/53\/B\/NZ5\/00143"],"award-info":[{"award-number":["2024\/53\/B\/NZ5\/00143"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbcan.2026.189670","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:20:55Z","timestamp":1785453655000},"page":"189670","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tumor-associated neutrophils crosstalk with non-cancerous components of the gastrointestinal tumor microenvironment"],"prefix":"10.1016","volume":"1881","author":[{"given":"Natalia","family":"\u0141ab\u0119d\u017a","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Jacenik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbcan.2026.189670_bb0005","series-title":"Gastrointestinal Cancers","year":"2022"},{"key":"10.1016\/j.bbcan.2026.189670_bb0010","doi-asserted-by":"crossref","DOI":"10.1002\/cncr.70245","article-title":"Gastrointestinal cancer statistics in 2022 and projection to 2050: GLOBOCAN estimates across 185 countries","volume":"132","author":"Danpanichkul","year":"2026","journal-title":"Cancer"},{"key":"10.1016\/j.bbcan.2026.189670_bb0015","author":"Cancer (IARC) TIA for R on"},{"key":"10.1016\/j.bbcan.2026.189670_bb0020","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bbcan.2026.189670_bb0025","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1200\/JCO.2010.27.9992","article-title":"Dual roles for immunity in gastrointestinal cancers","volume":"28","author":"Ferrone","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0030","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s43556-025-00361-9","article-title":"Gastrointestinal cancer: molecular pathogenesis and targeted therapy","volume":"6","author":"Jin","year":"2025","journal-title":"Mol. Biomed."},{"key":"10.1016\/j.bbcan.2026.189670_bb0035","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/s41577-021-00534-x","article-title":"The inflammatory pathogenesis of colorectal cancer","volume":"21","author":"Schmitt","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0040","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s11658-025-00744-4","article-title":"The heterogeneous roles of neutrophils in gastric cancer: scaffold or target?","volume":"30","author":"Qin","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.bbcan.2026.189670_bb0045","doi-asserted-by":"crossref","first-page":"32090","DOI":"10.1038\/s41598-025-13892-6","article-title":"Comprehensive analysis of the tumor immune microenvironment in gastric cancer and peritoneal metastasis based on single-cell RNA sequencing analysis","volume":"15","author":"Sun","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2026.189670_bb0050","article-title":"Immune microenvironment regulation and clinical immunotherapy strategies of metastatic liver cancer","volume":"16","author":"Liu","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0055","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.trecan.2021.01.012","article-title":"Liver inflammation and hepatobiliary cancers","volume":"7","author":"Leone","year":"2021","journal-title":"Trends Cancer"},{"key":"10.1016\/j.bbcan.2026.189670_bb0060","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41571-020-0363-5","article-title":"The tumour microenvironment in pancreatic cancer \u2014 clinical challenges and opportunities","volume":"17","author":"Ho","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0065","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bbcan.2026.189670_bb0070","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nrc.2016.52","article-title":"Neutrophils in cancer: neutral no more","volume":"16","author":"Coffelt","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbcan.2026.189670_bb0075","article-title":"Tumor-associated neutrophils as a new prognostic factor in cancer: a systematic review and meta-analysis","volume":"9","author":"Shen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2026.189670_bb0080","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1172\/JCI37223","article-title":"Neutrophils responsive to endogenous IFN-\u03b2 regulate tumor angiogenesis and growth in a mouse tumor model","volume":"120","author":"Jablonska","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2026.189670_bb0085","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/sj.neo.7900110","article-title":"Expression of interleukin-8 promotes neutrophil infiltration and genetic instability in mutatect tumors","volume":"2","author":"Haqqani","year":"2000","journal-title":"Neoplasia"},{"key":"10.1016\/j.bbcan.2026.189670_bb0090","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ccr.2009.06.017","article-title":"Polarization of tumor-associated neutrophil phenotype by TGF-\u03b2: \u201cN1\u201d versus \u201cN2\u201d TAN","volume":"16","author":"Fridlender","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2026.189670_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2016.00629","article-title":"The essential role of type I interferons in differentiation and activation of tumor-associated neutrophils","volume":"7","author":"Pylaeva","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0100","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/imr.13176","article-title":"N1 versus N2 and PMN-MDSC: a critical appraisal of current concepts on tumor-associated neutrophils and new directions for human oncology","volume":"314","author":"Antuamwine","year":"2023","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbcan.2026.189670_bb0105","first-page":"639","article-title":"N2 neutrophils and tumor progression in breast cancer: molecular pathways and implications","volume":"17","author":"Obeagu","year":"2025","journal-title":"Breast Cancer (Auckl.)"},{"key":"10.1016\/j.bbcan.2026.189670_bb0110","doi-asserted-by":"crossref","first-page":"5762","DOI":"10.1097\/MS9.0000000000003609","article-title":"N1 and N2 neutrophil subtypes in breast cancer: functional implications and clinical perspectives: a narrative review","volume":"87","author":"Obeagu","year":"2025","journal-title":"Ann. Med. Surg. (Lond.)"},{"key":"10.1016\/j.bbcan.2026.189670_bb0115","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.ajpath.2011.05.031","article-title":"Tumor-recruited neutrophils and neutrophil TIMP-free MMP-9 regulate coordinately the levels of tumor angiogenesis and efficiency of malignant cell intravasation","volume":"179","author":"Bekes","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0120","series-title":"Adv Exp Med Biol","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-030-35723-8_1","article-title":"Neutrophils in the tumor microenvironment","volume":"1224","author":"Wu","year":"2020"},{"key":"10.1016\/j.bbcan.2026.189670_bb0125","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1172\/JCI130952","article-title":"Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils","volume":"130","author":"Mahiddine","year":"2026","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2026.189670_bb0130","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ccr.2011.08.012","article-title":"Tumor entrained neutrophils inhibit seeding in the premetastatic lung","volume":"20","author":"Granot","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2026.189670_bb0135","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.freeradbiomed.2010.08.031","article-title":"Neutrophil-derived ROS contribute to oxidative DNA damage induction by quartz particles","volume":"49","author":"van Berlo","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbcan.2026.189670_bb0140","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aag1711","article-title":"Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps","volume":"8","author":"Park","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbcan.2026.189670_bb0145","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1158\/0008-5472.CAN-15-1591","article-title":"Neutrophil extracellular traps promote the development and progression of liver metastases after surgical stress","volume":"76","author":"Tohme","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189670_bb0150","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/pcmr.12818","article-title":"Evidence and impact of neutrophil extracellular traps in malignant melanoma","volume":"33","author":"Schedel","year":"2020","journal-title":"Pigm. Cell Melanoma Res."},{"key":"10.1016\/j.bbcan.2026.189670_bb0155","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1002\/ijc.30671","article-title":"NET-producing CD16high CD62Ldim neutrophils migrate to tumor sites and predict improved survival in patients with HNSCC","volume":"140","author":"Millrud","year":"2017","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbcan.2026.189670_bb0160","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ccell.2025.12.003","article-title":"Single-cell integration and multi-modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancer","volume":"44","author":"Marteau","year":"2026","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2026.189670_bb0165","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.ccell.2022.10.008","article-title":"High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer","volume":"40","author":"Salcher","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2026.189670_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.710704","article-title":"Neutrophil-lymphocyte ratio and circulating tumor cells counts predict prognosis in gastrointestinal cancer patients","volume":"11","author":"Qian","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0175","doi-asserted-by":"crossref","first-page":"32171","DOI":"10.18632\/oncotarget.16291","article-title":"Neutrophil-to-lymphocyte ratio as prognostic indicator in gastrointestinal cancers: a systematic review and meta-analysis","volume":"8","author":"Bowen","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbcan.2026.189670_bb0180","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s13046-024-03178-6","article-title":"Tumor-associated neutrophils upregulate Nectin2 expression, creating the immunosuppressive microenvironment in pancreatic ductal adenocarcinoma","volume":"43","author":"Luo","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189670_bb0185","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1136\/gutjnl-2016-313075","article-title":"Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway","volume":"66","author":"Wang","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.bbcan.2026.189670_bb0190","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1158\/1078-0432.CCR-16-2047","article-title":"The interplay between neutrophils and CD8+ T cells improves survival in human colorectal cancer","volume":"23","author":"Governa","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189670_bb0195","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/nm.3909","article-title":"The prognostic landscape of genes and infiltrating immune cells across human cancers","volume":"21","author":"Gentles","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbcan.2026.189670_bb0200","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1136\/jclinpath-2021-207702","article-title":"Clinicopathological significance of neutrophil-rich colorectal carcinoma","volume":"76","author":"Rottmann","year":"2023","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0205","doi-asserted-by":"crossref","first-page":"4326","DOI":"10.1158\/1078-0432.CCR-20-0071","article-title":"Prognostic significance of immune cell populations identified by machine learning in colorectal cancer using routine hematoxylin and eosin\u2013stained sections","volume":"26","author":"V\u00e4yrynen","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189670_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064814","article-title":"High myeloperoxidase positive cell infiltration in colorectal cancer is an independent favorable prognostic factor","volume":"8","author":"Droeser","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2026.189670_bb0215","doi-asserted-by":"crossref","DOI":"10.1186\/s10020-026-01555-9","article-title":"Prognostic significance and tumor cell interactions of tumor-associated neutrophils in gastric cancer","author":"Nam","year":"2026","journal-title":"Mol. Med."},{"key":"10.1016\/j.bbcan.2026.189670_bb0220","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1048922","article-title":"Cancer-associated fibroblasts, and clinicopathological characteristics and prognosis of gastric cancer: a systematic review and meta-analysis","volume":"13","author":"Wei","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0225","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.3390\/cancers17152484","article-title":"Cancer-associated fibroblasts: immunosuppressive crosstalk with tumor-infiltrating immune cells and implications for therapeutic resistance","volume":"17","author":"Pawar","year":"2025","journal-title":"Cancers"},{"key":"10.1016\/j.bbcan.2026.189670_bb0230","first-page":"793","article-title":"Cancer-associated fibroblasts in the single-cell era","volume":"3","author":"Lavie","year":"2022","journal-title":"Nat. Can."},{"key":"10.1016\/j.bbcan.2026.189670_bb0235","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.3390\/cancers13184720","article-title":"The role of cancer-associated fibroblasts in cancer invasion and metastasis","volume":"13","author":"Asif","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.bbcan.2026.189670_bb0240","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12964-023-01125-0","article-title":"What is new in cancer-associated fibroblast biomarkers?","volume":"21","author":"Zhao","year":"2023","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.bbcan.2026.189670_bb0245","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.3390\/cancers13051172","article-title":"Cancer-associated fibroblast-induced resistance to chemotherapy and radiotherapy in gastrointestinal cancers","volume":"13","author":"Ham","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.bbcan.2026.189670_bb0250","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41467-021-20982-2","article-title":"Stromal-driven and amyloid \u03b2-dependent induction of neutrophil extracellular traps modulates tumor growth","volume":"12","author":"Munir","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2026.189670_bb0255","article-title":"FGF19-induced inflammatory CAF promoted neutrophil extracellular trap formation in the liver metastasis of colorectal cancer","volume":"10","author":"Li","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bbcan.2026.189670_bb0260","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/s41419-018-0458-4","article-title":"Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma","volume":"9","author":"Cheng","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbcan.2026.189670_bb0265","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1245\/s10434-023-14586-x","article-title":"Cancer-associated fibroblast-derived IL-8 upregulates PD-L1 expression in gastric cancer through the NF-\u03baB pathway","volume":"31","author":"Lou","year":"2024","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0270","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.immuni.2020.03.001","article-title":"CXCR1 and CXCR2 chemokine receptor agonists produced by tumors induce neutrophil extracellular traps that interfere with immune cytotoxicity","volume":"52","author":"Teijeira","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.bbcan.2026.189670_bb0275","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1186\/s12885-022-09847-z","article-title":"Interleukin-8 produced from cancer-associated fibroblasts suppresses proliferation of the OCUCh-LM1 cancer cell line","volume":"22","author":"Tanaka","year":"2022","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bbcan.2026.189670_bb0280","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.147","article-title":"Role of chemokine systems in cancer and inflammatory diseases","volume":"3","author":"Li","year":"2022","journal-title":"MedComm"},{"key":"10.1016\/j.bbcan.2026.189670_bb0285","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.263","article-title":"The IL-6\u2013STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression","volume":"5","author":"Zhu","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbcan.2026.189670_bb0290","article-title":"Tumor-educated neutrophils activate mesenchymal stem cells to promote gastric cancer growth and metastasis","volume":"8","author":"Zhang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0295","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.semcancer.2019.06.003","article-title":"The multifaceted role of mesenchymal stem cells in cancer","volume":"60","author":"Timaner","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0300","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/cac2.12156","article-title":"The role of myeloid-derived suppressor cells in gastrointestinal cancer","volume":"41","author":"Cui","year":"2021","journal-title":"Cancer Commun."},{"key":"10.1016\/j.bbcan.2026.189670_bb0305","doi-asserted-by":"crossref","first-page":"12150","DOI":"10.1038\/ncomms12150","article-title":"Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards","volume":"7","author":"Bronte","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2026.189670_bb0310","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.it.2016.01.004","article-title":"The nature of myeloid-derived suppressor cells in the tumor microenvironment","volume":"37","author":"Kumar","year":"2016","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0315","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41389-022-00398-3","article-title":"Neutrophils and polymorphonuclear myeloid-derived suppressor cells: an emerging battleground in cancer therapy","volume":"11","author":"Raskov","year":"2022","journal-title":"Oncogenesis"},{"key":"10.1016\/j.bbcan.2026.189670_bb0320","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.smim.2017.12.004","article-title":"Neutrophils and PMN-MDSC: their biological role and interaction with stromal cells","volume":"35","author":"Zhou","year":"2018","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0325","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s12672-025-04244-x","article-title":"Research trends and emerging frontiers of tumor-associated macrophages in gastric cancer: a bibliometric analysis","volume":"17","author":"Han","year":"2025","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0330","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3390\/cells14100741","article-title":"Tumor-associated macrophages: polarization, immunoregulation, and immunotherapy","volume":"14","author":"Saeed","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.bbcan.2026.189670_bb0335","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41392-025-02325-5","article-title":"Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bbcan.2026.189670_bb0340","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41571-022-00620-6","article-title":"Clinical relevance of tumour-associated macrophages","volume":"19","author":"Pittet","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0345","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41586-022-05400-x","article-title":"Liver tumour immune microenvironment subtypes and neutrophil heterogeneity","volume":"612","author":"Xue","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2026.189670_bb0350","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/hep.29914","article-title":"Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in non-alcoholic steatohepatitis","volume":"68","author":"van der Windt","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.bbcan.2026.189670_bb0355","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1053\/j.gastro.2016.02.040","article-title":"Tumor-associated neutrophils recruit macrophages and T-regulatory cells to promote progression of hepatocellular carcinoma and resistance to sorafenib","volume":"150","author":"Zhou","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2026.189670_bb0360","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1002\/hep.30630","article-title":"A positive feedback loop between cancer stem-like cells and tumor-associated neutrophils controls hepatocellular carcinoma progression","volume":"70","author":"Zhou","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.bbcan.2026.189670_bb0365","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1089\/ten.tea.2017.0232","article-title":"The immunomodulatory role of BMP-2 on macrophages to accelerate osteogenesis","volume":"24","author":"Wei","year":"2018","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.bbcan.2026.189670_bb0370","article-title":"Protumor macrophage polarization mediated by BMP2\/4\u2013ACVR1 signaling orchestrates an immunosuppressive microenvironment during tumor initiation","author":"Wang","year":"2026","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189670_bb0375","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000023024","article-title":"TGF-\u03b22 is a prognostic biomarker correlated with immune cell infiltration in colorectal cancer","volume":"99","author":"Tu","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.bbcan.2026.189670_bb0380","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1158\/2326-6066.CIR-24-0534","article-title":"Neutrophil extracellular traps modulate recruitment and immunosuppression of macrophages in pancreatic adenocarcinoma","volume":"13","author":"Pratt","year":"2025","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.bbcan.2026.189670_bb0385","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.18632\/aging.202264","article-title":"Tumor-associated macrophages promote pancreatic ductal adenocarcinoma progression by inducing epithelial-to-mesenchymal transition","volume":"13","author":"Xiong","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bbcan.2026.189670_bb0390","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70054","article-title":"Single-cell characterization of differentiation trajectories and drug resistance features in gastric cancer with peritoneal metastasis","volume":"14","author":"Peng","year":"2024","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.bbcan.2026.189670_bb0395","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/HEP.0000000000000590","article-title":"Single-cell immune profiling of mouse liver aging reveals Cxcl2+ macrophages recruit neutrophils to aggravate liver injury","volume":"79","author":"Liu","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.bbcan.2026.189670_bb0400","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1186\/1471-2407-14-330","article-title":"Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner","volume":"14","author":"Xu","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bbcan.2026.189670_bb0405","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s12935-022-02717-5","article-title":"Crosstalk between tumor-associated macrophages and tumor cells promotes chemoresistance via CXCL5\/PI3K\/AKT\/mTOR pathway in gastric cancer","volume":"22","author":"Su","year":"2022","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.bbcan.2026.189670_bb0410","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41389-020-00249-z","article-title":"CXCL5 promotes gastric cancer metastasis by inducing epithelial-mesenchymal transition and activating neutrophils","volume":"9","author":"Mao","year":"2020","journal-title":"Oncogenesis"},{"key":"10.1016\/j.bbcan.2026.189670_bb0415","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/s41420-023-01524-9","article-title":"The role of CXCL family members in different diseases","volume":"9","author":"Zhou","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.bbcan.2026.189670_bb0420","article-title":"Multifaceted roles of chemokine C-X-C motif ligand 7 in inflammatory diseases and cancer","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0425","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3390\/molecules27010137","article-title":"Roles of the CXCL8-CXCR1\/2 axis in the tumor microenvironment and immunotherapy","volume":"27","author":"Han","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.bbcan.2026.189670_bb0430","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s40364-025-00807-w","article-title":"T cells in cancer: mechanistic insights and therapeutic advances","volume":"13","author":"Pu","year":"2025","journal-title":"Biomark. Res."},{"key":"10.1016\/j.bbcan.2026.189670_bb0435","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1186\/s12967-025-07097-8","article-title":"MNDA promotes immunosuppression in microsatellite instability-high colorectal cancer by facilitating PMN-MDSC infiltration via H3K18 lactylation","volume":"23","author":"Zhang","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbcan.2026.189670_bb0440","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2016.1258504","article-title":"CD13hi neutrophil-like myeloid-derived suppressor cells exert immune suppression through Arginase 1 expression in pancreatic ductal adenocarcinoma","volume":"6","author":"Zhang","year":"2017","journal-title":"OncoImmunology"},{"key":"10.1016\/j.bbcan.2026.189670_bb0445","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201910681","article-title":"Neutrophils suppress tumor-infiltrating T cells in colon cancer via matrix metalloproteinase-mediated activation of TGF\u03b2","volume":"12","author":"Germann","year":"2020","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bbcan.2026.189670_bb0450","doi-asserted-by":"crossref","first-page":"7316","DOI":"10.1038\/s41467-022-35096-6","article-title":"Inflammation promotes resistance to immune checkpoint inhibitors in high microsatellite instability colorectal cancer","volume":"13","author":"Sui","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbcan.2026.189670_bb0455","series-title":"Microsatellite Instable Colorectal Cancer: Molecular Insights and Therapeutic Advances","author":"Bassam","year":"2025"},{"key":"10.1016\/j.bbcan.2026.189670_bb0460","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1158\/2326-6066.CIR-19-0934","article-title":"Infiltration by IL22-producing T cells promotes neutrophil recruitment and predicts favorable clinical outcome in human colorectal cancer","volume":"8","author":"Tosti","year":"2020","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.bbcan.2026.189670_bb0465","series-title":"Molecular Biology of the Cell, 4th Edition","article-title":"Helper T cells and lymphocyte activation","author":"Alberts","year":"2002"},{"key":"10.1016\/j.bbcan.2026.189670_bb0470","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41392-023-01471-y","article-title":"T cells in health and disease","volume":"8","author":"Sun","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bbcan.2026.189670_bb0475","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.3390\/cancers15061650","article-title":"Role and potential of different T helper cell subsets in adoptive cell therapy","volume":"15","author":"Andreu-Sanz","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.bbcan.2026.189670_bb0480","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41416-022-02056-2","article-title":"Th2 cells inhibit growth of colon and pancreas cancers by promoting anti-tumorigenic responses from macrophages and eosinophils","volume":"128","author":"Jacenik","year":"2023","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbcan.2026.189670_bb0485","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.785222","article-title":"Neutrophil extracellular traps promote T cell exhaustion in the tumor microenvironment","volume":"12","author":"Kaltenmeier","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0490","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1548234","article-title":"Deciphering T-cell exhaustion in the tumor microenvironment: paving the way for innovative solid tumor therapies","volume":"16","author":"Nair","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0495","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/imm.12876","article-title":"Endoplasmic reticulum stress induced LOX-1+ CD15+ polymorphonuclear myeloid-derived suppressor cells in hepatocellular carcinoma","volume":"154","author":"Nan","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.bbcan.2026.189670_bb0500","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110978","article-title":"Reactive oxygen species in immune cells: a new antitumor target","volume":"133","author":"Wang","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbcan.2026.189670_bb0505","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2024.2318053","article-title":"Arginase-1 specific CD8+ T cells react toward malignant and regulatory myeloid cells","volume":"13","author":"Gl\u00f6ckner","year":"2024","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.bbcan.2026.189670_bb0510","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ejca.2020.03.013","article-title":"The prognostic value of tumour-infiltrating lymphocytes in pancreatic cancer: a systematic review and meta-analysis","volume":"132","author":"Orhan","year":"2020","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.bbcan.2026.189670_bb0515","doi-asserted-by":"crossref","first-page":"15179","DOI":"10.1038\/srep15179","article-title":"Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis","volume":"5","author":"Shang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbcan.2026.189670_bb0520","doi-asserted-by":"crossref","first-page":"6245","DOI":"10.1097\/JS9.0000000000002733","article-title":"Intratumoral IL-33+CD4+FoxP3+ regulatory T cell infiltration determines poor clinical outcomes and intensive immunoevasive contexture in patients with pancreatic cancer after surgical resection: a cohort study","volume":"111","author":"Pu","year":"2025","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.bbcan.2026.189670_bb0525","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1053\/j.gastro.2008.03.020","article-title":"A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4+CD25+Foxp3+ T cells","volume":"135","author":"Hoechst","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2026.189670_bb0530","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1158\/0008-5472.CAN-09-1882","article-title":"Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer","volume":"70","author":"Pan","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189670_bb0535","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.jhep.2021.07.032","article-title":"Regulatory T-cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis","volume":"75","author":"Wang","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0540","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115847","article-title":"PD-1+\/CXCR6+CD8+T lymphocytes promote MASLD malignant progression through inflammatory and immune dysregulation","volume":"168","author":"Wang","year":"2026","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0545","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s13046-015-0256-0","article-title":"Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1\/PD-1 signalling pathway in hepatocellular carcinoma","volume":"34","author":"He","year":"2015","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbcan.2026.189670_bb0550","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s00262-025-04049-5","article-title":"Unraveling the complex role of tumor-associated neutrophils within solid tumors","volume":"74","author":"Wang","year":"2025","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.bbcan.2026.189670_bb0555","article-title":"Targeting Deltex E3 ubiquitin ligase 2 inhibits tumor-associated neutrophils and sensitizes hepatocellular carcinoma cells to immunotherapy","volume":"12","author":"Wu","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bbcan.2026.189670_bb0560","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2025.2601394","article-title":"Neutrophil extracellular trap inhibition revitalizes PDAC immunotherapy responsiveness via reduced fibrosis and TCF1+CD8+ progenitor T-cell expansion","volume":"14","author":"Niemann","year":"2025","journal-title":"OncoImmunology"},{"key":"10.1016\/j.bbcan.2026.189670_bb0565","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41577-020-00452-4","article-title":"\u03b3\u03b4 T cells in tissue physiology and surveillance","volume":"21","author":"Ribot","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0570","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.3389\/fimmu.2019.01690","article-title":"Regulatory interactions between neutrophils, tumor cells and T cells","volume":"10","author":"Oberg","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0575","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/imm.12993","article-title":"Interleukin-17-producing \u03b3\u03b4 T (\u03b3\u03b417) cells in inflammatory diseases","volume":"155","author":"Akitsu","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.bbcan.2026.189670_bb0580","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.immuni.2014.03.013","article-title":"\u03b3\u03b4T17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer","volume":"40","author":"Wu","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.bbcan.2026.189670_bb0585","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2004990","article-title":"Tumor-associated neutrophils suppress pro-tumoral IL-17+ \u03b3\u03b4 T cells through induction of oxidative stress","volume":"16","author":"Mensurado","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0590","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/s41388-020-01561-z","article-title":"The role of natural killer cell in gastrointestinal cancer: killer or helper","volume":"40","author":"Wang","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.bbcan.2026.189670_bb0595","doi-asserted-by":"crossref","first-page":"9521","DOI":"10.3390\/ijms24119521","article-title":"NK cells in cancer: mechanisms of dysfunction and therapeutic potential","volume":"24","author":"Portale","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbcan.2026.189670_bb0600","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.cell.2018.10.014","article-title":"Anti-NKG2A mAb is a checkpoint inhibitor that promotes anti-tumor immunity by unleashing both T and NK cells","volume":"175","author":"Andr\u00e9","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2026.189670_bb0605","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02821","article-title":"Intrinsic expression of immune checkpoint molecule TIGIT could help tumor growth in vivo by suppressing the function of NK and CD8+ T cells","volume":"9","author":"Zhou","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0610","article-title":"Intra-tumoral NK cells and their association with patient outcomes: a novel prognostic model incorporating NK cells and clinicopathologic features in gastric cancer","volume":"16","author":"Oshi","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0615","article-title":"NK cell infiltration is associated with improved overall survival in solid cancers: a systematic review and meta-analysis","volume":"14","author":"Nersesian","year":"2020","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0620","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.97201.3","article-title":"Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived stem cell factor","volume":"13","author":"Mao","year":"2024","journal-title":"eLife"},{"key":"10.1016\/j.bbcan.2026.189670_bb0625","doi-asserted-by":"crossref","first-page":"5365","DOI":"10.1096\/fj.201701103R","article-title":"Angiogenin and the MMP9-TIMP2 axis are up-regulated in proangiogenic, decidual NK-like cells from patients with colorectal cancer","volume":"32","author":"Bruno","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.bbcan.2026.189670_bb0630","article-title":"Region-specific CD16+ neutrophils promote colorectal cancer progression by inhibiting natural killer cells","volume":"11","author":"Zhang","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bbcan.2026.189670_bb0635","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/hep.23054","article-title":"Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor","volume":"50","author":"Hoechst","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.bbcan.2026.189670_bb0640","doi-asserted-by":"crossref","first-page":"12621","DOI":"10.18632\/oncotarget.2181","article-title":"Neutrophils with protumor potential could efficiently suppress tumor growth after cytokine priming and in presence of normal NK cells","volume":"5","author":"Sun","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbcan.2026.189670_bb0645","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.mucimm.2023.03.006","article-title":"iNKT cell-neutrophil crosstalk promotes colorectal cancer pathogenesis","volume":"16","author":"Lattanzi","year":"2023","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0650","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2215\/CJN.09430915","article-title":"B cells, antibodies, and more","volume":"11","author":"Hoffman","year":"2016","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0655","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1649812","article-title":"The dual immunomodulatory role of B cells in tumorigenesis: mechanisms, microenvironment crosstalk, and therapeutic implications","volume":"16","author":"Lv","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0660","doi-asserted-by":"crossref","DOI":"10.1016\/j.imlet.2025.107064","article-title":"B cells are major players in cancer immunity","volume":"276","author":"Bouloudani","year":"2025","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.bbcan.2026.189670_bb0665","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.3390\/cancers17182996","article-title":"The role of tumor-infiltrating B lymphocytes in colorectal cancer patients: a systematic review of immune landscape evolution","volume":"17","author":"Fagarasan","year":"2025","journal-title":"Cancers"},{"key":"10.1016\/j.bbcan.2026.189670_bb0670","doi-asserted-by":"crossref","first-page":"46","DOI":"10.21037\/tgh-23-127","article-title":"B cells present a double-sided effect in digestive system tumors: a review for tumor microenvironment","volume":"9","author":"Xu","year":"2024","journal-title":"Transl. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0675","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ccell.2024.12.004","article-title":"Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10","volume":"43","author":"Lee","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbcan.2026.189670_bb0680","series-title":"Crossroads Innate Adapt Immun IV","first-page":"57","article-title":"Innate-Like B cells and their rules of engagement","author":"Baumgarth","year":"2013"},{"key":"10.1016\/j.bbcan.2026.189670_bb0685","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1158\/2326-6066.CIR-20-0839","article-title":"Tumor-associated neutrophils drive B-cell recruitment and their differentiation to plasma cells","volume":"9","author":"Shaul","year":"2021","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.bbcan.2026.189670_bb0690","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1615\/CritRevImmunol.v30.i6.30","article-title":"Endothelial cells as key determinants of the tumor microenvironment: interaction with tumor cells, extracellular matrix and immune killer cells","volume":"30","author":"Chouaib","year":"2010","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0695","doi-asserted-by":"crossref","DOI":"10.1097\/IN9.0000000000000043","article-title":"Dysfunctional intestinal microvascular endothelial cells: insights and therapeutic implications in gastrointestinal inflammation","volume":"6","author":"Park","year":"2024","journal-title":"Immunometabolism"},{"key":"10.1016\/j.bbcan.2026.189670_bb0700","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1338918","article-title":"Overcoming cancer risk in inflammatory bowel disease: new insights into preventive strategies and pathogenesis mechanisms including interactions of immune cells, cancer signaling pathways, and gut microbiota","volume":"14","author":"Zhang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0705","doi-asserted-by":"crossref","first-page":"12493","DOI":"10.1073\/pnas.0601807103","article-title":"Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis","volume":"103","author":"Nozawa","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbcan.2026.189670_bb0710","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1182\/blood-2012-04-421040","article-title":"VEGF-A recruits a proangiogenic MMP-9\u2013delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue","volume":"120","author":"Christoffersson","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bbcan.2026.189670_bb0715","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1001\/archsurg.134.12.1325","article-title":"Proinflammatory mediators stimulate neutrophil-directed angiogenesis","volume":"134","author":"McCourt","year":"1999","journal-title":"Arch. Surg."},{"key":"10.1016\/j.bbcan.2026.189670_bb0720","doi-asserted-by":"crossref","DOI":"10.1172\/JCI174545","article-title":"Tissue-specific reprogramming leads to angiogenic neutrophil specialization and tumor vascularization in colorectal cancer","volume":"134","author":"Bui","year":"2024","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2026.189670_bb0725","doi-asserted-by":"crossref","first-page":"21598","DOI":"10.1073\/pnas.2008112117","article-title":"Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer","volume":"117","author":"Itatani","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbcan.2026.189670_bb0730","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.cell.2024.02.005","article-title":"Neutrophil profiling illuminates anti-tumor antigen-presenting potency","volume":"187","author":"Wu","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.bbcan.2026.189670_bb0735","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/s42003-025-07958-4","article-title":"OPN3-mediated positive regulation of angiogenesis in HUVECs through VEGFR2 interaction","volume":"8","author":"Luo","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0740","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12964-023-01196-z","article-title":"Neutrophil extracellular traps promote angiogenesis in gastric cancer","volume":"21","author":"Yang","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.bbcan.2026.189670_bb0745","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.4049\/jimmunol.1900240","article-title":"Neutrophil extracellular trap\u2013associated CEACAM1 as a putative therapeutic target to prevent metastatic progression of colon carcinoma","volume":"204","author":"Rayes","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0750","article-title":"Reprogramming tumor-associated macrophages in gastric cancer: a pathway to enhanced immunotherapy","volume":"16","author":"He","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbcan.2026.189670_bb0755","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1038\/s41467-025-57465-7","article-title":"Antigen-presenting cancer associated fibroblasts enhance antitumor immunity and predict immunotherapy response","volume":"16","author":"Song","year":"2025","journal-title":"Nat. Commun."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X26001423?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304419X26001423?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:18:15Z","timestamp":1789517895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304419X26001423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":151,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0304419X26001423"],"URL":"https:\/\/doi.org\/10.1016\/j.bbcan.2026.189670","relation":{},"ISSN":["0304-419X"],"issn-type":[{"value":"0304-419X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tumor-associated neutrophils crosstalk with non-cancerous components of the gastrointestinal tumor microenvironment","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbcan.2026.189670","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"189670"}}