{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:10:31Z","timestamp":1791198631453,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.bbi.2008.04.001","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T04:33:49Z","timestamp":1210739629000},"page":"1087-1095","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":144,"title":["Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior"],"prefix":"10.1016","volume":"22","author":[{"given":"Ma\u00eft\u00e9","family":"Moreau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Andr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C.","family":"O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara A.","family":"Dumich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith W.","family":"Kelley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Dantzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Lestage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Castanon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2008.04.001_bib1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/07853890310004075","article-title":"Cytokines, stress and depressive illness: brain\u2013immune interactions","volume":"35","author":"Anisman","year":"2003","journal-title":"Ann. Med."},{"key":"10.1016\/j.bbi.2008.04.001_bib2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/00004714-200202000-00014","article-title":"Increased depressive ratings in patients with hepatitis C receiving interferon-alpha-based immunotherapy are related to interferon-alpha-induced changes in the serotonergic system","volume":"22","author":"Bonaccorso","year":"2002","journal-title":"J. Clin. Psychopharmacol."},{"issue":"Suppl 3","key":"10.1016\/j.bbi.2008.04.001_bib3","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1086\/314072","article-title":"Preventing tuberculosis with Bacillus Calmette-Guerin vaccine: a meta-analysis of the literature","volume":"31","author":"Brewer","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.bbi.2008.04.001_bib4","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1200\/JCO.2000.18.10.2143","article-title":"Early depressive symptoms in cancer patients receiving interleukin 2 and\/or interferon alfa-2b therapy","volume":"18","author":"Capuron","year":"2000","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbi.2008.04.001_bib5","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0306-4530(01)00030-0","article-title":"Association between immune activation and early depressive symptoms in cancer patients treated with interleukin-2-based therapy","volume":"26","author":"Capuron","year":"2001","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbi.2008.04.001_bib6","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0893-133X(01)00407-9","article-title":"Neurobehavioral effects of interferon-alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions","volume":"26","author":"Capuron","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2008.04.001_bib7","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/sj.mp.4000995","article-title":"Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy","volume":"7","author":"Capuron","year":"2002","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2008.04.001_bib8","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0006-3223(03)00173-2","article-title":"Interferon-alpha-induced changes in tryptophan metabolism. Relationship to depression and paroxetine treatment","volume":"54","author":"Capuron","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2008.04.001_bib9","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0889-1591(02)00008-9","article-title":"Effects of antidepressants on cytokine production and actions","volume":"16","author":"Castanon","year":"2002","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2008.04.001_bib10","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1084\/jem.133.2.362","article-title":"Measurement of resistance to experimental tuberculosis in albino mice. The immune phase","volume":"133","author":"Costello","year":"1971","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbi.2008.04.001_bib60","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/sj.mp.4001457","article-title":"In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice","volume":"9","author":"Cryan","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2008.04.001_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/YCO.0b013e3280117733","article-title":"Animal models of mood disorders: Recent developments","volume":"20","author":"Cryan","year":"2007","journal-title":"Curr. Opin. Psychiatry"},{"key":"10.1016\/j.bbi.2008.04.001_bib12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0891-5849(00)00341-5","article-title":"Tryptophan metabolism through the kynurenine pathway in rat brain and liver slices","volume":"29","author":"Dale","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbi.2008.04.001_bib13","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ncl.2006.03.003","article-title":"Cytokine, sickness behavior, and depression","volume":"24","author":"Dantzer","year":"2006","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.bbi.2008.04.001_bib14","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2008.04.001_bib15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.bbr.2004.11.024","article-title":"Behavioral responses during the forced swim test are not affected by anti-inflammatory agents or acute illness induced by lipopolysaccharide","volume":"160","author":"Deak","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2008.04.001_bib16","doi-asserted-by":"crossref","first-page":"R926","DOI":"10.1152\/ajpregu.00694.2005","article-title":"Novel quantitative phenotypes of exercise training in mouse models","volume":"290","author":"De Bono","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbi.2008.04.001_bib17","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.neubiorev.2005.03.016","article-title":"Endotoxin- or pro-inflammatory cytokine-induced sickness behavior as an animal model of depression: focus on anhedonia","volume":"29","author":"De La Garza","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbi.2008.04.001_bib18","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.pbb.2005.04.019","article-title":"Effects of interleukin-1 and endotoxin in the forced swim and tail suspension tests in mice","volume":"81","author":"Dunn","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbi.2008.04.001_bib19","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.neubiorev.2005.03.023","article-title":"Cytokines as mediators of depression: what can we learn from animal studies?","volume":"29","author":"Dunn","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbi.2008.04.001_bib20","doi-asserted-by":"crossref","first-page":"6227","DOI":"10.1073\/pnas.1034823100","article-title":"Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression","volume":"100","author":"El Yacoubi","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbi.2008.04.001_bib21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.biopsych.2005.05.001","article-title":"Mood disorders in the medically ill: scientific review and recommendations","volume":"58","author":"Evans","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2008.04.001_bib22","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.psyneuen.2007.03.005","article-title":"Lipopolysaccharide induces delayed FosB\/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior","volume":"32","author":"Frenois","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbi.2008.04.001_bib23","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/jb\/mvj072","volume":"139","author":"Fujigaki","year":"2006","journal-title":"J. Biochem."},{"key":"10.1016\/j.bbi.2008.04.001_bib24","unstructured":"Godbout, J.P., Moreau, M., Lestage, J., Chen, J., Sparkman, N.L., Connor, J.O., Castanon, N., Kelley, K.W., Dantzer, R., Johnson, R.W., in press. Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system. Neuropsychopharmacology."},{"key":"10.1016\/j.bbi.2008.04.001_bib25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/glia.20090","article-title":"Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons","volume":"49","author":"Guillemin","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2008.04.001_bib26","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1038\/nm1669","article-title":"Antidepressant actions of the exercise-regulated gene VGF","volume":"13","author":"Hunsberger","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbi.2008.04.001_bib27","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1358\/mf.2001.23.8.662131","article-title":"Lipopolysaccharide-mediated immobility in mice: reversal by cyclooxygenase enzyme inhibitors","volume":"23","author":"Jain","year":"2001","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.bbi.2008.04.001_bib28","first-page":"975","article-title":"Time course and cellular localization of interleukin-10 mRNA and protein expression in autoimmune inflammation of the rat central nervous system","volume":"152","author":"Jander","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbi.2008.04.001_bib29","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0306-4522(03)00365-8","article-title":"Prolonged effects of polyriboinosinic:polyribocytidylic acid on spontaneous running wheel activity and brain interferon-alpha mRNA in rats: a model for immunologically induced fatigue","volume":"120","author":"Katafuchi","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2008.04.001_bib30","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bbr.2003.08.008","article-title":"Behavioral effects of infection with interferon-gamma adenovector","volume":"151","author":"Kwant","year":"2004","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2008.04.001_bib31","first-page":"324","article-title":"Decreased whole blood 5-hydroxytryptamine (serotonin) in AIDS patients","volume":"1","author":"Launay","year":"1988","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"10.1016\/j.bbi.2008.04.001_bib32","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S0889-1591(02)00014-4","article-title":"The enzyme indoleamine 2,3-dioxygenase is induced in the mouse brain in response to peripheral administration of lipopolysaccharide and superantigen","volume":"16","author":"Lestage","year":"2002","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2008.04.001_bib33","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/135245859800400104","article-title":"The cytokine storm in multiple sclerosis","volume":"4","author":"Link","year":"1998","journal-title":"Mult. Scler."},{"key":"10.1016\/j.bbi.2008.04.001_bib34","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0006-3223(00)01028-3","article-title":"Genetic differences in the tail-suspension test and its relationship to imipramine response among 11 inbred strains of mice","volume":"49","author":"Liu","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2008.04.001_bib35","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.tins.2004.08.001","article-title":"BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders","volume":"27","author":"Mattson","year":"2004","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbi.2008.04.001_bib36","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00213-002-1273-1","article-title":"Dissociating anorexia and anhedonia elicited by interleukin-1beta: antidepressant and gender effects on responding for \u201cfree chow\u201d and \u201cearned\u201d sucrose intake","volume":"165","author":"Merali","year":"2003","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbi.2008.04.001_bib37","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/BF02246218","article-title":"Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by imipramine","volume":"117","author":"Monleon","year":"1995","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbi.2008.04.001_bib38","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1086\/431603","article-title":"Bacille Calmette-Guerin inoculation induces chronic activation of peripheral and brain indoleamine 2,3-dioxygenase in mice","volume":"192","author":"Moreau","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bbi.2008.04.001_bib39","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/sj.mp.4002006","article-title":"The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression","volume":"12","author":"Muller","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2008.04.001_bib40","unstructured":"O\u2019Connor, J.C., Lawson, M.A., Andre, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K.W., Dantzer, R., in press. Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Mol. Psychiatry."},{"key":"10.1016\/j.bbi.2008.04.001_bib41","unstructured":"Ordway, D., Henao-Tamayo, M., Smith, E., Shanley, C., Harton, M., Troudt, J., Bai, X., Basaraba, R.J., Orme, I.M., Chan, E.D., in press. Animal model of Mycobacterium abscessus lung infection. J. Leukoc. Biol."},{"key":"10.1016\/j.bbi.2008.04.001_bib42","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1515\/REVNEURO.2000.11.1.53","article-title":"Animal models of depression: utility for transgenic research","volume":"11","author":"Porsolt","year":"2000","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.bbi.2008.04.001_bib43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bbi.2004.05.001","article-title":"Depressive symptoms and viral clearance in patients receiving interferon-alpha and ribavirin for hepatitis C","volume":"19","author":"Raison","year":"2005","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2008.04.001_bib44","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.it.2005.11.006","article-title":"Cytokines sing the blues: inflammation and the pathogenesis of depression","volume":"27","author":"Raison","year":"2006","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bbi.2008.04.001_bib45","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.bbi.2006.03.003","article-title":"Immunity and emotions: lipopolysaccharide increases defensive behaviours and potentiates despair in mice","volume":"20","author":"Renault","year":"2006","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2008.04.001_bib46","first-page":"512","article-title":"Sequential production of Th1 and Th2 cytokines in response to live Bacillus Calmette-Guerin","volume":"86","author":"Sander","year":"1995","journal-title":"Immunology"},{"key":"10.1016\/j.bbi.2008.04.001_bib47","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0024-3205(99)00430-0","article-title":"Differential effect of chronic antidepressant treatments on lipopolysaccharide-induced depressive-like behavioural symptoms in the rat","volume":"65","author":"Shen","year":"1999","journal-title":"Life Sci."},{"key":"10.1016\/j.bbi.2008.04.001_bib48","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbi.2008.04.001_bib49","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/978-1-4615-4709-9_68","article-title":"Interferon-gamma-dependent\/independent expression of indoleamine 2,3-dioxygenase. Studies with interferon-gamma-knockout mice","volume":"467","author":"Takikawa","year":"1999","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbi.2008.04.001_bib50","doi-asserted-by":"crossref","first-page":"5657","DOI":"10.1073\/pnas.96.10.5657","article-title":"Tumor necrosis factor alpha is a determinant of pathogenesis and disease progression in mycobacterial infection in the central nervous system","volume":"96","author":"Tsenova","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbi.2008.04.001_bib51","doi-asserted-by":"crossref","first-page":"6343","DOI":"10.4049\/jimmunol.169.11.6343","article-title":"In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL\/6 mice","volume":"169","author":"Turner","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2008.04.001_bib52","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/sj.mp.4001600","article-title":"IDO and interferon-alpha-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity","volume":"10","author":"Wichers","year":"2005","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2008.04.001_bib53","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.2174\/0929867033457179","article-title":"Interferon-gamma-induced conversion of tryptophan: immunologic and neuropsychiatric aspects","volume":"10","author":"Wirleitner","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbi.2008.04.001_bib54","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0006-8993(95)01415-2","article-title":"Endotoxin produces a depressive-like episode in rats","volume":"711","author":"Yirmiya","year":"1996","journal-title":"Brain Res."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159108000779?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159108000779?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:19:01Z","timestamp":1760167141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159108000779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":55,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0889159108000779"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2008.04.001","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2008.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}