{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:43:22Z","timestamp":1786985002762,"version":"build-2736575974"},"reference-count":55,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.bbi.2009.08.012","type":"journal-article","created":{"date-parts":[[2009,9,5]],"date-time":"2009-09-05T04:56:14Z","timestamp":1252126574000},"page":"784-791","source":"Crossref","is-referenced-by-count":17,"title":["Neuregulin-1, the fetal endothelium, and brain damage in preterm newborns"],"prefix":"10.1016","volume":"24","author":[{"given":"Insa","family":"Hoffmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Bueter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Zscheppang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Jantje","family":"Brinkhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Liese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Riemke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"D\u00f6rk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Dammann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane E.L.","family":"Dammann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bbi.2009.08.012_bib1","first-page":"231","article-title":"The gene expression profile of human umbilical vein endothelial cells stimulated with lipopolysaccharide using cDNA microarray analysis","volume":"12","author":"Ahn","year":"2003","journal-title":"Int. J. Mol. Med."},{"issue":"5","key":"10.1016\/j.bbi.2009.08.012_bib2","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.brainresbull.2006.02.017","article-title":"Localization of neuregulin-1alpha (heregulin-alpha) and one of its receptors, ErbB-4 tyrosine kinase, in developing and adult human brain","volume":"69","author":"Bernstein","year":"2006","journal-title":"Brain Res. Bull."},{"issue":"2","key":"10.1016\/j.bbi.2009.08.012_bib3","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/schbul\/sbj052","article-title":"Prenatal infection as a risk factor for schizophrenia","volume":"32","author":"Brown","year":"2006","journal-title":"Schizophr. Bull."},{"issue":"5\u20136","key":"10.1016\/j.bbi.2009.08.012_bib4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cyto.2007.02.002","article-title":"ErbB receptors in fetal endothelium-A potential linkage point for inflammation-associated neonatal disorders","volume":"36","author":"Bueter","year":"2006","journal-title":"Cytokine"},{"key":"10.1016\/j.bbi.2009.08.012_bib4a","doi-asserted-by":"crossref","DOI":"10.1203\/PDR.0b013e3181baa083","article-title":"Endoplasmic reticulum stress, inflammation, and perinatal brain damage","author":"Bueter","year":"2009","journal-title":"Pediatr. Res. [Epub ahead of print]"},{"issue":"6632","key":"10.1016\/j.bbi.2009.08.012_bib5","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/387512a0","article-title":"Neuregulin-2, a new ligand of ErbB3\/ErbB4-receptor tyrosine kinases","volume":"387","author":"Carraway","year":"1997","journal-title":"Nature"},{"issue":"1\u20133","key":"10.1016\/j.bbi.2009.08.012_bib6","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.schres.2007.12.474","article-title":"Elevated neuregulin-1 and ErbB4 protein in the prefrontal cortex of schizophrenic patients","volume":"100","author":"Chong","year":"2008","journal-title":"Schizophr. Res."},{"issue":"12","key":"10.1016\/j.bbi.2009.08.012_bib7","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1164\/rccm.200205-468OC","article-title":"Role of neuregulin-1 beta in the developing lung","volume":"167","author":"Dammann","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"10","key":"10.1016\/j.bbi.2009.08.012_bib8","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.placenta.2004.03.004","article-title":"Fetal vasculitis in preterm newborns: interrelationships, modifiers, and antecedents","volume":"25","author":"Dammann","year":"2004","journal-title":"Placenta"},{"issue":"5","key":"10.1016\/j.bbi.2009.08.012_bib9","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.earlhumdev.2008.12.010","article-title":"Immaturity, perinatal inflammation, and retinopathy of prematurity: a multi-hit hypothesis","volume":"85","author":"Dammann","year":"2009","journal-title":"Early Hum. Dev."},{"issue":"3","key":"10.1016\/j.bbi.2009.08.012_bib10","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000111119","article-title":"Neuregulin-1: a potential endogenous protector in perinatal brain white matter damage","volume":"93","author":"Dammann","year":"2007","journal-title":"Neonatology"},{"issue":"3 Pt 1","key":"10.1016\/j.bbi.2009.08.012_bib11","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1542\/peds.104.3.541","article-title":"Brain damage in preterm newborns: might enhancement of developmentally regulated endogenous protection open a door for prevention?","volume":"104","author":"Dammann","year":"1999","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.bbi.2009.08.012_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.earlhumdev.2004.04.009","article-title":"Inflammatory brain damage in preterm newborns \u2013 dry numbers, wet lab, and causal inferences","volume":"79","author":"Dammann","year":"2004","journal-title":"Early Hum. Dev."},{"issue":"Suppl. 1","key":"10.1016\/j.bbi.2009.08.012_bib13","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1471-0528.2005.00576.x","article-title":"Lung and brain damage in preterm newborns, and their association with gestational age, prematurity subgroup, infection\/inflammation and long term outcome","volume":"112","author":"Dammann","year":"2005","journal-title":"Bjog"},{"issue":"1","key":"10.1016\/j.bbi.2009.08.012_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/labinvest.3700366","article-title":"Lipopolysaccharide signaling in endothelial cells","volume":"86","author":"Dauphinee","year":"2006","journal-title":"Lab. Invest."},{"issue":"3","key":"10.1016\/j.bbi.2009.08.012_bib15","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/1098-1136(200012)32:3<304::AID-GLIA90>3.0.CO;2-Z","article-title":"Neuregulins and erbB receptor expression in adult human oligodendrocytes","volume":"32","author":"Deadwyler","year":"2000","journal-title":"Glia"},{"issue":"3","key":"10.1016\/j.bbi.2009.08.012_bib16","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1055\/s-2006-924554","article-title":"Interleukin-10 high producer allele and ultrasound-defined periventricular white matter abnormalities in preterm infants: a preliminary study","volume":"37","author":"Dordelmann","year":"2006","journal-title":"Neuropediatrics"},{"issue":"1\u20132","key":"10.1016\/j.bbi.2009.08.012_bib17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0165-0378(97)00065-X","article-title":"Pre-term labor: an intra-uterine inflammatory response syndrome?","volume":"36","author":"Dudley","year":"1997","journal-title":"J. Reprod. Immunol."},{"issue":"2","key":"10.1016\/j.bbi.2009.08.012_bib18","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.brainresrev.2005.11.006","article-title":"Neuregulins: versatile growth and differentiation factors in nervous system development and human disease","volume":"51","author":"Esper","year":"2006","journal-title":"Brain Res. Rev."},{"issue":"1","key":"10.1016\/j.bbi.2009.08.012_bib19","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0014-4827(02)00102-7","article-title":"Neuregulins: functions, forms, and signaling strategies","volume":"284","author":"Falls","year":"2003","journal-title":"Exp. Cell Res."},{"issue":"19","key":"10.1016\/j.bbi.2009.08.012_bib20","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1056\/NEJMra041996","article-title":"Neonatal brain injury","volume":"351","author":"Ferriero","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.bbi.2009.08.012_bib21","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1542\/peds.89.1.91","article-title":"The Denver II: a major revision and restandardization of the Denver Developmental Screening Test","volume":"89","author":"Frankenburg","year":"1992","journal-title":"Pediatrics"},{"issue":"6555","key":"10.1016\/j.bbi.2009.08.012_bib22","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/378390a0","article-title":"Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor","volume":"378","author":"Gassmann","year":"1995","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bbi.2009.08.012_bib23","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.mcn.2004.08.001","article-title":"Neuregulin-1beta induces neurite extension and arborization in cultured hippocampal neurons","volume":"27","author":"Gerecke","year":"2004","journal-title":"Mol. Cell Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.bbi.2009.08.012_bib24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11010-007-9541-3","article-title":"Heregulin protects mesenchymal stem cells from serum deprivation and hypoxia-induced apoptosis","volume":"305","author":"Gui","year":"2007","journal-title":"Mol. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.bbi.2009.08.012_bib25","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s00406-007-0756-9","article-title":"Interleukin-1 beta gene polymorphism and its interactions with neuregulin-1 gene polymorphism are associated with schizophrenia","volume":"258","author":"Hanninen","year":"2007","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"issue":"4","key":"10.1016\/j.bbi.2009.08.012_bib26","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.neuroimage.2008.05.058","article-title":"Genetic variation in the schizophrenia-risk gene neuregulin1 correlates with differences in frontal brain activation in a working memory task in healthy individuals","volume":"42","author":"Krug","year":"2008","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.bbi.2009.08.012_bib27","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1056\/NEJM199401203300308","article-title":"Cerebral palsy","volume":"330","author":"Kuban","year":"1994","journal-title":"N. Engl. J. Med."},{"issue":"12","key":"10.1016\/j.bbi.2009.08.012_bib28","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1093\/hmg\/ddl122","article-title":"Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia","volume":"15","author":"Li","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbi.2009.08.012_bib29","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.brainres.2007.09.037","article-title":"Neuroprotection by neuregulin-1 in a rat model of permanent focal cerebral ischemia","volume":"1184","author":"Li","year":"2007","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.bbi.2009.08.012_bib30","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.expneurol.2006.01.010","article-title":"Progressive dopamine neuron loss following supra-nigral lipopolysaccharide (LPS) infusion into rats exposed to LPS prenatally","volume":"199","author":"Ling","year":"2006","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.bbi.2009.08.012_bib31","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/jcbfm.2008.94","article-title":"Neuregulin-1 signaling in brain endothelial cells","volume":"29","author":"Lok","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"12","key":"10.1016\/j.bbi.2009.08.012_bib32","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1089\/neu.2007.0372","article-title":"Effect of neuregulin-1 on histopathological and functional outcome after controlled cortical impact in mice","volume":"24","author":"Lok","year":"2007","journal-title":"J. Neurotrauma"},{"issue":"5","key":"10.1016\/j.bbi.2009.08.012_bib33","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1159\/000095162","article-title":"Lipopolysaccharide and TNF-alpha produce very similar changes in gene expression in human endothelial cells","volume":"43","author":"Magder","year":"2006","journal-title":"J. Vasc. Res."},{"issue":"6555","key":"10.1016\/j.bbi.2009.08.012_bib34","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/378386a0","article-title":"Multiple essential functions of neuregulin in development","volume":"378","author":"Meyer","year":"1995","journal-title":"Nature"},{"issue":"18","key":"10.1016\/j.bbi.2009.08.012_bib35","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1242\/dev.124.18.3575","article-title":"Isoform-specific expression and function of neuregulin","volume":"124","author":"Meyer","year":"1997","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.bbi.2009.08.012_bib36","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/01.yco.0000214341.52249.59","article-title":"An update on the genetics of schizophrenia","volume":"19","author":"Norton","year":"2006","journal-title":"Curr. Opin. Psychiatry"},{"issue":"2","key":"10.1016\/j.bbi.2009.08.012_bib37","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.yexcr.2004.01.014","article-title":"Enaptin, a giant actin-binding protein, is an element of the nuclear membrane and the actin cytoskeleton","volume":"295","author":"Padmakumar","year":"2004","journal-title":"Exp. Cell Res."},{"issue":"11","key":"10.1016\/j.bbi.2009.08.012_bib38","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1002\/glia.20530","article-title":"IGF-1 protects oligodendrocyte progenitors against TNFalpha-induced damage by activation of PI3K\/Akt and interruption of the mitochondrial apoptotic pathway","volume":"55","author":"Pang","year":"2007","journal-title":"Glia"},{"issue":"6680","key":"10.1016\/j.bbi.2009.08.012_bib39","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/30012","article-title":"Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells","volume":"393","author":"Qiu","year":"1998","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbi.2009.08.012_bib40","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1055\/s-2006-956773","article-title":"The role of inflammation and infection in preterm birth","volume":"25","author":"Romero","year":"2007","journal-title":"Semin. Reprod. Med."},{"issue":"5","key":"10.1016\/j.bbi.2009.08.012_bib41","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.siny.2006.05.001","article-title":"Inflammation in preterm and term labour and delivery","volume":"11","author":"Romero","year":"2006","journal-title":"Semin. Fetal Neonatal Med."},{"issue":"5","key":"10.1016\/j.bbi.2009.08.012_bib41a","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.molmed.2009.03.004","article-title":"Regulation of the aging process by autophagy","volume":"15","author":"Salminen","year":"2009","journal-title":"Trends. Mol. Med."},{"key":"10.1016\/j.bbi.2009.08.012_bib42","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.brainres.2008.07.106","article-title":"Prenatal inflammatory effects on nigrostriatal development in organotypic cultures","volume":"1233","author":"Snyder-Keller","year":"2008","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.bbi.2009.08.012_bib43","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1086\/345442","article-title":"Association of neuregulin 1 with schizophrenia confirmed in a Scottish population","volume":"72","author":"Stefansson","year":"2003","journal-title":"Am. J. Hum. Genet."},{"issue":"4","key":"10.1016\/j.bbi.2009.08.012_bib44","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1086\/342734","article-title":"Neuregulin 1 and susceptibility to schizophrenia","volume":"71","author":"Stefansson","year":"2002","journal-title":"Am. J. Hum. Genet."},{"issue":"3","key":"10.1016\/j.bbi.2009.08.012_bib45","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.pcl.2009.03.005","article-title":"Neurodevelopmental outcome of the premature infant","volume":"56","author":"Stephens","year":"2009","journal-title":"Pediatr. Clin. North Am."},{"issue":"24","key":"10.1016\/j.bbi.2009.08.012_bib46","doi-asserted-by":"crossref","first-page":"5757","DOI":"10.1523\/JNEUROSCI.4748-04.2005","article-title":"The ErbB4 neuregulin receptor mediates suppression of oligodendrocyte maturation","volume":"25","author":"Sussman","year":"2005","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.bbi.2009.08.012_bib47","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1055\/s-2007-1023283","article-title":"Analysis of a 1992 birth sample in Germany. 1: new percentile values of the body weight of newborn infants","volume":"56","author":"Voigt","year":"1996","journal-title":"Geburtshilfe Frauenheilkd"},{"issue":"3","key":"10.1016\/j.bbi.2009.08.012_bib48","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1128\/MCB.14.3.1909","article-title":"Structural and functional aspects of the multiplicity of Neu differentiation factors","volume":"14","author":"Wen","year":"1994","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.bbi.2009.08.012_bib49","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.neuroimage.2007.12.041","article-title":"Association of 5\u2019 end neuregulin-1 (NRG1) gene variation with subcortical medial frontal microstructure in humans","volume":"40","author":"Winterer","year":"2008","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.bbi.2009.08.012_bib50","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.nbd.2005.01.027","article-title":"Neuroprotection by neuregulin-1 following focal stroke is associated with the attenuation of ischemia-induced pro-inflammatory and stress gene expression","volume":"19","author":"Xu","year":"2005","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.bbi.2009.08.012_bib51","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.bbrc.2004.07.149","article-title":"Neuregulin-1 is neuroprotective and attenuates inflammatory responses induced by ischemic stroke","volume":"322","author":"Xu","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"18","key":"10.1016\/j.bbi.2009.08.012_bib52","doi-asserted-by":"crossref","first-page":"9562","DOI":"10.1073\/pnas.94.18.9562","article-title":"Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4","volume":"94","author":"Zhang","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"17","key":"10.1016\/j.bbi.2009.08.012_bib53","doi-asserted-by":"crossref","first-page":"10261","DOI":"10.1074\/jbc.273.17.10261","article-title":"Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes","volume":"273","author":"Zhao","year":"1998","journal-title":"J. Biol. Chem."}],"updated-by":[{"DOI":"10.1016\/j.bbi.2011.03.011","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000}}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159109003973?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159109003973?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T12:37:50Z","timestamp":1685104670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159109003973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0889159109003973"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2009.08.012","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}