{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:14:13Z","timestamp":1791245653631,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.bbi.2008.07.008","type":"journal-article","created":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T05:48:11Z","timestamp":1217569691000},"page":"1248-1256","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":158,"title":["Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia"],"prefix":"10.1016","volume":"22","author":[{"given":"Mark R.","family":"Hutchinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis L.","family":"Northcutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey W.","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Kearney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra L.","family":"Berkelhammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa C.","family":"Loram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"Rozeske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sondra T.","family":"Bland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven F.","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd T.","family":"Gleeson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda R.","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2008.07.008_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1055\/s-2008-1052538","article-title":"Chronic hypoventilation and development of brain stem gliosis","volume":"16","author":"Becker","year":"1985","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.bbi.2008.07.008_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1995.75.1.1","article-title":"Central control of breathing in mammals: neuronal circuitry, membrane properties, and neurotransmitters","volume":"75","author":"Bianchi","year":"1995","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbi.2008.07.008_bib3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00401-004-0895-2","article-title":"Glial and neuronal alterations in the nucleus tractus solitarii of sudden infant death syndrome victims","volume":"108","author":"Biondo","year":"2004","journal-title":"Acta Neuropathol. (Berl.)"},{"key":"10.1016\/j.bbi.2008.07.008_bib4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0014-2999(97)00177-5","article-title":"Arachidonic acid and its metabolites are involved in the expression of morphine dependence in guinea-pig isolated ileum","volume":"330","author":"Capasso","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbi.2008.07.008_bib5","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0304-3959(95)90018-7","article-title":"Avoiding fallacies in nociceptive measurements","volume":"63","author":"Carmody","year":"1995","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2008.07.008_bib6","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/S0022-3565(24)36668-6","article-title":"Activation of mu opioid receptors inhibits microglial cell chemotaxis","volume":"281","author":"Chao","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbi.2008.07.008_bib7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/glia.1070","article-title":"Characterization of a novel brain-derived microglial cell line isolated from neonatal rat brain","volume":"35","author":"Cheepsunthorn","year":"2001","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2008.07.008_bib8","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1038\/sj.npp.1301377","article-title":"Minocycline attenuates neuronal cell death and improves cognitive impairment in Alzheimer\u2019s disease models","volume":"32","author":"Choi","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2008.07.008_bib9","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bbi.2007.07.014","article-title":"A novel role of minocycline: attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia","volume":"22","author":"Cui","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2008.07.008_bib10","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.humimm.2006.05.002","article-title":"Association of sudden infant death syndrome with VEGF and IL-6 gene polymorphisms","volume":"67","author":"Dashash","year":"2006","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.bbi.2008.07.008_bib11","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1523\/JNEUROSCI.4371-06.2007","article-title":"Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid","volume":"27","author":"Fan","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2008.07.008_bib1a","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1111\/j.1471-4159.2006.03799.x","article-title":"Minocycline neuroprotects, reduces microgliosis, and inhibitors caspase protease expression early after spinal cord injury","volume":"97","author":"Festoff","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbi.2008.07.008_bib12","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1523\/JNEUROSCI.0003-06.2006","article-title":"Activated microglia contribute to the maintenance of chronic pain after spinal cord injury","volume":"26","author":"Hains","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2008.07.008_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia","volume":"32","author":"Hargreaves","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2008.07.008_bib14","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/sleep\/30.5.551","article-title":"Morphine-induced acetylcholine release at the hypoglossal motor nucleus: implications for opioid-induced respiratory suppression","volume":"30","author":"Horner","year":"2006","journal-title":"Sleep"},{"key":"10.1016\/j.bbi.2008.07.008_bib15","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1100\/tsw.2007.230","article-title":"Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence and reward","volume":"7","author":"Hutchinson","year":"2007","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.bbi.2008.07.008_bib16","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.bbi.2008.05.004","article-title":"Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia","volume":"22","author":"Hutchinson","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2008.07.008_bib17","doi-asserted-by":"crossref","first-page":"7353","DOI":"10.1523\/JNEUROSCI.1850-04.2004","article-title":"A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine","volume":"24","author":"Johnston","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2008.07.008_bib18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbr.2004.05.006","article-title":"Inhibition of morphine analgesia by LPS: role of opioid and NMDA receptors and spinal glia","volume":"156","author":"Johnston","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2008.07.008_bib19","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1517\/13543784.16.7.935","article-title":"Ibudilast (AV-411): a new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes","volume":"16","author":"Ledeboer","year":"2007","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.bbi.2008.07.008_bib20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.pain.2005.02.009","article-title":"Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation","volume":"115","author":"Ledeboer","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2008.07.008_bib21","article-title":"AV411, a blood brain barrier permeable glial activation inhibitor, reduces morphine withdrawal behaviors in rats","author":"Lewis","year":"2006","journal-title":"Proc. Soc. Neurosci."},{"key":"10.1016\/j.bbi.2008.07.008_bib22","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0304-3940(01)02324-2","article-title":"Minocycline blocks nitric oxide-induced neurotoxicity by inhibition p38 MAP kinase in rat cerebellar granule neurons","volume":"315","author":"Lin","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbi.2008.07.008_bib23","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1161\/01.STR.0000251791.64910.cd","article-title":"Chronic treatment with minocycline preserves adult new neurons and reduces functional impairment after focal cerebral ischemia","volume":"38","author":"Liu","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2008.07.008_bib24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00213-007-0955-0","article-title":"Improvement by minocycline of methamphetamine-induced impairment of recognition memory in mice","volume":"196","author":"Mizoguchi","year":"2008","journal-title":"Psychopharmacology (Berl)."},{"key":"10.1016\/j.bbi.2008.07.008_bib25","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1213\/01.ANE.0000184254.85567.80","article-title":"A novel molecule with peripheral opioids properties: the effects on hypercarbic and hypoxic ventilation at steady-state compared with morphine and placebo","volume":"102","author":"Modalen","year":"2006","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.bbi.2008.07.008_bib26","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.2165\/00003495-200666180-00005","article-title":"Patient-controlled analgesia in the management of postoperative pain","volume":"66","author":"Momeni","year":"2006","journal-title":"Drugs"},{"key":"10.1016\/j.bbi.2008.07.008_bib27","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.humimm.2006.07.010","article-title":"IL6 G-174C associated with sudden infant death syndrome in a Caucasian Australian cohort","volume":"67","author":"Moscovis","year":"2006","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.bbi.2008.07.008_bib28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbr.2004.05.029","article-title":"Effect of MS-153, a glutamate transporter activator, on the conditioned rewarding effects of morphine, methamphetamine and cocaine in mice","volume":"156","author":"Nakagawa","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2008.07.008_bib29","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1196\/annals.1307.047","article-title":"Involvement of glial glutamate transporters in morphine dependence","volume":"1025","author":"Nakagawa","year":"2004","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.bbi.2008.07.008_bib30","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1038\/sj.npp.1301007","article-title":"Direct evidence of astrocytic modulation in the development of rewarding effects induced by drugs of abuse","volume":"31","author":"Narita","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2008.07.008_bib31","doi-asserted-by":"crossref","first-page":"9980","DOI":"10.1523\/JNEUROSCI.22-22-09980.2002","article-title":"The role of spinal neuroimmune activation in morphine tolerance\/hyperalgesia in neuropathic and sham-operated rats","volume":"22","author":"Raghavendra","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2008.07.008_bib32","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1124\/jpet.103.052407","article-title":"Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy","volume":"306","author":"Raghavendra","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbi.2008.07.008_bib33","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0304-3959(03)00138-6","article-title":"Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines","volume":"104","author":"Raghavendra","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2008.07.008_bib34","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/sj.npp.1300315","article-title":"Attenuation of morphine tolerance, withdrawal-induced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats","volume":"29","author":"Raghavendra","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2008.07.008_bib35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/glia.20051","article-title":"Minocycline inhibits neuronal death and glial activation induced by beta-amyloid peptide in rat hippocampus","volume":"48","author":"Ryu","year":"2004","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2008.07.008_bib36","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.expneurol.2005.12.016","article-title":"Minocycline or iNOS inhibition block 3-nitrotyrosine increases and blood\u2013brain barrier leakiness in amyloid beta-peptide-injected rat hippocampus","volume":"198","author":"Ryu","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbi.2008.07.008_bib37","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pain.2005.02.003","article-title":"Interleukin-1 antagonizes morphine analgesia and underlies morphine tolerance","volume":"115","author":"Shavit","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2008.07.008_bib38","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1188\/07.CJON.293-296","article-title":"Opioid safety: is your patient at risk for respiratory depression?","volume":"11","author":"Smith","year":"2007","journal-title":"Clin. J. Oncol. Nurs."},{"key":"10.1016\/j.bbi.2008.07.008_bib39","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0168-0102(00)00226-1","article-title":"The involvement of glial cells in the development of morphine tolerance","volume":"39","author":"Song","year":"2001","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.bbi.2008.07.008_bib40","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/BF02190691","article-title":"Beta-endorphin immunoreactivity in spinal fluid and hypoxanthine in vitreous humour related to brain stem gliosis in sudden infant death victims","volume":"153","author":"Storm","year":"1994","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.bbi.2008.07.008_bib41","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neulet.2004.05.038","article-title":"Minocycline suppresses hypoxic activation of rodent microglia in culture","volume":"366","author":"Suk","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbi.2008.07.008_bib42","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/S0198-8859(00)00183-X","article-title":"Association of IL-10 genotype with sudden infant death syndrome","volume":"61","author":"Summers","year":"2000","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.bbi.2008.07.008_bib43","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/S0022-3565(24)29652-X","article-title":"Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain","volume":"297","author":"Sweitzer","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbi.2008.07.008_bib44","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1523\/JNEUROSCI.21-08-02580.2001","article-title":"Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia","volume":"21","author":"Tikka","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2008.07.008_bib45","doi-asserted-by":"crossref","first-page":"7527","DOI":"10.4049\/jimmunol.166.12.7527","article-title":"Minocycline provides neuroprotection against N-methyl-d-aspartate neurotoxicity by inhibiting microglia","volume":"166","author":"Tikka","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2008.07.008_bib46","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1002\/jnr.21325","article-title":"Neuroinflammation and regulation of glial glutamate uptake in neurological disorders","volume":"85","author":"Tilleux","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbi.2008.07.008_bib47","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0090-6980(99)00042-8","article-title":"Biochemical changes in prostanoids and cerebral expression of cyclooxygenase (COX)-1 and COX-2 during morphine sulfate infusion in the newborn piglet","volume":"58","author":"Tumbaga","year":"1999","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.bbi.2008.07.008_bib48","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1369-1600.2007.00070.x","article-title":"Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade","volume":"12","author":"Tzschentke","year":"2007","journal-title":"Addict. Biol."},{"key":"10.1016\/j.bbi.2008.07.008_bib49","first-page":"1958","article-title":"SIDS cases have increased levels of interleukin-6 in cerebropsinal fluid","volume":"65","author":"Vege","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.bbi.2008.07.008_bib50","doi-asserted-by":"crossref","first-page":"8692","DOI":"10.1523\/JNEUROSCI.23-25-08692.2003","article-title":"Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases","volume":"23","author":"Viviani","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2008.07.008_bib51","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbi.2006.10.011","article-title":"Glia as the \u201cbad guys\u201d: implications for improving clinical pain control and the clinical utility of opioids","volume":"21","author":"Watkins","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2008.07.008_bib52","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nrd1251","article-title":"Glia: a novel drug discovery target for clinical pain","volume":"2","author":"Watkins","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbi.2008.07.008_bib53","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1046\/j.1360-0443.1999.9479612.x","article-title":"Mechanisms of fatal opioid overdose","volume":"94","author":"White","year":"1999","journal-title":"Addiction"},{"key":"10.1016\/j.bbi.2008.07.008_bib54","doi-asserted-by":"crossref","first-page":"15769","DOI":"10.1073\/pnas.95.26.15769","article-title":"Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia","volume":"95","author":"Yrjanheikki","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159108003115?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159108003115?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:19:59Z","timestamp":1760167199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159108003115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":55,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0889159108003115"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2008.07.008","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2008.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}