{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:05:06Z","timestamp":1789826706983,"version":"4.0.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.bbi.2007.01.001","type":"journal-article","created":{"date-parts":[[2007,2,9]],"date-time":"2007-02-09T07:06:04Z","timestamp":1171004764000},"page":"767-774","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":114,"title":["Buprenorphine ameliorates the effect of surgery on hypothalamus\u2013pituitary\u2013adrenal axis, natural killer cell activity and metastatic colonization in rats in comparison with morphine or fentanyl treatment"],"prefix":"10.1016","volume":"21","author":[{"given":"Silvia","family":"Franchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto E.","family":"Panerai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Sacerdote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2007.01.001_bib1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0165-5728(95)00159-X","article-title":"Inhibition of primary murine macrophage cytokine production in vitro following treatment with the kappa-opioid agonist U50-488H","volume":"64","author":"Alicea","year":"1996","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2007.01.001_bib2","first-page":"492","article-title":"Effect of anesthesia based on large versus small doses of fentanyl on natural killer cell cytotoxicity in the perioperative period","volume":"82","author":"Beilin","year":"1996","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.bbi.2007.01.001_bib3","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1213\/01.ANE.0000078586.82810.3B","article-title":"The effects of postoperative pain management on immune responses to surgery","volume":"97","author":"Beilin","year":"2003","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.bbi.2007.01.001_bib4","first-page":"578","article-title":"The price of anticancer intervention. Does surgery promote metastasis","volume":"3","author":"Ben-Eliyahu","year":"2002","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.bbi.2007.01.001_bib5","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/(SICI)1097-0215(19990315)80:6<880::AID-IJC14>3.0.CO;2-Y","article-title":"Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activity","volume":"80","author":"Ben-Eliyahu","year":"1999","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbi.2007.01.001_bib6","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0002-9610(94)90070-1","article-title":"Perioperative immunomodulation in cancer surgery","volume":"167","author":"Colacchio","year":"1994","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.bbi.2007.01.001_bib7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1521-6616(03)00177-3","article-title":"No detrimental effect from chronic exposure to buprenorphine on corticosteroid-binding globulin and corticosensitive immune parameters","volume":"109","author":"D\u2019Elia","year":"2003","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.bbi.2007.01.001_bib8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0165-5728(97)00219-1","article-title":"Opioid modulation of immune responses: effects on phagocyte and lymphoid cell populations","volume":"83","author":"Eisenstein","year":"1998","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2007.01.001_bib9","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.2165\/00003495-200363190-00003","article-title":"Transdermal buprenorphine","volume":"63","author":"Evans","year":"2003","journal-title":"Drugs"},{"key":"10.1016\/j.bbi.2007.01.001_bib10","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S0022-3565(25)12317-3","article-title":"Assessment of the involvement of central nervous system and peripheral opioid receptors in the immunomodulatory effects of acute morphine treatment in rats","volume":"276","author":"Fecho","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbi.2007.01.001_bib11","first-page":"633","article-title":"A mechanism of action for morphine-induced immunosuppression: corticosterone mediates morphine-induced suppression of natural killer activity","volume":"277","author":"Freier","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbi.2007.01.001_bib12","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/(SICI)1097-0142(19970201)79:3<474::AID-CNCR8>3.0.CO;2-I","article-title":"Autologous tumor killing activity as a prognostic factor in primary resected non small carcinoma of the lung","volume":"79","author":"Fujisawa","year":"1997","journal-title":"Cancer"},{"key":"10.1016\/j.bbi.2007.01.001_bib13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0165-5728(02)00165-0","article-title":"The analgesic drug tramadol prevents the effect of surgery on natural killer cell activity and metastatic colonization in rats","volume":"129","author":"Gaspani","year":"2002","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2007.01.001_bib14","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0165-5728(02)00419-8","article-title":"Enhanced humoral response in kappa-opioid receptor knock-out mice","volume":"134","author":"Gaveriaux Ruff","year":"2003","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2007.01.001_bib15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0162-3109(00)00198-3","article-title":"Differential effects of buprenorphine and morphine on immune and neuroendocrine functions following acute administration in the rat mesencephalon periacqueductal gray","volume":"48","author":"Gomez-Flores","year":"2000","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.bbi.2007.01.001_bib16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/ijc.2910300118","article-title":"Role of NK cells in the control of metastatic spread and growth of tumor cells in mice","volume":"30","author":"Gorelik","year":"1982","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbi.2007.01.001_bib17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0165-5728(97)00218-X","article-title":"Opioid mediated effects on the immune system: sympathetic nervous system involvement","volume":"83","author":"Hall","year":"1998","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2007.01.001_bib18","first-page":"213","article-title":"The role of natural killer cells in the control of tumor growth and metastasis","volume":"780","author":"Hanna","year":"1985","journal-title":"Biochem. Biophys. Acta"},{"key":"10.1016\/j.bbi.2007.01.001_bib19","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0002-9610(84)90459-8","article-title":"Altered helper and suppressor lymphocyte populations in surgical patients. A measure of postoperative immunosuppression","volume":"148","author":"Hansbrough","year":"1984","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.bbi.2007.01.001_bib20","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0014-2999(85)90186-4","article-title":"Effect of mu and kappa opioid receptor agonists on rat plasma corticosterone levels","volume":"116","author":"Hayes","year":"1985","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbi.2007.01.001_bib21","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1126\/science.7025208","article-title":"Natural killer cells: their role in defenses against disease","volume":"214","author":"Herberman","year":"1981","journal-title":"Science"},{"key":"10.1016\/j.bbi.2007.01.001_bib22","first-page":"190","article-title":"Preoperative natural killer cell activity: correlation with distant metastasis in curatively research colorectal carcinomas","volume":"82","author":"Koda","year":"1997","journal-title":"Int. Surg."},{"key":"10.1016\/j.bbi.2007.01.001_bib23","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/bjs.1800721002","article-title":"The influence of surgical operations on components of the human immune system","volume":"72","author":"Lennard","year":"1985","journal-title":"Br. J. Surg."},{"key":"10.1016\/j.bbi.2007.01.001_bib24","first-page":"199","article-title":"Prognostic risk assessment in primary breast cancer by behavioral and immunological parameters","volume":"150","author":"Levy","year":"1985","journal-title":"Health Psychol."},{"key":"10.1016\/j.bbi.2007.01.001_bib25","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.1016\/j.jpainsymman.2005.01.012","article-title":"Pharmacokinetic-pharmacodynamic modeling of opioids","volume":"29","author":"Lotsch","year":"2005","journal-title":"J Pain Symptom. Manage."},{"key":"10.1016\/j.bbi.2007.01.001_bib26","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.pain.2004.04.020","article-title":"Chronic fentanyl or buprenorphine infusion in the mouse: similar analgesic profile but different effects on immune responses","volume":"110","author":"Martucci","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2007.01.001_bib27","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bbi.2004.07.004","article-title":"Marginating pulmonary NK activity and resistance to experimental tumor metastasis: suppression by surgery and the prophylactic use of a beta-adrenergic antagonist and prostaglandin synthesis inhibitors","volume":"19","author":"Melamed","year":"2005","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2007.01.001_bib28","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1007\/s00213-005-2239-x","article-title":"Randomized clinical trial to compare the effect s of metadone and buprenorphine on the immune system in drug abusers","volume":"179","author":"Neri","year":"2005","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbi.2007.01.001_bib29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0090-9556(25)08299-6","article-title":"Pharmacokinetic analysis of entherohepatic circulation of buprenorphine and its active metabolite, norbuprenorphine, in rats","volume":"22","author":"Ohtani","year":"1994","journal-title":"Drug. Metab. Dispos."},{"key":"10.1016\/j.bbi.2007.01.001_bib30","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/brbi.1994.1022","article-title":"The role of LGL, NK cells in surgery induced promotion of metastasis and its attenuation by morphine","volume":"8","author":"Page","year":"1994","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2007.01.001_bib31","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0165-5728(95)00132-8","article-title":"The development of sexual dimorphism in natural killer cell activity and resistance to tumor metastasis in the Fisher 344 rat","volume":"63","author":"Page","year":"1995","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2007.01.001_bib32","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/bja\/81.2.216","article-title":"Pre-operative versus postoperative administration of morphine: impact on the neuroendocrine, behavioural and metastatic-enhancing effects of surgery","volume":"81","author":"Page","year":"1998","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.bbi.2007.01.001_bib33","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0304-3959(00)00403-6","article-title":"Evidence that post-operative pain is a mediator of the tumor promoting effects of surgery in rats","author":"Page","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2007.01.001_bib34","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1001\/archsurg.1994.01420330087016","article-title":"Effects of major and minor surgery on plasma glutamine and cytokine levels","volume":"129","author":"Payne","year":"1992","journal-title":"Arch. Surg."},{"key":"10.1016\/j.bbi.2007.01.001_bib35","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0006-2952(93)90508-T","article-title":"Mechanism of morphine-induced immunomodulation","volume":"46","author":"Peterson","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbi.2007.01.001_bib36","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1001\/archsurg.1991.01410270082013","article-title":"Mechanism of surgical stress impairment of human perioperative natural killer cell cytotoxicity","volume":"126","author":"Pollok","year":"1991","journal-title":"Arch. Surg."},{"key":"10.1016\/j.bbi.2007.01.001_bib37","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/00008877-200411000-00002","article-title":"Behaviour-based assessment of the duration of laparotomy-induced abdominal pain and the analgesic effects of carprofen and buprenorphine in rats","volume":"15","author":"Roughan","year":"2004","journal-title":"Behavioural Pharmacol."},{"key":"10.1016\/j.bbi.2007.01.001_bib38","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/sj.bjp.0701138","article-title":"Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity study","volume":"121","author":"Sacerdote","year":"1997","journal-title":"Br. J . Pharmacol."},{"key":"10.1016\/j.bbi.2007.01.001_bib39","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0304-3959(97)00055-9","article-title":"Effects of tramadol on immune responses and nociceptive thresholds in mice","volume":"72","author":"Sacerdote","year":"1997","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2007.01.001_bib40","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1097\/00000539-200006000-00028","article-title":"Effect of tramadol and morphine on immune responses and pain after surgery in cancer patients","volume":"90","author":"Sacerdote","year":"2000","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.bbi.2007.01.001_bib41","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1093\/infdis\/166.6.1459","article-title":"Impaired humoral immunity is associated with development of methicillin-resistant Staphylococcus aureus infections after esophageal surgery","volume":"166","author":"Saito","year":"1992","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bbi.2007.01.001_bib42","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF00199955","article-title":"Evidence for the role of natural immunity in the control of metastatic spread of head and neck cancer","volume":"25","author":"Schantz","year":"1987","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.bbi.2007.01.001_bib43","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000078444","article-title":"Effects of fentanyl on natural killer cell activity and on resistance to tumor metastasis in rats","volume":"11","author":"Shavit","year":"2004","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.bbi.2007.01.001_bib44","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1001\/archsurg.1987.01400230050009","article-title":"The prognostic significance of natural killer cytotoxicity in patients with colorectal cancer","volume":"122","author":"Tartre","year":"1987","journal-title":"Arch. Surg."},{"key":"10.1016\/j.bbi.2007.01.001_bib45","first-page":"1125","article-title":"Molecular response to surgical stress: specific and simultaneous heat shock protein induction in the adrenal cortex, aorta and vena cava","volume":"110","author":"Udelsman","year":"1991","journal-title":"Surgery"},{"key":"10.1016\/j.bbi.2007.01.001_bib46","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/01.mjt.0000132250.95650.85","article-title":"Opioid therapy and immunosuppression","volume":"11","author":"Vallejo","year":"2004","journal-title":"Am. J. Ther."},{"key":"10.1016\/j.bbi.2007.01.001_bib47","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1189\/jlb.71.5.782","article-title":"The immunosuppressive effects of chronic morphine treatment are partially dependent on corticosterone and mediated by the mu opioid receptor","volume":"71","author":"Wang","year":"2002","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bbi.2007.01.001_bib48","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.4049\/jimmunol.134.6.4267","article-title":"Role of organ-associated NK cells in decreased formation of experimental metastases in lung and liver","volume":"134","author":"Wiltrout","year":"1985","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2007.01.001_bib49","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1124\/jpet.104.082560","article-title":"Pharmacokinetic\u2013pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: Role of receptor equilibration kinetics","volume":"313","author":"Yassen","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbi.2007.01.001_bib50","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1001\/archsurg.1991.01410280056007","article-title":"Effect of morphine on growth of metastatic colon cancer in vivo","volume":"126","author":"Yeager","year":"1991","journal-title":"Arch. Surg."},{"key":"10.1016\/j.bbi.2007.01.001_bib51","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/00000542-199509000-00008","article-title":"Morphine inhibits spontaneous and cytokine enhanced natural killer cell cytotoxicity in volunteers","volume":"83","author":"Yeager","year":"1996","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bbi.2007.01.001_bib52","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/BF03020942","article-title":"Intrathecal morphine suppresses NK activity following abdominal surgery","volume":"47","author":"Yokota","year":"2000","journal-title":"Can. J. Anaesth."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159107000037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159107000037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:17:21Z","timestamp":1760167041000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159107000037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S0889159107000037"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2007.01.001","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Buprenorphine ameliorates the effect of surgery on hypothalamus\u2013pituitary\u2013adrenal axis, natural killer cell activity and metastatic colonization in rats in comparison with morphine or fentanyl treatment","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2007.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}