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L. et al. Esophageal organoids from human pluripotent stem cells delineate Sox2 functions during esophageal specification. Cell Stem Cell 23, 501\u2013515 e507 (2018). doi:https:\/\/doi.org\/10.1016\/j.stem.2018.08.008.","DOI":"10.1016\/j.stem.2018.08.008"},{"key":"10.1016\/j.bbcan.2026.189722_bb0470","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1172\/JCI89950","article-title":"Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells","volume":"127","author":"Hawkins","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbcan.2026.189722_bb0475","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.049541","article-title":"iPSCs derived from esophageal atresia patients reveal SOX2 dysregulation at the anterior foregut stage","volume":"15","author":"Raad","year":"2022","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bbcan.2026.189722_bb0480","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022493","article-title":"Barx1-mediated inhibition of Wnt signaling in the mouse thoracic foregut controls tracheo-esophageal septation and epithelial differentiation","volume":"6","author":"Woo","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbcan.2026.189722_bb0485","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.devcel.2005.01.015","article-title":"The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling","volume":"8","author":"Kim","year":"2005","journal-title":"Dev. 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Neurosci."},{"key":"10.1016\/j.bbcan.2026.189722_bb0505","first-page":"C171","article-title":"Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium","volume":"287","author":"Daniely","year":"2004","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.bbcan.2026.189722_bb0510","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/19539","article-title":"p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development","volume":"398","author":"Yang","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bbcan.2026.189722_bb0515","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1242\/dev.071191","article-title":"DeltaNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation","volume":"139","author":"Romano","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.bbcan.2026.189722_bb0520","doi-asserted-by":"crossref","first-page":"8105","DOI":"10.1073\/pnas.1221216110","article-title":"p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia","volume":"110","author":"Pignon","year":"2013","journal-title":"Proc. Natl. Acad. Sci. 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Cell Biol."},{"key":"10.1016\/j.bbcan.2026.189722_bb0595","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.gastro.2005.06.007","article-title":"Expression pattern of Wnt signaling components in the adult intestine","volume":"129","author":"Gregorieff","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbcan.2026.189722_bb0600","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1101\/gad.1674008","article-title":"The intestinal stem cell","volume":"22","author":"Barker","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbcan.2026.189722_bb0605","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1073\/pnas.1113890109","article-title":"Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells","volume":"109","author":"Kim","year":"2012","journal-title":"Proc. Natl. Acad. Sci. 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Med."},{"key":"10.1016\/j.bbcan.2026.189722_bb0675","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2019.04.007","article-title":"Achalasia and associated esophageal cancer risk: what lessons can we learn from the molecular analysis of Barrett\u2019s-associated adenocarcinoma?","volume":"1872","author":"Nesteruk","year":"2019","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.bbcan.2026.189722_bb0680","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112238","article-title":"HOXA13 promotes colon cancer progression through beta-catenin-dependent WNT pathway","volume":"395","author":"Gu","year":"2020","journal-title":"Exp. 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