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Orthop. Surg. Res."},{"key":"10.1016\/j.bbcan.2026.189678_bb0700","doi-asserted-by":"crossref","unstructured":"Karabacak, M., Carr, M. T., Schupper, A. J., Bhimani, A. D., Steinberger, J., & Margetis, K. (n.d.). An interpretable machine learning approach to predict survival outcomes in spinal and sacropelvic chordomas. Spine, https:\/\/doi.org\/10.1097\/BRS.0000000000005002.","DOI":"10.1097\/BRS.0000000000005002"},{"issue":"1","key":"10.1016\/j.bbcan.2026.189678_bb0705","article-title":"Differences in stromal component of chordoma are associated with contrast enhancement in MRI and differential gene expression in RNA sequencing","volume":"12","author":"Park","year":"2022","journal-title":"Sci. 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