{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:26:56Z","timestamp":1760236016418,"version":"build-2065373602"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.bbi.2006.06.001","type":"journal-article","created":{"date-parts":[[2006,7,22]],"date-time":"2006-07-22T07:17:05Z","timestamp":1153552625000},"page":"112-124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Uncovering molecular elements of brain\u2013body communication during development and treatment of neuropathic pain"],"prefix":"10.1016","volume":"21","author":[{"given":"Reeteka","family":"Sud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracey A.","family":"Ignatowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crystal P.K.","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert N.","family":"Spengler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2006.06.001_bib1","unstructured":"Ariniello, L., 1999. Neuropathic Pain (Society for Neuroscience)."},{"key":"10.1016\/j.bbi.2006.06.001_bib2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2006.06.001_bib3","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1469-7793.1999.0439m.x","article-title":"Presynaptic alpha2-adrenoreceptors control excitatory, but not inhibitory, transmission at rat hippocampal synapses","volume":"519","author":"Boehm","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbi.2006.06.001_bib4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/neu.20085","article-title":"Functional imaging of the human trigeminal system: opportunities for new insights into pain processing in health and disease","volume":"61","author":"Borsook","year":"2004","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.bbi.2006.06.001_bib5","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1002\/hup.621","article-title":"Clinical experience with dual action antidepressants in different chronic pain syndromes","volume":"19","author":"Briley","year":"2004","journal-title":"Human Psychopharmacol."},{"key":"10.1016\/j.bbi.2006.06.001_bib6","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.pain.2004.10.006","article-title":"Acute and persistent pain modulation of attention-related anterior cingulate fMRI activations","volume":"113","author":"Buffington","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2006.06.001_bib7","doi-asserted-by":"crossref","first-page":"H69","DOI":"10.1152\/ajpheart.01223.2003","article-title":"Distinct cAMP signaling pathways differentially regulate alpha(2C)-adrenoceptor expression: role in serum induction in human arteriolar smooth muscle cells","volume":"288","author":"Chotani","year":"2005","journal-title":"Am. J. Physiol. - Heart & Circulatory Physiol."},{"key":"10.1016\/j.bbi.2006.06.001_bib8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0006-8993(00)01965-X","article-title":"Brain-derived TNFalpha: involvement in neuroplastic changes implicated in the conscious perception of persistent pain","volume":"859","author":"Covey","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2006.06.001_bib9","first-page":"357","article-title":"Expression of neuron-associated tumor necrosis factor alpha in the brain is increased during persistent pain","volume":"27","author":"Covey","year":"2002","journal-title":"Reg. Anesth. Pain Med."},{"key":"10.1016\/j.bbi.2006.06.001_bib10","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.expneurol.2004.11.002","article-title":"Tumor necrosis factor receptor 1 and 2 proteins are differentially regulated during Wallerian degeneration of mouse sciatic nerve","volume":"192","author":"George","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbi.2006.06.001_bib11","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia","volume":"32","author":"Hargreaves","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2006.06.001_bib12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0165-5728(96)00098-7","article-title":"Changes in noradrenergic sensitivity to tumor necrosis factor-alpha in brains of rats administered clonidine","volume":"70","author":"Ignatowski","year":"1996","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2006.06.001_bib13","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0006-8993(99)01782-5","article-title":"Brain-derived TNFalpha mediates neuropathic pain","volume":"841","author":"Ignatowski","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2006.06.001_bib14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0165-5728(97)00107-0","article-title":"Neuronal-associated tumor necrosis factor (TNF alpha): its role in noradrenergic functioning and modification of its expression following antidepressant drug administration","volume":"79","author":"Ignatowski","year":"1997","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2006.06.001_bib15","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0006-8993(94)91350-1","article-title":"Tumor necrosis factor-alpha: presynaptic sensitivity is modified after antidepressant drug administration","volume":"665","author":"Ignatowski","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2006.06.001_bib16","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.neuropharm.2004.11.001","article-title":"The dissipation of neuropathic pain paradoxically involves the presence of tumor necrosis factor-alpha","volume":"48","author":"Ignatowski","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbi.2006.06.001_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0304-3959(89)90047-X","article-title":"Noxious stimuli produce prolonged changes in CA1 region of the rat hippocampus","volume":"39","author":"Khanna","year":"1989","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2006.06.001_bib18","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1126\/science.305.5682.326","article-title":"Prolonging the Agony","volume":"305","author":"Marx","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.bbi.2006.06.001_bib19","first-page":"R821","article-title":"Abrogation of alpha-adrenergic vasoactivity in chronically inflamed rat knee joints","volume":"281","author":"McDougall","year":"2001","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbi.2006.06.001_bib20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1749-6632.2001.tb05830.x","article-title":"Plasticity of the hippocampus: adaptation to chronic stress and allostatic load","volume":"933","author":"McEwen","year":"2001","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.bbi.2006.06.001_bib21","doi-asserted-by":"crossref","first-page":"9703","DOI":"10.1074\/jbc.272.15.9703","article-title":"The second intracellular loop of the alpha2-adrenergic receptors determines subtype-specific coupling to cAMP production","volume":"272","author":"Nasman","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbi.2006.06.001_bib22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0165-5728(00)00244-7","article-title":"Antidepressant drug administration modifies the interactive relationship between alpha(2)-adrenergic sensitivity and levels of TNF in the rat brain","volume":"107","author":"Nickola","year":"2000","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2006.06.001_bib23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00004770-200102000-00001","article-title":"Quantitation of catecholamines in inflamed human dental pulp by high-performance liquid chromatography","volume":"27","author":"Nup","year":"2001","journal-title":"J. Endodontics"},{"key":"10.1016\/j.bbi.2006.06.001_bib24","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1097\/00007632-200405150-00006","article-title":"TNF-\u03b1 and TNF-\u03b1 receptor type 1 upregulation in glia and neurons after peripheral nerve injury. Studies in murine DRG and spinal cord","volume":"29","author":"Ohtori","year":"2004","journal-title":"Spine"},{"key":"10.1016\/j.bbi.2006.06.001_bib25","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1046\/j.1460-9568.2003.02626.x","article-title":"Tumor necrosis factor receptor type-1 in sensory neurons contributes to induction of chronic enhancement of inflammatory hyperalgesia in rat","volume":"17","author":"Parada","year":"2003","journal-title":"Eur. J. Neurosci."},{"year":"1996","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","key":"10.1016\/j.bbi.2006.06.001_bib26"},{"key":"10.1016\/j.bbi.2006.06.001_bib27","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.brainres.2004.01.029","article-title":"Alpha 2-adrenergic receptor inhibition of cAMP accumulation is transformed to facilitation by tumor necrosis factor-alpha","volume":"1004","author":"Renauld","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2006.06.001_bib28","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/jnr.10101","article-title":"Tumor necrosis factor expressed by primary hippocampal neurons and SH-SY5Y cells is regulated by alpha(2)-adrenergic receptor activation","volume":"67","author":"Renauld","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbi.2006.06.001_bib29","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.brainres.2004.07.028","article-title":"Amitriptyline administration transforms tumor necrosis factor-alpha regulation of norepinephrine release in the brain","volume":"1023","author":"Reynolds","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2006.06.001_bib30","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/jnr.20407","article-title":"Effect of tumor necrosis factor-alpha on the reciprocal G-protein-induced regulation of norepinephrine release by the alpha(2)-adrenergic receptor","volume":"79","author":"Reynolds","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbi.2006.06.001_bib31","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1124\/jpet.104.067835","article-title":"Brain-derived tumor necrosis factor-alpha and its involvement in noradrenergic neuron functioning involved in the mechanism of action of an antidepressant","volume":"310","author":"Reynolds","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbi.2006.06.001_bib32","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.neuroscience.2005.02.023","article-title":"An antidepressant mechanism of desipramine is to decrease tumor necrosis factor-alpha production culminating in increases in noradrenergic neurotransmission","volume":"133","author":"Reynolds","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2006.06.001_bib33","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/08869634.2003.11746254","article-title":"Clinical evaluation of amitriptyline for the control of chronic pain caused by temporomandibular joint disorder","volume":"21","author":"Rizzati-Barbosa","year":"2003","journal-title":"Cranio"},{"key":"10.1016\/j.bbi.2006.06.001_bib34","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s004010050583","article-title":"Chronic constriction model of rat sciatic nerve: nerve blood flow, morphologic and biochemical alterations","volume":"93","author":"Sasaki","year":"1997","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbi.2006.06.001_bib35","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0304-3940(03)00695-5","article-title":"Spinal nerve ligation induces transient upregulation of tumor necrosis factor receptors 1 and 2 in injured and adjacent uninjured dorsal root ganglia in the rat","volume":"347","author":"Schafers","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbi.2006.06.001_bib36","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0169-328X(94)90386-7","article-title":"Distribution of alpha 2-adrenergic receptor subtype gene expression in rat brain","volume":"21","author":"Scheinin","year":"1994","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.bbi.2006.06.001_bib37","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1471-4159.1986.tb12961.x","article-title":"Beta2-adrenergic receptors on peripheral nerves","volume":"46","author":"Schreurs","year":"1986","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbi.2006.06.001_bib38","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0306-4522(93)90186-J","article-title":"Cyclic AMP modulates but does not mediate the inhibition of [3H] norepinephrine release by activation of alpha-2 adrenergic receptors in cultured rat ganglion cells","volume":"52","author":"Schwartz","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2006.06.001_bib39","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.4049\/jimmunol.148.11.3441","article-title":"Regulation of tumor-necrosis-factor production by adrenaline and beta-adrenergic agonists","volume":"148","author":"Severn","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2006.06.001_bib40","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/exnr.1998.6797","article-title":"Hyperalgesia in experimental neuropathy is dependent on the TNF receptor 1","volume":"151","author":"Sommer","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbi.2006.06.001_bib41","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.4049\/jimmunol.145.5.1430","article-title":"Stimulation of alpha-adrenergic receptor augments the production of macrophage-derived tumor-necrosis-factor","volume":"145","author":"Spengler","year":"1990","journal-title":"J. Immunol."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159106002509?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159106002509?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:16:22Z","timestamp":1760166982000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159106002509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0889159106002509"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2006.06.001","relation":{},"ISSN":["0889-1591"],"issn-type":[{"type":"print","value":"0889-1591"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Uncovering molecular elements of brain\u2013body communication during development and treatment of neuropathic pain","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2006.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}